LT3178849T - Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui - Google Patents

Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui

Info

Publication number
LT3178849T
LT3178849T LTEP16197459.7T LT16197459T LT3178849T LT 3178849 T LT3178849 T LT 3178849T LT 16197459 T LT16197459 T LT 16197459T LT 3178849 T LT3178849 T LT 3178849T
Authority
LT
Lithuania
Prior art keywords
antibodies
lag
combination
treat tumors
tumors
Prior art date
Application number
LTEP16197459.7T
Other languages
English (en)
Inventor
Alan J. Korman
Nils Lonberg
David J. Fontana
Andres A. Gutierrez
Mark J. Selby
Katherine E. Lewis
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of LT3178849T publication Critical patent/LT3178849T/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
LTEP16197459.7T 2013-09-20 2014-09-18 Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui LT3178849T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361880606P 2013-09-20 2013-09-20
US201462014471P 2014-06-19 2014-06-19

Publications (1)

Publication Number Publication Date
LT3178849T true LT3178849T (lt) 2019-06-10

Family

ID=51743546

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP18209399.7T LT3508502T (lt) 2013-09-20 2014-09-18 Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui
LTEP16197459.7T LT3178849T (lt) 2013-09-20 2014-09-18 Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP18209399.7T LT3508502T (lt) 2013-09-20 2014-09-18 Anti-lag-3 antikūnų ir anti-pd-1 antikūnų derinys, skirtas navikų gydymui

Country Status (24)

Country Link
US (4) US10081681B2 (lt)
EP (4) EP4249065A3 (lt)
JP (3) JP6595458B2 (lt)
KR (4) KR20240033088A (lt)
CN (2) CN105793287B (lt)
AU (3) AU2014323523B2 (lt)
BR (2) BR122023024195A2 (lt)
CA (1) CA2924524A1 (lt)
CY (2) CY1121723T1 (lt)
DK (2) DK3178849T3 (lt)
EA (1) EA036902B1 (lt)
ES (2) ES2728578T3 (lt)
FI (1) FI3508502T3 (lt)
HR (2) HRP20230603T1 (lt)
HU (2) HUE044730T2 (lt)
IL (3) IL244547B (lt)
LT (2) LT3508502T (lt)
MX (2) MX2016003103A (lt)
PL (2) PL3508502T3 (lt)
PT (2) PT3508502T (lt)
RS (2) RS64268B1 (lt)
SG (2) SG10201802264PA (lt)
SI (2) SI3508502T1 (lt)
WO (1) WO2015042246A1 (lt)

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