ATE279410T1 - 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen - Google Patents

3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen

Info

Publication number
ATE279410T1
ATE279410T1 AT01948983T AT01948983T ATE279410T1 AT E279410 T1 ATE279410 T1 AT E279410T1 AT 01948983 T AT01948983 T AT 01948983T AT 01948983 T AT01948983 T AT 01948983T AT E279410 T1 ATE279410 T1 AT E279410T1
Authority
AT
Austria
Prior art keywords
inhibitors
aminopyrazoles
cyclin
dependent kinases
useful
Prior art date
Application number
AT01948983T
Other languages
English (en)
Inventor
Mark E Salvati
Spencer David Kimball
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE279410T1 publication Critical patent/ATE279410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01948983T 2000-02-07 2001-01-23 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen ATE279410T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18060900P 2000-02-07 2000-02-07
PCT/US2001/002208 WO2001057034A1 (en) 2000-02-07 2001-01-23 3-aminopyrazole inhibitors of cyclin dependent kinases

Publications (1)

Publication Number Publication Date
ATE279410T1 true ATE279410T1 (de) 2004-10-15

Family

ID=22661092

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01948983T ATE279410T1 (de) 2000-02-07 2001-01-23 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen

Country Status (11)

Country Link
US (2) US6482842B2 (de)
EP (1) EP1268472B1 (de)
JP (1) JP2003522174A (de)
AT (1) ATE279410T1 (de)
AU (2) AU2972701A (de)
CA (1) CA2399274A1 (de)
DE (1) DE60106409T2 (de)
DK (1) DK1268472T3 (de)
ES (1) ES2228905T3 (de)
PT (1) PT1268472E (de)
WO (1) WO2001057034A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
PT1939203E (pt) 2000-04-25 2015-02-04 Icos Corp Inibidores da isoforma delta da fosfatidil-inositol 3-quinase humana
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2003287692A1 (en) * 2002-11-12 2004-06-03 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor supression and regression
WO2004098589A1 (en) * 2003-05-02 2004-11-18 Elan Pharmaceuticals, Inc. 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
MXPA06001742A (es) * 2003-08-13 2006-08-11 Bf Res Inst Inc Sondas para enfermedades en las cuales se acumula amiloide, agentes para tincion del amiloide, farmacos para tratamiento y profilaxis de enfermedades con amiloide acumulado, y sondas para diagnostico de ovillos neurofibrilares y agentes para tincion
WO2005047504A1 (en) * 2003-11-07 2005-05-26 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor suppression and regression
ES2605792T3 (es) 2004-05-13 2017-03-16 Icos Corporation Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana
EP1899304A1 (de) * 2005-05-23 2008-03-19 Arena Pharmaceuticals, Inc. 5-amino-1h-pyrazol-3-carbonsäurederivate als agonisten des g-protein-gekoppelten rezeptors (gpcr) rup38 zur behandlung von stoffwechselerkrankungen damit
CN104042618B (zh) 2008-11-13 2018-02-16 吉利德卡利斯托加公司 恶性血液病的治疗
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
EP2456443A1 (de) 2009-07-21 2012-05-30 Gilead Calistoga LLC Behandlung von lebererkrankungen mit pi3k-hemmern
EA201691327A1 (ru) 2012-03-05 2017-03-31 Джилид Калистога Ллс Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она
EP3083623A1 (de) 2013-12-20 2016-10-26 Gilead Calistoga LLC Polymorphe formen eines hydrochloridsalzes aus (s)-2-(9h-purin-6-ylamino)propyl)-5-fluor-3-phenylchinazolin-4 (3h)-on
NZ736970A (en) 2013-12-20 2018-11-30 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416683A (en) * 1980-09-16 1983-11-22 Eli Lilly And Company Benzamides, compositions and agricultural method
JPS6033552A (ja) * 1983-08-04 1985-02-20 Fuji Photo Film Co Ltd カラ−画像形成方法
EP0178035B1 (de) * 1984-05-12 1990-01-03 FISONS plc Antiinflammatorische 1,N-Diarylpyrazol-3-amine, deren Zusammensetzungen und Verfahren zu deren Herstellung
JPH0743522B2 (ja) * 1985-07-05 1995-05-15 コニカ株式会社 ５―アミノ―１ｈ―ピラゾール系化合物を用いる写真用マゼンタカプラーの合成方法
JPH01258695A (ja) * 1988-04-07 1989-10-16 Yamanouchi Pharmaceut Co Ltd （ピラゾリルアミノ）メチレンビス（ホスホン酸）誘導体及びその医薬
WO1993005044A1 (en) * 1991-09-03 1993-03-18 Yamanouchi Pharmaceutical Co.,Ltd. Pyrazolotriazole derivative
JPH06210063A (ja) * 1993-01-14 1994-08-02 Kousaku Ishikawa パチンコゲーム機における持ち玉返却機構
AU700964B2 (en) * 1994-11-10 1999-01-14 Cor Therapeutics, Inc. Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
DE19744676A1 (de) 1997-10-10 1999-04-15 Forschungszentrum Borstel Zent Kombinationspräparate für die Therapie von Tumoren
GB9904932D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
HN2000000051A (es) 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
DE60024631T2 (de) 1999-07-26 2006-06-14 Banyu Pharma Co Ltd Biaryl-harnstoff-derivate
AP2002002442A0 (en) 1999-08-12 2002-03-31 Pharmacia Italia Spa 3(5)-Amino-pyrazole derivatives, process for their preparation and their preparation and their use as antitumor agents.
US6387900B1 (en) * 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents

Also Published As

Publication number Publication date
ES2228905T3 (es) 2005-04-16
DK1268472T3 (da) 2004-12-06
US20010047019A1 (en) 2001-11-29
CA2399274A1 (en) 2001-08-09
DE60106409D1 (de) 2004-11-18
US6610724B2 (en) 2003-08-26
AU2972701A (en) 2001-08-14
WO2001057034A1 (en) 2001-08-09
DE60106409T2 (de) 2006-02-02
AU2001229727B2 (en) 2004-10-14
JP2003522174A (ja) 2003-07-22
EP1268472A1 (de) 2003-01-02
PT1268472E (pt) 2005-01-31
US6482842B2 (en) 2002-11-19
US20030018058A1 (en) 2003-01-23
EP1268472B1 (de) 2004-10-13

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