NZ545284A - Pyrazole compounds useful as protein kinase inhibitors - Google Patents

Pyrazole compounds useful as protein kinase inhibitors

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Publication number
NZ545284A
NZ545284A NZ545284A NZ54528401A NZ545284A NZ 545284 A NZ545284 A NZ 545284A NZ 545284 A NZ545284 A NZ 545284A NZ 54528401 A NZ54528401 A NZ 54528401A NZ 545284 A NZ545284 A NZ 545284A
Authority
NZ
New Zealand
Prior art keywords
ring
optionally substituted
aliphatic
alkyl
formula
Prior art date
Application number
NZ545284A
Other languages
English (en)
Inventor
Robert Davies
David Bebbington
Ronald Knegtel
Marion Wannamaker
Pan Li
Cornelia Forester
Albert Pierce
David Kay
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27398347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ545284(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NZ545284A publication Critical patent/NZ545284A/en

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
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  • Endocrinology (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
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  • Urology & Nephrology (AREA)
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NZ545284A 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors NZ545284A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US25788700P 2000-12-21 2000-12-21
US28694901P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
NZ545284A true NZ545284A (en) 2007-06-29

Family

ID=27398347

Family Applications (4)

Application Number Title Priority Date Filing Date
NZ545284A NZ545284A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors
NZ525008A NZ525008A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors
NZ525009A NZ525009A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors
NZ525014A NZ525014A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors

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NZ525008A NZ525008A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors
NZ525009A NZ525009A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors
NZ525014A NZ525014A (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors

Country Status (23)

Country Link
US (7) US7098330B2 (OSRAM)
EP (8) EP1318814B1 (OSRAM)
JP (9) JP4105948B2 (OSRAM)
KR (4) KR20030032035A (OSRAM)
CN (3) CN100355750C (OSRAM)
AP (1) AP2003002762A0 (OSRAM)
AT (8) ATE327992T1 (OSRAM)
AU (9) AU2001290944A1 (OSRAM)
BR (1) BR0114088A (OSRAM)
CA (8) CA2422379C (OSRAM)
DE (8) DE60120194T2 (OSRAM)
DK (1) DK1318997T3 (OSRAM)
ES (3) ES2266259T3 (OSRAM)
HU (4) HUP0302411A2 (OSRAM)
IL (6) IL154817A0 (OSRAM)
MX (8) MXPA03002294A (OSRAM)
NO (4) NO20031190L (OSRAM)
NZ (4) NZ545284A (OSRAM)
PE (1) PE20020451A1 (OSRAM)
PL (1) PL361676A1 (OSRAM)
PT (2) PT1318997E (OSRAM)
TW (1) TWI303636B (OSRAM)
WO (8) WO2002022605A1 (OSRAM)

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US6982260B1 (en) 1999-11-22 2006-01-03 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
MXPA02006338A (es) 1999-12-24 2002-12-13 Aventis Pharma Ltd Azaindoles.
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2002022605A1 (en) * 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2002050073A1 (en) * 2000-12-19 2002-06-27 Smithkline Beecham P.L.C. Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors
DK1343782T3 (da) 2000-12-21 2009-08-24 Smithkline Beecham Corp Pyrimidinaminer som angiogenesemodulatorer
AP2003002825A0 (en) * 2000-12-21 2003-09-30 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors
WO2002079163A1 (en) * 2001-03-30 2002-10-10 Smithkline Beecham Corporation Aminopyridine derivatives as estrogen receptor modulators
CA2446864C (en) 2001-05-16 2011-02-15 Vertex Pharmaceuticals Incorporated Inhibitors of src and other protein kinases
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
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