BR112014031080A2 - métodos e composições de geração de alelos knock-out condicionais. - Google Patents
métodos e composições de geração de alelos knock-out condicionais.Info
- Publication number
- BR112014031080A2 BR112014031080A2 BR112014031080A BR112014031080A BR112014031080A2 BR 112014031080 A2 BR112014031080 A2 BR 112014031080A2 BR 112014031080 A BR112014031080 A BR 112014031080A BR 112014031080 A BR112014031080 A BR 112014031080A BR 112014031080 A2 BR112014031080 A2 BR 112014031080A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- conditional knock
- generating conditional
- out alleles
- Prior art date
Links
- 108700028369 Alleles Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261658670P | 2012-06-12 | 2012-06-12 | |
PCT/US2013/045382 WO2013188522A2 (en) | 2012-06-12 | 2013-06-12 | Methods and compositions for generating conditional knock-out alleles |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014031080A2 true BR112014031080A2 (pt) | 2018-05-08 |
Family
ID=49758880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014031080A BR112014031080A2 (pt) | 2012-06-12 | 2013-06-12 | métodos e composições de geração de alelos knock-out condicionais. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20150128300A1 (pt) |
EP (1) | EP2858486A4 (pt) |
JP (1) | JP6279562B2 (pt) |
KR (1) | KR20150023670A (pt) |
CN (1) | CN104540382A (pt) |
BR (1) | BR112014031080A2 (pt) |
CA (1) | CA2876076A1 (pt) |
HK (1) | HK1209276A1 (pt) |
MX (1) | MX2014015204A (pt) |
RU (1) | RU2014153918A (pt) |
WO (1) | WO2013188522A2 (pt) |
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-
2013
- 2013-06-12 JP JP2015517390A patent/JP6279562B2/ja not_active Expired - Fee Related
- 2013-06-12 KR KR1020157000353A patent/KR20150023670A/ko not_active Application Discontinuation
- 2013-06-12 WO PCT/US2013/045382 patent/WO2013188522A2/en active Application Filing
- 2013-06-12 EP EP13804001.9A patent/EP2858486A4/en not_active Withdrawn
- 2013-06-12 CA CA 2876076 patent/CA2876076A1/en not_active Abandoned
- 2013-06-12 MX MX2014015204A patent/MX2014015204A/es unknown
- 2013-06-12 US US14/407,869 patent/US20150128300A1/en not_active Abandoned
- 2013-06-12 RU RU2014153918A patent/RU2014153918A/ru not_active Application Discontinuation
- 2013-06-12 BR BR112014031080A patent/BR112014031080A2/pt not_active IP Right Cessation
- 2013-06-12 CN CN201380042657.8A patent/CN104540382A/zh active Pending
-
2015
- 2015-10-20 HK HK15110302.5A patent/HK1209276A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2876076A1 (en) | 2013-12-19 |
WO2013188522A2 (en) | 2013-12-19 |
JP6279562B2 (ja) | 2018-02-14 |
EP2858486A2 (en) | 2015-04-15 |
EP2858486A4 (en) | 2016-04-13 |
US20150128300A1 (en) | 2015-05-07 |
JP2015519082A (ja) | 2015-07-09 |
RU2014153918A (ru) | 2016-07-27 |
HK1209276A1 (en) | 2016-04-01 |
MX2014015204A (es) | 2015-08-07 |
CN104540382A (zh) | 2015-04-22 |
WO2013188522A3 (en) | 2014-04-10 |
KR20150023670A (ko) | 2015-03-05 |
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