LT3765615T - Nauji tiksliniai crispr dnr fermentai ir sistemos - Google Patents

Nauji tiksliniai crispr dnr fermentai ir sistemos

Info

Publication number
LT3765615T
LT3765615T LTEPPCT/US2019/022375T LTUS2019022375T LT3765615T LT 3765615 T LT3765615 T LT 3765615T LT US2019022375 T LTUS2019022375 T LT US2019022375T LT 3765615 T LT3765615 T LT 3765615T
Authority
LT
Lithuania
Prior art keywords
systems
dna targeting
novel crispr
crispr dna
targeting enzymes
Prior art date
Application number
LTEPPCT/US2019/022375T
Other languages
English (en)
Inventor
Shaorong Chong
Winston X. YAN
David A. Scott
David R. Cheng
Pratyusha HUNNEWELL
Original Assignee
Arbor Biotechnologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbor Biotechnologies, Inc. filed Critical Arbor Biotechnologies, Inc.
Publication of LT3765615T publication Critical patent/LT3765615T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
LTEPPCT/US2019/022375T 2018-03-14 2019-03-14 Nauji tiksliniai crispr dnr fermentai ir sistemos LT3765615T (lt)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201862642919P 2018-03-14 2018-03-14
US201862666397P 2018-05-03 2018-05-03
US201862672489P 2018-05-16 2018-05-16
US201862679628P 2018-06-01 2018-06-01
US201862703857P 2018-07-26 2018-07-26
US201862740856P 2018-10-03 2018-10-03
US201862746528P 2018-10-16 2018-10-16
US201862772038P 2018-11-27 2018-11-27
US201862775885P 2018-12-05 2018-12-05
PCT/US2019/022375 WO2019178427A1 (en) 2018-03-14 2019-03-14 Novel crispr dna targeting enzymes and systems

Publications (1)

Publication Number Publication Date
LT3765615T true LT3765615T (lt) 2023-10-10

Family

ID=65995864

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2019/022375T LT3765615T (lt) 2018-03-14 2019-03-14 Nauji tiksliniai crispr dnr fermentai ir sistemos

Country Status (17)

Country Link
US (6) US10808245B2 (lt)
EP (2) EP4257696A3 (lt)
JP (2) JP7457653B2 (lt)
CN (1) CN112041444A (lt)
AU (1) AU2019236210A1 (lt)
CA (1) CA3093334A1 (lt)
DE (1) DE202019005567U1 (lt)
DK (1) DK3765615T3 (lt)
ES (1) ES2952978T3 (lt)
FI (1) FI3765615T3 (lt)
HR (1) HRP20230828T1 (lt)
HU (1) HUE063005T2 (lt)
LT (1) LT3765615T (lt)
PL (1) PL3765615T3 (lt)
PT (1) PT3765615T (lt)
SI (1) SI3765615T1 (lt)
WO (1) WO2019178427A1 (lt)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3615672A1 (en) 2017-04-28 2020-03-04 Editas Medicine, Inc. Methods and systems for analyzing guide rna molecules
EP3635104A1 (en) 2017-06-09 2020-04-15 Editas Medicine, Inc. Engineered cas9 nucleases
WO2019014564A1 (en) 2017-07-14 2019-01-17 Editas Medicine, Inc. SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
EP4257696A3 (en) 2018-03-14 2024-01-24 Arbor Biotechnologies, Inc. Novel crispr dna targeting enzymes and systems
US20210198664A1 (en) 2018-05-16 2021-07-01 Arbor Biotechnologies, Inc. Novel crispr-associated systems and components
MX2021004898A (es) * 2018-10-29 2021-06-18 Univ China Agricultural Enzima de crispr/cas12f y sistema novedosos.
CA3129835A1 (en) * 2019-02-15 2020-08-20 Sigma-Aldrich Co. Llc Crispr/cas fusion proteins and systems
AU2020311438A1 (en) * 2019-07-11 2021-12-16 Arbor Biotechnologies, Inc. Novel CRISPR DNA targeting enzymes and systems
WO2021016075A1 (en) 2019-07-19 2021-01-28 Flagship Pioneering Innovations Vi, Llc Recombinase compositions and methods of use
EP4017872A1 (en) 2019-08-20 2022-06-29 Fred Hutchinson Cancer Center T-cell immunotherapy specific for wt-1
WO2021123397A1 (en) * 2019-12-20 2021-06-24 Biogemma IMPROVING EFFICIENCY OF BASE EDITING USING TypeV CRISPR ENZYMES
EP4121532A4 (en) * 2020-03-17 2024-03-13 Broad Inst Inc SYSTEMS AND METHODS FOR HIGH-THROUGHPUT CRISPR SYSTEM DIAGNOSTIC
WO2021202800A1 (en) * 2020-03-31 2021-10-07 Arbor Biotechnologies, Inc. Compositions comprising a cas12i2 variant polypeptide and uses thereof
CN116803122A (zh) * 2020-04-06 2023-09-22 上海诺基亚贝尔股份有限公司 报告波束故障
EP4158020A2 (en) * 2020-05-29 2023-04-05 Arbor Biotechnologies, Inc. Compositions comprising a cas12i2 polypeptide and uses thereof
EP4165172A2 (en) * 2020-06-16 2023-04-19 Arbor Biotechnologies, Inc. Cells modified by a cas12i polypeptide
CN111690773B (zh) * 2020-06-17 2021-08-20 山东舜丰生物科技有限公司 利用新型Cas酶进行目标核酸检测的方法和系统
CN111733216B (zh) * 2020-06-22 2023-03-28 山东舜丰生物科技有限公司 一种提高目标核酸检测效率的方法
WO2022066973A1 (en) 2020-09-24 2022-03-31 Fred Hutchinson Cancer Research Center Immunotherapy targeting pbk or oip5 antigens
CN116724053A (zh) 2020-09-24 2023-09-08 弗雷德哈钦森癌症中心 靶向sox2抗原的免疫治疗
TW202222841A (zh) 2020-10-06 2022-06-16 福瑞德哈金森腫瘤研究中心 用於治療表現mage-a1之疾病的組成物及方法
AU2021368756A1 (en) * 2020-10-30 2023-06-08 Arbor Biotechnologies, Inc. Compositions comprising an rna guide targeting pdcd1 and uses thereof
CA3199777A1 (en) * 2020-10-30 2022-05-05 Arbor Biotechnologies, Inc. Compositions comprising an rna guide targeting b2m and uses thereof
US20230416732A1 (en) * 2020-10-30 2023-12-28 Arbor Biotechnologies, Inc. Compositions comprising an rna guide targeting bcl11a and uses thereof
JP2023548588A (ja) * 2020-10-30 2023-11-17 アーバー バイオテクノロジーズ， インコーポレイテッド Ｔｒａｃを標的とするｒｎａガイドを含む組成物及びその使用
WO2022104164A1 (en) * 2020-11-13 2022-05-19 Triplebar Bio, Inc. Multiparametric discovery and optimization platform
CN116601293A (zh) * 2020-12-07 2023-08-15 中国科学院动物研究所 工程化的Cas效应蛋白及其使用方法
CN112195164B (zh) * 2020-12-07 2021-04-23 中国科学院动物研究所 工程化的Cas效应蛋白及其使用方法
CA3201767A1 (en) 2020-12-14 2022-06-23 Thomas M. Schmitt Compositions and methods for cellular immunotherapy
WO2022140343A1 (en) 2020-12-22 2022-06-30 Vertex Pharmaceuticals Incorporated Compositions comprising an rna guide targeting dmpk and uses thereof
WO2022140340A1 (en) 2020-12-22 2022-06-30 Vertex Pharmaceuticals Incorporated Compositions comprising an rna guide targeting dmd and uses thereof
WO2022150608A1 (en) * 2021-01-08 2022-07-14 Arbor Biotechnologies, Inc. Compositions comprising a variant crispr nuclease polypeptide and uses thereof
WO2022159585A1 (en) * 2021-01-20 2022-07-28 Arbor Biotechnologies, Inc. Cas1212 fusion molecules and uses thereof
CA3207525A1 (en) 2021-02-11 2022-08-18 Shaorong Chong Compositions comprising a variant cas12i4 polypeptide and uses thereof
CN113046355B (zh) * 2021-04-20 2023-04-07 上海交通大学 一种中温原核Argonaute蛋白PbAgo表征及应用
EP4349979A1 (en) * 2021-05-27 2024-04-10 Institute Of Zoology, Chinese Academy Of Sciences Engineered cas12i nuclease, effector protein and use thereof
CN115851665A (zh) * 2021-05-27 2023-03-28 中国科学院动物研究所 工程化的Cas12i核酸酶及其效应蛋白以及用途
CA3222023A1 (en) 2021-06-01 2022-12-08 Arbor Biotechnologies, Inc. Gene editing systems comprising a crispr nuclease and uses thereof
EP4347831A2 (en) 2021-06-04 2024-04-10 Arbor Biotechnologies, Inc. Gene editing systems comprising an rna guide targeting transthyretin (ttr) and uses thereof
KR20240034746A (ko) 2021-06-04 2024-03-14 아버 바이오테크놀로지스, 인크. 하이드록시산 산화효소 1(hao1)을 표적으로 하는 rna 가이드를 포함하는 유전자 편집 시스템 및 이의 용도
US20230034581A1 (en) 2021-06-04 2023-02-02 Arbor Biotechnologies, Inc. Gene editing systems comprising an rna guide targeting lactate dehydrogenase a (ldha) and uses thereof
WO2022266849A1 (zh) * 2021-06-22 2022-12-29 中国科学院脑科学与智能技术卓越创新中心 新型CRISPR-Cas13蛋白的筛选及其应用
WO2023288281A2 (en) 2021-07-15 2023-01-19 Fred Hutchinson Cancer Center Chimeric polypeptides
WO2023010084A2 (en) * 2021-07-30 2023-02-02 Arbor Biotechnologies, Inc. Gene editing systems comprising a nuclease and uses thereof
WO2023018856A1 (en) 2021-08-11 2023-02-16 Arbor Biotechnologies, Inc. Gene editing systems comprising an rna guide targeting polypyrimidine tract binding protein 1 (ptbp1) and uses thereof
WO2023018858A1 (en) 2021-08-11 2023-02-16 Arbor Biotechnologies, Inc. Gene editing systems comprising an rna guide targeting stathmin 2 (stmn2) and uses thereof
WO2023019243A1 (en) * 2021-08-12 2023-02-16 Arbor Biotechnologies, Inc. Compositions comprising a variant cas12i3 polypeptide and uses thereof
WO2023029532A1 (en) * 2021-08-30 2023-03-09 Huigene Therapeutics Co., Ltd. Engineered cas6 protein and uses thereof
WO2023034475A1 (en) 2021-09-01 2023-03-09 Arbor Biotechnologies, Inc. Cells modified by a cas12i polypeptide
US20230287456A1 (en) * 2021-09-10 2023-09-14 Arbor Biotechnologies, Inc. Compositions comprising a cas12i polypeptide and uses thereof
AU2022371442A1 (en) 2021-10-21 2024-04-18 Vertex Pharmaceuticals Incorporated Hypoimmune cells
WO2023078314A1 (en) * 2021-11-02 2023-05-11 Huidagene Therapeutics Co., Ltd. Novel crispr-cas12i systems and uses thereof
CN114015674A (zh) 2021-11-02 2022-02-08 辉二(上海)生物科技有限公司 新型CRISPR-Cas12i系统
WO2023104185A1 (en) * 2021-12-09 2023-06-15 Beijing Institute For Stem Cell And Regenerative Medicine Engineered cas12b effector proteins and methods of use thereof
WO2023122805A1 (en) 2021-12-20 2023-06-29 Vestaron Corporation Sorbitol driven selection pressure method
WO2023122433A1 (en) 2021-12-22 2023-06-29 Arbor Biotechnologies, Inc. Gene editing systems targeting hydroxyacid oxidase 1 (hao1) and lactate dehydrogenase a (ldha)
WO2023174249A1 (zh) * 2022-03-18 2023-09-21 山东舜丰生物科技有限公司 活性改善的Cas蛋白及其应用
CN114591983B (zh) * 2022-04-12 2023-07-21 中山大学 一种基于dna纳米技术的蛋白质邻近标记方法及其应用
WO2023204008A1 (ja) * 2022-04-21 2023-10-26 株式会社島津製作所 微生物判別用のデータベースを構築する方法および装置
WO2023215725A1 (en) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
CN114921439B (zh) * 2022-06-16 2024-04-26 尧唐(上海)生物科技有限公司 CRISPR-Cas效应子蛋白、其基因编辑系统及应用
WO2024011173A1 (en) * 2022-07-07 2024-01-11 The Regents Of The University Of California Compositions and methods for editing cytoplasmic dna
WO2024008145A1 (zh) * 2022-07-07 2024-01-11 山东舜丰生物科技有限公司 Cas酶及其应用
WO2024017189A1 (en) * 2022-07-18 2024-01-25 Beijing Institute For Stem Cell And Regenerative Medicine Tnpb-based genome editor
WO2024020567A1 (en) * 2022-07-22 2024-01-25 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
WO2024026406A2 (en) 2022-07-29 2024-02-01 Vestaron Corporation Next Generation ACTX Peptides
CN115786378B (zh) * 2022-09-22 2023-12-01 态创生物科技(广州)有限公司 体内靶向诱变的系统
CN115716880A (zh) * 2022-12-07 2023-02-28 云舟生物科技(广州)股份有限公司 一种核定位荧光蛋白及其应用
CN116590237B (zh) * 2023-05-29 2023-10-31 上海贝斯昂科生物科技有限公司 一种遗传修饰的自然杀伤细胞及其制备和用途
CN116854787B (zh) * 2023-09-05 2023-11-07 四川大学 一种Cas7-11蛋白的抑制剂及其应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
JP4772045B2 (ja) 2004-07-16 2011-09-14 アメリカ合衆国 Ｃｍｖ／ｒ核酸コンストラクトを含むａｉｄｓに対するワクチン
WO2012164565A1 (en) 2011-06-01 2012-12-06 Yeda Research And Development Co. Ltd. Compositions and methods for downregulating prokaryotic genes
ES2658401T3 (es) 2012-12-12 2018-03-09 The Broad Institute, Inc. Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas
EP4234696A3 (en) 2012-12-12 2023-09-06 The Broad Institute Inc. Crispr-cas component systems, methods and compositions for sequence manipulation
PL2784162T3 (pl) * 2012-12-12 2016-01-29 Broad Inst Inc Opracowanie systemów, metod oraz zoptymalizowanych kompozycji przewodnikowych do manipulacji sekwencyjnej
HUE052676T2 (hu) 2013-10-11 2021-05-28 Massachusetts Eye & Ear Infirmary Eljárások õsi vírusszekvenciák elõrejelzésére és alkalmazásaik
LT3066201T (lt) 2013-11-07 2018-08-10 Editas Medicine, Inc. Su crispr susiję būdai ir kompozicijos su valdančiomis grnr
AU2015236128A1 (en) 2014-03-25 2016-11-10 Editas Medicine Inc. CRISPR/CAS-related methods and compositions for treating HIV infection and AIDS
EP3122880B1 (en) 2014-03-26 2021-05-05 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating sickle cell disease
WO2015148860A1 (en) 2014-03-26 2015-10-01 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating beta-thalassemia
EP3126497B1 (en) 2014-04-01 2018-12-12 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
WO2015153791A1 (en) 2014-04-01 2015-10-08 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
WO2015157070A2 (en) 2014-04-09 2015-10-15 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating cystic fibrosis
KR20230152175A (ko) 2014-04-18 2023-11-02 에디타스 메디신, 인코포레이티드 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
CA2952697A1 (en) * 2014-06-16 2015-12-23 The Johns Hopkins University Compositions and methods for the expression of crispr guide rnas using the h1 promoter
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
WO2016094872A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
CA2971391C (en) * 2014-12-17 2023-05-09 E. I. Du Pont De Nemours And Company Compositions and methods for efficient gene editing in e. coli using guide rna/cas endonuclease systems in combination with circular polynucleotide modification templates.
WO2016106236A1 (en) 2014-12-23 2016-06-30 The Broad Institute Inc. Rna-targeting system
EP3277816B1 (en) 2015-04-01 2020-06-17 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy
EP3294888A1 (en) 2015-05-11 2018-03-21 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating hiv infection and aids
CA3012631A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
US20170211142A1 (en) 2015-10-22 2017-07-27 The Broad Institute, Inc. Novel crispr enzymes and systems
WO2017075475A1 (en) 2015-10-30 2017-05-04 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating herpes simplex virus
JP2019500899A (ja) 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
US20190264186A1 (en) * 2016-01-22 2019-08-29 The Broad Institute Inc. Crystal structure of crispr cpf1
EP3433364A1 (en) 2016-03-25 2019-01-30 Editas Medicine, Inc. Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
US10337051B2 (en) 2016-06-16 2019-07-02 The Regents Of The University Of California Methods and compositions for detecting a target RNA
JP7267013B2 (ja) 2016-06-17 2023-05-01 ザ・ブロード・インスティテュート・インコーポレイテッド Ｖｉ型ｃｒｉｓｐｒオルソログ及び系
US20210166783A1 (en) * 2016-08-17 2021-06-03 The Broad Institute, Inc. Methods for identifying class 2 crispr-cas systems
US11352647B2 (en) * 2016-08-17 2022-06-07 The Broad Institute, Inc. Crispr enzymes and systems
US11041164B2 (en) * 2017-06-22 2021-06-22 Ut-Battelle, Llc Genes for enhancing drought and heat tolerance in plants and methods of use
EP3765616B1 (en) 2018-03-14 2023-07-19 Arbor Biotechnologies, Inc. Novel crispr dna and rna targeting enzymes and systems
EP4257696A3 (en) 2018-03-14 2024-01-24 Arbor Biotechnologies, Inc. Novel crispr dna targeting enzymes and systems
CN112004932B (zh) 2018-04-20 2023-01-10 中国农业大学 一种CRISPR/Cas效应蛋白及系统
WO2019217943A1 (en) 2018-05-11 2019-11-14 Beam Therapeutics Inc. Methods of editing single nucleotide polymorphism using programmable base editor systems
JP2021532794A (ja) * 2018-08-03 2021-12-02 ビーム セラピューティクス インク． マルチエフェクター核酸塩基エディターおよびそれを用いて核酸標的配列を改変する方法
MX2021004898A (es) 2018-10-29 2021-06-18 Univ China Agricultural Enzima de crispr/cas12f y sistema novedosos.
EP3924480A4 (en) 2019-02-13 2023-08-02 Beam Therapeutics, Inc. MODIFIED IMMUNE CELLS HAVING ADENOSINE DEAMINASE BASE EDITORS TO MODIFY A NUCLEOBASE IN A TARGET SEQUENCE
WO2020168088A1 (en) 2019-02-13 2020-08-20 Beam Therapeutics Inc. Compositions and methods for treating glycogen storage disease type 1a
CN114040970A (zh) 2019-02-13 2022-02-11 比姆医疗股份有限公司 使用腺苷脱氨酶碱基编辑器编辑疾病相关基因的方法，包括遗传性疾病的治疗
CN114190093A (zh) 2019-02-13 2022-03-15 比姆医疗股份有限公司 使用腺苷酸脱氨酶碱基编辑器破坏疾病相关基因的剪接受体位点，包括用于治疗遗传性疾病
KR20210139265A (ko) 2019-02-13 2021-11-22 빔 테라퓨틱스, 인크. 표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법
CN113811607A (zh) 2019-03-07 2021-12-17 加利福尼亚大学董事会 CRISPR-Cas效应子多肽和其使用方法
CA3140093A1 (en) 2019-05-21 2020-11-26 Beam Therapeutics Inc. Methods of editing a single nucleotide polymorphism using programmable base editor systems
CN111690720B (zh) 2020-06-16 2021-06-15 山东舜丰生物科技有限公司 利用修饰的单链核酸进行靶核酸检测的方法
CN112195164B (zh) 2020-12-07 2021-04-23 中国科学院动物研究所 工程化的Cas效应蛋白及其使用方法

Also Published As

Publication number Publication date
EP3765615A1 (en) 2021-01-20
US11912992B2 (en) 2024-02-27
DE202019005567U1 (de) 2021-02-16
CN112041444A (zh) 2020-12-04
US20200063126A1 (en) 2020-02-27
WO2019178427A1 (en) 2019-09-19
CA3093334A1 (en) 2019-09-19
US10808245B2 (en) 2020-10-20
US20220098579A1 (en) 2022-03-31
US20210123047A1 (en) 2021-04-29
JP7457653B2 (ja) 2024-03-28
HUE063005T2 (hu) 2023-12-28
US20200407716A1 (en) 2020-12-31
JP2024019739A (ja) 2024-02-09
EP4257696A3 (en) 2024-01-24
PT3765615T (pt) 2023-08-28
EP4257696A2 (en) 2023-10-11
AU2019236210A1 (en) 2020-09-10
HRP20230828T1 (hr) 2023-11-10
DK3765615T3 (da) 2023-08-21
PL3765615T3 (pl) 2023-11-13
JP2021516970A (ja) 2021-07-15
EP3765615B1 (en) 2023-06-28
FI3765615T3 (fi) 2023-08-29
US11168324B2 (en) 2021-11-09
ES2952978T3 (es) 2023-11-07
SI3765615T1 (sl) 2023-10-30
US20200407715A1 (en) 2020-12-31
US20230183688A1 (en) 2023-06-15

Similar Documents

Publication Publication Date Title
HUE063005T2 (hu) Új CRISPR DNS-célzó enzimek és rendszerek
PT3765616T (pt) Novas enzimas e sistemas de direcionamento de dna e rna crispr
IL281159A (en) New CRISPR enzymes and systems
IL282746A (en) Enzyme and a new CRISPR/CAS12F system
EP3727469A4 (en) NEW CRISPR ENZYMES AND SYSTEMS
IL290678A (en) New crispr enzymes and systems
EP3500671A4 (en) NEW CRISPR ENZYMS AND SYSTEMS
EP3500670A4 (en) NEW CRISPR SYSTEMS AND ENZYMES
SG10202010311SA (en) Novel Crispr Enzymes and Systems
IL291095A (en) A new dna crisper targeting enzymes and systems
IL283169A (en) CRISPR-CAS12J enzyme and system
IL291478A (en) New type vi crispr enzymes and their systems
EP3673055A4 (en) RNA TARGETING METHODS AND COMPOSITIONS
EP3583220A4 (en) PROCEDURES AND COMPOSITIONS FOR GENERAL TRANSFER IN THE VASCULAR SYSTEM
EP3500677A4 (en) UNIQUE GUIDE RNA, CRISPR / CAS9 SYSTEMS AND METHODS OF USE
EP3313989A4 (en) Modified crispr rna and modified single crispr rna and uses thereof
EP3621443A4 (en) LIPASE ENZYMS
EP3571304A4 (en) TARGETED ACTIVATION IN PLANTS
EP3638317A4 (en) TARGETED NONVIRAL DNA INSERTIONS
IL281171A (en) Cellulose-synthase-like enzymes and uses thereof
EP3996738A4 (en) NOVEL ENZYMES AND SYSTEMS TARGETING CRISPR DNA
EP3277743A4 (en) HYPERBRANCHED POLYMERS AND POLYPLEXES AND DNA OR RNA DELIVERY SYSTEMS THEREWITH
EP3983536A4 (en) NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
EP4010468A4 (en) CAST-MEDIATED DNA TARGETING IN PLANTS
EP3562942A4 (en) MODIFIED CRISPR RNA AND ITS USES