EA201690617A1 - Комбинирование anti-lag-3-антител и анти-pd-1-антител для лечения опухолей - Google Patents
Комбинирование anti-lag-3-антител и анти-pd-1-антител для лечения опухолейInfo
- Publication number
- EA201690617A1 EA201690617A1 EA201690617A EA201690617A EA201690617A1 EA 201690617 A1 EA201690617 A1 EA 201690617A1 EA 201690617 A EA201690617 A EA 201690617A EA 201690617 A EA201690617 A EA 201690617A EA 201690617 A1 EA201690617 A1 EA 201690617A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- tumors
- lag
- treatment
- combining
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
Обеспечены способы клинического лечения опухолей (например, солидных опухолей поздней стадии) с использованием анти-LAG-3-антитела в комбинации с анти-PD-1-антителом.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361880606P | 2013-09-20 | 2013-09-20 | |
US201462014471P | 2014-06-19 | 2014-06-19 | |
PCT/US2014/056277 WO2015042246A1 (en) | 2013-09-20 | 2014-09-18 | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201690617A1 true EA201690617A1 (ru) | 2016-07-29 |
EA036902B1 EA036902B1 (ru) | 2021-01-13 |
Family
ID=51743546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690617A EA036902B1 (ru) | 2013-09-20 | 2014-09-18 | Комбинирование anti-lag-3-антител и анти-pd-1-антител для лечения опухолей |
Country Status (24)
Country | Link |
---|---|
US (4) | US10081681B2 (ru) |
EP (4) | EP3178849B1 (ru) |
JP (3) | JP6595458B2 (ru) |
KR (4) | KR20230008255A (ru) |
CN (2) | CN105793287B (ru) |
AU (3) | AU2014323523B2 (ru) |
BR (2) | BR112016005816A2 (ru) |
CA (1) | CA2924524A1 (ru) |
CY (2) | CY1121723T1 (ru) |
DK (2) | DK3178849T3 (ru) |
EA (1) | EA036902B1 (ru) |
ES (2) | ES2947575T3 (ru) |
FI (1) | FI3508502T3 (ru) |
HR (2) | HRP20230603T1 (ru) |
HU (2) | HUE062317T2 (ru) |
IL (3) | IL244547B (ru) |
LT (2) | LT3178849T (ru) |
MX (2) | MX2016003103A (ru) |
PL (2) | PL3508502T3 (ru) |
PT (2) | PT3508502T (ru) |
RS (2) | RS64268B1 (ru) |
SG (2) | SG10201802264PA (ru) |
SI (2) | SI3508502T1 (ru) |
WO (1) | WO2015042246A1 (ru) |
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