HK1113588A1 - Recombinant n-glycosylated proteins from procaryotic cells - Google Patents

Recombinant n-glycosylated proteins from procaryotic cells

Info

Publication number
HK1113588A1
HK1113588A1 HK08109020.7A HK08109020A HK1113588A1 HK 1113588 A1 HK1113588 A1 HK 1113588A1 HK 08109020 A HK08109020 A HK 08109020A HK 1113588 A1 HK1113588 A1 HK 1113588A1
Authority
HK
Hong Kong
Prior art keywords
recombinant
proteins
glycosylated proteins
procaryotic cells
glycosylated
Prior art date
Application number
HK08109020.7A
Other languages
English (en)
Inventor
Markus Aebi
Michael Kowarik
Umesh Ahuja
Original Assignee
Eth Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eth Zuerich filed Critical Eth Zuerich
Publication of HK1113588A1 publication Critical patent/HK1113588A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK08109020.7A 2005-05-11 2008-08-14 Recombinant n-glycosylated proteins from procaryotic cells HK1113588A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05010276 2005-05-11
PCT/EP2006/004397 WO2006119987A2 (en) 2005-05-11 2006-05-10 Recombinant n-glycosylated proteins from procaryotic cells

Publications (1)

Publication Number Publication Date
HK1113588A1 true HK1113588A1 (en) 2008-10-10

Family

ID=37396912

Family Applications (3)

Application Number Title Priority Date Filing Date
HK08109020.7A HK1113588A1 (en) 2005-05-11 2008-08-14 Recombinant n-glycosylated proteins from procaryotic cells
HK11111186.8A HK1156983A1 (zh) 2005-05-11 2011-10-19 來自原核細胞的重組 -糖基化蛋白質
HK15105466.7A HK1205193A1 (en) 2005-05-11 2015-06-09 Recombinant n-glycosylated proteins from procaryotic cells n-

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK11111186.8A HK1156983A1 (zh) 2005-05-11 2011-10-19 來自原核細胞的重組 -糖基化蛋白質
HK15105466.7A HK1205193A1 (en) 2005-05-11 2015-06-09 Recombinant n-glycosylated proteins from procaryotic cells n-

Country Status (19)

Country Link
US (3) US8753864B2 (xx)
EP (3) EP1888761B1 (xx)
JP (3) JP5356807B2 (xx)
KR (2) KR101524636B1 (xx)
CN (2) CN101360831B (xx)
AT (1) ATE483027T1 (xx)
AU (1) AU2006245969B8 (xx)
CA (1) CA2607595C (xx)
CY (1) CY1116285T1 (xx)
DE (1) DE602006017207D1 (xx)
DK (2) DK2311972T3 (xx)
ES (3) ES2703061T3 (xx)
HK (3) HK1113588A1 (xx)
HR (1) HRP20150312T1 (xx)
IL (2) IL187293A (xx)
PL (1) PL2311972T3 (xx)
PT (2) PT2311972E (xx)
SI (1) SI2311972T1 (xx)
WO (1) WO2006119987A2 (xx)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
DE60303591T2 (de) 2002-03-07 2007-03-01 Eidgenössische Technische Hochschule Zürich System und methode zur herstellung von rekombinanten, glykosylierten protein in prokaryontischen wirtszellen
MXPA05010773A (es) 2003-04-09 2005-12-12 Neose Technologies Inc Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos.
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
ES2560657T3 (es) 2004-01-08 2016-02-22 Ratiopharm Gmbh Glicosilación con unión en O de péptidos G-CSF
NZ593986A (en) * 2004-03-03 2013-07-26 Revance Therapeutics Inc Compositions comprising a protein and a carrier for topical diagnostic and therapeutic transport
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
EP1814573B1 (en) 2004-10-29 2016-03-09 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
ES2449195T3 (es) 2005-01-10 2014-03-18 Ratiopharm Gmbh Factor estimulante de colonias de granulocitos glicopegilado
CN106039294A (zh) * 2005-03-03 2016-10-26 雷文斯治疗公司 用于局部施用和经皮肤递送肉毒杆菌毒素的组合物和方法
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
JP5216580B2 (ja) 2005-05-25 2013-06-19 ノヴォ ノルディスク アー／エス グリコペグ化第ｉｘ因子
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
WO2008011633A2 (en) 2006-07-21 2008-01-24 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
WO2009089154A2 (en) 2008-01-03 2009-07-16 Cornell Research Foundation, Inc. Glycosylated protein expression in prokaryotes
EP2242505A4 (en) * 2008-01-08 2012-03-07 Biogenerix Ag GLYCOCONJUGATION OF POLYPEPTIDES USING OLIGOSACCHARYLTRANSFERASES
EP3427749A1 (en) * 2008-02-20 2019-01-16 GlaxoSmithKline Biologicals SA Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells
JP5619630B2 (ja) 2008-02-27 2014-11-05 ノボ・ノルデイスク・エー／エス 結合型第ｖｉｉｉ因子分子
PL2411503T3 (pl) * 2009-03-27 2018-01-31 Eidgenoessische Technische Hochschule Zuerich Salmonella enterica prezentująca n-glikan z c. jejuni lub jego pochodne
KR101855380B1 (ko) * 2009-11-19 2018-05-08 글락소스미스클라인 바이오로지칼즈 에스.에이. 원핵세포에서 면역원성 폴리사카라이드를 제조하는 생합성 시스템
JP5925699B2 (ja) 2010-02-11 2016-05-25 ザ・ガバナーズ・オブ・ザ・ユニバーシティー・オブ・アルバータ Ｎ結合型グリカン化合物
KR20130063510A (ko) 2010-05-06 2013-06-14 글리코박신 아게 캡슐형 그람-양성 세균 생체접합체 백신
JP2013539963A (ja) * 2010-09-03 2013-10-31 ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ 複数のｎ結合型グリコシル化シークオンを含んでいるペプチド
AU2012306345A1 (en) 2011-09-06 2014-03-20 Glycovaxyn Ag Bioconjugate vaccines made in prokaryotic cells
CA3125293A1 (en) 2012-11-07 2014-05-15 Glaxosmithkline Biologicals Sa Production of recombinant vaccine in e. coli by enzymatic conjugation
EP2945651B1 (en) 2013-01-17 2018-03-07 ARSANIS Biosciences GmbH Mdr e. coli specific antibody
US9931392B2 (en) 2013-01-18 2018-04-03 London School Of Hygiene And Tropical Medicine Glycosylation method
GB201301085D0 (en) 2013-01-22 2013-03-06 London School Hygiene & Tropical Medicine Glycoconjugate Vaccine
MX357888B (es) * 2013-03-15 2018-07-27 Asieris Pharmaceutical Tech Co Ltd Sales basicas de adicion de nitroxolina y usos de las mismas.
ES2753369T3 (es) * 2013-04-05 2020-04-08 Univ Alberta Vacuna de Campylobacter
CN106062203B (zh) * 2013-10-11 2020-08-07 葛兰素史密丝克莱恩生物有限公司 宿主细胞修饰的方法
CN106535927B (zh) 2014-02-24 2019-09-20 葛兰素史密丝克莱恩生物有限公司 新颖多糖及其用途
CA2945542C (en) 2014-04-17 2024-03-05 Glycovaxyn Ag Modified host cells and uses thereof
CN106795545A (zh) 2014-08-08 2017-05-31 格林考瓦因有限公司 用于生物缀合物产生的修饰宿主细胞和杂合寡糖
LT3240895T (lt) * 2014-12-30 2022-04-11 Glaxosmithkline Biologicals S.A. Kompozicijos ir būdai, skirti baltymų glikozilinimui
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
GB201518668D0 (en) * 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Immunogenic Comosition
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
BR112019015425A2 (pt) 2017-01-27 2020-05-26 University Of Florida Research Foundation, Incorporated Uma vacina de segurança alimentar para controlar salmonella enterica e reduzir campylobacter em aves domésticas
GB201712678D0 (en) 2017-08-07 2017-09-20 Glaxosmithkline Biologicals Sa Process for the manipulation of nucleic acids
US11898187B2 (en) 2017-08-15 2024-02-13 Northwestern University Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
WO2019175147A1 (en) 2018-03-12 2019-09-19 Janssen Vaccines & Prevention B.V. Vaccines against intra-abdominal infections
US11530432B2 (en) 2018-03-19 2022-12-20 Northwestern University Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
WO2019204346A1 (en) 2018-04-16 2019-10-24 Northwestern University METHODS FOR CO-ACTIVATING IN VITRO NON-STANDARD AMINO ACID (nsAA) INCORPORATION AND GLYCOSYLATION IN CRUDE CELLLYSATES
US20220054632A1 (en) 2018-12-12 2022-02-24 Glaxosmithkline Biologicals Sa Modified carrier proteins for o-linked glycosylation
HRP20231026T1 (hr) 2019-03-18 2023-12-08 Janssen Pharmaceuticals, Inc. Postupci za proizvodnju biokonjugata polisaharida o-antigena e. coli, njihovi pripravci i postupci njihove primjene
CN113924112A (zh) 2019-03-18 2022-01-11 杨森制药公司 大肠杆菌o-抗原多糖的生物缀合物、其生产方法及其使用方法
EP3757217A1 (en) 2019-06-27 2020-12-30 GlaxoSmithKline Biologicals S.A. Methods for protein purification
EP3770269A1 (en) 2019-07-23 2021-01-27 GlaxoSmithKline Biologicals S.A. Quantification of bioconjugate glycosylation
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
JP7485771B2 (ja) 2020-01-16 2024-05-16 ヤンセン ファーマシューティカルズ，インコーポレーテッド ＦｉｍＨ変異体、その組成物、及びその使用
JP2023530154A (ja) 2020-06-18 2023-07-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 赤痢菌４価（Ｓｈｉｇｅｌｌａ４Ｖ）バイオコンジュゲート
CA3185639A1 (en) 2020-06-25 2021-12-30 Glaxosmithkline Biologicals Sa Vaccine
PE20231385A1 (es) 2020-09-17 2023-09-12 Janssen Pharmaceuticals Inc Composiciones de vacunas multivalentes y usos de las mismas
MX2023008251A (es) 2021-01-12 2023-07-26 Janssen Pharmaceuticals Inc Mutantes de fimh, composiciones con estos y uso de estos.
UY39710A (es) 2021-04-01 2022-09-30 Janssen Pharmaceuticals Inc Producción de bioconjugados de o18 de e. coli
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170204B1 (de) 1984-08-01 1991-09-25 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Neue genetische Sequenzen, die durch sie codierten Interferon-Peptide vom Typ I und diese sie produzierende Organismen
US5643758A (en) 1987-03-10 1997-07-01 New England Biolabs, Inc. Production and purification of a protein fused to a binding protein
WO1994026906A2 (en) 1993-05-14 1994-11-24 The Upjohn Company CLONED DNA ENCODING A UDP-GALNAc:POLYPEPTIDE,N-ACETYLGALACTOS AMINYLTRANSFERASE
US6503744B1 (en) 1999-02-01 2003-01-07 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
CA2363297C (en) 1999-03-02 2011-08-09 Michael J. Betenbaugh Engineering intracellular sialylation pathways
US20020127219A1 (en) * 1999-12-30 2002-09-12 Okkels Jens Sigurd Lysosomal enzymes and lysosomal enzyme activators
MXPA02011016A (es) 2000-05-12 2004-03-16 Neose Technologies Inc Glicopeptidos recombinantes de glucolisacion in vitro.
US6803225B2 (en) 2000-06-30 2004-10-12 Flanders Interuniversity Institute For Biotechnology Protein glycosylation modification in Pichia pastoris
DE10113573A1 (de) 2001-03-20 2002-02-28 Messer Griesheim Gmbh Verfahren zum Regenerieren von Schwefelsäure aus schwefelhaltigen Reststoffen
DE60303591T2 (de) 2002-03-07 2007-03-01 Eidgenössische Technische Hochschule Zürich System und methode zur herstellung von rekombinanten, glykosylierten protein in prokaryontischen wirtszellen
KR20100119905A (ko) 2002-03-07 2010-11-11 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 원핵 숙주에서의 재조합 글리코실화 단백질 생산 방법 및 생산계
ES2391525T3 (es) 2002-08-01 2012-11-27 National Research Council Of Canada Glucanos y glucopéptidos de Campylobacter

Also Published As

Publication number Publication date
JP5356807B2 (ja) 2013-12-04
CN101360831A (zh) 2009-02-04
KR101524636B1 (ko) 2015-06-03
US8753864B2 (en) 2014-06-17
US9551019B2 (en) 2017-01-24
PT1888761E (pt) 2011-01-03
DK2311972T3 (en) 2015-04-27
KR101408653B1 (ko) 2014-06-17
EP2853600B1 (en) 2018-09-19
PL2311972T3 (pl) 2015-08-31
AU2006245969A1 (en) 2006-11-16
ES2353814T3 (es) 2011-03-07
WO2006119987A3 (en) 2007-03-08
JP5687637B2 (ja) 2015-03-18
EP2853600A1 (en) 2015-04-01
JP5827303B2 (ja) 2015-12-02
JP2012100678A (ja) 2012-05-31
CA2607595A1 (en) 2006-11-16
CA2607595C (en) 2018-11-27
US20140323700A1 (en) 2014-10-30
HK1205193A1 (en) 2015-12-11
DE602006017207D1 (de) 2010-11-11
ES2703061T3 (es) 2019-03-06
AU2006245969B8 (en) 2011-08-25
CN103396478A (zh) 2013-11-20
EP2311972A1 (en) 2011-04-20
IL187293A (en) 2013-06-27
HK1156983A1 (zh) 2016-11-25
ATE483027T1 (de) 2010-10-15
US20100062484A1 (en) 2010-03-11
EP1888761A2 (en) 2008-02-20
JP2014042533A (ja) 2014-03-13
IL226857A (en) 2017-08-31
US20160326563A1 (en) 2016-11-10
AU2006245969B2 (en) 2011-06-02
DK1888761T3 (da) 2010-11-01
ES2535084T3 (es) 2015-05-05
WO2006119987A2 (en) 2006-11-16
SI2311972T1 (sl) 2015-08-31
JP2008539743A (ja) 2008-11-20
EP1888761B1 (en) 2010-09-29
CN103396478B (zh) 2016-09-28
KR20140019482A (ko) 2014-02-14
KR20080048990A (ko) 2008-06-03
PT2311972E (pt) 2015-05-13
CN101360831B (zh) 2013-07-10
CY1116285T1 (el) 2017-02-08
IL226857A0 (en) 2013-07-31
IL187293A0 (en) 2008-04-13
HRP20150312T1 (hr) 2015-07-31
EP2311972B1 (en) 2015-01-21

Similar Documents

Publication Publication Date Title
HK1205193A1 (en) Recombinant n-glycosylated proteins from procaryotic cells n-
MX2008001865A (es) Proteinas de fusion de albumina.
MX336807B (es) Composiciones y metodos para producir una composicion.
MX2009002816A (es) Proteinas de fusion de albumina.
WO2005003296A3 (en) Albumin fusion proteins
WO2005077042A3 (en) Albumin fusion proteins
MX2010005783A (es) Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas.
WO2007146038A3 (en) Albumin fusion proteins
NZ591415A (en) Haemophilus influenzae type B
MX348154B (es) Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
IL213319A (en) Polylysis peptides for use in the treatment of bacterial infections
SG165339A1 (en) Incorporation of non-naturally encoded amino acids into proteins
WO2007076162A3 (en) Antimicrobial cathelicidin peptides
WO2007103490A3 (en) System for the expression of orthogonal translation components in eubacterial host cells
TW200740841A (en) Polypeptides having antimicrobial activity and polynucleotides encoding same
MX2010004371A (es) Proteasa de streptomyces.
WO2008136865A3 (en) (s)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs
IL172729A0 (en) Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
MY150226A (en) Novel h5 proteins, nucleic acid molecules and vectors encoding for those, and medicinal use
WO2007060213A3 (en) Erythropoietin polypeptides and uses thereof
EP1978994A4 (en) BMP-7 VARIANTS COMPOSITIONS, METHODS AND USES
WO2008040190A8 (en) Small peptides for anti-angiogenesis and use thereof
TW200734350A (en) Polypeptides having antimicrobial activity and polynucleotides encoding same
WO2006017355A3 (en) Improved aprotinin variants
TW200700076A (en) Polypeptides having antimicrobial activity and polynucleotides encoding same