CY1122795T1 - Ινδαζολο-3-καρβοξαμιδια και η χρηση τους ως αναστολεις του σηματοδοτικου μονοπατιου wnt/b-κατενινης - Google Patents

Ινδαζολο-3-καρβοξαμιδια και η χρηση τους ως αναστολεις του σηματοδοτικου μονοπατιου wnt/b-κατενινης

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Publication number
CY1122795T1
CY1122795T1 CY20191100205T CY191100205T CY1122795T1 CY 1122795 T1 CY1122795 T1 CY 1122795T1 CY 20191100205 T CY20191100205 T CY 20191100205T CY 191100205 T CY191100205 T CY 191100205T CY 1122795 T1 CY1122795 T1 CY 1122795T1
Authority
CY
Cyprus
Prior art keywords
wnt
indazole
signaling pathway
diseases
carboxamides
Prior art date
Application number
CY20191100205T
Other languages
English (en)
Inventor
John Hood
Sunil Kumar Kc
Original Assignee
Samumed, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed, Llc filed Critical Samumed, Llc
Publication of CY1122795T1 publication Critical patent/CY1122795T1/el

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Αποκαλύπτονται ενώσεις ινδαζoλο-3-καρβοξαμιδίου για τη θεραπευτική αντιμετώπιση διαφόρων νόσων και παθολογιών. Ειδικότερα, η παρούσα αποκάλυψη αφορά στη χρήση μιας ένωσης ινδαζολο-3-καρβοξαμιδίου ή αναλόγων αυτής για τη θεραπευτική αντιμετώπιση διαταραχών που χαρακτηρίζονται από την ενεργοποίηση του σηματοδοτικού μονοπατιού Wnt (π.χ. καρκίνος, μη φυσιολογικός πολλαπλασιασμός κυττάρων, αγγειογένεση και οστεοαρθρίτιδα), τη διαμόρφωση κυτταρικών συμβάντων διά της μεσολάβησης του σηματοδοτικού μονοπατιού Wnt, καθώς και γενετικών παθήσεων και νευρολογικών παθήσεων/διαταραχών/ασθενειών που οφείλονται σε μεταλλάξεις ή σε δυσλειτουργία του μονοπατιού Wnt και/ή ενός ή περισσότερων συστατικών του σηματοδότη Wnt. Παρέχονται επίσης μέθοδοι για τη θεραπευτική αντιμετώπιση νοσημάτων που σχετίζονται με το Wnt.
CY20191100205T 2011-09-14 2019-02-14 Ινδαζολο-3-καρβοξαμιδια και η χρηση τους ως αναστολεις του σηματοδοτικου μονοπατιου wnt/b-κατενινης CY1122795T1 (el)

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