WO1999057253A3 - Crystallizable jnk complexes - Google Patents
Crystallizable jnk complexes Download PDFInfo
- Publication number
- WO1999057253A3 WO1999057253A3 PCT/US1999/009824 US9909824W WO9957253A3 WO 1999057253 A3 WO1999057253 A3 WO 1999057253A3 US 9909824 W US9909824 W US 9909824W WO 9957253 A3 WO9957253 A3 WO 9957253A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- relates
- complexes
- jnk3
- molecules
- active site
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99920350A EP1076692A2 (en) | 1998-05-04 | 1999-05-04 | Crystallizable jnk complexes |
JP2000547209A JP2002513562A (en) | 1998-05-04 | 1999-05-04 | Crystallizable JNK complex |
AU37868/99A AU3786899A (en) | 1998-05-04 | 1999-05-04 | Crystallizable jnk complexes |
US09/706,128 US7383135B1 (en) | 1998-05-04 | 2000-11-03 | Methods of designing inhibitors for JNK kinases |
US12/150,328 US8002891B2 (en) | 1998-05-04 | 2008-04-25 | Crystallization of C-Jun N-Terminal Kinase 3 (JNK3) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8405698P | 1998-05-04 | 1998-05-04 | |
US60/084,056 | 1998-05-04 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/706,128 Continuation US7383135B1 (en) | 1998-05-04 | 2000-11-03 | Methods of designing inhibitors for JNK kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999057253A2 WO1999057253A2 (en) | 1999-11-11 |
WO1999057253A3 true WO1999057253A3 (en) | 1999-12-16 |
Family
ID=22182612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/009824 WO1999057253A2 (en) | 1998-05-04 | 1999-05-04 | Crystallizable jnk complexes |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1076692A2 (en) |
JP (1) | JP2002513562A (en) |
AU (1) | AU3786899A (en) |
WO (1) | WO1999057253A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US7383135B1 (en) * | 1998-05-04 | 2008-06-03 | Vertex Pharmaceuticals Incorporated | Methods of designing inhibitors for JNK kinases |
JP2003514899A (en) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | 3,4-Dihydro- (1H) -quinazolin-2-one compounds as CSBP / p38 kinase inhibitors |
US6638908B1 (en) | 2000-08-09 | 2003-10-28 | Yale University | Crystals of the large ribosomal subunit |
US6987184B2 (en) | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
AU2003212796A1 (en) * | 2002-01-11 | 2003-07-30 | Vertex Pharmaceuticals Incorporated | Crystal structures of jnk-inhibitor complexes and binding pockets thereof |
CA2478338A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
JP4584909B2 (en) * | 2003-05-09 | 2010-11-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Hepatitis C virus NS5B polymerase inhibitor binding pocket |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006246A2 (en) * | 1995-08-09 | 1997-02-20 | Vertex Pharmaceuticals Incorporated | Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them |
-
1999
- 1999-05-04 JP JP2000547209A patent/JP2002513562A/en active Pending
- 1999-05-04 AU AU37868/99A patent/AU3786899A/en not_active Abandoned
- 1999-05-04 EP EP99920350A patent/EP1076692A2/en not_active Withdrawn
- 1999-05-04 WO PCT/US1999/009824 patent/WO1999057253A2/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006246A2 (en) * | 1995-08-09 | 1997-02-20 | Vertex Pharmaceuticals Incorporated | Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them |
Non-Patent Citations (1)
Title |
---|
XIE, X. ET AL: "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis", STRUCTURE, vol. 6, 15 August 1998 (1998-08-15), pages 983 - 991, XP002118848 * |
Also Published As
Publication number | Publication date |
---|---|
AU3786899A (en) | 1999-11-23 |
WO1999057253A2 (en) | 1999-11-11 |
JP2002513562A (en) | 2002-05-14 |
EP1076692A2 (en) | 2001-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1997006246A3 (en) | Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them | |
WO2005105988A3 (en) | Crystal structure of human jak3 kinase domain complex and binding pockets thereof | |
WO2003092607A3 (en) | Crystal structure of aurora-2 protein and binding pockets thereof | |
EP1435957A4 (en) | Inhibitors of gsk-3 and crystal structures of gsk-3beta protein and protein complexes | |
WO2008137834A3 (en) | Crystal structure of smyd3 protein | |
CA2353845A1 (en) | Integrated data bank combining system | |
WO2004063337A3 (en) | Kunitz domain library | |
WO1999057253A3 (en) | Crystallizable jnk complexes | |
WO1999050637A3 (en) | Isolated multimeric complexes useful in analysis of t cells, peptides useful in making the complexes, and uses thereof | |
WO2005056785A3 (en) | Crystal structure of interleukin-2 tyrosine kinase (itk) and binding pockets thereof | |
EP0921194A3 (en) | TRAILLK-2: a member of the TNF ligand family | |
Scott | The struggle for the schools. | |
WO2004023270A3 (en) | Crystal structure of angiotensin-converting enzyme-related carboxypeptidase | |
EP0919620A3 (en) | TRAILLK-3: a member of the TNF ligand family | |
WO2004035804A3 (en) | Crystals and stuctures of a bacterial nucleic acid binding protein | |
Norden | Yes and no to the Holocaust Museums. | |
AU2003230925A1 (en) | Methods or renal cell carcinoma prognosis and treatment selection with carbonic anhydrase ix | |
WO2005028506A3 (en) | Crystal structure of fms-like tyrosine kinase | |
WO2000060507A3 (en) | Analyzing molecule and protein diversity | |
WO2003060102A3 (en) | Crystal structures of jnk-inhibitor complexes and binding pockets thereof | |
Stearns | The Internet-enabled virtual public library. | |
KR19990018617A (en) | Book binding method to provide easy reading | |
Banks | Does building traffic affect circulation, OPAC searching, or reference desk activity? | |
Bruseth | Late holocene environmental change and human adaptive strategies in Northeast Texas | |
Gregory | Tuned-in, turned-on Platypus. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2000 547209 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09706128 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1999920350 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1999920350 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1999920350 Country of ref document: EP |