BR0114088A - Compostos de pirazol úteis como inibidores de proteìna quinase - Google Patents

Compostos de pirazol úteis como inibidores de proteìna quinase

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Publication number
BR0114088A
BR0114088A BR0114088-4A BR0114088A BR0114088A BR 0114088 A BR0114088 A BR 0114088A BR 0114088 A BR0114088 A BR 0114088A BR 0114088 A BR0114088 A BR 0114088A
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Prior art keywords
ring
protein kinase
kinase inhibitors
pyrazole compounds
compounds
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BR0114088-4A
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English (en)
Inventor
Robert Davies
David Bebbington
Ronald Knegtel
Marion Wannamaker
Pan Li
Cornelia Forester
Albert Pierce
David Kay
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Vertex Pharmaceuticals Incorpo
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27398347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0114088(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Incorpo filed Critical Vertex Pharmaceuticals Incorpo
Publication of BR0114088A publication Critical patent/BR0114088A/pt

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Abstract

"COMPOSTOS DE PIRAZOL úTEIS COMO INIBIDORES DE PROTEìNA QUINASE". A presente invenção refere-se a novos compostos de pirazol de fórmula II em que o Anel C é selecionado de um anel de fenila, piridinila, pirimidinila, piridazinila, pirazinila ou 1,2,4-triazinila, e R^ 2^, R^ 2'^, R^ x^, e R^ y^, são descritos na especificação. Anel C tem um substituinte orto e é opcionalmente substituído nas posições não-orto. R^ 2^ e R^ 2'^ são opcionalmente tomados juntos com seus átomos intervenientes para formar um sistema de anéis fundidos tal como um anel de imidazol; e R^ x^ e R^ y^ são opcionalmente tomados juntos com seus átomos intervenientes para formar um sistema de anéis fundidos, tal como um anel de quinazolina. Os compostos são úteis como inibidores de proteína quinase, especialmente como inibidores de GSK-3, para tratar doenças tais como diabetes e mal de Alzheimer.
BR0114088-4A 2000-09-15 2001-09-14 Compostos de pirazol úteis como inibidores de proteìna quinase BR0114088A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US25788700P 2000-12-21 2000-12-21
US28694901P 2001-04-27 2001-04-27
PCT/US2001/028940 WO2002022607A1 (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors

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BR0114088A true BR0114088A (pt) 2003-06-17

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BR0114088-4A BR0114088A (pt) 2000-09-15 2001-09-14 Compostos de pirazol úteis como inibidores de proteìna quinase

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KR (4) KR100876069B1 (pt)
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US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2002050073A1 (en) * 2000-12-19 2002-06-27 Smithkline Beecham P.L.C. Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors
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