HUE063005T2 - Új CRISPR DNS-célzó enzimek és rendszerek - Google Patents
Új CRISPR DNS-célzó enzimek és rendszerekInfo
- Publication number
- HUE063005T2 HUE063005T2 HUE19714925A HUE19714925A HUE063005T2 HU E063005 T2 HUE063005 T2 HU E063005T2 HU E19714925 A HUE19714925 A HU E19714925A HU E19714925 A HUE19714925 A HU E19714925A HU E063005 T2 HUE063005 T2 HU E063005T2
- Authority
- HU
- Hungary
- Prior art keywords
- systems
- dna targeting
- novel crispr
- crispr dna
- targeting enzymes
- Prior art date
Links
- 108091033409 CRISPR Proteins 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642919P | 2018-03-14 | 2018-03-14 | |
| US201862666397P | 2018-05-03 | 2018-05-03 | |
| US201862672489P | 2018-05-16 | 2018-05-16 | |
| US201862679628P | 2018-06-01 | 2018-06-01 | |
| US201862703857P | 2018-07-26 | 2018-07-26 | |
| US201862740856P | 2018-10-03 | 2018-10-03 | |
| US201862746528P | 2018-10-16 | 2018-10-16 | |
| US201862772038P | 2018-11-27 | 2018-11-27 | |
| US201862775885P | 2018-12-05 | 2018-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE063005T2 true HUE063005T2 (hu) | 2023-12-28 |
Family
ID=65995864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE19714925A HUE063005T2 (hu) | 2018-03-14 | 2019-03-14 | Új CRISPR DNS-célzó enzimek és rendszerek |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US10808245B2 (hu) |
| EP (2) | EP3765615B1 (hu) |
| JP (2) | JP7457653B2 (hu) |
| CN (1) | CN112041444A (hu) |
| AU (1) | AU2019236210A1 (hu) |
| CA (1) | CA3093334A1 (hu) |
| DE (1) | DE202019005567U1 (hu) |
| DK (1) | DK3765615T3 (hu) |
| ES (1) | ES2952978T3 (hu) |
| FI (1) | FI3765615T3 (hu) |
| HR (1) | HRP20230828T1 (hu) |
| HU (1) | HUE063005T2 (hu) |
| LT (1) | LT3765615T (hu) |
| PL (1) | PL3765615T3 (hu) |
| PT (1) | PT3765615T (hu) |
| SI (1) | SI3765615T1 (hu) |
| WO (1) | WO2019178427A1 (hu) |
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| PT3765615T (pt) | 2018-03-14 | 2023-08-28 | Arbor Biotechnologies Inc | Novas enzimas e sistemas de direcionamento de dna crispr |
| US20210198664A1 (en) | 2018-05-16 | 2021-07-01 | Arbor Biotechnologies, Inc. | Novel crispr-associated systems and components |
| CN113136375B (zh) * | 2018-10-29 | 2023-01-06 | 中国农业大学 | 新型CRISPR/Cas12f酶和系统 |
| JP2022520104A (ja) * | 2019-02-15 | 2022-03-28 | シグマ－アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム |
| US20220372456A1 (en) * | 2019-07-11 | 2022-11-24 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| JP2022542839A (ja) | 2019-07-19 | 2022-10-07 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | リコンビナーゼ組成物及び使用方法 |
| KR20220050176A (ko) | 2019-08-20 | 2022-04-22 | 프레드 헛친슨 켄서 리서치 센터 | Wt-1에 특이적인 t-세포 면역요법 |
| EP4077652A1 (en) * | 2019-12-20 | 2022-10-26 | Limagrain Europe | Improving efficiency of base editing using typev crispr enzymes |
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| AU2020441580B2 (en) * | 2020-04-06 | 2024-05-23 | Nokia Technologies Oy | Reporting beam failure |
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| CN111733216B (zh) * | 2020-06-22 | 2023-03-28 | 山东舜丰生物科技有限公司 | 一种提高目标核酸检测效率的方法 |
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| WO2022066973A1 (en) | 2020-09-24 | 2022-03-31 | Fred Hutchinson Cancer Research Center | Immunotherapy targeting pbk or oip5 antigens |
| TW202222841A (zh) | 2020-10-06 | 2022-06-16 | 福瑞德哈金森腫瘤研究中心 | 用於治療表現mage-a1之疾病的組成物及方法 |
| US20230399639A1 (en) * | 2020-10-30 | 2023-12-14 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting b2m and uses thereof |
| JP2023549080A (ja) * | 2020-10-30 | 2023-11-22 | アーバー バイオテクノロジーズ， インコーポレイテッド | Ｂｃｌ１１ａを標的とするｒｎａガイドを含む組成物及びその使用 |
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| WO2024011173A1 (en) * | 2022-07-07 | 2024-01-11 | The Regents Of The University Of California | Compositions and methods for editing cytoplasmic dna |
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| WO2019178427A1 (en) | 2019-09-19 |
| EP3765615B1 (en) | 2023-06-28 |
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| CA3093334A1 (en) | 2019-09-19 |
| US20210123047A1 (en) | 2021-04-29 |
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