DE60039616D1 - INHIBITOREN DER c-JUN N-TERMINALEN KINASE (JNK) UND ANDERE PROTEIN-KINASEN - Google Patents
INHIBITOREN DER c-JUN N-TERMINALEN KINASE (JNK) UND ANDERE PROTEIN-KINASENInfo
- Publication number
- DE60039616D1 DE60039616D1 DE60039616T DE60039616T DE60039616D1 DE 60039616 D1 DE60039616 D1 DE 60039616D1 DE 60039616 T DE60039616 T DE 60039616T DE 60039616 T DE60039616 T DE 60039616T DE 60039616 D1 DE60039616 D1 DE 60039616D1
- Authority
- DE
- Germany
- Prior art keywords
- jnk
- jun
- inhibitors
- protein kinases
- terminal kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14879599P | 1999-08-13 | 1999-08-13 | |
US16692299P | 1999-11-22 | 1999-11-22 | |
US21151700P | 2000-06-14 | 2000-06-14 | |
PCT/US2000/022445 WO2001012621A1 (en) | 1999-08-13 | 2000-08-11 | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60039616D1 true DE60039616D1 (de) | 2008-09-04 |
Family
ID=27386739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60039616T Expired - Lifetime DE60039616D1 (de) | 1999-08-13 | 2000-08-11 | INHIBITOREN DER c-JUN N-TERMINALEN KINASE (JNK) UND ANDERE PROTEIN-KINASEN |
Country Status (22)
Country | Link |
---|---|
US (2) | US6693108B2 (de) |
EP (1) | EP1218369B1 (de) |
JP (1) | JP2003531103A (de) |
KR (1) | KR20020030791A (de) |
CN (1) | CN1222520C (de) |
AR (1) | AR032130A1 (de) |
AT (1) | ATE402163T1 (de) |
AU (1) | AU6909600A (de) |
BR (1) | BR0013551A (de) |
CA (1) | CA2381882C (de) |
CO (1) | CO5200770A1 (de) |
CZ (1) | CZ2002534A3 (de) |
DE (1) | DE60039616D1 (de) |
HK (1) | HK1045507A1 (de) |
HU (1) | HUP0300340A3 (de) |
MX (1) | MXPA02001565A (de) |
MY (1) | MY133159A (de) |
NO (1) | NO20020713L (de) |
NZ (1) | NZ517694A (de) |
PL (1) | PL366110A1 (de) |
SK (1) | SK3572002A3 (de) |
WO (1) | WO2001012621A1 (de) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
CN101481359A (zh) | 1999-04-15 | 2009-07-15 | 布里斯托尔-迈尔斯斯奎布公司 | 环状蛋白酪氨酸激酶抑制剂 |
US7119114B1 (en) | 1999-08-19 | 2006-10-10 | Signal Pharmaceuticals, Llc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto |
US20040072888A1 (en) | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
CA2422380C (en) | 2000-09-15 | 2009-03-24 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
CN100340555C (zh) | 2000-12-21 | 2007-10-03 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的吡唑化合物 |
WO2002062792A1 (fr) * | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Inhibiteur de jnk |
US6987184B2 (en) | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
WO2002083668A1 (en) * | 2001-04-10 | 2002-10-24 | Vertex Pharmaceuticals Incorporated | Isoxaxole derivatives as inhibitors of src and other protein kinases |
WO2002083667A2 (en) | 2001-04-13 | 2002-10-24 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
CA2440842A1 (en) | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Novel 1h-indazole compounds |
US6727364B2 (en) * | 2001-04-30 | 2004-04-27 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
US6787555B2 (en) * | 2001-04-30 | 2004-09-07 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
US6790846B2 (en) * | 2001-05-24 | 2004-09-14 | The Procter & Gamble Company | Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity |
DE60232510D1 (de) * | 2001-06-15 | 2009-07-16 | Vertex Pharma | 5-(2-aminopyrimidin-4-yl)benzisoxazole als proteinkinasehemmer |
US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
DE60214198T2 (de) | 2001-07-03 | 2007-08-09 | Vertex Pharmaceuticals Inc., Cambridge | Isoxazolyl-pyrimidines als inhibitoren von src- und lck-protein-kinasen |
US7683078B2 (en) | 2001-07-23 | 2010-03-23 | Laboratoires Serono S.A. | Arylsulfonamide derivatives as C-Jun-N-Terminal Kinases (JNK's) inhibitors |
EP1435948A1 (de) * | 2001-08-06 | 2004-07-14 | Pharmacia Italia S.p.A. | Aminoisoxazol-derivate mit wirkung als kinasehemmer |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
EP1448556A1 (de) * | 2001-11-01 | 2004-08-25 | Janssen Pharmaceutica N.V. | Heteroarylamine als inhibitoren der glycogensynthasekinase-3-beta (gsk3-inhibitoren) |
JP2005518371A (ja) | 2001-12-10 | 2005-06-23 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療に於けるこれらの使用 |
GB0129476D0 (en) * | 2001-12-10 | 2002-01-30 | Syngenta Participations Ag | Organic compounds |
AU2003235741B8 (en) * | 2002-01-07 | 2009-01-15 | Eisai R&D Management Co., Ltd. | Deazapurines and uses thereof |
AU2003212796A1 (en) * | 2002-01-11 | 2003-07-30 | Vertex Pharmaceuticals Incorporated | Crystal structures of jnk-inhibitor complexes and binding pockets thereof |
CN102392028B (zh) | 2002-02-12 | 2013-08-14 | 佐蒂斯P有限责任公司 | 指导b2:b1除虫菌素比例的除虫链霉菌基因 |
AU2003217961B2 (en) * | 2002-03-08 | 2008-02-28 | Signal Pharmaceuticals, Llc | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
AU2003247425B2 (en) * | 2002-05-22 | 2007-03-08 | Amgen Inc. | Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain |
EP1525308A4 (de) * | 2002-05-30 | 2006-11-02 | Celgene Corp | Verfahren zur verwendung von jnk- oder mkk-inhibitoren zur modulation der zelldifferenzierung und zur behandlung von myeloproliferativen störungen und myelodysplastischen syndromen |
KR20050004214A (ko) | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
EP1542972A4 (de) | 2002-07-29 | 2008-01-23 | Nitromed Inc | Cyclooxygenase-2-selektive inhibitoren, zusammensetzung und anwendungsverfahren |
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MXPA02001565A (es) | 2005-07-14 |
US20050026967A1 (en) | 2005-02-03 |
NO20020713L (no) | 2002-04-12 |
CZ2002534A3 (cs) | 2002-07-17 |
HUP0300340A2 (hu) | 2003-06-28 |
SK3572002A3 (en) | 2002-07-02 |
CA2381882A1 (en) | 2001-02-22 |
WO2001012621A1 (en) | 2001-02-22 |
BR0013551A (pt) | 2003-06-17 |
CN1222520C (zh) | 2005-10-12 |
AR032130A1 (es) | 2003-10-29 |
AU6909600A (en) | 2001-03-13 |
CN1378541A (zh) | 2002-11-06 |
ATE402163T1 (de) | 2008-08-15 |
NO20020713D0 (no) | 2002-02-12 |
EP1218369A1 (de) | 2002-07-03 |
EP1218369A4 (de) | 2005-06-22 |
HK1045507A1 (zh) | 2002-11-29 |
US6693108B2 (en) | 2004-02-17 |
CA2381882C (en) | 2011-01-25 |
PL366110A1 (en) | 2005-01-24 |
JP2003531103A (ja) | 2003-10-21 |
MY133159A (en) | 2007-10-31 |
US7169798B2 (en) | 2007-01-30 |
KR20020030791A (ko) | 2002-04-25 |
EP1218369B1 (de) | 2008-07-23 |
HUP0300340A3 (en) | 2005-04-28 |
US20030149051A1 (en) | 2003-08-07 |
CO5200770A1 (es) | 2002-09-27 |
NZ517694A (en) | 2005-03-24 |
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