BR0114088A - Compostos de pirazol úteis como inibidores de proteìna quinase - Google Patents
Compostos de pirazol úteis como inibidores de proteìna quinaseInfo
- Publication number
- BR0114088A BR0114088A BR0114088-4A BR0114088A BR0114088A BR 0114088 A BR0114088 A BR 0114088A BR 0114088 A BR0114088 A BR 0114088A BR 0114088 A BR0114088 A BR 0114088A
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- protein kinase
- kinase inhibitors
- pyrazole compounds
- compounds
- Prior art date
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
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- Obesity (AREA)
- Pulmonology (AREA)
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- Neurology (AREA)
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- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
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- Communicable Diseases (AREA)
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Abstract
"COMPOSTOS DE PIRAZOL úTEIS COMO INIBIDORES DE PROTEìNA QUINASE". A presente invenção refere-se a novos compostos de pirazol de fórmula II em que o Anel C é selecionado de um anel de fenila, piridinila, pirimidinila, piridazinila, pirazinila ou 1,2,4-triazinila, e R^ 2^, R^ 2'^, R^ x^, e R^ y^, são descritos na especificação. Anel C tem um substituinte orto e é opcionalmente substituído nas posições não-orto. R^ 2^ e R^ 2'^ são opcionalmente tomados juntos com seus átomos intervenientes para formar um sistema de anéis fundidos tal como um anel de imidazol; e R^ x^ e R^ y^ são opcionalmente tomados juntos com seus átomos intervenientes para formar um sistema de anéis fundidos, tal como um anel de quinazolina. Os compostos são úteis como inibidores de proteína quinase, especialmente como inibidores de GSK-3, para tratar doenças tais como diabetes e mal de Alzheimer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23279500P | 2000-09-15 | 2000-09-15 | |
US25788700P | 2000-12-21 | 2000-12-21 | |
US28694901P | 2001-04-27 | 2001-04-27 | |
PCT/US2001/028940 WO2002022607A1 (en) | 2000-09-15 | 2001-09-14 | Pyrazole compounds useful as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0114088A true BR0114088A (pt) | 2003-06-17 |
Family
ID=27398347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0114088-4A BR0114088A (pt) | 2000-09-15 | 2001-09-14 | Compostos de pirazol úteis como inibidores de proteìna quinase |
Country Status (24)
Country | Link |
---|---|
US (7) | US7115739B2 (pt) |
EP (8) | EP1317450B1 (pt) |
JP (9) | JP4111824B2 (pt) |
KR (4) | KR100876069B1 (pt) |
CN (3) | CN1473161A (pt) |
AP (1) | AP2003002762A0 (pt) |
AT (8) | ATE346064T1 (pt) |
AU (9) | AU2001296871A1 (pt) |
BR (1) | BR0114088A (pt) |
CA (8) | CA2422299C (pt) |
DE (8) | DE60110616T3 (pt) |
DK (1) | DK1318997T3 (pt) |
ES (3) | ES2266258T3 (pt) |
HK (8) | HK1057543A1 (pt) |
HU (4) | HUP0302172A2 (pt) |
IL (6) | IL154817A0 (pt) |
MX (8) | MXPA03002294A (pt) |
NO (4) | NO20031188L (pt) |
NZ (4) | NZ525014A (pt) |
PE (1) | PE20020451A1 (pt) |
PL (1) | PL361676A1 (pt) |
PT (2) | PT1317448E (pt) |
TW (1) | TWI303636B (pt) |
WO (8) | WO2002022607A1 (pt) |
Families Citing this family (398)
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ES2271958T3 (es) * | 1996-09-04 | 2007-04-16 | Intertrust Technologies Corp | Sistemas, procedimientos y tecnicas fiables de soporte de infraestructuras para comercio electronico seguro, transacciones electronicas, control y automatizacion de procedimientos comerciales, informatica distribuida y gestion de derechos. |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
US6982260B1 (en) | 1999-11-22 | 2006-01-03 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
CZ301750B6 (cs) | 1999-12-24 | 2010-06-09 | Aventis Pharma Limited | Bicyklický pyrrolový derivát, jeho použití pri výrobe léciva, farmaceutická kompozice tento derivát obsahující a pro použití pri lécení |
MXPA03002294A (es) * | 2000-09-15 | 2005-09-08 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de proteina cinasa. |
US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
WO2002050073A1 (en) * | 2000-12-19 | 2002-06-27 | Smithkline Beecham P.L.C. | Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors |
PT1343782E (pt) * | 2000-12-21 | 2009-06-29 | Smithkline Beecham Corp | Pirimidinoaminas como moduladores de angiogénese |
EP1345922B1 (en) | 2000-12-21 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7276523B2 (en) | 2001-03-30 | 2007-10-02 | Smithkline Beecham Corporation | Aminopyridine derivatives as estrogen receptor modulators |
JP4316893B2 (ja) | 2001-05-16 | 2009-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | Srcおよび他のプロテインキナーゼのインヒビター |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
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