DE602006019826D1 - Kristallstruktur von tak1-tab1 - Google Patents

Kristallstruktur von tak1-tab1

Info

Publication number
DE602006019826D1
DE602006019826D1 DE602006019826T DE602006019826T DE602006019826D1 DE 602006019826 D1 DE602006019826 D1 DE 602006019826D1 DE 602006019826 T DE602006019826 T DE 602006019826T DE 602006019826 T DE602006019826 T DE 602006019826T DE 602006019826 D1 DE602006019826 D1 DE 602006019826D1
Authority
DE
Germany
Prior art keywords
tak1
relates
molecules
molecular complexes
coordinates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006019826T
Other languages
English (en)
Inventor
Graham Cheetham
Kieron Brown
Sarah Vial
Neesha Dedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE602006019826D1 publication Critical patent/DE602006019826D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
DE602006019826T 2005-02-23 2006-02-23 Kristallstruktur von tak1-tab1 Active DE602006019826D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65560605P 2005-02-23 2005-02-23
PCT/US2006/006286 WO2006091673A2 (en) 2005-02-23 2006-02-23 Crystal structure of tak1-tab1

Publications (1)

Publication Number Publication Date
DE602006019826D1 true DE602006019826D1 (de) 2011-03-10

Family

ID=36927986

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006019826T Active DE602006019826D1 (de) 2005-02-23 2006-02-23 Kristallstruktur von tak1-tab1

Country Status (5)

Country Link
US (2) US20070178573A1 (de)
EP (1) EP1851310B1 (de)
AT (1) ATE496991T1 (de)
DE (1) DE602006019826D1 (de)
WO (1) WO2006091673A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011100502A1 (en) 2010-02-11 2011-08-18 OSI Pharmaceuticals, LLC 7-aminofuropyridine derivatives
WO2012166722A1 (en) * 2011-06-03 2012-12-06 The General Hospital Corporation Treating colorectal, pancreatic, and lung cancer
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
SG10201508927SA (en) * 2015-10-29 2017-05-30 Agency Science Tech & Res Protein crystal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000070030A1 (en) * 1999-05-19 2000-11-23 Amgen Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
JP2003135070A (ja) * 2001-11-01 2003-05-13 Tanabe Seiyaku Co Ltd Ｔａｋ１−ｔａｂ１融合蛋白質
US20050261836A1 (en) * 2001-12-05 2005-11-24 Wuyi Meng Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof
ES2340475T3 (es) * 2002-05-01 2010-06-04 Vertex Pharmaceuticals Incorporated Estructura cristalizada de proteina aurora-2 y sus bolsillos de union.
WO2004087862A2 (en) * 2003-04-01 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Tak1-mediated inhibition of osteogenesis

Also Published As

Publication number Publication date
ATE496991T1 (de) 2011-02-15
WO2006091673A2 (en) 2006-08-31
EP1851310B1 (de) 2011-01-26
US20110171714A1 (en) 2011-07-14
US20070178573A1 (en) 2007-08-02
EP1851310A2 (de) 2007-11-07
WO2006091673A3 (en) 2007-04-19

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