PT3765615T - Novas enzimas e sistemas de direcionamento de dna crispr - Google Patents
Novas enzimas e sistemas de direcionamento de dna crisprInfo
- Publication number
- PT3765615T PT3765615T PT197149255T PT19714925T PT3765615T PT 3765615 T PT3765615 T PT 3765615T PT 197149255 T PT197149255 T PT 197149255T PT 19714925 T PT19714925 T PT 19714925T PT 3765615 T PT3765615 T PT 3765615T
- Authority
- PT
- Portugal
- Prior art keywords
- systems
- dna targeting
- novel crispr
- crispr dna
- targeting enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642919P | 2018-03-14 | 2018-03-14 | |
| US201862666397P | 2018-05-03 | 2018-05-03 | |
| US201862672489P | 2018-05-16 | 2018-05-16 | |
| US201862679628P | 2018-06-01 | 2018-06-01 | |
| US201862703857P | 2018-07-26 | 2018-07-26 | |
| US201862740856P | 2018-10-03 | 2018-10-03 | |
| US201862746528P | 2018-10-16 | 2018-10-16 | |
| US201862772038P | 2018-11-27 | 2018-11-27 | |
| US201862775885P | 2018-12-05 | 2018-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3765615T true PT3765615T (pt) | 2023-08-28 |
Family
ID=65995864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT197149255T PT3765615T (pt) | 2018-03-14 | 2019-03-14 | Novas enzimas e sistemas de direcionamento de dna crispr |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US10808245B2 (pt) |
| EP (2) | EP3765615B1 (pt) |
| JP (2) | JP7457653B2 (pt) |
| CN (1) | CN112041444A (pt) |
| AU (1) | AU2019236210A1 (pt) |
| CA (1) | CA3093334A1 (pt) |
| DE (1) | DE202019005567U1 (pt) |
| DK (1) | DK3765615T3 (pt) |
| ES (1) | ES2952978T3 (pt) |
| FI (1) | FI3765615T3 (pt) |
| HR (1) | HRP20230828T1 (pt) |
| HU (1) | HUE063005T2 (pt) |
| LT (1) | LT3765615T (pt) |
| PL (1) | PL3765615T3 (pt) |
| PT (1) | PT3765615T (pt) |
| SI (1) | SI3765615T1 (pt) |
| WO (1) | WO2019178427A1 (pt) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4095263A1 (en) | 2017-01-06 | 2022-11-30 | Editas Medicine, Inc. | Methods of assessing nuclease cleavage |
| EP3615672A1 (en) | 2017-04-28 | 2020-03-04 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
| CN110997908A (zh) | 2017-06-09 | 2020-04-10 | 爱迪塔斯医药公司 | 工程化的cas9核酸酶 |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| WO2019178427A1 (en) | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| WO2019222555A1 (en) | 2018-05-16 | 2019-11-21 | Arbor Biotechnologies, Inc. | Novel crispr-associated systems and components |
| JP7216877B2 (ja) * | 2018-10-29 | 2023-02-02 | 中国▲農▼▲業▼大学 | 新規なＣＲＩＳＰＲ／Ｃａｓ１２ｆ酵素およびシステム |
| US10947517B2 (en) * | 2019-02-15 | 2021-03-16 | Sigma-Aldrich Co. Llc | CRISPR/Cas fusion proteins and systems |
| WO2021007563A1 (en) * | 2019-07-11 | 2021-01-14 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| CA3147875A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| AU2020334064A1 (en) | 2019-08-20 | 2022-03-03 | Fred Hutchinson Cancer Center | T-cell immunotherapy specific for WT-1 |
| EP4077652A1 (en) * | 2019-12-20 | 2022-10-26 | Limagrain Europe | Improving efficiency of base editing using typev crispr enzymes |
| US20220228150A1 (en) * | 2020-03-17 | 2022-07-21 | Gowtham THAKKU | Crispr system high throughput diagnostic systems and methods |
| EP4127154A1 (en) * | 2020-03-31 | 2023-02-08 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i2 variant polypeptide and uses thereof |
| JP2023520907A (ja) * | 2020-04-06 | 2023-05-22 | ノキア テクノロジーズ オサケユイチア | ビーム障害報告 |
| WO2021216512A1 (en) * | 2020-04-20 | 2021-10-28 | The Regents Of The University Of California | Crispr systems in plants |
| EP4158020A4 (en) * | 2020-05-29 | 2024-06-26 | Arbor Biotechnologies, Inc. | COMPOSITIONS COMPRISING A CAS12I2 POLYPEPTIDE AND THEIR USES |
| US20230235305A1 (en) * | 2020-06-16 | 2023-07-27 | Arbor Biotechnologies, Inc. | Cells modified by a cas12i polypeptide |
| CN111690773B (zh) * | 2020-06-17 | 2021-08-20 | 山东舜丰生物科技有限公司 | 利用新型Cas酶进行目标核酸检测的方法和系统 |
| CN111733216B (zh) * | 2020-06-22 | 2023-03-28 | 山东舜丰生物科技有限公司 | 一种提高目标核酸检测效率的方法 |
| WO2022066973A1 (en) | 2020-09-24 | 2022-03-31 | Fred Hutchinson Cancer Research Center | Immunotherapy targeting pbk or oip5 antigens |
| WO2022066965A2 (en) | 2020-09-24 | 2022-03-31 | Fred Hutchinson Cancer Research Center | Immunotherapy targeting sox2 antigens |
| WO2022076353A1 (en) | 2020-10-06 | 2022-04-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for treating mage-a1-expressing disease |
| CA3200016A1 (en) * | 2020-10-30 | 2022-05-05 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting trac and uses thereof |
| WO2022094309A1 (en) * | 2020-10-30 | 2022-05-05 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting b2m and uses thereof |
| CA3199751A1 (en) * | 2020-10-30 | 2022-05-05 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting bcl11a and uses thereof |
| AU2021368756A1 (en) * | 2020-10-30 | 2023-06-08 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting pdcd1 and uses thereof |
| EP4244353A1 (en) | 2020-11-13 | 2023-09-20 | Triplebar Bio, Inc. | Multiparametric discovery and optimization platform |
| CN114517224A (zh) * | 2020-11-18 | 2022-05-20 | 山东舜丰生物科技有限公司 | 一种利用优化的单链核酸检测器进行核酸检测的方法 |
| CN113308451B (zh) * | 2020-12-07 | 2023-07-25 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| WO2022120520A1 (en) * | 2020-12-07 | 2022-06-16 | Institute Of Zoology, Chinese Academy Of Sciences | Engineered cas effector proteins and methods of use thereof |
| CA3201767A1 (en) | 2020-12-14 | 2022-06-23 | Thomas M. Schmitt | Compositions and methods for cellular immunotherapy |
| WO2022140343A1 (en) | 2020-12-22 | 2022-06-30 | Vertex Pharmaceuticals Incorporated | Compositions comprising an rna guide targeting dmpk and uses thereof |
| WO2022140340A1 (en) | 2020-12-22 | 2022-06-30 | Vertex Pharmaceuticals Incorporated | Compositions comprising an rna guide targeting dmd and uses thereof |
| WO2022150608A1 (en) * | 2021-01-08 | 2022-07-14 | Arbor Biotechnologies, Inc. | Compositions comprising a variant crispr nuclease polypeptide and uses thereof |
| TW202246497A (zh) * | 2021-01-20 | 2022-12-01 | 美商阿伯生物技術公司 | Ｃａｓ１２ｉ２融合分子及其用途 |
| EP4291642A2 (en) | 2021-02-11 | 2023-12-20 | Arbor Biotechnologies, Inc. | Compositions comprising a variant cas12i4 polypeptide and uses thereof |
| CN113046355B (zh) * | 2021-04-20 | 2023-04-07 | 上海交通大学 | 一种中温原核Argonaute蛋白PbAgo表征及应用 |
| CN113151215B (zh) * | 2021-05-27 | 2022-11-18 | 中国科学院动物研究所 | 工程化的Cas12i核酸酶及其效应蛋白以及用途 |
| JP2024522112A (ja) * | 2021-05-27 | 2024-06-11 | 中国科学院動物研究所 | エンジニアリングされたＣａｓ１２ｉヌクレアーゼ、エフェクタータンパク質及びその用途 |
| EP4347818A2 (en) | 2021-06-01 | 2024-04-10 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| US20230034581A1 (en) | 2021-06-04 | 2023-02-02 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting lactate dehydrogenase a (ldha) and uses thereof |
| US20220396782A1 (en) | 2021-06-04 | 2022-12-15 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting transthyretin (ttr) and uses thereof |
| WO2022256642A2 (en) | 2021-06-04 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting hydroxyacid oxidase 1 (hao1) and uses thereof |
| WO2022266849A1 (zh) * | 2021-06-22 | 2022-12-29 | 中国科学院脑科学与智能技术卓越创新中心 | 新型CRISPR-Cas13蛋白的筛选及其应用 |
| WO2023288281A2 (en) | 2021-07-15 | 2023-01-19 | Fred Hutchinson Cancer Center | Chimeric polypeptides |
| WO2023010084A2 (en) * | 2021-07-30 | 2023-02-02 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a nuclease and uses thereof |
| WO2023018856A1 (en) | 2021-08-11 | 2023-02-16 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting polypyrimidine tract binding protein 1 (ptbp1) and uses thereof |
| MX2024001878A (es) | 2021-08-11 | 2024-02-29 | Arbor Biotechnologies Inc | Sistemas de edicion de gen que comprenden una guia de arn dirigida a estatmina 2 (stmn2) y usos de los mismos. |
| WO2023019243A1 (en) * | 2021-08-12 | 2023-02-16 | Arbor Biotechnologies, Inc. | Compositions comprising a variant cas12i3 polypeptide and uses thereof |
| WO2023029532A1 (en) * | 2021-08-30 | 2023-03-09 | Huigene Therapeutics Co., Ltd. | Engineered cas6 protein and uses thereof |
| WO2023034475A1 (en) | 2021-09-01 | 2023-03-09 | Arbor Biotechnologies, Inc. | Cells modified by a cas12i polypeptide |
| US20230287456A1 (en) * | 2021-09-10 | 2023-09-14 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i polypeptide and uses thereof |
| AU2022371442A1 (en) | 2021-10-21 | 2024-04-18 | Vertex Pharmaceuticals Incorporated | Hypoimmune cells |
| CN114015674B (zh) | 2021-11-02 | 2024-08-30 | 辉大(上海)生物科技有限公司 | 一种CRISPR-Cas12i系统 |
| IL312553A (en) * | 2021-11-02 | 2024-07-01 | Huidagene Therapeutics Singapore Pte Ltd | Novel CRISPR-CAS12I systems and their uses |
| CN116254246A (zh) * | 2021-12-09 | 2023-06-13 | 北京干细胞与再生医学研究院 | 工程化cas12b效应蛋白及其使用方法 |
| WO2023122805A1 (en) | 2021-12-20 | 2023-06-29 | Vestaron Corporation | Sorbitol driven selection pressure method |
| WO2023122433A1 (en) | 2021-12-22 | 2023-06-29 | Arbor Biotechnologies, Inc. | Gene editing systems targeting hydroxyacid oxidase 1 (hao1) and lactate dehydrogenase a (ldha) |
| WO2023174249A1 (zh) * | 2022-03-18 | 2023-09-21 | 山东舜丰生物科技有限公司 | 活性改善的Cas蛋白及其应用 |
| CN114591983B (zh) * | 2022-04-12 | 2023-07-21 | 中山大学 | 一种基于dna纳米技术的蛋白质邻近标记方法及其应用 |
| WO2023204008A1 (ja) * | 2022-04-21 | 2023-10-26 | 株式会社島津製作所 | 微生物判別用のデータベースを構築する方法および装置 |
| WO2023208003A1 (en) * | 2022-04-25 | 2023-11-02 | Huidagene Therapeutics Co., Ltd. | Novel crispr-cas12i systems and uses thereof |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| CN114921439B (zh) * | 2022-06-16 | 2024-04-26 | 尧唐(上海)生物科技有限公司 | CRISPR-Cas效应子蛋白、其基因编辑系统及应用 |
| WO2024011173A1 (en) * | 2022-07-07 | 2024-01-11 | The Regents Of The University Of California | Compositions and methods for editing cytoplasmic dna |
| WO2024008145A1 (zh) * | 2022-07-07 | 2024-01-11 | 山东舜丰生物科技有限公司 | Cas酶及其应用 |
| WO2024017189A1 (en) * | 2022-07-18 | 2024-01-25 | Beijing Institute For Stem Cell And Regenerative Medicine | Tnpb-based genome editor |
| US20240035010A1 (en) * | 2022-07-22 | 2024-02-01 | Arbor Biotechnologies, Inc. | Compositions comprising a variant polypeptide and uses thereof |
| WO2024026406A2 (en) | 2022-07-29 | 2024-02-01 | Vestaron Corporation | Next Generation ACTX Peptides |
| CN115786378B (zh) * | 2022-09-22 | 2023-12-01 | 态创生物科技(广州)有限公司 | 体内靶向诱变的系统 |
| WO2024118747A1 (en) | 2022-11-30 | 2024-06-06 | Arbor Biotechnologies, Inc. | Reverse transcriptase-mediated genetic editing of transthyretin (ttr) and uses thereof |
| CN115716880A (zh) * | 2022-12-07 | 2023-02-28 | 云舟生物科技(广州)股份有限公司 | 一种核定位荧光蛋白及其应用 |
| US20240301447A1 (en) | 2023-02-15 | 2024-09-12 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
| CN116590237B (zh) * | 2023-05-29 | 2023-10-31 | 上海贝斯昂科生物科技有限公司 | 一种遗传修饰的自然杀伤细胞及其制备和用途 |
| CN116854787B (zh) * | 2023-09-05 | 2023-11-07 | 四川大学 | 一种Cas7-11蛋白的抑制剂及其应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| AU2005274948B2 (en) | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| US20140113376A1 (en) | 2011-06-01 | 2014-04-24 | Rotem Sorek | Compositions and methods for downregulating prokaryotic genes |
| BR112015013784A2 (pt) | 2012-12-12 | 2017-07-11 | Massachusetts Inst Technology | aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas |
| PL2896697T3 (pl) * | 2012-12-12 | 2016-01-29 | Broad Inst Inc | Projektowanie systemów, sposoby i optymalizowane kompozycje kierujące do manipulacji sekwencją |
| EP2825654B1 (en) | 2012-12-12 | 2017-04-26 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
| EP3060575B1 (en) | 2013-10-11 | 2018-12-05 | Massachusetts Eye & Ear Infirmary | Methods of predicting ancestral virus sequences and uses thereof |
| JP2016536021A (ja) | 2013-11-07 | 2016-11-24 | エディタス・メディシン，インコーポレイテッド | ＣＲＩＳＰＲ関連方法および支配ｇＲＮＡのある組成物 |
| CA2943622A1 (en) | 2014-03-25 | 2015-10-01 | Editas Medicine Inc. | Crispr/cas-related methods and compositions for treating hiv infection and aids |
| US11242525B2 (en) | 2014-03-26 | 2022-02-08 | Editas Medicine, Inc. | CRISPR/CAS-related methods and compositions for treating sickle cell disease |
| WO2015148860A1 (en) | 2014-03-26 | 2015-10-01 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating beta-thalassemia |
| WO2015153791A1 (en) | 2014-04-01 | 2015-10-08 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2) |
| EP4123024A1 (en) | 2014-04-01 | 2023-01-25 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1) |
| EP3129485B2 (en) | 2014-04-09 | 2022-12-21 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating cystic fibrosis |
| SG10201912171PA (en) | 2014-04-18 | 2020-02-27 | Editas Medicine Inc | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| EA039693B1 (ru) * | 2014-06-16 | 2022-02-28 | Дзе Джонс Хопкинс Юниверсити | Композиции и способы для экспрессии рнк-проводников crispr с использованием промотора h1 |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| MX2017007907A (es) * | 2014-12-17 | 2017-09-18 | Du Pont | Composiciones y métodos para la edición genética eficaz en e. coli usando sistemas de ácido desoxirribonucleico (arn) guía/endonucleasa de sistema asociado a repeticiones palindrómicas cortas agrupadas regularmente espaciadas (cas) en combinación con moldes de modificación de polinucleótido circular. |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| EP3748004A1 (en) | 2015-04-01 | 2020-12-09 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy |
| CA2985615A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating hiv infection and aids |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| US20170211142A1 (en) | 2015-10-22 | 2017-07-27 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| EP3368670A1 (en) | 2015-10-30 | 2018-09-05 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus |
| JP2019500899A (ja) | 2015-11-23 | 2019-01-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作 |
| JP6914274B2 (ja) | 2016-01-22 | 2021-08-04 | ザ・ブロード・インスティテュート・インコーポレイテッド | Ｃｒｉｓｐｒｃｐｆ１の結晶構造 |
| WO2017165862A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| KR20230156150A (ko) | 2016-06-17 | 2023-11-13 | 더 브로드 인스티튜트, 인코퍼레이티드 | 제vi형 crispr 오솔로그 및 시스템 |
| CN110114461A (zh) * | 2016-08-17 | 2019-08-09 | 博德研究所 | 新型crispr酶和系统 |
| EP3500967A1 (en) | 2016-08-17 | 2019-06-26 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
| US11041164B2 (en) * | 2017-06-22 | 2021-06-22 | Ut-Battelle, Llc | Genes for enhancing drought and heat tolerance in plants and methods of use |
| DK3765616T3 (da) | 2018-03-14 | 2023-08-21 | Arbor Biotechnologies Inc | Nye enzymer og systemer målrettet crispr dna og rna |
| WO2019178427A1 (en) * | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| WO2019201331A1 (zh) | 2018-04-20 | 2019-10-24 | 中国农业大学 | 一种CRISPR/Cas效应蛋白及系统 |
| EP3790963A4 (en) | 2018-05-11 | 2022-04-20 | Beam Therapeutics, Inc. | METHODS OF EDITING MONONUCLEOTIDE POLYMORPHISM USING PROGRAMMABLE BASE EDITOR SYSTEMS |
| CN112805379B (zh) * | 2018-08-03 | 2024-08-20 | 比姆医疗股份有限公司 | 多效应核碱基编辑器和使用其修饰核酸靶序列的方法 |
| JP7216877B2 (ja) | 2018-10-29 | 2023-02-02 | 中国▲農▼▲業▼大学 | 新規なＣＲＩＳＰＲ／Ｃａｓ１２ｆ酵素およびシステム |
| US20220170027A1 (en) | 2019-02-13 | 2022-06-02 | Beam Therapeutics Inc. | Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence |
| CA3129157A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| CN114040970B (zh) | 2019-02-13 | 2024-09-27 | 比姆医疗股份有限公司 | 使用腺苷脱氨酶碱基编辑器编辑疾病相关基因的方法，包括遗传性疾病的治疗 |
| AU2020221355A1 (en) | 2019-02-13 | 2021-08-12 | Beam Therapeutics Inc. | Compositions and methods for treating glycogen storage disease type 1a |
| WO2020168075A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Splice acceptor site disruption of a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease |
| MX2021010559A (es) | 2019-03-07 | 2021-12-15 | Univ California | Polipéptidos efectores de crispr-cas y métodos de uso de estos. |
| EP3972654A4 (en) | 2019-05-21 | 2024-07-03 | Beam Therapeutics Inc | METHODS FOR EDITING SINGLE NUCLEOTIDE POLYMORPHISM USING PROGRAMMABLE BASE EDITOR SYSTEMS |
| CN111690720B (zh) | 2020-06-16 | 2021-06-15 | 山东舜丰生物科技有限公司 | 利用修饰的单链核酸进行靶核酸检测的方法 |
| CN113308451B (zh) | 2020-12-07 | 2023-07-25 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
-
2019
- 2019-03-14 WO PCT/US2019/022375 patent/WO2019178427A1/en unknown
- 2019-03-14 SI SI201930599T patent/SI3765615T1/sl unknown
- 2019-03-14 PL PL19714925.5T patent/PL3765615T3/pl unknown
- 2019-03-14 AU AU2019236210A patent/AU2019236210A1/en active Pending
- 2019-03-14 FI FIEP19714925.5T patent/FI3765615T3/fi active
- 2019-03-14 CA CA3093334A patent/CA3093334A1/en active Pending
- 2019-03-14 DK DK19714925.5T patent/DK3765615T3/da active
- 2019-03-14 PT PT197149255T patent/PT3765615T/pt unknown
- 2019-03-14 HU HUE19714925A patent/HUE063005T2/hu unknown
- 2019-03-14 EP EP19714925.5A patent/EP3765615B1/en active Active
- 2019-03-14 LT LTEPPCT/US2019/022375T patent/LT3765615T/lt unknown
- 2019-03-14 JP JP2020547204A patent/JP7457653B2/ja active Active
- 2019-03-14 HR HRP20230828TT patent/HRP20230828T1/hr unknown
- 2019-03-14 EP EP23179442.1A patent/EP4257696A3/en active Pending
- 2019-03-14 DE DE202019005567.3U patent/DE202019005567U1/de active Active
- 2019-03-14 CN CN201980018464.6A patent/CN112041444A/zh active Pending
- 2019-03-14 ES ES19714925T patent/ES2952978T3/es active Active
- 2019-11-11 US US16/680,104 patent/US10808245B2/en active Active
-
2020
- 2020-09-14 US US17/020,414 patent/US20200407716A1/en active Pending
- 2020-09-14 US US17/020,215 patent/US20200407715A1/en active Pending
- 2020-12-31 US US17/139,678 patent/US11168324B2/en active Active
-
2021
- 2021-10-08 US US17/497,725 patent/US20220098579A1/en active Pending
-
2022
- 2022-12-09 US US18/064,171 patent/US11912992B2/en active Active
-
2024
- 2024-01-05 JP JP2024000695A patent/JP2024019739A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200407715A1 (en) | 2020-12-31 |
| FI3765615T3 (fi) | 2023-08-29 |
| AU2019236210A1 (en) | 2020-09-10 |
| WO2019178427A1 (en) | 2019-09-19 |
| US20200407716A1 (en) | 2020-12-31 |
| DK3765615T3 (da) | 2023-08-21 |
| US20230183688A1 (en) | 2023-06-15 |
| US20200063126A1 (en) | 2020-02-27 |
| EP3765615A1 (en) | 2021-01-20 |
| DE202019005567U1 (de) | 2021-02-16 |
| CN112041444A (zh) | 2020-12-04 |
| ES2952978T3 (es) | 2023-11-07 |
| US11168324B2 (en) | 2021-11-09 |
| HUE063005T2 (hu) | 2023-12-28 |
| US20220098579A1 (en) | 2022-03-31 |
| LT3765615T (lt) | 2023-10-10 |
| JP7457653B2 (ja) | 2024-03-28 |
| JP2024019739A (ja) | 2024-02-09 |
| EP4257696A3 (en) | 2024-01-24 |
| US20210123047A1 (en) | 2021-04-29 |
| HRP20230828T1 (hr) | 2023-11-10 |
| US10808245B2 (en) | 2020-10-20 |
| EP3765615B1 (en) | 2023-06-28 |
| CA3093334A1 (en) | 2019-09-19 |
| PL3765615T3 (pl) | 2023-11-13 |
| US11912992B2 (en) | 2024-02-27 |
| JP2021516970A (ja) | 2021-07-15 |
| EP4257696A2 (en) | 2023-10-11 |
| SI3765615T1 (sl) | 2023-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3765615T3 (pl) | Nowe enzymy i układy crispr ukierunkowane na dna | |
| PT3765616T (pt) | Novas enzimas e sistemas de direcionamento de dna e rna crispr | |
| IL281159A (en) | New CRISPR enzymes and systems | |
| IL282746A (en) | Enzyme and a new CRISPR/CAS12F system | |
| EP3727469A4 (en) | NEW CRISPR ENZYMES AND SYSTEMS | |
| IL290678B1 (en) | New crispr enzymes and systems | |
| IL291095A (en) | A new dna crisper targeting enzymes and systems | |
| EP3500671A4 (en) | NEW CRISPR ENZYMS AND SYSTEMS | |
| EP3500670A4 (en) | NEW CRISPR SYSTEMS AND ENZYMES | |
| IL291478A (en) | New type vi crispr enzymes and their systems | |
| SG10202010311SA (en) | Novel Crispr Enzymes and Systems | |
| IL283169A (en) | CRISPR-CAS12J enzyme and system | |
| EP3673055A4 (en) | RNA TARGETING METHODS AND COMPOSITIONS | |
| EP3583220A4 (en) | PROCEDURES AND COMPOSITIONS FOR GENERAL TRANSFER IN THE VASCULAR SYSTEM | |
| EP3621443A4 (en) | LIPASE ENZYMS | |
| EP3571304A4 (en) | TARGETED ACTIVATION IN PLANTS | |
| EP3500677A4 (en) | UNIQUE GUIDE RNA, CRISPR / CAS9 SYSTEMS AND METHODS OF USE | |
| EP3313989A4 (en) | Modified crispr rna and modified single crispr rna and uses thereof | |
| EP3638317A4 (en) | TARGETED NONVIRAL DNA INSERTIONS | |
| IL281171A (en) | Cellulose-synthase-like enzymes and their uses | |
| EP3996738A4 (en) | NOVEL ENZYMES AND SYSTEMS TARGETING CRISPR DNA | |
| EP3983536A4 (en) | NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS | |
| EP3277743A4 (en) | HYPERBRANCHED POLYMERS AND POLYPLEXES AND DNA OR RNA DELIVERY SYSTEMS THEREWITH | |
| EP4021924A4 (en) | NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS | |
| EP4010468A4 (en) | CAST-MEDIATED DNA TARGETING IN PLANTS |