US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
US5580737A
(en)
|
1990-06-11 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
|
US6872816B1
(en)
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
US7150982B2
(en)
|
1991-09-09 |
2006-12-19 |
Third Wave Technologies, Inc. |
RNA detection assays
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
US5651981A
(en)
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
USRE45721E1
(en)
|
1994-08-20 |
2015-10-06 |
Gendaq, Ltd. |
Relating to binding proteins for recognition of DNA
|
US5767099A
(en)
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
US5725493A
(en)
|
1994-12-12 |
1998-03-10 |
Avery; Robert Logan |
Intravitreal medicine delivery
|
US6057153A
(en)
|
1995-01-13 |
2000-05-02 |
Yale University |
Stabilized external guide sequences
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
US5851548A
(en)
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
US6299895B1
(en)
|
1997-03-24 |
2001-10-09 |
Neurotech S.A. |
Device and method for treating ophthalmic diseases
|
US6203986B1
(en)
|
1998-10-22 |
2001-03-20 |
Robert H. Singer |
Visualization of RNA in living cells
|
PT1129064E
(pt)
|
1998-11-12 |
2008-01-31 |
Invitrogen Corp |
Reagentes de transfecção
|
EP1154691A4
(en)
|
1999-01-05 |
2004-07-07 |
Massachusetts Eye & Ear Infirm |
TARGETED ADMINISTRATION OF REGULATED RELEASE MEDICINE TO RETINA AND CHOROID THROUGH SCLEROTIC
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
US20090130718A1
(en)
|
1999-02-04 |
2009-05-21 |
Diversa Corporation |
Gene site saturation mutagenesis
|
US20020164575A1
(en)
|
1999-09-14 |
2002-11-07 |
Sangamo Biosciences, Inc., A Delaware Corporation |
Gene identification
|
US6416777B1
(en)
|
1999-10-21 |
2002-07-09 |
Alcon Universal Ltd. |
Ophthalmic drug delivery device
|
ES2231257T3
(es)
|
1999-10-21 |
2005-05-16 |
Alcon Inc. |
Dispositivo para la administracion de farmacos.
|
ATE309536T1
(de)
|
1999-12-06 |
2005-11-15 |
Sangamo Biosciences Inc |
Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
|
US6852530B2
(en)
|
2000-04-12 |
2005-02-08 |
Dana Farber Cancer Institute, Inc. |
Self-extinguishing recombinases, nucleic acids encoding them and methods of using the same
|
AU2001257331A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
AU5391401A
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences Inc |
Targeted modification of chromatin structure
|
US7563255B2
(en)
|
2001-05-03 |
2009-07-21 |
Massachusetts Eye And Ear Infirmary |
Implantable drug delivery device and use thereof
|
AU2003219847A1
(en)
|
2002-02-21 |
2003-09-09 |
The Wistar Institute Of Anatomy And Biology |
Methods and compositions for reversibly controlling expression of target genes in cells
|
US20070020627A1
(en)
|
2002-06-11 |
2007-01-25 |
The Scripps Research Institute |
Artificial transcription factors
|
EP1546170A4
(en)
|
2002-09-20 |
2007-08-29 |
Univ Yale |
RIBOSWITCHS, METHODS OF USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES
|
AU2003304086A1
(en)
|
2002-10-23 |
2004-11-26 |
Massachussetts Institute Of Technlogy |
Context sensitive parallel optimization of zinc finger dna binding domains
|
US7021555B2
(en)
|
2004-01-06 |
2006-04-04 |
Zoo Med Laboratories, Inc. |
Spraying/misting for plants and animals
|
WO2005070948A1
(en)
|
2004-01-23 |
2005-08-04 |
Intronn, Inc. |
Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated rna trans splicing
|
US7919277B2
(en)
|
2004-04-28 |
2011-04-05 |
Danisco A/S |
Detection and typing of bacterial strains
|
WO2006002547A1
(en)
|
2004-07-06 |
2006-01-12 |
UNIVERSITé DE SHERBROOKE |
A target-dependent nucleic acid adapter
|
WO2006023207A2
(en)
|
2004-08-19 |
2006-03-02 |
The United States Of America As Represented By The Secretary Of Health And Human Services, Nih |
Coacervate of anionic and cationic polymer forming microparticles for the sustained release of therapeutic agents
|
JP5101288B2
(ja)
|
2004-10-05 |
2012-12-19 |
カリフォルニア インスティテュート オブ テクノロジー |
アプタマー調節される核酸及びその利用
|
JP2008529558A
(ja)
|
2005-02-18 |
2008-08-07 |
ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド |
髄膜炎/敗血症に関連する大腸菌由来のタンパク質および核酸
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
US20100055793A1
(en)
|
2005-07-25 |
2010-03-04 |
Johns Hopkins University |
Site-specific modification of the human genome using custom-designed zinc finger nucleases
|
WO2007014275A2
(en)
|
2005-07-26 |
2007-02-01 |
Sangamo Biosciences, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
DK2341149T3
(en)
|
2005-08-26 |
2017-02-27 |
Dupont Nutrition Biosci Aps |
Use of CRISPR-associated genes (Cas)
|
AU2012244264B2
(en)
|
2005-08-26 |
2015-08-06 |
Dupont Nutrition Biosciences Aps |
Use
|
WO2007106690A2
(en)
|
2006-03-15 |
2007-09-20 |
Siemens Healthcare Diagnostics Inc. |
Degenerate nucleobase analogs
|
DK2018441T3
(da)
|
2006-05-19 |
2012-01-02 |
Danisco |
Mærkede mikroorganismer og fremgangsmåde til mærkning
|
AU2007267887B2
(en)
|
2006-05-25 |
2013-05-30 |
Sangamo Therapeutics, Inc. |
Variant Foki Cleavage Half-Domains
|
US9150626B2
(en)
|
2006-06-02 |
2015-10-06 |
President And Fellows Of Harvard College |
Protein surface remodeling
|
EP2034848B1
(en)
|
2006-06-16 |
2016-10-19 |
DuPont Nutrition Biosciences ApS |
Streptococcus thermophilus bacterium
|
US9201063B2
(en)
|
2006-11-16 |
2015-12-01 |
General Electric Company |
Sequential analysis of biological samples
|
NZ579002A
(en)
|
2007-03-02 |
2012-03-30 |
Danisco |
Cultures with improved phage resistance
|
WO2008118394A1
(en)
|
2007-03-23 |
2008-10-02 |
New York University |
Methods of affecting nitrogen assimilation in plants
|
WO2008122314A1
(de)
|
2007-04-10 |
2008-10-16 |
Qiagen Gmbh |
Rna-interferenz tags
|
WO2008151032A2
(en)
|
2007-05-31 |
2008-12-11 |
Washington University In St. Louis |
Arrays and methods comprising m. smithii gene products
|
AR068552A1
(es)
|
2007-09-25 |
2009-11-18 |
Pastoral Greenhouse Gas Res Lt |
Polipeptidos y polinucleotidos del fago omegamru y sus usos para detectar, apuntar e inhibir celulas microbianas metanogenicas
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
FR2925918A1
(fr)
|
2007-12-28 |
2009-07-03 |
Pasteur Institut |
Typage et sous-typage moleculaire de salmonella par identification des sequences nucleotidiques variables des loci crispr
|
WO2009146179A1
(en)
|
2008-04-15 |
2009-12-03 |
University Of Iowa Research Foundation |
Zinc finger nuclease for the cftr gene and methods of use thereof
|
CA2725601A1
(en)
|
2008-04-28 |
2009-11-05 |
President And Fellows Of Harvard College |
Supercharged proteins for cell penetration
|
JP2010017179A
(ja)
|
2008-06-11 |
2010-01-28 |
Sumitomo Chemical Co Ltd |
Dnaを定量又は検出する方法
|
JP2010017178A
(ja)
|
2008-06-11 |
2010-01-28 |
Sumitomo Chemical Co Ltd |
Dnaを定量又は検出する方法
|
US8546553B2
(en)
|
2008-07-25 |
2013-10-01 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic RNAi-like system and methods of use
|
JP2010068800A
(ja)
|
2008-08-19 |
2010-04-02 |
Sumitomo Chemical Co Ltd |
Dnaを定量又は検出する方法
|
JP2010048566A
(ja)
|
2008-08-19 |
2010-03-04 |
Sumitomo Chemical Co Ltd |
Dnaを定量又は検出する方法
|
EP2159286A1
(en)
|
2008-09-01 |
2010-03-03 |
Consiglio Nazionale Delle Ricerche |
Method for obtaining oligonucleotide aptamers and uses thereof
|
WO2010026537A1
(en)
|
2008-09-05 |
2010-03-11 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Novel multimodular assembly useful for intracellular delivery
|
US8636884B2
(en)
|
2008-09-15 |
2014-01-28 |
Abbott Diabetes Care Inc. |
Cationic polymer based wired enzyme formulations for use in analyte sensors
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
US9115386B2
(en)
|
2008-09-26 |
2015-08-25 |
Children's Medical Center Corporation |
Selective oxidation of 5-methylcytosine by TET-family proteins
|
WO2010046648A2
(en)
|
2008-10-21 |
2010-04-29 |
Animal Health Trust |
Diagnostic test for streptococcus equi
|
US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
EP2362915B1
(en)
|
2008-11-07 |
2016-12-21 |
DuPont Nutrition Biosciences ApS |
Bifidobacteria crispr sequences
|
US9133467B2
(en)
|
2008-11-10 |
2015-09-15 |
Two Blades Foundation |
Pathogen-inducible promoters and their use in enhancing the disease resistance of plants
|
CA2852487C
(en)
|
2008-11-11 |
2017-01-31 |
Alimentary Health Limited |
Bifidobacterium longum strain ah1714
|
GB2466177A
(en)
|
2008-12-03 |
2010-06-16 |
Arab Science & Technology Found |
Bacteriophage selection and breeding
|
US20110016540A1
(en)
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
US9175338B2
(en)
|
2008-12-11 |
2015-11-03 |
Pacific Biosciences Of California, Inc. |
Methods for identifying nucleic acid modifications
|
CN102317473A
(zh)
|
2008-12-11 |
2012-01-11 |
加利福尼亚太平洋生物科学股份有限公司 |
核酸模板的分类
|
ES2499032T3
(es)
|
2008-12-12 |
2014-09-26 |
Dupont Nutrition Biosciences Aps |
Grupo genético de cepas de Streptococcus thermophilus que tiene propiedades reológicas únicas para fermentación láctica
|
WO2010075424A2
(en)
|
2008-12-22 |
2010-07-01 |
The Regents Of University Of California |
Compositions and methods for downregulating prokaryotic genes
|
US8389679B2
(en)
|
2009-02-05 |
2013-03-05 |
The Regents Of The University Of California |
Targeted antimicrobial moieties
|
KR20100093626A
(ko)
|
2009-02-17 |
2010-08-26 |
서강대학교산학협력단 |
슈도모나스 애루지노사에 대한 파아지 치료
|
CN102421897B
(zh)
|
2009-03-06 |
2015-12-16 |
合成基因组股份有限公司 |
用于克隆和操作基因组的方法
|
WO2010129019A2
(en)
|
2009-04-27 |
2010-11-11 |
Pacific Biosciences Of California, Inc. |
Real-time sequencing methods and systems
|
JP2012525146A
(ja)
|
2009-04-28 |
2012-10-22 |
プレジデント アンド フェロウズ オブ ハーバード カレッジ |
細胞透過のための過剰に荷電されたタンパク質
|
WO2010132092A2
(en)
|
2009-05-12 |
2010-11-18 |
The Scripps Research Institute |
Cytidine deaminase fusions and related methods
|
US9063156B2
(en)
|
2009-06-12 |
2015-06-23 |
Pacific Biosciences Of California, Inc. |
Real-time analytical methods and systems
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
EP2287323A1
(en)
|
2009-07-31 |
2011-02-23 |
Association Institut de Myologie |
Widespread gene delivery to the retina using systemic administration of AAV vectors
|
US20120178647A1
(en)
|
2009-08-03 |
2012-07-12 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
AU2010279572B2
(en)
|
2009-08-03 |
2017-02-02 |
Recombinetics, Inc. |
Methods and compositions for targeted gene modification
|
GB0913681D0
(en)
|
2009-08-05 |
2009-09-16 |
Glaxosmithkline Biolog Sa |
Immunogenic composition
|
US8889394B2
(en)
|
2009-09-07 |
2014-11-18 |
Empire Technology Development Llc |
Multiple domain proteins
|
CA2773879A1
(en)
|
2009-09-25 |
2011-03-31 |
Basf Plant Science Company Gmbh |
Plants having enhanced yield-related traits and a method for making the same
|
US9677125B2
(en)
|
2009-10-21 |
2017-06-13 |
General Electric Company |
Detection of plurality of targets in biological samples
|
US20110269119A1
(en)
|
2009-10-30 |
2011-11-03 |
Synthetic Genomics, Inc. |
Encoding text into nucleic acid sequences
|
MX2012005069A
(es)
|
2009-10-30 |
2012-07-17 |
Synthetic Genomics Inc |
Codificar texto hacia secuencias de acido nucleico.
|
SG10201406801XA
(en)
|
2009-11-02 |
2014-11-27 |
Univ Washington |
Therapeutic nuclease compositions and methods
|
US20120315670A1
(en)
|
2009-11-02 |
2012-12-13 |
Gen9, Inc. |
Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell
|
US20110104787A1
(en)
|
2009-11-05 |
2011-05-05 |
President And Fellows Of Harvard College |
Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
|
US20110142886A1
(en)
|
2009-12-01 |
2011-06-16 |
Intezyne Technologies, Incorporated |
Pegylated polyplexes for polynucleotide delivery
|
RU2495468C1
(ru)
|
2010-02-05 |
2013-10-10 |
Кэнон Кабусики Кайся |
Негативная фоточувствительная полимерная композиция, способ формирования паттерна и головка для выбрасывания жидкости
|
PT2534173T
(pt)
|
2010-02-08 |
2019-10-31 |
Sangamo Therapeutics Inc |
Semidomínios de clivagem manipulados
|
US20120027786A1
(en)
|
2010-02-23 |
2012-02-02 |
Massachusetts Institute Of Technology |
Genetically programmable pathogen sense and destroy
|
JP2013520989A
(ja)
|
2010-03-05 |
2013-06-10 |
シンセティック ジェノミクス インコーポレーテッド |
ゲノムのクローニングおよび操作のための方法
|
US10087431B2
(en)
|
2010-03-10 |
2018-10-02 |
The Regents Of The University Of California |
Methods of generating nucleic acid fragments
|
US10645934B2
(en)
|
2010-03-12 |
2020-05-12 |
Brookhaven Science Associates/Brookhaven National Laboratory |
Enterobacter sp-638 and methods of use thereof
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
EP2569425B1
(en)
|
2010-05-10 |
2016-07-06 |
The Regents of The University of California |
Endoribonuclease compositions and methods of use thereof
|
CN103025344B
(zh)
|
2010-05-17 |
2016-06-29 |
桑格摩生物科学股份有限公司 |
新型dna-结合蛋白及其用途
|
GB201008267D0
(en)
|
2010-05-18 |
2010-06-30 |
Univ Edinburgh |
Cationic lipids
|
WO2011146862A1
(en)
|
2010-05-21 |
2011-11-24 |
Bellicum Pharmaceuticals, Inc. |
Methods for inducing selective apoptosis
|
JP5957646B2
(ja)
|
2010-06-04 |
2016-07-27 |
サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. |
オリゴヌクレオチド送達のための新規な低分子量カチオン性脂質
|
EP2580331A4
(en)
|
2010-06-14 |
2013-11-27 |
Univ Iowa State Res Found Inc |
NUCLEASE ACTIVITY OF THE TAL EFFECTOR AND FUSION PROTEIN FOKI
|
WO2012031205A2
(en)
|
2010-09-03 |
2012-03-08 |
The Brigham And Women's Hospital, Inc. |
Lipid-polymer hybrid particles
|
AU2011305572B2
(en)
|
2010-09-20 |
2016-08-04 |
Diane Goll |
Microencapsulation process and product
|
AU2011316980A1
(en)
|
2010-10-20 |
2013-04-18 |
Dupont Nutrition Biosciences Aps |
Lactococcus CRISPR-Cas sequences
|
CN103327970A
(zh)
|
2010-11-26 |
2013-09-25 |
约翰内斯堡威特沃特斯兰德大学 |
聚合物-脂质纳米粒子的聚合基质作为药物剂型
|
KR101255338B1
(ko)
|
2010-12-15 |
2013-04-16 |
포항공과대학교 산학협력단 |
표적 세포에 대한 폴리뉴클레오티드 전달체
|
JP6143675B2
(ja)
|
2010-12-16 |
2017-06-07 |
セルジーン コーポレイション |
難溶性薬物の制御放出経口剤形及びその使用
|
EP2663654A1
(en)
|
2011-01-14 |
2013-11-20 |
Life Technologies Corporation |
Methods, compositions, and kits for detecting rare cells
|
US9499592B2
(en)
|
2011-01-26 |
2016-11-22 |
President And Fellows Of Harvard College |
Transcription activator-like effectors
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
WO2012125445A2
(en)
|
2011-03-11 |
2012-09-20 |
President And Fellows Of Harvard College |
Small molecule-dependent inteins and uses thereof
|
US8709466B2
(en)
|
2011-03-31 |
2014-04-29 |
International Business Machines Corporation |
Cationic polymers for antimicrobial applications and delivery of bioactive materials
|
EP2694091B1
(en)
|
2011-04-05 |
2019-03-13 |
Cellectis |
Method for the generation of compact tale-nucleases and uses thereof
|
WO2012148953A1
(en)
|
2011-04-25 |
2012-11-01 |
Stc.Unm |
Solid compositions for pharmaceutical use
|
WO2012158985A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms
|
WO2012158986A2
(en)
|
2011-05-17 |
2012-11-22 |
Transposagen Biopharmaceuticals, Inc. |
Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
AU2011369769B2
(en)
|
2011-05-30 |
2015-09-03 |
The University Of Tokyo |
High-strength polypropylene fiber and method for producing same
|
US20140113376A1
(en)
|
2011-06-01 |
2014-04-24 |
Rotem Sorek |
Compositions and methods for downregulating prokaryotic genes
|
EP3378938A1
(en)
|
2011-06-10 |
2018-09-26 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
Methods for the treatment of leber congenital amaurosis
|
EP2543255B2
(en)
|
2011-07-04 |
2022-12-28 |
DSM IP Assets B.V. |
Anti-listerial mixed culture and method for producing cheese
|
WO2013012674A1
(en)
|
2011-07-15 |
2013-01-24 |
The General Hospital Corporation |
Methods of transcription activator like effector assembly
|
EP2734622B1
(en)
|
2011-07-19 |
2018-09-05 |
Vivoscript, Inc. |
Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
EP2591770B1
(en)
|
2011-11-14 |
2016-03-16 |
Silenseed Ltd |
Compositions for siRNA delivery and methods of manufacturing and using same
|
US8450107B1
(en)
|
2011-11-30 |
2013-05-28 |
The Broad Institute Inc. |
Nucleotide-specific recognition sequences for designer TAL effectors
|
LT2791160T
(lt)
|
2011-12-16 |
2022-06-10 |
Modernatx, Inc. |
Modifikuotos mrnr sudėtys
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
NZ630900A
(en)
|
2012-02-24 |
2016-10-28 |
Hutchinson Fred Cancer Res |
Compositions and methods for the treatment of hemoglobinopathies
|
CN104204225A
(zh)
|
2012-02-29 |
2014-12-10 |
桑格摩生物科学股份有限公司 |
治疗亨廷顿氏病的方法和组合物
|
SG11201405783VA
(en)
|
2012-03-17 |
2014-10-30 |
Univ California |
Fast diagnosis and personalized treatments for acne
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
US11518997B2
(en)
|
2012-04-23 |
2022-12-06 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome engineering in plants
|
RU2658437C2
(ru)
|
2012-05-02 |
2018-06-21 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Направленная модификация малатдегидрогеназы
|
CA2871524C
(en)
|
2012-05-07 |
2021-07-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease-mediated targeted integration of transgenes
|
WO2013169398A2
(en)
|
2012-05-09 |
2013-11-14 |
Georgia Tech Research Corporation |
Systems and methods for improving nuclease specificity and activity
|
BR112014029417B1
(pt)
|
2012-05-25 |
2023-03-07 |
Cellectis |
Método ex vivo para a preparação de células t para imunoterapia
|
US20150017136A1
(en)
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
WO2014184143A1
(en)
|
2013-05-13 |
2014-11-20 |
Cellectis |
Cd19 specific chimeric antigen receptor and uses thereof
|
DK3241902T3
(en)
|
2012-05-25 |
2018-05-07 |
Univ California |
METHODS AND COMPOSITIONS FOR RNA DIRECTIVE TARGET DNA MODIFICATION AND FOR RNA DIRECTIVE MODULATION OF TRANSCRIPTION
|
US20140056868A1
(en)
|
2012-05-30 |
2014-02-27 |
University of Washington Center for Commercialization |
Supercoiled MiniVectors as a Tool for DNA Repair, Alteration and Replacement
|
WO2013188037A2
(en)
|
2012-06-11 |
2013-12-19 |
Agilent Technologies, Inc |
Method of adaptor-dimer subtraction using a crispr cas6 protein
|
BR112014031080A2
(pt)
|
2012-06-12 |
2018-05-08 |
Genentech Inc |
métodos e composições de geração de alelos knock-out condicionais.
|
EP2674501A1
(en)
|
2012-06-14 |
2013-12-18 |
Agence nationale de sécurité sanitaire de l'alimentation,de l'environnement et du travail |
Method for detecting and identifying enterohemorrhagic Escherichia coli
|
US9688971B2
(en)
|
2012-06-15 |
2017-06-27 |
The Regents Of The University Of California |
Endoribonuclease and methods of use thereof
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
AU2013282323B2
(en)
|
2012-06-29 |
2018-05-10 |
Massachusetts Institute Of Technology |
Massively parallel combinatorial genetics
|
DK3196301T3
(en)
|
2012-07-11 |
2019-01-14 |
Sangamo Therapeutics Inc |
METHODS AND COMPOSITIONS FOR TREATING MONOGENIC DISEASES
|
JP6329537B2
(ja)
|
2012-07-11 |
2018-05-23 |
サンガモ セラピューティクス, インコーポレイテッド |
生物学的薬剤の送達のための方法および組成物
|
EP3494997B1
(en)
|
2012-07-25 |
2019-09-18 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
US10058078B2
(en)
|
2012-07-31 |
2018-08-28 |
Recombinetics, Inc. |
Production of FMDV-resistant livestock by allele substitution
|
JP6340366B2
(ja)
|
2012-07-31 |
2018-06-06 |
イェダ リサーチ アンド デベロップメント カンパニー リミテッド |
運動ニューロン疾患を診断および処置する方法
|
EP2880171B1
(en)
|
2012-08-03 |
2018-10-03 |
The Regents of The University of California |
Methods and compositions for controlling gene expression by rna processing
|
DK2890780T3
(da)
|
2012-08-29 |
2020-09-21 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand
|
CA2883502C
(en)
|
2012-09-04 |
2021-05-04 |
Cellectis |
Multi-chain chimeric antigen receptor and uses thereof
|
WO2014039513A2
(en)
|
2012-09-04 |
2014-03-13 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
|
RU2665811C2
(ru)
|
2012-09-07 |
2018-09-04 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Локусы fad3 для выполнения операций и соответствующие связывающиеся со специфическими сайтами-мишенями белки, способные к вызову направленных разрывов
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
US20140075593A1
(en)
|
2012-09-07 |
2014-03-13 |
Dow Agrosciences Llc |
Fluorescence activated cell sorting (facs) enrichment to generate plants
|
WO2014043143A1
(en)
|
2012-09-11 |
2014-03-20 |
Life Technologies Corporation |
Nucleic acid amplification
|
GB201216564D0
(en)
|
2012-09-17 |
2012-10-31 |
Univ Edinburgh |
Genetically edited animal
|
US10612053B2
(en)
|
2012-09-18 |
2020-04-07 |
The Translational Genomics Research Institute |
Isolated genes and transgenic organisms for producing biofuels
|
WO2014059173A2
(en)
|
2012-10-10 |
2014-04-17 |
Sangamo Biosciences, Inc. |
T cell modifying compounds and uses thereof
|
US20150267176A1
(en)
|
2012-10-12 |
2015-09-24 |
The General Hospital Corporation |
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
|
CA3233048A1
(en)
|
2012-10-23 |
2014-05-01 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
US20140115728A1
(en)
|
2012-10-24 |
2014-04-24 |
A. Joseph Tector |
Double knockout (gt/cmah-ko) pigs, organs and tissues
|
CA2889502A1
(en)
|
2012-10-30 |
2014-05-08 |
Recombinetics, Inc. |
Control of sexual maturation in animals
|
BR112015009812A2
(pt)
|
2012-10-31 |
2017-08-22 |
Cellectis |
Método para a inserção genética específica em um genoma de planta, célula de planta transformada e seu uso, planta resistente a herbicidas, kit, vetor, e célula hospedeira
|
BR112015009931A2
(pt)
|
2012-10-31 |
2017-12-05 |
Two Blades Found |
gene, proteína, molécula de ácido nucleico, vetor, célula hospedeira, métodos para a preparação in vitro de um gene mutante e para gerar uma planta, planta mutante, produto, semente de planta mutante, anticorpo, uso de um anticorpo, sonda genética, par de oligonucleotídeos iniciadores, e, uso de sonda genética
|
US20150315576A1
(en)
|
2012-11-01 |
2015-11-05 |
Massachusetts Institute Of Technology |
Genetic device for the controlled destruction of dna
|
BR122019025678B1
(pt)
|
2012-11-01 |
2023-04-18 |
Factor Bioscience Inc |
Composições que compreendem ácido nucleico que codifica uma proteína de edição gênica
|
US20140127752A1
(en)
|
2012-11-07 |
2014-05-08 |
Zhaohui Zhou |
Method, composition, and reagent kit for targeted genomic enrichment
|
US9879227B2
(en)
|
2012-11-09 |
2018-01-30 |
Marco Archetti |
Diffusible factors and cancer cells
|
AU2013348113A1
(en)
|
2012-11-20 |
2015-06-11 |
J.R. Simplot Company |
TAL-mediated transfer DNA insertion
|
WO2014081855A1
(en)
|
2012-11-20 |
2014-05-30 |
Universite De Montreal |
Methods and compositions for muscular dystrophies
|
WO2014081730A1
(en)
|
2012-11-20 |
2014-05-30 |
Cold Spring Harbor Laboratory |
Mutations in solanaceae plants that modulate shoot architecture and enhance yield-related phenotypes
|
DK2925864T3
(en)
|
2012-11-27 |
2019-02-11 |
Childrens Medical Ct Corp |
DIRECTIONAL TARGETING OF DISTANT BCL11A CONTROLS FOR FETAL HEMOGLOBIN REINUCTION
|
WO2014085261A1
(en)
|
2012-11-29 |
2014-06-05 |
North Carolina State University |
Synthetic pathway for biological carbon dioxide sequestration
|
WO2014082644A1
(en)
|
2012-11-30 |
2014-06-05 |
WULFF, Peter, Samuel |
Circular rna for inhibition of microrna
|
US20160010154A1
(en)
|
2012-11-30 |
2016-01-14 |
The Parkinson's Institute |
Screening assays for therapeutics for parkinson's disease
|
JP2016500254A
(ja)
|
2012-12-05 |
2016-01-12 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
代謝疾患の調節のための方法および組成物
|
ES2757325T3
(es)
|
2012-12-06 |
2020-04-28 |
Sigma Aldrich Co Llc |
Modificación y regulación del genoma en base a CRISPR
|
CA2892821C
(en)
|
2012-12-06 |
2022-04-26 |
Synthetic Genomics, Inc. |
Algal mutants having a locked-in high light acclimated phenotype
|
WO2014089513A1
(en)
|
2012-12-06 |
2014-06-12 |
Synthetic Genomics, Inc. |
Autonomous replication sequences and episomal dna molecules
|
WO2014089348A1
(en)
|
2012-12-07 |
2014-06-12 |
Synthetic Genomics, Inc. |
Nannochloropsis spliced leader sequences and uses therefor
|
BR112015013311A2
(pt)
|
2012-12-07 |
2017-11-14 |
Haplomics Inc |
indução de tolerancia e reparação de mutação do fator 8
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
DK2931897T3
(en)
|
2012-12-12 |
2018-02-05 |
Broad Inst Inc |
CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS
|
EP4234696A3
(en)
|
2012-12-12 |
2023-09-06 |
The Broad Institute Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
IL239344B1
(en)
|
2012-12-12 |
2024-02-01 |
Broad Inst Inc |
Systems engineering, methods and optimal guiding components for sequence manipulation
|
IL300461A
(en)
|
2012-12-12 |
2023-04-01 |
Harvard College |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
EP2784162B1
(en)
|
2012-12-12 |
2015-04-08 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
EP2931892B1
(en)
|
2012-12-12 |
2018-09-12 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
PL2931898T3
(pl)
|
2012-12-12 |
2016-09-30 |
Le Cong |
Projektowanie i optymalizacja systemów, sposoby i kompozycje do manipulacji sekwencją z domenami funkcjonalnymi
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
CA2893579A1
(en)
|
2012-12-13 |
2014-06-19 |
Dow Agrosciences Llc |
Dna detection methods for site specific nuclease activity
|
RU2015128052A
(ru)
|
2012-12-13 |
2017-01-19 |
Дау Агросайенсиз Ллс |
Точный таргетинг генов в отношении конкретного локуса кукурузы
|
WO2014093852A1
(en)
|
2012-12-13 |
2014-06-19 |
Massachusetts Institute Of Technology |
Recombinase-based logic and memory systems
|
KR20220139433A
(ko)
|
2012-12-17 |
2022-10-14 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 인간 게놈 조작
|
PL2934097T3
(pl)
|
2012-12-21 |
2018-11-30 |
Cellectis |
Ziemniaki o ograniczonej słodkości indukowanej chłodem
|
AU2014207618A1
(en)
|
2013-01-16 |
2015-08-06 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
CN103233028B
(zh)
|
2013-01-25 |
2015-05-13 |
南京徇齐生物技术有限公司 |
一种无物种限制无生物安全性问题的真核生物基因打靶方法及螺旋结构dna序列
|
WO2014124226A1
(en)
|
2013-02-07 |
2014-08-14 |
The Rockefeller University |
Sequence specific antimicrobials
|
WO2014127287A1
(en)
|
2013-02-14 |
2014-08-21 |
Massachusetts Institute Of Technology |
Method for in vivo tergated mutagenesis
|
US20150353885A1
(en)
|
2013-02-21 |
2015-12-10 |
Cellectis |
Method to counter-select cells or organisms by linking loci to nuclease components
|
ES2522765B2
(es)
|
2013-02-22 |
2015-03-18 |
Universidad De Alicante |
Método para dectectar inserciones de espaciadores en estructuras CRISPR
|
AU2014218621B2
(en)
|
2013-02-25 |
2019-11-07 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
EP2922393B2
(en)
|
2013-02-27 |
2022-12-28 |
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Gene editing in the oocyte by cas9 nucleases
|
US10612043B2
(en)
|
2013-03-09 |
2020-04-07 |
Agilent Technologies, Inc. |
Methods of in vivo engineering of large sequences using multiple CRISPR/cas selections of recombineering events
|
CA2905289C
(en)
|
2013-03-12 |
2023-03-07 |
Pioneer Hi-Bred International, Inc. |
Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
|
CN105283539A
(zh)
|
2013-03-12 |
2016-01-27 |
桑格摩生物科学股份有限公司 |
用于hla的修饰的方法和组合物
|
JP2016519652A
(ja)
|
2013-03-14 |
2016-07-07 |
カリブー・バイオサイエンシーズ・インコーポレイテッド |
核酸ターゲティング核酸の組成物および方法
|
EP2971041B1
(en)
|
2013-03-15 |
2018-11-28 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
WO2014144094A1
(en)
|
2013-03-15 |
2014-09-18 |
J.R. Simplot Company |
Tal-mediated transfer dna insertion
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
US20140349400A1
(en)
|
2013-03-15 |
2014-11-27 |
Massachusetts Institute Of Technology |
Programmable Modification of DNA
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
JP2016512048A
(ja)
|
2013-03-15 |
2016-04-25 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
CRISPR/Casシステムを使用した植物ゲノム操作
|
CA2906970C
(en)
|
2013-03-21 |
2021-05-18 |
Ospedale San Raffaele Srl |
Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
|
CA2908253C
(en)
|
2013-04-04 |
2024-01-09 |
Trustees Of Dartmouth College |
Compositions and methods for in vivo excision of hiv-1 proviral dna
|
JP2016522679A
(ja)
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いたゲノム編集の治療的使用
|
CN105263312A
(zh)
|
2013-04-05 |
2016-01-20 |
美国陶氏益农公司 |
用于在植物基因组内整合外源序列的方法和组合物
|
US20150056629A1
(en)
|
2013-04-14 |
2015-02-26 |
Katriona Guthrie-Honea |
Compositions, systems, and methods for detecting a DNA sequence
|
US20160040155A1
(en)
|
2013-04-16 |
2016-02-11 |
University Of Washington Through Its Center For Commercialization |
Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
|
SG11201508028QA
(en)
|
2013-04-16 |
2015-10-29 |
Regeneron Pharma |
Targeted modification of rat genome
|
WO2014172470A2
(en)
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
CN103224947B
(zh)
|
2013-04-28 |
2015-06-10 |
陕西师范大学 |
一种基因打靶系统
|
WO2014182700A1
(en)
|
2013-05-10 |
2014-11-13 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
WO2014183071A2
(en)
|
2013-05-10 |
2014-11-13 |
Whitehead Institute For Biomedical Research |
In vitro production of red blood cells with sortaggable proteins
|
WO2014184744A1
(en)
|
2013-05-13 |
2014-11-20 |
Cellectis |
Methods for engineering highly active t cell for immunotherapy
|
AU2014265331B2
(en)
|
2013-05-15 |
2019-12-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
WO2014186686A2
(en)
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
WO2014190181A1
(en)
|
2013-05-22 |
2014-11-27 |
Northwestern University |
Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
EP3004339B1
(en)
|
2013-05-29 |
2021-07-07 |
Cellectis |
New compact scaffold of cas9 in the type ii crispr system
|
US20160122774A1
(en)
|
2013-05-29 |
2016-05-05 |
Cellectis |
A method for producing precise dna cleavage using cas9 nickase activity
|
CA2913830C
(en)
|
2013-05-29 |
2021-06-29 |
Cellectis |
Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
US20150067922A1
(en)
*
|
2013-05-30 |
2015-03-05 |
The Penn State Research Foundation |
Gene targeting and genetic modification of plants via rna-guided genome editing
|
US20140359795A1
(en)
|
2013-05-31 |
2014-12-04 |
Recombinetics, Inc. |
Genetic techniques for making animals with sortable sperm
|
JP6488283B2
(ja)
|
2013-05-31 |
2019-03-20 |
セレクティスCellectis |
C−cケモカイン受容体5型(ccr5)遺伝子を開裂するlaglidadgホーミングエンドヌクレアーゼおよびその用途
|
AU2014273091B2
(en)
|
2013-05-31 |
2019-12-12 |
Cellectis |
A LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
|
EP3603679B1
(en)
|
2013-06-04 |
2022-08-10 |
President and Fellows of Harvard College |
Rna-guided transcriptional regulation
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
WO2014197748A2
(en)
|
2013-06-05 |
2014-12-11 |
Duke University |
Rna-guided gene editing and gene regulation
|
CN105283553B
(zh)
|
2013-06-11 |
2021-06-25 |
克隆技术实验室有限公司 |
蛋白质富集的微泡及其制备和使用方法
|
EP3008181B1
(en)
|
2013-06-11 |
2019-11-06 |
The Regents of The University of California |
Methods and compositions for target dna modification
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
KR20160030187A
(ko)
|
2013-06-17 |
2016-03-16 |
더 브로드 인스티튜트, 인코퍼레이티드 |
간의 표적화 및 치료를 위한 CRISPRCas 시스템, 벡터 및 조성물의 전달 및 용도
|
EP3011035B1
(en)
|
2013-06-17 |
2020-05-13 |
The Broad Institute, Inc. |
Assay for quantitative evaluation of target site cleavage by one or more crispr-cas guide sequences
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
SG11201510327TA
(en)
|
2013-06-17 |
2016-01-28 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
AU2014281027A1
(en)
|
2013-06-17 |
2016-01-28 |
Massachusetts Institute Of Technology |
Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
|
EP3011034B1
(en)
|
2013-06-17 |
2019-08-07 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
US20160369268A1
(en)
|
2013-07-01 |
2016-12-22 |
The Board Of Regents Of The University Of Texas System |
Transcription activator-like effector (tale) libraries and methods of synthesis and use
|
CN103343120B
(zh)
|
2013-07-04 |
2015-03-04 |
中国科学院遗传与发育生物学研究所 |
一种小麦基因组定点改造方法
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
SG11201600059QA
(en)
|
2013-07-09 |
2016-02-26 |
Harvard College |
Multiplex rna-guided genome engineering
|
KR102285485B1
(ko)
|
2013-07-10 |
2021-08-04 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 유전자 조절 및 편집을 위한 직교 cas9 단백질
|
WO2015004241A2
(en)
|
2013-07-10 |
2015-01-15 |
Novartis Ag |
Multiple proteases deficient filamentous fungal cells and methods of use thereof
|
SI3019619T1
(sl)
|
2013-07-11 |
2021-12-31 |
Modernatx, Inc. |
Sestave, ki zajemajo sintetične polinukleotide, ki kodirajo proteine, pozvezane s crispr, in sintetične sgrna, ter metode uporabe
|
CN105392885B
(zh)
|
2013-07-19 |
2020-11-03 |
赖瑞克斯生物科技公司 |
用于产生双等位基因敲除的方法和组合物
|
CN103388006B
(zh)
|
2013-07-26 |
2015-10-28 |
华东师范大学 |
一种基因定点突变的构建方法
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
US10421957B2
(en)
|
2013-07-29 |
2019-09-24 |
Agilent Technologies, Inc. |
DNA assembly using an RNA-programmable nickase
|
WO2015017866A1
(en)
|
2013-08-02 |
2015-02-05 |
Enevolv, Inc. |
Processes and host cells for genome, pathway, and biomolecular engineering
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
US20150044772A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
Crispr/cas system-based novel fusion protein and its applications in genome editing
|
WO2015024017A2
(en)
|
2013-08-16 |
2015-02-19 |
President And Fellows Of Harvard College |
Rna polymerase, methods of purification and methods of use
|
WO2015021990A1
(en)
|
2013-08-16 |
2015-02-19 |
University Of Copenhagen |
Rna probing method and reagents
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
CN105829536A
(zh)
|
2013-08-22 |
2016-08-03 |
纳幕尔杜邦公司 |
用于在不掺入选择性转基因标记的情况下,在植物基因组中产生基因修饰的方法,以及用于这种方法的组合物
|
AU2014312295C1
(en)
|
2013-08-28 |
2020-08-13 |
Sangamo Therapeutics, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
SG10201801658XA
(en)
|
2013-08-29 |
2018-03-28 |
Univ Temple |
Methods and compositions for rna-guided treatment of hiv infection
|
JP6535333B2
(ja)
|
2013-09-04 |
2019-06-26 |
シーエスアイアール |
遺伝子発現をサイレンシングする遺伝子制御エレメントを標的とする部位特異的ヌクレアーゼ単一細胞アッセイ
|
DK3041498T3
(da)
|
2013-09-05 |
2022-05-09 |
Massachusetts Inst Technology |
Afstemning af mikrobielle populationer med programmerbare nukleaser
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
WO2015040075A1
(en)
|
2013-09-18 |
2015-03-26 |
Genome Research Limited |
Genomic screening methods using rna-guided endonucleases
|
TW201542816A
(zh)
|
2013-09-18 |
2015-11-16 |
Kymab Ltd |
方法、細胞與生物體
|
US10822606B2
(en)
|
2013-09-27 |
2020-11-03 |
The Regents Of The University Of California |
Optimized small guide RNAs and methods of use
|
WO2015048577A2
(en)
|
2013-09-27 |
2015-04-02 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
WO2015052231A2
(en)
|
2013-10-08 |
2015-04-16 |
Technical University Of Denmark |
Multiplex editing system
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
AU2014337248B2
(en)
|
2013-10-17 |
2020-09-24 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
EP3057432B1
(en)
|
2013-10-17 |
2018-11-21 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
CN105916983A
(zh)
|
2013-10-25 |
2016-08-31 |
塞勒克提斯公司 |
用于高效且特异性靶向包含高度重复基序的dna序列的稀有切割核酸内切酶的设计
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
RU2687369C2
(ru)
|
2013-11-04 |
2019-05-13 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Универсальная донорная система для направленного воздействия на гены
|
AU2014346559B2
(en)
|
2013-11-07 |
2020-07-09 |
Editas Medicine,Inc. |
CRISPR-related methods and compositions with governing gRNAs
|
EP3068905A4
(en)
|
2013-11-11 |
2017-07-05 |
Sangamo BioSciences, Inc. |
Methods and compositions for treating huntington's disease
|
DK3492593T3
(da)
|
2013-11-13 |
2021-11-08 |
Childrens Medical Center |
Nukleasemedieret regulering af genekspression
|
WO2015073867A1
(en)
|
2013-11-15 |
2015-05-21 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Engineering neural stem cells using homologous recombination
|
CA2930315A1
(en)
|
2013-11-18 |
2015-05-21 |
Yale University |
Compositions and methods of using transposons
|
AU2014350051A1
(en)
|
2013-11-18 |
2016-07-07 |
Crispr Therapeutics Ag |
CRISPR-Cas system materials and methods
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
WO2015075056A1
(en)
|
2013-11-19 |
2015-05-28 |
Thermo Fisher Scientific Baltics Uab |
Programmable enzymes for isolation of specific dna fragments
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
CN105960413B
(zh)
|
2013-11-20 |
2020-03-27 |
泰莱托恩基金会 |
人工dna-结合蛋白及其用途
|
BR112016011169A2
(pt)
|
2013-11-22 |
2017-09-19 |
Cellectis |
Método para a produção de células imunes ex vivo que são resistentes a um fármaco análogo de purina, célula t isolada resistente a um análogo de purina, composição farmacêutica e uso das mesmas
|
CN103642836A
(zh)
|
2013-11-26 |
2014-03-19 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立脆性x综合症灵长类动物模型的方法
|
CN103614415A
(zh)
|
2013-11-27 |
2014-03-05 |
苏州同善生物科技有限公司 |
一种基于crispr基因敲除技术建立肥胖症大鼠动物模型的方法
|
EP3074515B1
(en)
|
2013-11-28 |
2018-11-14 |
Horizon Discovery Limited |
Somatic haploid human cell line
|
EP3080143B1
(en)
|
2013-12-09 |
2019-02-20 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating hemophilia
|
SG10201700961TA
(en)
|
2013-12-11 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for the targeted modification of a genome
|
EP4219699A1
(en)
|
2013-12-12 |
2023-08-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
US9840699B2
(en)
|
2013-12-12 |
2017-12-12 |
President And Fellows Of Harvard College |
Methods for nucleic acid editing
|
CA2932439A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
RU2016128077A
(ru)
|
2013-12-12 |
2018-12-06 |
Те Брод Инститьют Инк. |
Доставка, применение и применения в терапии систем и композиций crispr-cas для лечения обусловленных hbv и вирусных заболеваний и нарушений
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
BR112016013520A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
CA2932475A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
WO2015089277A1
(en)
|
2013-12-12 |
2015-06-18 |
The Regents Of The University Of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
EP3079725B1
(en)
|
2013-12-12 |
2019-10-16 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
JP6542226B2
(ja)
|
2013-12-13 |
2019-07-10 |
セレクティス |
ヌクレアーゼを使用して藻類形質転換細胞を選択する新しい方法
|
JP2016539653A
(ja)
|
2013-12-13 |
2016-12-22 |
セレクティス |
微小藻類のゲノム操作のためのCas9ヌクレアーゼプラットフォーム
|
US20150191744A1
(en)
|
2013-12-17 |
2015-07-09 |
University Of Massachusetts |
Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
|
PT3083958T
(pt)
|
2013-12-19 |
2019-06-27 |
Amyris Inc |
Métodos de integração genómica
|
EP3985124A1
(en)
|
2013-12-26 |
2022-04-20 |
The General Hospital Corporation |
Multiplex guide rnas
|
EP3089989B1
(en)
|
2013-12-31 |
2020-06-24 |
The Regents of The University of California |
Cas9 crystals and methods of use thereof
|
CN103668472B
(zh)
|
2013-12-31 |
2014-12-24 |
北京大学 |
利用CRISPR/Cas9系统构建真核基因敲除文库的方法
|
WO2015105928A1
(en)
|
2014-01-08 |
2015-07-16 |
President And Fellows Of Harvard College |
Rna-guided gene drives
|
MX2016009243A
(es)
|
2014-01-14 |
2017-03-08 |
Lam Therapeutics Inc |
Métodos de mutagénesis.
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
CA2936646A1
(en)
|
2014-01-24 |
2015-07-30 |
North Carolina State University |
Methods and compositions for sequences guiding cas9 targeting
|
EP3096609B1
(en)
|
2014-01-24 |
2021-09-22 |
Children's Medical Center Corporation |
High-throughput mouse model for optimizing antibody affinities
|
US10354746B2
(en)
|
2014-01-27 |
2019-07-16 |
Georgia Tech Research Corporation |
Methods and systems for identifying CRISPR/Cas off-target sites
|
CN104805078A
(zh)
|
2014-01-28 |
2015-07-29 |
北京大学 |
用于高效基因组编辑的rna分子的设计、合成及其应用
|
US9850525B2
(en)
|
2014-01-29 |
2017-12-26 |
Agilent Technologies, Inc. |
CAS9-based isothermal method of detection of specific DNA sequence
|
US20150291969A1
(en)
|
2014-01-30 |
2015-10-15 |
Chromatin, Inc. |
Compositions for reduced lignin content in sorghum and improving cell wall digestibility, and methods of making the same
|
WO2015115903A1
(en)
|
2014-02-03 |
2015-08-06 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Site-specific dna break-induced genome editing using engineered nucleases
|
ES2802984T3
(es)
|
2014-02-11 |
2021-01-22 |
Univ Colorado Regents |
Ingeniería del genoma multiplex mediante CRISPR
|
EP3105325B1
(en)
|
2014-02-13 |
2019-12-04 |
Takara Bio USA, Inc. |
Methods of depleting a target molecule from an initial collection of nucleic acids, and compositions and kits for practicing the same
|
CA2937711C
(en)
|
2014-02-14 |
2020-10-20 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
BR112016019068A2
(pt)
|
2014-02-18 |
2017-10-10 |
Univ Duke |
construto, vetor recombinante, composição farmacêutica, método de inibição de replicação viral ou expressão de uma sequência alvo em uma célula infectada com um vírus, polipeptídeo de sau cas9 recombinante, construto de sau cas9 recombinante, construto recombinante para expressão de um rna guia individual e kit
|
EP3110454B1
(en)
|
2014-02-24 |
2020-11-18 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease-mediated targeted integration
|
US20170015994A1
(en)
|
2014-02-24 |
2017-01-19 |
Massachusetts Institute Of Technology |
Methods for in vivo genome editing
|
CN106232803A
(zh)
|
2014-02-27 |
2016-12-14 |
孟山都技术公司 |
用于定点基因组修饰的组合物和方法
|
CN103820441B
(zh)
|
2014-03-04 |
2017-05-17 |
黄行许 |
CRISPR‑Cas9特异性敲除人CTLA4基因的方法以及用于特异性靶向CTLA4基因的sgRNA
|
CN103820454B
(zh)
|
2014-03-04 |
2016-03-30 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA
|
EP3114227B1
(en)
|
2014-03-05 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
EP3553176A1
(en)
|
2014-03-10 |
2019-10-16 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
EP3693384B1
(en)
|
2014-03-11 |
2024-01-24 |
Cellectis |
Method for generating t-cells compatible for allogenic transplantation
|
JP2017512767A
(ja)
|
2014-03-12 |
2017-05-25 |
プレシジョン バイオサイエンシズ,インク. |
改変ヌクレアーゼを用いたジストロフィン遺伝子エクソンの欠失
|
WO2015138870A2
(en)
|
2014-03-13 |
2015-09-17 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeted epigenetic modification
|
WO2015138855A1
(en)
|
2014-03-14 |
2015-09-17 |
The Regents Of The University Of California |
Vectors and methods for fungal genome engineering by crispr-cas9
|
JP6777549B2
(ja)
|
2014-03-14 |
2020-10-28 |
サイバス ユーエス エルエルシー |
オリゴヌクレオチド仲介型遺伝子修復を使用した標的遺伝子修飾の効率を高めるための方法および組成物
|
CA2942762C
(en)
|
2014-03-18 |
2023-10-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
US10323073B2
(en)
|
2014-03-20 |
2019-06-18 |
UNIVERSITé LAVAL |
CRISPR-based methods and products for increasing frataxin levels and uses thereof
|
EP3122870B1
(en)
|
2014-03-25 |
2022-06-29 |
Ginkgo Bioworks Inc. |
Methods and genetic systems for cell engineering
|
WO2015148670A1
(en)
|
2014-03-25 |
2015-10-01 |
Editas Medicine Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
EP3981876A1
(en)
|
2014-03-26 |
2022-04-13 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
WO2015148860A1
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta-thalassemia
|
CA2943794C
(en)
|
2014-03-26 |
2023-01-24 |
University Of Maryland, College Park |
Targeted genome editing in zygotes of domestic large animals
|
WO2015153791A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
|
EP3498845B1
(en)
|
2014-04-01 |
2022-06-22 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
|
WO2015153760A2
(en)
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
EP3126495A1
(en)
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
CN103911376B
(zh)
|
2014-04-03 |
2017-02-15 |
黄行许 |
CRISPR‑Cas9靶向敲除乙肝病毒cccDNA及其特异性sgRNA
|
US20170022499A1
(en)
|
2014-04-03 |
2017-01-26 |
Massachusetts Institute Of Techology |
Methods and compositions for the production of guide rna
|
US11439712B2
(en)
|
2014-04-08 |
2022-09-13 |
North Carolina State University |
Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes
|
WO2015157070A2
(en)
|
2014-04-09 |
2015-10-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating cystic fibrosis
|
WO2015157534A1
(en)
|
2014-04-10 |
2015-10-15 |
The Regents Of The University Of California |
Methods and compositions for using argonaute to modify a single stranded target nucleic acid
|
AU2015245469B2
(en)
|
2014-04-11 |
2020-11-12 |
Cellectis |
Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
|
CN106536739B
(zh)
|
2014-04-14 |
2021-08-03 |
内梅西斯生物有限公司 |
治疗剂
|
CN103923911B
(zh)
|
2014-04-14 |
2016-06-08 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人CCR5基因的方法以及用于特异性靶向CCR5基因的sgRNA
|
US20170029805A1
(en)
|
2014-04-14 |
2017-02-02 |
Maxcyte, Inc. |
Methods and compositions for modifying genomic dna
|
GB201406970D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
SG10201809157VA
(en)
|
2014-04-18 |
2018-11-29 |
Editas Medicine Inc |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
CN104004778B
(zh)
|
2014-06-06 |
2016-03-02 |
重庆高圣生物医药有限责任公司 |
含有CRISPR/Cas9系统的靶向敲除载体及其腺病毒和应用
|
CN104109687A
(zh)
|
2014-07-14 |
2014-10-22 |
四川大学 |
运动发酵单胞菌CRISPR-Cas9系统的构建与应用
|
CN104178461B
(zh)
|
2014-08-14 |
2017-02-01 |
北京蛋白质组研究中心 |
携带cas9的重组腺病毒及其应用
|
ES2780904T3
(es)
|
2014-08-17 |
2020-08-27 |
Broad Inst Inc |
Edición genómica usando nickasas Cas9
|
CN104342457A
(zh)
|
2014-10-17 |
2015-02-11 |
杭州师范大学 |
一种将外源基因定点整合到靶标基因的方法
|
CN104504304B
(zh)
|
2014-11-03 |
2017-08-25 |
深圳先进技术研究院 |
一种成簇的规律间隔的短回文重复序列识别方法及装置
|
CN104404036B
(zh)
|
2014-11-03 |
2017-12-01 |
赛业(苏州)生物科技有限公司 |
基于CRISPR/Cas9技术的条件性基因敲除方法
|
KR20230070319A
(ko)
|
2014-11-21 |
2023-05-22 |
리제너론 파마슈티칼스 인코포레이티드 |
쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
|
CN104450774A
(zh)
|
2014-12-04 |
2015-03-25 |
中国农业科学院作物科学研究所 |
一种大豆CRISPR/Cas9体系的构建及其在大豆基因修饰中的应用
|
CN104531704B
(zh)
|
2014-12-09 |
2019-05-21 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物FGF5基因的方法
|
CN104531705A
(zh)
|
2014-12-09 |
2015-04-22 |
中国农业大学 |
利用CRISPR-Cas9系统敲除动物myostatin基因的方法
|
CN104480144B
(zh)
|
2014-12-12 |
2017-04-12 |
武汉大学 |
用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒
|
CN104745626B
(zh)
|
2014-12-19 |
2018-05-01 |
中国航天员科研训练中心 |
一种条件性基因敲除动物模型的快速构建方法及应用
|
CN104560864B
(zh)
|
2014-12-22 |
2017-08-11 |
中国科学院微生物研究所 |
利用CRISPR‑Cas9系统构建的敲除IFN‑β基因的293T细胞系
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
CN104651398A
(zh)
|
2014-12-24 |
2015-05-27 |
杭州师范大学 |
利用CRISPR-Cas9特异敲出microRNA基因家族的方法
|
CN104498493B
(zh)
|
2014-12-30 |
2017-12-26 |
武汉大学 |
CRISPR/Cas9特异性敲除乙型肝炎病毒的方法以及用于特异性靶向HBV DNA的gRNA
|
CN104651399B
(zh)
|
2014-12-31 |
2018-11-16 |
广西大学 |
一种利用CRISPR/Cas系统在猪胚胎细胞中实现基因敲除的方法
|
CN104651392B
(zh)
|
2015-01-06 |
2018-07-31 |
华南农业大学 |
一种利用CRISPR/Cas9系统定点突变P/TMS12-1获得温敏不育系的方法
|
CN104593422A
(zh)
|
2015-01-08 |
2015-05-06 |
中国农业大学 |
一种抗蓝耳病克隆猪的制备方法
|
CN104611370A
(zh)
|
2015-01-16 |
2015-05-13 |
深圳市科晖瑞生物医药有限公司 |
一种剔除β2-微球蛋白基因片段的方法
|
CN104725626B
(zh)
|
2015-01-22 |
2016-06-29 |
漳州亚邦化学有限公司 |
一种适用于人造石英石的不饱和树脂的制备方法
|
CN104593418A
(zh)
|
2015-02-06 |
2015-05-06 |
中国医学科学院医学实验动物研究所 |
一种人源化大鼠药物评价动物模型建立的方法
|
CN104726494B
(zh)
|
2015-02-12 |
2018-10-23 |
中国人民解放军第二军医大学 |
CRISPR-Cas9技术构建染色体易位干细胞及动物模型的方法
|
CN104928321B
(zh)
|
2015-02-12 |
2018-06-01 |
中国科学院西北高原生物研究所 |
一种由Crispr/Cas9诱导的鳞片缺失斑马鱼模式及建立方法
|
CN104805099B
(zh)
|
2015-03-02 |
2018-04-13 |
中国人民解放军第二军医大学 |
一种安全编码Cas9蛋白的核酸分子及其表达载体
|
CN104651401B
(zh)
|
2015-03-05 |
2019-03-08 |
东华大学 |
一种mir-505双等位基因敲除的方法
|
CN104673816A
(zh)
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
CN104726449A
(zh)
|
2015-03-23 |
2015-06-24 |
国家纳米科学中心 |
一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
CN104762321A
(zh)
|
2015-04-22 |
2015-07-08 |
东北林业大学 |
基于CRISPR/Cas9系统靶向敲除KHV基因的敲除载体构建方法及其crRNA原件
|
CN104805118A
(zh)
|
2015-04-22 |
2015-07-29 |
扬州大学 |
一种苏禽黄鸡胚胎干细胞特定基因进行靶向敲除方法
|
CN104894068A
(zh)
|
2015-05-04 |
2015-09-09 |
南京凯地生物科技有限公司 |
一种利用CRISPR/Cas9制备CAR-T细胞的方法
|
CN104846010B
(zh)
|
2015-05-18 |
2018-07-06 |
安徽省农业科学院水稻研究所 |
一种删除转基因水稻筛选标记基因的方法
|
CN104894075B
(zh)
|
2015-05-28 |
2019-08-06 |
华中农业大学 |
CRISPR/Cas9和Cre/lox系统编辑伪狂犬病毒基因组制备疫苗方法和应用
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
CA3012607A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzymes and systems
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
EP3353297A1
(en)
|
2015-09-24 |
2018-08-01 |
Crispr Therapeutics AG |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
AU2016340078A1
(en)
|
2015-10-16 |
2018-04-12 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions utilizing Cpf1 for RNA-guided gene editing
|
US20170211142A1
(en)
|
2015-10-22 |
2017-07-27 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
WO2017099494A1
(ko)
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
JP7272952B2
(ja)
|
2016-12-05 |
2023-05-12 |
エディタス・メディシン、インコーポレイテッド |
内因性および起源DNAのワンショットガイドRNA(ogRNA)標的化のためのシステムおよび方法
|