PE20151893A1 - Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular - Google Patents

Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular

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Publication number
PE20151893A1
PE20151893A1 PE2015002015A PE2015002015A PE20151893A1 PE 20151893 A1 PE20151893 A1 PE 20151893A1 PE 2015002015 A PE2015002015 A PE 2015002015A PE 2015002015 A PE2015002015 A PE 2015002015A PE 20151893 A1 PE20151893 A1 PE 20151893A1
Authority
PE
Peru
Prior art keywords
antibodies
grp78
antigen
binding fragments
tumor cells
Prior art date
Application number
PE2015002015A
Other languages
English (en)
Inventor
Parkash Gill
Ren Liu
Original Assignee
Parkash Gill
Ren Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581763&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20151893(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Parkash Gill, Ren Liu filed Critical Parkash Gill
Publication of PE20151893A1 publication Critical patent/PE20151893A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
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    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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Abstract

La presente solicitud proporciona, entre otros, anticuerpos o fragmentos de union a antigeno de los mismos, dirigidos al GRP78 de superficie celular expresado en celulas tumorales, celulas tumorales endoteliales y celulas cancerosas en estadio inicial. Estos anticuerpos anti GRP78 y fragmentos de union a antigeno de los mismos tienen una alta afinidad por GRP78 y son menos inmunogenicos en comparacion a sus anticuerpos parentales no modificados en una especie determinada, por ejemplo la humana y funcionan para inhibir GRP78. De forma relevante, estos nuevos anticuerpos aislados y fragmentos de union a antigeno de los mismos atenuan la senalizacion P13K y promueven la apoptosis en celulas tumorales, mientras que al mismo tiempo no afectan a las celulas normales. Estos anticuerpos y fragmentos de union a antigeno de los mismos son utiles para tratamientos terapeuticos para el cancer dirigidos a UPR
PE2015002015A 2013-03-14 2014-03-14 Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular PE20151893A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361781395P 2013-03-14 2013-03-14

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PE20151893A1 true PE20151893A1 (es) 2015-12-30

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PE2015002015A PE20151893A1 (es) 2013-03-14 2014-03-14 Tratamiento del cancer usando anticuerpos que se unen a grp78 en la superficie celular

Country Status (14)

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US (4) US20160185853A1 (es)
EP (1) EP2970443A4 (es)
JP (1) JP2016520527A (es)
KR (1) KR20160043927A (es)
CN (1) CN105452292A (es)
AU (1) AU2014236309A1 (es)
BR (1) BR112015023212A2 (es)
CA (1) CA2906688A1 (es)
MX (1) MX2015012922A (es)
PE (1) PE20151893A1 (es)
PH (1) PH12015502112A1 (es)
RU (1) RU2015142815A (es)
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