BR112014006127A2 - indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização wnt/b-catenina - Google Patents
indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização wnt/b-cateninaInfo
- Publication number
- BR112014006127A2 BR112014006127A2 BR112014006127A BR112014006127A BR112014006127A2 BR 112014006127 A2 BR112014006127 A2 BR 112014006127A2 BR 112014006127 A BR112014006127 A BR 112014006127A BR 112014006127 A BR112014006127 A BR 112014006127A BR 112014006127 A2 BR112014006127 A2 BR 112014006127A2
- Authority
- BR
- Brazil
- Prior art keywords
- indazol
- wnt
- carboxamides
- inhibitors
- signaling pathway
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201161534601P | 2011-09-14 | 2011-09-14 | |
US201261624646P | 2012-04-16 | 2012-04-16 | |
PCT/US2012/055172 WO2013040215A1 (en) | 2011-09-14 | 2012-09-13 | Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
Publications (1)
Publication Number | Publication Date |
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BR112014006127A2 true BR112014006127A2 (pt) | 2017-04-04 |
Family
ID=47883736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112014006127A BR112014006127A2 (pt) | 2011-09-14 | 2012-09-13 | indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização wnt/b-catenina |
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US (6) | US9221793B2 (pt) |
EP (2) | EP2755483B1 (pt) |
JP (2) | JP2014526510A (pt) |
KR (1) | KR102010611B1 (pt) |
CN (2) | CN109705097B (pt) |
AU (2) | AU2012308570B2 (pt) |
BR (1) | BR112014006127A2 (pt) |
CA (1) | CA2848659C (pt) |
CL (1) | CL2014000642A1 (pt) |
CO (1) | CO6940416A2 (pt) |
CY (1) | CY1122795T1 (pt) |
DK (1) | DK2755483T3 (pt) |
ES (1) | ES2711777T3 (pt) |
HR (1) | HRP20190281T1 (pt) |
HU (1) | HUE041576T2 (pt) |
IL (1) | IL231536A (pt) |
IN (1) | IN2014CN02646A (pt) |
LT (1) | LT2755483T (pt) |
ME (1) | ME03332B (pt) |
MX (2) | MX341504B (pt) |
MY (1) | MY184882A (pt) |
PE (1) | PE20141678A1 (pt) |
PL (1) | PL2755483T3 (pt) |
PT (1) | PT2755483T (pt) |
RS (1) | RS58462B1 (pt) |
RU (1) | RU2627693C2 (pt) |
SG (3) | SG10202002005SA (pt) |
SI (1) | SI2755483T1 (pt) |
WO (1) | WO2013040215A1 (pt) |
ZA (1) | ZA201402623B (pt) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2987487T3 (da) | 2009-08-10 | 2020-12-07 | Samumed Llc | Indazolinhibitorer af wnt-signalvejen og terapeutiske anvendelser deraf |
DK3001903T3 (en) | 2009-12-21 | 2017-12-18 | Samumed Llc | 1H-PYRAZOLO [3,4 -?] PYRIDINES AND THERAPEUTIC APPLICATIONS THEREOF |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
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