MA29612B1 - Composes et methodes de modulation de la kinase et instructions afferentes - Google Patents
Composes et methodes de modulation de la kinase et instructions afferentesInfo
- Publication number
- MA29612B1 MA29612B1 MA30548A MA30548A MA29612B1 MA 29612 B1 MA29612 B1 MA 29612B1 MA 30548 A MA30548 A MA 30548A MA 30548 A MA30548 A MA 30548A MA 29612 B1 MA29612 B1 MA 29612B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- methods
- related instructions
- modulating kinase
- raf
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 3
- 108060006633 protein kinase Proteins 0.000 abstract 3
- KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 abstract 1
- 101150113474 MAPK10 gene Proteins 0.000 abstract 1
- 101150031398 MAPK9 gene Proteins 0.000 abstract 1
- 101150101215 Mapk8 gene Proteins 0.000 abstract 1
- 101100381978 Mus musculus Braf gene Proteins 0.000 abstract 1
- 230000001594 aberrant effect Effects 0.000 abstract 1
- -1 c-Raf-1 Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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