ATE555447T1 - Kristallstruktur der polo-like-kinase 3 (plk3) und bindungstaschen dafür - Google Patents
Kristallstruktur der polo-like-kinase 3 (plk3) und bindungstaschen dafürInfo
- Publication number
- ATE555447T1 ATE555447T1 AT07796198T AT07796198T ATE555447T1 AT E555447 T1 ATE555447 T1 AT E555447T1 AT 07796198 T AT07796198 T AT 07796198T AT 07796198 T AT07796198 T AT 07796198T AT E555447 T1 ATE555447 T1 AT E555447T1
- Authority
- AT
- Austria
- Prior art keywords
- plk3
- relates
- binding pockets
- molecules
- polo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Theoretical Computer Science (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81342706P | 2006-06-14 | 2006-06-14 | |
PCT/US2007/014149 WO2007146436A2 (en) | 2006-06-14 | 2007-06-14 | Crystal structure of polo-like kinase 3 (plk3) and binding pockets thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE555447T1 true ATE555447T1 (de) | 2012-05-15 |
Family
ID=38832575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07796198T ATE555447T1 (de) | 2006-06-14 | 2007-06-14 | Kristallstruktur der polo-like-kinase 3 (plk3) und bindungstaschen dafür |
Country Status (4)
Country | Link |
---|---|
US (1) | US7700340B2 (de) |
EP (1) | EP2064322B1 (de) |
AT (1) | ATE555447T1 (de) |
WO (1) | WO2007146436A2 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009087196A1 (en) * | 2008-01-10 | 2009-07-16 | Janssen Pharmaceutica Nv | Method for measuring plk4 activity |
US11501853B2 (en) | 2020-07-20 | 2022-11-15 | Recursion Pharmaceuticals, Inc. | Preemptible-based scaffold hopping |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4886646A (en) * | 1988-03-23 | 1989-12-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Hanging drop crystal growth apparatus and method |
US5096676A (en) * | 1989-01-27 | 1992-03-17 | Mcpherson Alexander | Crystal growing apparatus |
US5130105A (en) * | 1990-10-23 | 1992-07-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Protein crystal growth tray assembly |
US5221410A (en) | 1991-10-09 | 1993-06-22 | Schering Corporation | Crystal forming device |
US5884230A (en) * | 1993-04-28 | 1999-03-16 | Immunex Corporation | Method and system for protein modeling |
US5400741A (en) | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
US20030077681A1 (en) * | 2001-04-17 | 2003-04-24 | Cogswell John P. | PLK3 protein-protein interactions |
US20050261836A1 (en) * | 2001-12-05 | 2005-11-24 | Wuyi Meng | Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof |
WO2004024759A1 (en) * | 2002-09-10 | 2004-03-25 | The University Of British Columbia | Methods and reagents for modulating cell proliferation |
GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
GB0326396D0 (en) * | 2003-11-12 | 2003-12-17 | Cyclacel Ltd | Method |
WO2006053125A2 (en) * | 2004-11-12 | 2006-05-18 | Aveo Pharmaceuticals, Inc. | Gp201: methods and compositions for treating cancer |
US20080201123A1 (en) * | 2006-08-17 | 2008-08-21 | The Penn State Research Foundation | Increased activity and efficiency of expansin-like proteins |
-
2007
- 2007-06-14 EP EP07796198A patent/EP2064322B1/de active Active
- 2007-06-14 US US11/818,698 patent/US7700340B2/en not_active Expired - Fee Related
- 2007-06-14 AT AT07796198T patent/ATE555447T1/de active
- 2007-06-14 WO PCT/US2007/014149 patent/WO2007146436A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP2064322A2 (de) | 2009-06-03 |
WO2007146436A3 (en) | 2008-04-17 |
US20080293579A1 (en) | 2008-11-27 |
EP2064322B1 (de) | 2012-04-25 |
WO2007146436A2 (en) | 2007-12-21 |
US7700340B2 (en) | 2010-04-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE457728T1 (de) | Kristallstruktur des aurora-2 proteins und dessen bindungstaschen | |
WO2005105988A3 (en) | Crystal structure of human jak3 kinase domain complex and binding pockets thereof | |
WO2002088078A3 (en) | INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3β PROTEIN AND PROTEIN COMPLEXES | |
WO2008137834A3 (en) | Crystal structure of smyd3 protein | |
CY1122672T1 (el) | Βελτιωμενα nanobodiestm εναντι του παραγοντα νεκρωσης ογκων αλφα | |
WO2008128050A3 (en) | Methods for identification of modulators of carm1 methyl transferase activity | |
WO2006032436A3 (en) | Use of microproteins as tryptase inhibitors | |
DK2343320T3 (da) | Anti-gitr-antistoffer og anvendelser deraf | |
WO2009070221A3 (en) | Alignment-unit-based virtual formatting methods and devices employing the methods | |
EA200801621A1 (ru) | Антитела, направленные на her-3, и их применение | |
ATE483027T1 (de) | Rekombinante n-glykosylierte proteine aus prokaryontischen zellen | |
WO2008028977A3 (en) | Serum albumin binding proteins with long half-lives | |
EA200601562A1 (ru) | Сокристаллы госсипола и их применение | |
WO2007079218A3 (en) | Metalloproteinase binding proteins | |
ATE496991T1 (de) | Kristallstruktur von tak1-tab1 | |
WO2004035604A3 (en) | Spleen tyrosine kinase catalytic domain:crystal structure and binding pockets thereof | |
WO2005056785A3 (en) | Crystal structure of interleukin-2 tyrosine kinase (itk) and binding pockets thereof | |
ATE555447T1 (de) | Kristallstruktur der polo-like-kinase 3 (plk3) und bindungstaschen dafür | |
WO2003048340A3 (en) | Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof | |
WO2008003707A3 (en) | Minimized small peptides with high affinity for factor viii and factor viii-like proteins | |
NO20054238L (no) | Inhibitorer av antigenpresentasjon ved MHC klasse II-molekyler og fremgangsmate for anvendelse av disse | |
ATE512159T1 (de) | Cyclodipeptidsynthetasen und ihre verwendung zur synthese von cyclo(leu-leu)cyclodipeptid | |
NO20025738D0 (no) | Metode | |
WO2008111088A3 (en) | Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases | |
WO2004023270A3 (en) | Crystal structure of angiotensin-converting enzyme-related carboxypeptidase |