JPS6147500A - キメラモノクロ−ナル抗体及びその製造法 - Google Patents

キメラモノクロ−ナル抗体及びその製造法

Info

Publication number
JPS6147500A
JPS6147500A JP16937084A JP16937084A JPS6147500A JP S6147500 A JPS6147500 A JP S6147500A JP 16937084 A JP16937084 A JP 16937084A JP 16937084 A JP16937084 A JP 16937084A JP S6147500 A JPS6147500 A JP S6147500A
Authority
JP
Japan
Prior art keywords
human
cells
monoclonal antibody
chimeric monoclonal
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16937084A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0373280B2 (https=
Inventor
Katsu Taniguchi
克 谷口
Yoshikazu Kurosawa
黒沢　良和
Kozo Sugita
杉田　幸三
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Research Development Corp of Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15885326&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS6147500(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Development Corp of Japan filed Critical Research Development Corp of Japan
Priority to JP16937084A priority Critical patent/JPS6147500A/ja
Priority to EP85102665A priority patent/EP0171496B1/en
Priority to DE1985102665 priority patent/DE171496T1/de
Priority to DE19853587360 priority patent/DE3587360T2/de
Priority to CA 476731 priority patent/CA1339201C/en
Publication of JPS6147500A publication Critical patent/JPS6147500A/ja
Publication of JPH0373280B2 publication Critical patent/JPH0373280B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP16937084A 1984-08-15 1984-08-15 キメラモノクロ−ナル抗体及びその製造法 Granted JPS6147500A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP16937084A JPS6147500A (ja) 1984-08-15 1984-08-15 キメラモノクロ−ナル抗体及びその製造法
EP85102665A EP0171496B1 (en) 1984-08-15 1985-03-08 Process for the production of a chimera monoclonal antibody
DE1985102665 DE171496T1 (de) 1984-08-15 1985-03-08 Chimaerischer monoklonaler antikoerper und verfahren zu seiner herstellung.
DE19853587360 DE3587360T2 (de) 1984-08-15 1985-03-08 Verfahren zur Herstellung von chimärischen monoklonalen Antikörpern.
CA 476731 CA1339201C (en) 1984-08-15 1985-03-18 Chimera monoclonal antibody and a production process thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16937084A JPS6147500A (ja) 1984-08-15 1984-08-15 キメラモノクロ−ナル抗体及びその製造法

Publications (2)

Publication Number Publication Date
JPS6147500A true JPS6147500A (ja) 1986-03-07
JPH0373280B2 JPH0373280B2 (https=) 1991-11-21

Family

ID=15885326

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16937084A Granted JPS6147500A (ja) 1984-08-15 1984-08-15 キメラモノクロ−ナル抗体及びその製造法

Country Status (4)

Country Link
EP (1) EP0171496B1 (https=)
JP (1) JPS6147500A (https=)
CA (1) CA1339201C (https=)
DE (2) DE3587360T2 (https=)

Cited By (29)

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JPS61119196A (ja) * 1984-08-27 1986-06-06 ザ　ボ−ド　オブ　トラステイ−ズ　オブ　ザ　リ−ランド　スタンフオ−ド　ジユニア　ユニバ−シテイ Ｄｎａスプライシング及び発現によるキメラ性受容体
JPS61134325A (ja) * 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
JPS6336786A (ja) * 1986-07-31 1988-02-17 Teijin Ltd 抗体ｌ鎖発現型核酸塩基配列，プラスミド，細胞及びキメラ抗体ｌ鎖
JPS6336796A (ja) * 1986-08-01 1988-02-17 Teijin Ltd マウス−ヒトキメラ抗体、それをコ−ドする発現型キメラｄｎａ配列、プラスミド及び細胞
JPS63112995A (ja) * 1986-07-07 1988-05-18 セントコ−・インコ−ポレ−テッド 腫瘍関連抗原に特異的なキメラ齧歯類／ヒト免疫グロブリン
JPS63501765A (ja) * 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング　インコ−ポレ−テッド 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
EP0327000A2 (en) 1988-01-30 1989-08-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation
JPH02501886A (ja) * 1986-10-27 1990-06-28 インターナショナル、ジェネティック、エンジニアリング、インコーポレーテッド ヒト腫瘍抗原に対し特異性を有するキメラ抗体
JPH02231567A (ja) * 1989-01-10 1990-09-13 Boehringer Mannheim Gmbh 血清又は血液中の物質を診断検出する方法
JPH02238883A (ja) * 1988-10-17 1990-09-21 Becton Dickinson & Co 抗―Ｌｅｕ　３ａアミノ酸配列
JPH03504556A (ja) * 1987-05-29 1991-10-09 タノツクス・バイオシステムズ・インコーポレーテツド Ｈｉｖ‐１を中和するモノクローナル抗体
JPH03254691A (ja) * 1990-03-02 1991-11-13 Japan Found Cancer Res 薬剤耐性癌に対するキメラ抗体およびその製造
JPH04501503A (ja) * 1988-05-18 1992-03-19 セントカー・インコーポレーテツド 血小板特異的キメラ免疫グロブリン
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JPH0584082A (ja) * 1990-10-18 1993-04-06 Boehringer Mannheim Gmbh 抗体遺伝子の可変部をコードするｄｎａフラグメントの単離法、キメラ抗体遺伝子の製法、キメラ抗体の取得法及び医薬の製法
JPH0690752A (ja) * 1990-10-17 1994-04-05 Wellcome Found Ltd:The 抗体産生
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DE3587360D1 (de) 1993-07-01
DE171496T1 (de) 1986-07-03
EP0171496A2 (en) 1986-02-19
CA1339201C (en) 1997-08-05
EP0171496B1 (en) 1993-05-26
EP0171496A3 (en) 1987-11-25
DE3587360T2 (de) 1993-10-14
JPH0373280B2 (https=) 1991-11-21

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