ATE346064T1 - Pyrazolverbindungen als protein-kinasehemmer - Google Patents

Pyrazolverbindungen als protein-kinasehemmer

Info

Publication number
ATE346064T1
ATE346064T1 AT01975210T AT01975210T ATE346064T1 AT E346064 T1 ATE346064 T1 AT E346064T1 AT 01975210 T AT01975210 T AT 01975210T AT 01975210 T AT01975210 T AT 01975210T AT E346064 T1 ATE346064 T1 AT E346064T1
Authority
AT
Austria
Prior art keywords
protein kinase
kinase inhibitors
pyrazole compounds
pyrazole
compounds
Prior art date
Application number
AT01975210T
Other languages
English (en)
Inventor
Robert Davies
David Bebbington
Haley Binch
Ronald Knegtel
Julian M C Golec
Sanjay Patel
Jean-Damien Vertex Ph Charrier
David Kay
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27398347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE346064(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE346064T1 publication Critical patent/ATE346064T1/de

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
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  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
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AT01975210T 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer ATE346064T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US25788700P 2000-12-21 2000-12-21
US28694901P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
ATE346064T1 true ATE346064T1 (de) 2006-12-15

Family

ID=27398347

Family Applications (8)

Application Number Title Priority Date Filing Date
AT01970969T ATE326458T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01977779T ATE326459T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01977783T ATE363284T1 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase- inhibitoren
AT01971006T ATE294797T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01971082T ATE327992T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01973050T ATE327991T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01975210T ATE346064T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01970971T ATE327990T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications Before (6)

Application Number Title Priority Date Filing Date
AT01970969T ATE326458T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01977779T ATE326459T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01977783T ATE363284T1 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase- inhibitoren
AT01971006T ATE294797T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01971082T ATE327992T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
AT01973050T ATE327991T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01970971T ATE327990T1 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Country Status (24)

Country Link
US (7) US7115739B2 (de)
EP (8) EP1317452B1 (de)
JP (9) JP2004509115A (de)
KR (4) KR20030030005A (de)
CN (3) CN100355750C (de)
AP (1) AP2003002762A0 (de)
AT (8) ATE326458T1 (de)
AU (9) AU2001291013A1 (de)
BR (1) BR0114088A (de)
CA (8) CA2422378C (de)
DE (8) DE60128709T2 (de)
DK (1) DK1318997T3 (de)
ES (3) ES2266258T3 (de)
HK (8) HK1057543A1 (de)
HU (4) HUP0302411A2 (de)
IL (6) IL154786A0 (de)
MX (8) MXPA03002297A (de)
NO (4) NO327708B1 (de)
NZ (4) NZ525014A (de)
PE (1) PE20020451A1 (de)
PL (1) PL361676A1 (de)
PT (2) PT1318997E (de)
TW (1) TWI303636B (de)
WO (8) WO2002022602A2 (de)

Families Citing this family (400)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1577816A3 (de) * 1996-09-04 2006-08-02 Intertrust Technologies Corp. Vertrauenswürdige Infrastrukturbetreuungssysteme, Verfahren und Techniken zum sicheren elektronischen Handel und zur Rechteverwaltung
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6982260B1 (en) 1999-11-22 2006-01-03 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
KR100755622B1 (ko) 1999-12-24 2007-09-04 아벤티스 파마 리미티드 아자인돌
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