ATE483027T1 - Rekombinante n-glykosylierte proteine aus prokaryontischen zellen - Google Patents
Rekombinante n-glykosylierte proteine aus prokaryontischen zellenInfo
- Publication number
- ATE483027T1 ATE483027T1 AT06753552T AT06753552T ATE483027T1 AT E483027 T1 ATE483027 T1 AT E483027T1 AT 06753552 T AT06753552 T AT 06753552T AT 06753552 T AT06753552 T AT 06753552T AT E483027 T1 ATE483027 T1 AT E483027T1
- Authority
- AT
- Austria
- Prior art keywords
- recombinant
- cells
- prokaryontic
- proteins
- glycosylated proteins
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05010276 | 2005-05-11 | ||
| PCT/EP2006/004397 WO2006119987A2 (en) | 2005-05-11 | 2006-05-10 | Recombinant n-glycosylated proteins from procaryotic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE483027T1 true ATE483027T1 (de) | 2010-10-15 |
Family
ID=37396912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06753552T ATE483027T1 (de) | 2005-05-11 | 2006-05-10 | Rekombinante n-glykosylierte proteine aus prokaryontischen zellen |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8753864B2 (de) |
| EP (3) | EP1888761B1 (de) |
| JP (3) | JP5356807B2 (de) |
| KR (2) | KR101408653B1 (de) |
| CN (2) | CN101360831B (de) |
| AT (1) | ATE483027T1 (de) |
| AU (1) | AU2006245969B8 (de) |
| CA (1) | CA2607595C (de) |
| CY (1) | CY1116285T1 (de) |
| DE (1) | DE602006017207D1 (de) |
| DK (2) | DK1888761T3 (de) |
| ES (3) | ES2535084T3 (de) |
| HK (3) | HK1113588A1 (de) |
| HR (1) | HRP20150312T1 (de) |
| IL (2) | IL187293A (de) |
| PL (1) | PL2311972T3 (de) |
| PT (2) | PT1888761E (de) |
| SI (1) | SI2311972T1 (de) |
| WO (1) | WO2006119987A2 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| WO2003074687A1 (en) | 2002-03-07 | 2003-09-12 | Eidgenössische Technische Hochschule Zürich | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
| EP2338333B1 (de) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylierungsverfahren und durch die Verfahren hergestellte Proteine/Peptide |
| WO2006127896A2 (en) | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated factor ix |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| AU2005206796B2 (en) | 2004-01-08 | 2011-06-16 | Ratiopharm Gmbh | O-linked glycosylation of peptides |
| EP1734984A4 (de) | 2004-03-03 | 2009-07-29 | Revance Therapeutics Inc | Zusammensetzungen und verfahren zur topischen diagnose und therapeutischer transport |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化 |
| EP2514757A3 (de) | 2005-01-10 | 2014-03-05 | ratiopharm GmbH | Glycopegylierter Granulozyten-Kolonie stimulierende Faktor |
| RU2007136616A (ru) * | 2005-03-03 | 2009-04-10 | Риванс Терапьютикс, Инк. (Us) | Композиция и способ для местного применения и чрескожного введения ботулинового токсина |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| WO2008011633A2 (en) | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
| KR20100016160A (ko) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법 |
| JP5876649B2 (ja) | 2007-06-12 | 2016-03-02 | ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ | ヌクレオチド糖の改良製造法 |
| EP2240595B2 (de) | 2008-01-03 | 2019-07-24 | Cornell Research Foundation, Inc. | Expression eines glycosylierten proteins in prokaryonten |
| EP2242505A4 (de) * | 2008-01-08 | 2012-03-07 | Biogenerix Ag | Glykokonjugation von polypeptiden unter verwendung von oligosaccharyltransferasen |
| EP3427749A1 (de) * | 2008-02-20 | 2019-01-16 | GlaxoSmithKline Biologicals SA | Biokonjugate aus rekombinanten n-glykosylierten proteinen aus prokaryontischen zellen |
| WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
| PT2411503T (pt) * | 2009-03-27 | 2017-11-15 | Eidgenössische Technische Hochschule Zürich | Salmonella enterica que apresenta n-glicano de c. jejuni ou derivados do mesmo |
| CA2780487C (en) * | 2009-11-19 | 2019-05-21 | Glycovaxyn Ag | Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells |
| JP5925699B2 (ja) | 2010-02-11 | 2016-05-25 | ザ・ガバナーズ・オブ・ザ・ユニバーシティー・オブ・アルバータ | Ｎ結合型グリカン化合物 |
| SG185433A1 (en) | 2010-05-06 | 2012-12-28 | Glycovaxyn Ag | Capsular gram-positive bacteria bioconjugate vaccines |
| WO2012027850A1 (en) * | 2010-09-03 | 2012-03-08 | Christine Szymanski | Peptide containing multiple n-linked glycosylation sequons |
| AU2012306345A1 (en) * | 2011-09-06 | 2014-03-20 | Glycovaxyn Ag | Bioconjugate vaccines made in prokaryotic cells |
| SG11201503308XA (en) | 2012-11-07 | 2015-05-28 | Glycovaxyn Ag | PRODUCTION OF RECOMBINANT VACCINE IN <i>E. COLI</i> BY ENZYMATIC CONJUGATION |
| CN105120896B (zh) | 2013-01-17 | 2019-11-12 | 阿尔萨尼斯生物科学有限责任公司 | 多重抗药性大肠杆菌特异性抗体 |
| WO2014111724A1 (en) | 2013-01-18 | 2014-07-24 | London School Of Hygiene And Tropical Medicine | Glycosylation method |
| GB201301085D0 (en) | 2013-01-22 | 2013-03-06 | London School Hygiene & Tropical Medicine | Glycoconjugate Vaccine |
| CA2907338C (en) | 2013-03-15 | 2019-09-17 | Asieris Pharmaceutical Technologies Co., Ltd. | Base addition salts of nitroxoline and uses thereof |
| ES2753369T3 (es) | 2013-04-05 | 2020-04-08 | Univ Alberta | Vacuna de Campylobacter |
| KR20160062169A (ko) * | 2013-10-11 | 2016-06-01 | 글리코박신 아게 | 숙주 세포 변형 방법 |
| EP3110441B1 (de) | 2014-02-24 | 2024-04-03 | GlaxoSmithKline Biologicals S.A. | Neuartiges polysaccharid und verwendungen davon |
| MX2016013631A (es) * | 2014-04-17 | 2017-02-28 | Glycovaxyn Ag | Celulas huespedes modificadas y usos de las mismas. |
| US10307474B2 (en) | 2014-08-08 | 2019-06-04 | Glaxosmithkline Biologicals S.A. | Modified host cells and hybrid oligosaccharides for use in bioconjugate production |
| CN107614679A (zh) * | 2014-12-30 | 2018-01-19 | 葛兰素史密丝克莱恩生物有限公司 | 用于蛋白糖基化的组合物和方法 |
| TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| GB201518668D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| US11000583B2 (en) * | 2017-01-27 | 2021-05-11 | University Of Florida Research Foundation, Incorporated | Food safety vaccine to control Salmonella enterica and reduce campylobacter in poultry |
| GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
| US11898187B2 (en) | 2017-08-15 | 2024-02-13 | Northwestern University | Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases |
| GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
| GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
| US20190275135A1 (en) | 2018-03-12 | 2019-09-12 | Janssen Pharmaceuticals, Inc | Vaccines against intra-abdominal infections |
| US11530432B2 (en) | 2018-03-19 | 2022-12-20 | Northwestern University | Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates |
| US11725224B2 (en) | 2018-04-16 | 2023-08-15 | Northwestern University | Methods for co-activating in vitro non-standard amino acid (nsAA) incorporation and glycosylation in crude cell lysates |
| JP2022513458A (ja) | 2018-12-12 | 2022-02-08 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Ｏ－結合型グリコシル化のための修飾キャリアタンパク質 |
| BR112021018258A2 (pt) | 2019-03-18 | 2022-02-08 | Glaxosmithkline Biologicals Sa | Método e célula hospedeira recombinante para preparar um bioconjugado, bioconjugado, e, composição |
| PE20212265A1 (es) | 2019-03-18 | 2021-11-30 | Janssen Pharmaceuticals Inc | Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos |
| EP3757217A1 (de) | 2019-06-27 | 2020-12-30 | GlaxoSmithKline Biologicals S.A. | Verfahren zur proteinaufreinigung |
| EP3770269A1 (de) | 2019-07-23 | 2021-01-27 | GlaxoSmithKline Biologicals S.A. | Quantifizierung von biokonjugatglykosylierung |
| EP3777884A1 (de) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogene zusammensetzung |
| WO2021144369A1 (en) | 2020-01-16 | 2021-07-22 | Janssen Pharmaceuticals, Inc. | Fimh mutant, compositions therewith and use thereof |
| CN115697396A (zh) | 2020-06-18 | 2023-02-03 | 葛兰素史克生物有限公司 | 志贺氏菌-四价（Shigella4V）生物缀合物 |
| US20230293657A1 (en) | 2020-06-25 | 2023-09-21 | Glaxosmithkline Biologicals Sa | Vaccine |
| IL308201A (en) | 2020-09-17 | 2024-01-01 | Janssen Pharmaceuticals Inc | Multivalent vaccine compositions and uses thereof |
| US11725028B2 (en) | 2021-01-12 | 2023-08-15 | Janssen Pharmaceuticals, Inc. | FimH mutants, compositions therewith and use thereof |
| JP2024514074A (ja) | 2021-04-01 | 2024-03-28 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | Ｅ．ｃｏｌｉ ｏ１８バイオコンジュゲートの産生 |
| WO2023118033A1 (en) | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccine |
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| DE3584198D1 (de) | 1984-08-01 | 1991-10-31 | Boehringer Ingelheim Int | Neue genetische sequenzen, die durch sie codierten interferon-peptide vom typ i und diese sie produzierende organismen. |
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| US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
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| WO2003074687A1 (en) | 2002-03-07 | 2003-09-12 | Eidgenössische Technische Hochschule Zürich | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
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2006
- 2006-05-10 PT PT06753552T patent/PT1888761E/pt unknown
- 2006-05-10 ES ES10179208.3T patent/ES2535084T3/es active Active
- 2006-05-10 DE DE602006017207T patent/DE602006017207D1/de active Active
- 2006-05-10 KR KR1020077028970A patent/KR101408653B1/ko active IP Right Grant
- 2006-05-10 DK DK06753552.6T patent/DK1888761T3/da active
- 2006-05-10 AU AU2006245969A patent/AU2006245969B8/en active Active
- 2006-05-10 CN CN200680020861XA patent/CN101360831B/zh active Active
- 2006-05-10 PL PL10179208T patent/PL2311972T3/pl unknown
- 2006-05-10 EP EP06753552A patent/EP1888761B1/de active Active
- 2006-05-10 WO PCT/EP2006/004397 patent/WO2006119987A2/en active Application Filing
- 2006-05-10 SI SI200631910T patent/SI2311972T1/sl unknown
- 2006-05-10 AT AT06753552T patent/ATE483027T1/de active
- 2006-05-10 JP JP2008510495A patent/JP5356807B2/ja active Active
- 2006-05-10 EP EP14199949.0A patent/EP2853600B1/de active Active
- 2006-05-10 ES ES06753552T patent/ES2353814T3/es active Active
- 2006-05-10 KR KR1020147001671A patent/KR101524636B1/ko active IP Right Grant
- 2006-05-10 DK DK10179208T patent/DK2311972T3/en active
- 2006-05-10 ES ES14199949T patent/ES2703061T3/es active Active
- 2006-05-10 CA CA2607595A patent/CA2607595C/en active Active
- 2006-05-10 CN CN201310241471.7A patent/CN103396478B/zh active Active
- 2006-05-10 US US11/920,175 patent/US8753864B2/en active Active
- 2006-05-10 PT PT101792083T patent/PT2311972E/pt unknown
- 2006-05-10 EP EP10179208.3A patent/EP2311972B1/de active Active
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2007
- 2007-11-11 IL IL187293A patent/IL187293A/en active IP Right Grant
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2008
- 2008-08-14 HK HK08109020.7A patent/HK1113588A1/xx unknown
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2011
- 2011-10-19 HK HK11111186.8A patent/HK1156983A1/zh unknown
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2012
- 2012-01-06 JP JP2012001342A patent/JP5687637B2/ja active Active
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2013
- 2013-06-10 IL IL226857A patent/IL226857A/en not_active IP Right Cessation
- 2013-12-03 JP JP2013250586A patent/JP5827303B2/ja active Active
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2014
- 2014-02-06 US US14/174,742 patent/US9551019B2/en active Active
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2015
- 2015-03-18 HR HRP20150312TT patent/HRP20150312T1/hr unknown
- 2015-04-15 CY CY20151100351T patent/CY1116285T1/el unknown
- 2015-06-09 HK HK15105466.7A patent/HK1205193A1/xx unknown
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2016
- 2016-05-19 US US15/159,535 patent/US20160326563A1/en not_active Abandoned
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