ATE327992T1 - Pyrazolverbindungen als protein-kinasehemmer - Google Patents

Pyrazolverbindungen als protein-kinasehemmer

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Publication number
ATE327992T1
ATE327992T1 AT01971082T AT01971082T ATE327992T1 AT E327992 T1 ATE327992 T1 AT E327992T1 AT 01971082 T AT01971082 T AT 01971082T AT 01971082 T AT01971082 T AT 01971082T AT E327992 T1 ATE327992 T1 AT E327992T1
Authority
AT
Austria
Prior art keywords
protein kinase
kinase inhibitors
pyrazole compounds
pyrazole
compounds
Prior art date
Application number
AT01971082T
Other languages
English (en)
Inventor
Robert Davies
David Bebbington
Ronald Knegtel
Marion Wannamaker
Pan Li
Cornelia Forester
Albert C Pierce
David Kay
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27398347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE327992(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE327992T1 publication Critical patent/ATE327992T1/de

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
AT01971082T 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer ATE327992T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US25788700P 2000-12-21 2000-12-21
US28694901P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
ATE327992T1 true ATE327992T1 (de) 2006-06-15

Family

ID=27398347

Family Applications (8)

Application Number Title Priority Date Filing Date
AT01977783T ATE363284T1 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase- inhibitoren
AT01973050T ATE327991T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01971006T ATE294797T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01970969T ATE326458T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01977779T ATE326459T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01971082T ATE327992T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01975210T ATE346064T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01970971T ATE327990T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications Before (5)

Application Number Title Priority Date Filing Date
AT01977783T ATE363284T1 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase- inhibitoren
AT01973050T ATE327991T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01971006T ATE294797T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01970969T ATE326458T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01977779T ATE326459T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT01975210T ATE346064T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01970971T ATE327990T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Country Status (23)

Country Link
US (7) US6638926B2 (de)
EP (8) EP1317452B1 (de)
JP (9) JP4922539B2 (de)
KR (4) KR100876069B1 (de)
CN (3) CN100355750C (de)
AP (1) AP2003002762A0 (de)
AT (8) ATE363284T1 (de)
AU (9) AU2001294558A1 (de)
BR (1) BR0114088A (de)
CA (8) CA2422378C (de)
DE (8) DE60124744T2 (de)
DK (1) DK1318997T3 (de)
ES (3) ES2266259T3 (de)
HU (4) HUP0302173A2 (de)
IL (6) IL154786A0 (de)
MX (8) MXPA03002299A (de)
NO (4) NO327708B1 (de)
NZ (4) NZ525008A (de)
PE (1) PE20020451A1 (de)
PL (1) PL361676A1 (de)
PT (2) PT1317448E (de)
TW (1) TWI303636B (de)
WO (8) WO2002022603A1 (de)

Families Citing this family (411)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1679668B1 (de) * 1996-09-04 2010-01-27 Intertrust Technologies Corp. Zuverlässige Infrastrukturhilfssysteme, Verfahren und Techniken für sicheren elektronischen Handel, elektronische Transaktionen, Handelsablaufsteuerung und Automatisierung, verteilte Verarbeitung und Rechteverwaltung
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6982260B1 (en) 1999-11-22 2006-01-03 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
WO2001047922A2 (en) 1999-12-24 2001-07-05 Aventis Pharma Limited Azaindoles
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