ATE457728T1 - Kristallstruktur des aurora-2 proteins und dessen bindungstaschen - Google Patents
Kristallstruktur des aurora-2 proteins und dessen bindungstaschenInfo
- Publication number
- ATE457728T1 ATE457728T1 AT03724367T AT03724367T ATE457728T1 AT E457728 T1 ATE457728 T1 AT E457728T1 AT 03724367 T AT03724367 T AT 03724367T AT 03724367 T AT03724367 T AT 03724367T AT E457728 T1 ATE457728 T1 AT E457728T1
- Authority
- AT
- Austria
- Prior art keywords
- aurora
- binding pockets
- protein
- provides
- crystal structure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37751002P | 2002-05-01 | 2002-05-01 | |
PCT/US2003/013605 WO2003092607A2 (en) | 2002-05-01 | 2003-05-01 | Crystal structure of aurora-2 protein and binding pockets thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE457728T1 true ATE457728T1 (de) | 2010-03-15 |
Family
ID=29401516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03724367T ATE457728T1 (de) | 2002-05-01 | 2003-05-01 | Kristallstruktur des aurora-2 proteins und dessen bindungstaschen |
Country Status (7)
Country | Link |
---|---|
US (3) | US7361492B2 (de) |
EP (1) | EP1549318B1 (de) |
AT (1) | ATE457728T1 (de) |
AU (1) | AU2003231232A1 (de) |
DE (1) | DE60331329D1 (de) |
ES (1) | ES2340475T3 (de) |
WO (1) | WO2003092607A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0124299D0 (en) * | 2001-10-10 | 2001-11-28 | Astrazeneca Ab | Crystal structure of enzyme and uses thereof |
US7444273B1 (en) * | 2002-06-21 | 2008-10-28 | Takeda San Diego, Inc. | Crystallization of aurora/LPL1P-related kinase |
GB0221169D0 (en) * | 2002-09-12 | 2002-10-23 | Univ Bath | Crystal |
US7422885B1 (en) | 2003-09-18 | 2008-09-09 | Schering Corporation | Crystalline form of the catalytic domain of Aurora 2 kinase and methods of use thereof |
EP1522580A1 (de) * | 2003-10-10 | 2005-04-13 | Embl | Kristalle eines aurora-a tpx2 Komplex, tpx-2 Bindungsstelle an aurora-a, aurora-a Liganden und deren Verwendung |
WO2005061519A1 (en) * | 2003-12-19 | 2005-07-07 | Takeda San Diego, Inc. | Kinase inhibitors |
JP2007533753A (ja) * | 2004-04-23 | 2007-11-22 | タケダ サン ディエゴ インコーポレイテッド | インドール誘導体及びキナーゼ阻害剤としてのその使用 |
EP1778669A2 (de) * | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase-inhibitoren |
DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
CA2587427A1 (en) | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
EP1851310B1 (de) * | 2005-02-23 | 2011-01-26 | Vertex Pharmaceuticals Incorporated | Kristallstruktur von tak1-tab1 |
EP1715036A1 (de) * | 2005-04-20 | 2006-10-25 | Boehringer Ingelheim International GmbH | Kristallstruktur eines Aurora-B/INCENP-Komplexes |
JP2008540335A (ja) * | 2005-04-27 | 2008-11-20 | アストラゼネカ・アクチエボラーグ | ピラゾリル・ピリミジン誘導体の疼痛治療における使用 |
KR101487027B1 (ko) | 2005-09-30 | 2015-01-28 | 미카나 테라퓨틱스, 인크. | 치환된 피라졸 화합물 |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US7588924B2 (en) * | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
GB2440736A (en) * | 2006-08-10 | 2008-02-13 | Medical Res Council | Crystals of mutant p53 polypeptidtes |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
DK2121919T3 (da) * | 2007-03-22 | 2012-05-21 | Heptares Therapeutics Ltd | Mutante g-proteinkoblede receptorer og fremgangsmåder til udvælgelse heraf |
JP2010527246A (ja) * | 2007-05-18 | 2010-08-12 | バイオリポックス エービー | 方法 |
WO2008153963A1 (en) * | 2007-06-08 | 2008-12-18 | The Trustees Of The University Of Pennsylvania | Structure of compstatin-c3 complex and use for rational drug design |
GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
EP2235171A1 (de) * | 2007-12-12 | 2010-10-06 | Aarhus Universitet (University Of Aarhus) | Kristallstruktur einer plasmamembran-protonenpumpe |
GB0724860D0 (en) | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
US20090274682A1 (en) * | 2008-02-05 | 2009-11-05 | The Trustees Of Princeton University | Demethylation and inactivation of protein phosphatase 2a |
GB0802474D0 (en) * | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
US20090233858A1 (en) * | 2008-02-26 | 2009-09-17 | The Trustees Of Princeton University | Structure of a protein phosphatase 2a holoenzyme: insights into tau dephosphorylation |
US20110112037A1 (en) * | 2008-03-05 | 2011-05-12 | Heptares Therapeutics Limited BioPark | Crystal structure |
WO2010011304A2 (en) * | 2008-07-21 | 2010-01-28 | Academia Sinica | Crystal structure of bifunctional transglycosylase pbp1b from e.coli and inhibitors thereof |
US20100081621A1 (en) * | 2008-08-15 | 2010-04-01 | Lauren Holden | Crystal structure of the catalytic domain of the viral restriction factor APOBEC3G |
WO2010062848A1 (en) * | 2008-11-26 | 2010-06-03 | Mikana Therapeutics, Inc. | Substituted pyrazole compounds |
EP2379715B1 (de) * | 2008-12-19 | 2016-10-26 | European Molecular Biology Laboratory (Embl) | Polypeptidfragmente mit endonuklease-aktivität und deren verwendung |
CN101792745B (zh) * | 2009-02-04 | 2014-09-17 | 中国科学院生物物理研究所 | 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构 |
GB0910725D0 (en) | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
MX352906B (es) | 2010-03-16 | 2017-12-13 | European Molecular Biology Laboratory Embl Star | Fragmentos de la subunidad pa de rna polimerasa dependiente de rna del virus pandemico h1n1 2009 de influenza a y su uso. |
US20140011700A1 (en) * | 2011-03-25 | 2014-01-09 | Bristol-Myers Squibb Company | Three-dimensional structure of h1n1 nucleoprotein in complex with antiviral compounds |
WO2013062987A1 (en) * | 2011-10-24 | 2013-05-02 | New York University | Methods for identifying janus kinase (jak) modulators for therapeutics |
US9732126B2 (en) * | 2012-07-12 | 2017-08-15 | Korea Research Institute Of Bioscience And Biotechnology | Method for crystallization of TRX-TXNIP complex mutein and 3D structure thereof |
FR3003871B1 (fr) * | 2013-03-29 | 2015-04-24 | Centre Nat Rech Scient | Proteine kinase aurora a mutee sensible a un inhibiteur |
US20150261911A1 (en) * | 2014-03-13 | 2015-09-17 | Heptares Therapeutics Limited | Crystal structure |
WO2017139321A1 (en) * | 2016-02-08 | 2017-08-17 | Brandeis University | Compositions and methods for inhibiting kinase activity |
WO2020028619A1 (en) | 2018-08-01 | 2020-02-06 | Beckman Coulter, Inc. | Sparc based microorganism detection method |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886646A (en) | 1988-03-23 | 1989-12-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Hanging drop crystal growth apparatus and method |
US5096676A (en) | 1989-01-27 | 1992-03-17 | Mcpherson Alexander | Crystal growing apparatus |
US5130105A (en) | 1990-10-23 | 1992-07-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Protein crystal growth tray assembly |
US5221410A (en) | 1991-10-09 | 1993-06-22 | Schering Corporation | Crystal forming device |
US5884230A (en) | 1993-04-28 | 1999-03-16 | Immunex Corporation | Method and system for protein modeling |
US5400741A (en) | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
CA2422367C (en) * | 2000-09-15 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
GB0124299D0 (en) * | 2001-10-10 | 2001-11-28 | Astrazeneca Ab | Crystal structure of enzyme and uses thereof |
-
2003
- 2003-05-01 AT AT03724367T patent/ATE457728T1/de not_active IP Right Cessation
- 2003-05-01 EP EP03724367A patent/EP1549318B1/de not_active Expired - Lifetime
- 2003-05-01 DE DE60331329T patent/DE60331329D1/de not_active Expired - Lifetime
- 2003-05-01 AU AU2003231232A patent/AU2003231232A1/en not_active Abandoned
- 2003-05-01 WO PCT/US2003/013605 patent/WO2003092607A2/en not_active Application Discontinuation
- 2003-05-01 ES ES03724367T patent/ES2340475T3/es not_active Expired - Lifetime
-
2004
- 2004-11-01 US US10/979,375 patent/US7361492B2/en not_active Expired - Fee Related
-
2008
- 2008-02-13 US US12/070,054 patent/US7809541B2/en not_active Expired - Fee Related
-
2010
- 2010-09-27 US US12/890,826 patent/US8124392B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2003092607B1 (en) | 2004-05-13 |
DE60331329D1 (de) | 2010-04-01 |
ES2340475T3 (es) | 2010-06-04 |
US20090287422A1 (en) | 2009-11-19 |
AU2003231232A1 (en) | 2003-11-17 |
EP1549318B1 (de) | 2010-02-17 |
WO2003092607A3 (en) | 2004-02-05 |
US7809541B2 (en) | 2010-10-05 |
EP1549318A2 (de) | 2005-07-06 |
AU2003231232A8 (en) | 2003-11-17 |
US20050143402A1 (en) | 2005-06-30 |
US8124392B2 (en) | 2012-02-28 |
WO2003092607A2 (en) | 2003-11-13 |
US7361492B2 (en) | 2008-04-22 |
US20110104782A1 (en) | 2011-05-05 |
EP1549318A4 (de) | 2006-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |