BR112014004213A2 - novas moléculas de fusão kif5b-ret e usos das mesmas - Google Patents
novas moléculas de fusão kif5b-ret e usos das mesmasInfo
- Publication number
- BR112014004213A2 BR112014004213A2 BR112014004213A BR112014004213A BR112014004213A2 BR 112014004213 A2 BR112014004213 A2 BR 112014004213A2 BR 112014004213 A BR112014004213 A BR 112014004213A BR 112014004213 A BR112014004213 A BR 112014004213A BR 112014004213 A2 BR112014004213 A2 BR 112014004213A2
- Authority
- BR
- Brazil
- Prior art keywords
- kif5b
- new
- fusion molecules
- ret fusion
- ret
- Prior art date
Links
- 230000004927 fusion Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161526613P | 2011-08-23 | 2011-08-23 | |
US201161537024P | 2011-09-20 | 2011-09-20 | |
US201161542112P | 2011-09-30 | 2011-09-30 | |
US201261594739P | 2012-02-03 | 2012-02-03 | |
PCT/US2012/051978 WO2013028817A1 (en) | 2011-08-23 | 2012-08-23 | Novel kif5b-ret fusion molecules and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014004213A2 true BR112014004213A2 (pt) | 2017-06-20 |
Family
ID=47746850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014004213A BR112014004213A2 (pt) | 2011-08-23 | 2012-08-23 | novas moléculas de fusão kif5b-ret e usos das mesmas |
Country Status (11)
Country | Link |
---|---|
US (4) | US9297011B2 (pt) |
EP (2) | EP2748192B2 (pt) |
AU (3) | AU2012298884B2 (pt) |
BR (1) | BR112014004213A2 (pt) |
CA (1) | CA2846197C (pt) |
DK (1) | DK2748192T3 (pt) |
ES (1) | ES2704126T3 (pt) |
HK (1) | HK1199461A1 (pt) |
IL (3) | IL230914B (pt) |
SG (2) | SG2014012728A (pt) |
WO (1) | WO2013028817A1 (pt) |
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US10023855B2 (en) * | 2011-10-31 | 2018-07-17 | Macrogen, Inc. | Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker |
US20150232940A1 (en) * | 2012-03-09 | 2015-08-20 | Insight Genetics, Inc | Methods and compositions relating to diagnosing and treating receptor tyrosine kinase related cancers |
CA3077553C (en) | 2012-09-25 | 2022-08-02 | Chugai Seiyaku Kabushiki Kaisha | Ret inhibitor |
EP4112738A1 (en) * | 2014-12-05 | 2023-01-04 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
CN104975080A (zh) * | 2015-05-29 | 2015-10-14 | 北京海思特临床检验所有限公司 | 检测肺癌kif5b-ret融合基因的引物、试剂盒及其使用方法 |
TN2018000027A1 (en) | 2015-07-16 | 2019-07-08 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
TWI757256B (zh) | 2015-11-02 | 2022-03-11 | 美商纜圖藥品公司 | 轉染過程重排之抑制劑 |
US20190002988A1 (en) * | 2015-12-08 | 2019-01-03 | Boehringer Ingelheim International Gmbh | Method of using a ret fusion gene as a biomarker to select non small cell lung cancer (nsclc) and thyroid cancer patients for a cancer treatment |
AR107912A1 (es) | 2016-03-17 | 2018-06-28 | Blueprint Medicines Corp | Inhibidores de ret |
EP3454886A1 (en) | 2016-05-13 | 2019-03-20 | Instituto de Medicina Molecular | Methods of treating diseases associated with ilc3 cells |
KR101859576B1 (ko) | 2016-06-30 | 2018-05-18 | 가톨릭대학교 산학협력단 | Kif5b-ret 융합 단백질을 특이적으로 검출하는 항체 및 이의 용도 |
WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
EP3548007A4 (en) * | 2016-12-01 | 2020-08-12 | Ignyta, Inc. | CANCER TREATMENT METHODS |
EP3571203B1 (en) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
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US11524963B2 (en) | 2018-01-18 | 2022-12-13 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors |
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US11304988B2 (en) | 2018-01-24 | 2022-04-19 | Northwestern University | Inhibiting tumor cell migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) |
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-
2012
- 2012-08-23 EP EP12825669.0A patent/EP2748192B2/en active Active
- 2012-08-23 ES ES12825669T patent/ES2704126T3/es active Active
- 2012-08-23 EP EP18199731.3A patent/EP3564261A1/en active Pending
- 2012-08-23 SG SG2014012728A patent/SG2014012728A/en unknown
- 2012-08-23 AU AU2012298884A patent/AU2012298884B2/en active Active
- 2012-08-23 BR BR112014004213A patent/BR112014004213A2/pt not_active Application Discontinuation
- 2012-08-23 CA CA2846197A patent/CA2846197C/en active Active
- 2012-08-23 WO PCT/US2012/051978 patent/WO2013028817A1/en active Application Filing
- 2012-08-23 SG SG10201606991RA patent/SG10201606991RA/en unknown
- 2012-08-23 DK DK12825669.0T patent/DK2748192T3/en active
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2014
- 2014-02-11 IL IL230914A patent/IL230914B/en unknown
- 2014-02-23 US US14/187,280 patent/US9297011B2/en active Active
- 2014-12-26 HK HK14113000.5A patent/HK1199461A1/xx unknown
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2016
- 2016-02-17 US US15/045,716 patent/US9884060B2/en active Active
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2017
- 2017-12-12 US US15/839,560 patent/US20180280391A1/en not_active Abandoned
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- 2018-01-24 AU AU2018200582A patent/AU2018200582A1/en not_active Abandoned
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EP2748192A4 (en) | 2015-07-15 |
IL230914A0 (en) | 2014-03-31 |
AU2012298884B2 (en) | 2017-11-16 |
IL230914B (en) | 2020-03-31 |
SG2014012728A (en) | 2014-06-27 |
US20180280391A1 (en) | 2018-10-04 |
EP2748192A1 (en) | 2014-07-02 |
AU2012298884A1 (en) | 2014-03-06 |
ES2704126T3 (es) | 2019-03-14 |
US20140243390A1 (en) | 2014-08-28 |
EP2748192B2 (en) | 2022-04-20 |
US9884060B2 (en) | 2018-02-06 |
US20170014413A1 (en) | 2017-01-19 |
EP2748192B1 (en) | 2018-11-14 |
US9297011B2 (en) | 2016-03-29 |
IL272855A (en) | 2020-04-30 |
US20230241065A1 (en) | 2023-08-03 |
AU2018200582A1 (en) | 2018-02-15 |
SG10201606991RA (en) | 2016-10-28 |
DK2748192T3 (en) | 2019-02-25 |
HK1199461A1 (en) | 2015-07-03 |
AU2020203244A1 (en) | 2020-06-04 |
CA2846197C (en) | 2024-01-16 |
WO2013028817A1 (en) | 2013-02-28 |
EP3564261A1 (en) | 2019-11-06 |
AU2020203244B2 (en) | 2023-04-13 |
CA2846197A1 (en) | 2013-02-28 |
IL281148A (en) | 2021-04-29 |
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