ATE457728T1 - Kristallstruktur des aurora-2 proteins und dessen bindungstaschen - Google Patents

Kristallstruktur des aurora-2 proteins und dessen bindungstaschen

Info

Publication number
ATE457728T1
ATE457728T1 AT03724367T AT03724367T ATE457728T1 AT E457728 T1 ATE457728 T1 AT E457728T1 AT 03724367 T AT03724367 T AT 03724367T AT 03724367 T AT03724367 T AT 03724367T AT E457728 T1 ATE457728 T1 AT E457728T1
Authority
AT
Austria
Prior art keywords
aurora
binding pockets
protein
provides
crystal structure
Prior art date
Application number
AT03724367T
Other languages
English (en)
Inventor
Graham Cheetham
Ronald Knegtel
Lovorka Swenson
Joyce Coll
Suzanne Renwick
Peter Weber
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE457728T1 publication Critical patent/ATE457728T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03724367T 2002-05-01 2003-05-01 Kristallstruktur des aurora-2 proteins und dessen bindungstaschen ATE457728T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37751002P 2002-05-01 2002-05-01
PCT/US2003/013605 WO2003092607A2 (en) 2002-05-01 2003-05-01 Crystal structure of aurora-2 protein and binding pockets thereof

Publications (1)

Publication Number Publication Date
ATE457728T1 true ATE457728T1 (de) 2010-03-15

Family

ID=29401516

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724367T ATE457728T1 (de) 2002-05-01 2003-05-01 Kristallstruktur des aurora-2 proteins und dessen bindungstaschen

Country Status (7)

Country Link
US (3) US7361492B2 (de)
EP (1) EP1549318B1 (de)
AT (1) ATE457728T1 (de)
AU (1) AU2003231232A1 (de)
DE (1) DE60331329D1 (de)
ES (1) ES2340475T3 (de)
WO (1) WO2003092607A2 (de)

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GB0124299D0 (en) * 2001-10-10 2001-11-28 Astrazeneca Ab Crystal structure of enzyme and uses thereof
US7444273B1 (en) * 2002-06-21 2008-10-28 Takeda San Diego, Inc. Crystallization of aurora/LPL1P-related kinase
GB0221169D0 (en) * 2002-09-12 2002-10-23 Univ Bath Crystal
US7422885B1 (en) 2003-09-18 2008-09-09 Schering Corporation Crystalline form of the catalytic domain of Aurora 2 kinase and methods of use thereof
EP1522580A1 (de) * 2003-10-10 2005-04-13 Embl Kristalle eines aurora-a tpx2 Komplex, tpx-2 Bindungsstelle an aurora-a, aurora-a Liganden und deren Verwendung
US7572914B2 (en) 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP1763524A1 (de) * 2004-04-23 2007-03-21 Takeda San Diego, Inc. Indolderivate und deren verwendung als kinaseinhibitoren
WO2006023931A2 (en) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2008520713A (ja) 2004-11-17 2008-06-19 ミイカナ セラピューティクス インコーポレイテッド キナーゼ阻害剤
DE602006019826D1 (de) * 2005-02-23 2011-03-10 Vertex Pharma Kristallstruktur von tak1-tab1
EP1715036A1 (de) * 2005-04-20 2006-10-25 Boehringer Ingelheim International GmbH Kristallstruktur eines Aurora-B/INCENP-Komplexes
CN101208093A (zh) * 2005-04-27 2008-06-25 阿斯利康(瑞典)有限公司 吡唑-嘧啶衍生物在治疗疼痛中的用途
CA2622352C (en) 2005-09-30 2014-05-27 Miikana Therapeutics, Inc. Substituted pyrazole compounds
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7588924B2 (en) * 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
GB2440736A (en) * 2006-08-10 2008-02-13 Medical Res Council Crystals of mutant p53 polypeptidtes
GEP20135728B (en) 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
ATE544854T1 (de) * 2007-03-22 2012-02-15 Heptares Therapeutics Ltd Mutante g-protein-gekoppelte rezeptoren und selektionsverfahren dafür
CN101816001A (zh) * 2007-05-18 2010-08-25 比奥里波克斯公司 基于白三烯c4合酶(ltc4s)晶体结构选择或设计调节剂的方法
WO2008153963A1 (en) * 2007-06-08 2008-12-18 The Trustees Of The University Of Pennsylvania Structure of compstatin-c3 complex and use for rational drug design
GB0724051D0 (en) * 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
US8577624B2 (en) * 2007-12-12 2013-11-05 Aarhus Universitet Crystal structure of a plasma membrane proton pump
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
US20090274682A1 (en) * 2008-02-05 2009-11-05 The Trustees Of Princeton University Demethylation and inactivation of protein phosphatase 2a
GB0802474D0 (en) * 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
WO2009108745A1 (en) * 2008-02-26 2009-09-03 The Trustees Of Princeton University Structure of a protein phosphatase 2a holoenzyme: insights into tau dephosphorylation
WO2008068534A2 (en) * 2008-03-05 2008-06-12 Heptares Therapeutics Limited Crystal structure of a betal -adremergi c receptor and uses thereof
WO2010011304A2 (en) 2008-07-21 2010-01-28 Academia Sinica Crystal structure of bifunctional transglycosylase pbp1b from e.coli and inhibitors thereof
US20100081621A1 (en) * 2008-08-15 2010-04-01 Lauren Holden Crystal structure of the catalytic domain of the viral restriction factor APOBEC3G
CA2743018A1 (en) * 2008-11-26 2010-06-03 Miikana Therapeutics, Inc. Substituted pyrazole compounds
KR20110127114A (ko) * 2008-12-19 2011-11-24 더 유럽피안 몰레큘러 바이올로지 래보러토리 엔도뉴클레아제 활성을 포함하는 폴리펩타이드 단편 및 이의 용도
CN101792745B (zh) * 2009-02-04 2014-09-17 中国科学院生物物理研究所 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
CA2790183A1 (en) 2010-03-16 2011-09-22 European Molecular Biology Laboratory (Embl) Influenza a 2009 pandemic h1n1 polypeptide fragments comprising endonuclease activity and their use
WO2012134967A2 (en) * 2011-03-25 2012-10-04 Bristol-Myers Squibb Company Three-dimensional structure of hin1 nucleoprotein in complex with antiviral compounds
WO2013062987A1 (en) * 2011-10-24 2013-05-02 New York University Methods for identifying janus kinase (jak) modulators for therapeutics
KR101636932B1 (ko) * 2012-07-12 2016-07-07 한국생명공학연구원 Ｔｒｘ-ｔｘｎｉｐ 복합체 변형 단백질의 결정화 방법 및 그의 입체구조
FR3003871B1 (fr) * 2013-03-29 2015-04-24 Centre Nat Rech Scient Proteine kinase aurora a mutee sensible a un inhibiteur
US20150261911A1 (en) * 2014-03-13 2015-09-17 Heptares Therapeutics Limited Crystal structure
WO2017139321A1 (en) * 2016-02-08 2017-08-17 Brandeis University Compositions and methods for inhibiting kinase activity
WO2020028619A1 (en) 2018-08-01 2020-02-06 Beckman Coulter, Inc. Sparc based microorganism detection method

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886646A (en) * 1988-03-23 1989-12-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Hanging drop crystal growth apparatus and method
US5096676A (en) * 1989-01-27 1992-03-17 Mcpherson Alexander Crystal growing apparatus
US5130105A (en) * 1990-10-23 1992-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Protein crystal growth tray assembly
US5221410A (en) * 1991-10-09 1993-06-22 Schering Corporation Crystal forming device
US5884230A (en) * 1993-04-28 1999-03-16 Immunex Corporation Method and system for protein modeling
US5400741A (en) * 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
DK1318997T3 (da) * 2000-09-15 2006-09-25 Vertex Pharma Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer
GB0124299D0 (en) * 2001-10-10 2001-11-28 Astrazeneca Ab Crystal structure of enzyme and uses thereof

Also Published As

Publication number Publication date
EP1549318A4 (de) 2006-03-08
US7361492B2 (en) 2008-04-22
US20050143402A1 (en) 2005-06-30
US20110104782A1 (en) 2011-05-05
US8124392B2 (en) 2012-02-28
US20090287422A1 (en) 2009-11-19
AU2003231232A8 (en) 2003-11-17
ES2340475T3 (es) 2010-06-04
DE60331329D1 (de) 2010-04-01
US7809541B2 (en) 2010-10-05
AU2003231232A1 (en) 2003-11-17
WO2003092607A2 (en) 2003-11-13
EP1549318A2 (de) 2005-07-06
EP1549318B1 (de) 2010-02-17
WO2003092607B1 (en) 2004-05-13
WO2003092607A3 (en) 2004-02-05

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