DE60331329D1 - Kristallstruktur des aurora-2 proteins und dessen bindungstaschen - Google Patents

Kristallstruktur des aurora-2 proteins und dessen bindungstaschen

Info

Publication number
DE60331329D1
DE60331329D1 DE60331329T DE60331329T DE60331329D1 DE 60331329 D1 DE60331329 D1 DE 60331329D1 DE 60331329 T DE60331329 T DE 60331329T DE 60331329 T DE60331329 T DE 60331329T DE 60331329 D1 DE60331329 D1 DE 60331329D1
Authority
DE
Germany
Prior art keywords
aurora
binding pockets
protein
provides
crystal structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331329T
Other languages
English (en)
Inventor
Graham Cheetham
Ronald Knegtel
Lovorka Swenson
Joyce T Coll
Suzanne Renwick
Peter Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60331329D1 publication Critical patent/DE60331329D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60331329T 2002-05-01 2003-05-01 Kristallstruktur des aurora-2 proteins und dessen bindungstaschen Expired - Lifetime DE60331329D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37751002P 2002-05-01 2002-05-01
PCT/US2003/013605 WO2003092607A2 (en) 2002-05-01 2003-05-01 Crystal structure of aurora-2 protein and binding pockets thereof

Publications (1)

Publication Number Publication Date
DE60331329D1 true DE60331329D1 (de) 2010-04-01

Family

ID=29401516

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331329T Expired - Lifetime DE60331329D1 (de) 2002-05-01 2003-05-01 Kristallstruktur des aurora-2 proteins und dessen bindungstaschen

Country Status (7)

Country Link
US (3) US7361492B2 (de)
EP (1) EP1549318B1 (de)
AT (1) ATE457728T1 (de)
AU (1) AU2003231232A1 (de)
DE (1) DE60331329D1 (de)
ES (1) ES2340475T3 (de)
WO (1) WO2003092607A2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0124299D0 (en) * 2001-10-10 2001-11-28 Astrazeneca Ab Crystal structure of enzyme and uses thereof
US7444273B1 (en) * 2002-06-21 2008-10-28 Takeda San Diego, Inc. Crystallization of aurora/LPL1P-related kinase
GB0221169D0 (en) * 2002-09-12 2002-10-23 Univ Bath Crystal
US7422885B1 (en) 2003-09-18 2008-09-09 Schering Corporation Crystalline form of the catalytic domain of Aurora 2 kinase and methods of use thereof
EP1522580A1 (de) * 2003-10-10 2005-04-13 Embl Kristalle eines aurora-a tpx2 Komplex, tpx-2 Bindungsstelle an aurora-a, aurora-a Liganden und deren Verwendung
WO2005061519A1 (en) * 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
JP2007533753A (ja) * 2004-04-23 2007-11-22 タケダ サン ディエゴ インコーポレイテッド インドール誘導体及びキナーゼ阻害剤としてのその使用
JP2008510734A (ja) * 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
EP1812439B2 (de) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinaseinhibitoren
US8153630B2 (en) 2004-11-17 2012-04-10 Miikana Therapeutics, Inc. Kinase inhibitors
ATE496991T1 (de) * 2005-02-23 2011-02-15 Vertex Pharma Kristallstruktur von tak1-tab1
EP1715036A1 (de) * 2005-04-20 2006-10-25 Boehringer Ingelheim International GmbH Kristallstruktur eines Aurora-B/INCENP-Komplexes
CN101208093A (zh) * 2005-04-27 2008-06-25 阿斯利康(瑞典)有限公司 吡唑-嘧啶衍生物在治疗疼痛中的用途
ES2535854T3 (es) 2005-09-30 2015-05-18 Miikana Therapeutics, Inc. Compuestos de pirazol sustituidos
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7588924B2 (en) * 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
GB2440736A (en) * 2006-08-10 2008-02-13 Medical Res Council Crystals of mutant p53 polypeptidtes
EA200970361A1 (ru) 2006-10-09 2010-02-26 Такеда Фармасьютикал Компани Лимитед Ингибиторы киназы
GB2456235B8 (en) * 2007-03-22 2009-12-09 Heptares Therapeutics Ltd Stable beta-adrenergic receptor mutants
WO2008142366A2 (en) * 2007-05-18 2008-11-27 Biolipox Ab Methods for selecting or designing modulators, based on the crystal structure of leukotriene c4 synthase (ltc4s)
US8442776B2 (en) * 2007-06-08 2013-05-14 The Trustees Of The University Of Pennsylvania Structure of compstatin-C3 complex and use for rational drug design
GB0724051D0 (en) * 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
EP2235171A1 (de) * 2007-12-12 2010-10-06 Aarhus Universitet (University Of Aarhus) Kristallstruktur einer plasmamembran-protonenpumpe
GB0724860D0 (en) * 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
US20090274682A1 (en) * 2008-02-05 2009-11-05 The Trustees Of Princeton University Demethylation and inactivation of protein phosphatase 2a
GB0802474D0 (en) * 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
WO2009108745A1 (en) * 2008-02-26 2009-09-03 The Trustees Of Princeton University Structure of a protein phosphatase 2a holoenzyme: insights into tau dephosphorylation
WO2008068534A2 (en) * 2008-03-05 2008-06-12 Heptares Therapeutics Limited Crystal structure of a betal -adremergi c receptor and uses thereof
WO2010011304A2 (en) * 2008-07-21 2010-01-28 Academia Sinica Crystal structure of bifunctional transglycosylase pbp1b from e.coli and inhibitors thereof
US20100081621A1 (en) * 2008-08-15 2010-04-01 Lauren Holden Crystal structure of the catalytic domain of the viral restriction factor APOBEC3G
CN102227219A (zh) * 2008-11-26 2011-10-26 迈卡纳治疗股份有限公司 取代的吡唑化合物
KR20170061193A (ko) * 2008-12-19 2017-06-02 유럽피안 몰레큘러 바이올로지 래보러토리 엔도뉴클레아제 활성을 포함하는 폴리펩티드 단편 및 이의 용도
CN101792745B (zh) * 2009-02-04 2014-09-17 中国科学院生物物理研究所 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
BR112012023166A2 (pt) * 2010-03-16 2020-08-25 European Molecular Biology Laboratory (Embl) fragmento de polipeptídeo, polinucleotídeo isolado, vetor recombinante, célula hospedeira recombinante, método para identificar compostos, composto, anticorpo, e, uso de um composto, de uma composição farmacêutica, ou de um anticorpo
US20140011700A1 (en) * 2011-03-25 2014-01-09 Bristol-Myers Squibb Company Three-dimensional structure of h1n1 nucleoprotein in complex with antiviral compounds
WO2013062987A1 (en) * 2011-10-24 2013-05-02 New York University Methods for identifying janus kinase (jak) modulators for therapeutics
US9732126B2 (en) * 2012-07-12 2017-08-15 Korea Research Institute Of Bioscience And Biotechnology Method for crystallization of TRX-TXNIP complex mutein and 3D structure thereof
FR3003871B1 (fr) * 2013-03-29 2015-04-24 Centre Nat Rech Scient Proteine kinase aurora a mutee sensible a un inhibiteur
US20150261911A1 (en) * 2014-03-13 2015-09-17 Heptares Therapeutics Limited Crystal structure
WO2017139321A1 (en) * 2016-02-08 2017-08-17 Brandeis University Compositions and methods for inhibiting kinase activity
WO2020028619A1 (en) 2018-08-01 2020-02-06 Beckman Coulter, Inc. Sparc based microorganism detection method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886646A (en) 1988-03-23 1989-12-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Hanging drop crystal growth apparatus and method
US5096676A (en) 1989-01-27 1992-03-17 Mcpherson Alexander Crystal growing apparatus
US5130105A (en) 1990-10-23 1992-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Protein crystal growth tray assembly
US5221410A (en) 1991-10-09 1993-06-22 Schering Corporation Crystal forming device
US5884230A (en) 1993-04-28 1999-03-16 Immunex Corporation Method and system for protein modeling
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
CN100355750C (zh) * 2000-09-15 2007-12-19 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡唑化合物
GB0124299D0 (en) * 2001-10-10 2001-11-28 Astrazeneca Ab Crystal structure of enzyme and uses thereof

Also Published As

Publication number Publication date
AU2003231232A1 (en) 2003-11-17
ES2340475T3 (es) 2010-06-04
AU2003231232A8 (en) 2003-11-17
US7809541B2 (en) 2010-10-05
ATE457728T1 (de) 2010-03-15
WO2003092607A2 (en) 2003-11-13
US20050143402A1 (en) 2005-06-30
US20110104782A1 (en) 2011-05-05
EP1549318A2 (de) 2005-07-06
EP1549318B1 (de) 2010-02-17
WO2003092607B1 (en) 2004-05-13
US8124392B2 (en) 2012-02-28
WO2003092607A3 (en) 2004-02-05
US20090287422A1 (en) 2009-11-19
US7361492B2 (en) 2008-04-22
EP1549318A4 (de) 2006-03-08

Similar Documents

Publication Publication Date Title
DE60331329D1 (de) Kristallstruktur des aurora-2 proteins und dessen bindungstaschen
WO2005105988A3 (en) Crystal structure of human jak3 kinase domain complex and binding pockets thereof
WO2002088078A3 (en) INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3β PROTEIN AND PROTEIN COMPLEXES
WO2008137834A3 (en) Crystal structure of smyd3 protein
WO2006069001A3 (en) Structural requirements for stat3 binding and recruitment to phosphototyrosine ligands
UA98295C2 (ru) Опухолево-ассоциированный пептид, который неспецифически связывается с молекулами ii класса лейкоцитарного антигена человека (hla)
WO2007079218A3 (en) Metalloproteinase binding proteins
WO2004035604A3 (en) Spleen tyrosine kinase catalytic domain:crystal structure and binding pockets thereof
NO20083268L (no) Antistoffer anvist til HER-3 og anvendelser derav
MX2007004841A (es) Triazoles utiles como inhibidores de proteinas cinasas.
WO2005017205A3 (en) Nucleic acid mapping using linear analysis
TW200745159A (en) IL-6 binding proteins
WO2008128050A3 (en) Methods for identification of modulators of carm1 methyl transferase activity
WO2004090106A3 (en) Crystal structures of human pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design
WO2003048340A3 (en) Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof
BRPI0412607A (pt) método para aprimorar a eficácia de proteìnas modificantes de reação biológica e muteìnas resultantes
WO2006079057A3 (en) Methods and compositions for specific inhibition of protein splicing by small molecules
MXPA05011085A (es) Composiciones y metodos relacionados a stop-1.
ATE496991T1 (de) Kristallstruktur von tak1-tab1
WO2005056785A3 (en) Crystal structure of interleukin-2 tyrosine kinase (itk) and binding pockets thereof
DK1051491T3 (da) Equin Fc Epsilon receptor-alfa-kæde-nukleinsyremolekyler, korresponderende proteiner og anvendelse heraf
WO1999057253A3 (en) Crystallizable jnk complexes
ATE555447T1 (de) Kristallstruktur der polo-like-kinase 3 (plk3) und bindungstaschen dafür
DK1622929T3 (da) Apo-2L (TRAIL) receptorbindingspeptider og anvendelser deraf
WO2004023270A3 (en) Crystal structure of angiotensin-converting enzyme-related carboxypeptidase

Legal Events

Date Code Title Description
8364 No opposition during term of opposition