BR112013005145A2 - anticorpos anti-cxcl13 e métodos para seu uso - Google Patents
anticorpos anti-cxcl13 e métodos para seu usoInfo
- Publication number
- BR112013005145A2 BR112013005145A2 BR112013005145A BR112013005145A BR112013005145A2 BR 112013005145 A2 BR112013005145 A2 BR 112013005145A2 BR 112013005145 A BR112013005145 A BR 112013005145A BR 112013005145 A BR112013005145 A BR 112013005145A BR 112013005145 A2 BR112013005145 A2 BR 112013005145A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- cxcl13
- antibodies
- cxcl13 antibodies
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
anticorpos anti-cxcl e médotos para seu uso. composições e métodos são fornecidos para o tratamento de doenças associadas à expressão do cxcl13, incluindo certas doenças autoimunes, doenças inflamatórias e cânceres. em particular, anticorpos monoclonais anti-cxcl13 foram desenvolvidos para neutralizar o cxcl13.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37967210P | 2010-09-02 | 2010-09-02 | |
US61/379,672 | 2010-09-02 | ||
US201161481645P | 2011-05-02 | 2011-05-02 | |
US61/481,645 | 2011-05-02 | ||
PCT/US2011/050177 WO2012031099A2 (en) | 2010-09-02 | 2011-09-01 | Anti-cxcl13 antibodies and methods of using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013005145A2 true BR112013005145A2 (pt) | 2016-05-10 |
BR112013005145B1 BR112013005145B1 (pt) | 2022-02-15 |
Family
ID=45773520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013005145-0A BR112013005145B1 (pt) | 2010-09-02 | 2011-09-01 | Anticorpo isolado ou seu fragmento de ligação ao antígeno que se liga especificamente ao cxcl13, composição e uso de uma composição |
Country Status (13)
Country | Link |
---|---|
US (3) | US9963504B2 (pt) |
EP (1) | EP2611832B1 (pt) |
JP (2) | JP6097690B2 (pt) |
KR (1) | KR101862236B1 (pt) |
CN (1) | CN103347896B (pt) |
AU (1) | AU2011295902B2 (pt) |
BR (1) | BR112013005145B1 (pt) |
CA (1) | CA2810217C (pt) |
DK (1) | DK2611832T3 (pt) |
MX (1) | MX353476B (pt) |
NZ (1) | NZ608318A (pt) |
SG (1) | SG188285A1 (pt) |
WO (1) | WO2012031099A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101754433B1 (ko) | 2009-05-08 | 2017-07-05 | 백시넥스 인코포레이티드 | 항-cd100 항체 및 이의 사용 방법 |
AU2011295902B2 (en) | 2010-09-02 | 2014-12-04 | Vaccinex, Inc. | Anti-CXCL13 antibodies and methods of using the same |
WO2012082494A2 (en) | 2010-12-14 | 2012-06-21 | Morehouse School Of Medicine | The use of anti-cxcl13 and anti-cxcr5 antibodies for the treatment or detection of cancer |
DK2766093T3 (en) | 2011-10-11 | 2018-06-06 | Vaccinex Inc | USE OF SEMAPHORIN-4D BINDING MOLECULES FOR MODULATING THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER |
CA2865928C (en) * | 2012-03-02 | 2021-02-16 | Vaccinex, Inc. | Cxcl13 antagonist for the treatment of sjogren's syndrome |
US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
EP2866830A4 (en) * | 2012-06-27 | 2015-12-09 | Jyant Technologies | ANTI-CXCL9, ANTI-CXCL10, ANTI-CXCL11, ANTI-CXCL13, ANTI-CXCR3 AND ANTI-CXCR5 AGENTS FOR THE INHIBITION OF INFLAMMATION |
JP2016502669A (ja) * | 2012-12-07 | 2016-01-28 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 抗mif抗体細胞遊走アッセイ |
WO2014121053A1 (en) * | 2013-01-31 | 2014-08-07 | Vaccinex, Inc. | Methods for increasing immunoglobulin a levels |
WO2014137355A1 (en) * | 2013-03-08 | 2014-09-12 | Vaccinex, Inc. | Anti-cxcl13 antibodies and associated epitope sequences |
DK3013350T3 (da) | 2013-06-25 | 2020-04-14 | Vaccinex Inc | Anvendelse af semaphorin-4D-hæmmende molekyler i kombination med en immunmodulerende terapi for at hæmme tumorvækst og metastaser |
CN108430506A (zh) * | 2015-09-15 | 2018-08-21 | 得克萨斯州大学系统董事会 | T细胞受体(tcr)结合抗体及其用途 |
PT3445397T (pt) | 2016-04-22 | 2023-01-13 | Vaccinex Inc | Exibição de proteína integral de membrana sobre viriões envelopados extracelulares de poxvírus |
CN109563143A (zh) | 2016-08-02 | 2019-04-02 | 瓦西尼斯公司 | 在牛痘病毒/真核细胞中产生多核苷酸文库的改良方法 |
MX2020005662A (es) | 2017-12-01 | 2020-08-20 | Pfizer | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos. |
EA202190647A1 (ru) * | 2018-09-17 | 2021-09-09 | Абкуро, Инк. | Антитела к klrg1 |
JP7098854B2 (ja) * | 2018-09-18 | 2022-07-12 | アイ-エムエービー バイオファーマ ユーエス リミテッド | 自己免疫疾患およびがんを治療するための抗cxcl13抗体 |
KR20230021747A (ko) | 2020-06-11 | 2023-02-14 | 백시넥스 인코포레이티드 | 말초 신경 재생을 촉진하기 위한 cxcl13 결합 분자의 용도 |
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- 2011-09-01 AU AU2011295902A patent/AU2011295902B2/en active Active
- 2011-09-01 CN CN201180052932.5A patent/CN103347896B/zh active Active
- 2011-09-01 BR BR112013005145-0A patent/BR112013005145B1/pt active IP Right Grant
- 2011-09-01 US US13/820,278 patent/US9963504B2/en active Active
- 2011-09-01 DK DK11822655.4T patent/DK2611832T3/en active
- 2011-09-01 WO PCT/US2011/050177 patent/WO2012031099A2/en active Application Filing
- 2011-09-01 SG SG2013013735A patent/SG188285A1/en unknown
- 2011-09-01 EP EP11822655.4A patent/EP2611832B1/en active Active
- 2011-09-01 NZ NZ60831811A patent/NZ608318A/en unknown
- 2011-09-01 JP JP2013527309A patent/JP6097690B2/ja active Active
- 2011-09-01 CA CA2810217A patent/CA2810217C/en active Active
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US20210087263A1 (en) | 2021-03-25 |
CN103347896A (zh) | 2013-10-09 |
AU2011295902B2 (en) | 2014-12-04 |
KR20130101046A (ko) | 2013-09-12 |
WO2012031099A3 (en) | 2012-06-07 |
US9963504B2 (en) | 2018-05-08 |
WO2012031099A2 (en) | 2012-03-08 |
MX2013002495A (es) | 2013-06-05 |
US20140147447A1 (en) | 2014-05-29 |
AU2011295902A1 (en) | 2013-04-11 |
EP2611832A2 (en) | 2013-07-10 |
CA2810217A1 (en) | 2012-03-08 |
EP2611832A4 (en) | 2014-03-05 |
US10829550B2 (en) | 2020-11-10 |
SG188285A1 (en) | 2013-04-30 |
NZ608318A (en) | 2015-03-27 |
DK2611832T3 (en) | 2018-02-26 |
US20150050287A9 (en) | 2015-02-19 |
WO2012031099A9 (en) | 2012-08-30 |
MX353476B (es) | 2018-01-15 |
KR101862236B1 (ko) | 2018-05-29 |
CA2810217C (en) | 2019-03-12 |
BR112013005145B1 (pt) | 2022-02-15 |
JP2017099379A (ja) | 2017-06-08 |
JP6097690B2 (ja) | 2017-03-15 |
US20180244764A1 (en) | 2018-08-30 |
JP2013539369A (ja) | 2013-10-24 |
EP2611832B1 (en) | 2017-11-29 |
CN103347896B (zh) | 2017-06-13 |
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