BR112015023212A2 - tratamento do câncer utilizando anticorpos que se ligam à grp78 da superfície celular - Google Patents

tratamento do câncer utilizando anticorpos que se ligam à grp78 da superfície celular

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Publication number
BR112015023212A2
BR112015023212A2 BR112015023212A BR112015023212A BR112015023212A2 BR 112015023212 A2 BR112015023212 A2 BR 112015023212A2 BR 112015023212 A BR112015023212 A BR 112015023212A BR 112015023212 A BR112015023212 A BR 112015023212A BR 112015023212 A2 BR112015023212 A2 BR 112015023212A2
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BR
Brazil
Prior art keywords
antibodies
grp78
antigen
cell surface
cells
Prior art date
Application number
BR112015023212A
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English (en)
Inventor
Gill Parkash
Liu Ren
Original Assignee
Gill Parkash
Liu Ren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581763&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015023212(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gill Parkash, Liu Ren filed Critical Gill Parkash
Publication of BR112015023212A2 publication Critical patent/BR112015023212A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
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    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

“tratamento do câncer utilizando anticorpos que dividem a grp78 da superfície celular” resumo este pedido proporciona, inter alia, anticorpos ou fragmentos dos mesmos de ligação a antígeno, visando grp78 da superfície celular expressas em células tumorais, células endoteliais tumorais, células cancerosas de início de tumor. estes anticorpos anti-grp78 ou fragmentos dos mesmos de ligação a antígeno têm uma elevada afinidade para grp78 e são menos imunogênicos em comparação com os seus anticorpos pais não modificados numa dada espécie, por exemplo, o ser humano, e funcionam de modo a inibir a grp78. de realçar que estes novos anticorpos isolados e os fragmentos dos mesmos de ligação a antígenos atenuam a sinalização de pi3k e promovem a apoptose em células tumorais, ao mesmo tempo em que deixam as células normais não afetadas. os anticorpos e os fragmentos dos mesmos de ligação a antígeno são úteis para tratamentos terapêuticos de câncer direcionados a upr. 1/1
BR112015023212A 2013-03-14 2014-03-14 tratamento do câncer utilizando anticorpos que se ligam à grp78 da superfície celular BR112015023212A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361781395P 2013-03-14 2013-03-14
PCT/US2014/028868 WO2014153056A2 (en) 2013-03-14 2014-03-14 Cancer treatment using antibodies that bing cell surface grp78

Publications (1)

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BR112015023212A2 true BR112015023212A2 (pt) 2017-11-21

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US (4) US20160185853A1 (pt)
EP (1) EP2970443A4 (pt)
JP (1) JP2016520527A (pt)
KR (1) KR20160043927A (pt)
CN (1) CN105452292A (pt)
AU (1) AU2014236309A1 (pt)
BR (1) BR112015023212A2 (pt)
CA (1) CA2906688A1 (pt)
MX (1) MX2015012922A (pt)
PE (1) PE20151893A1 (pt)
PH (1) PH12015502112A1 (pt)
RU (1) RU2015142815A (pt)
SG (1) SG11201507563SA (pt)
WO (1) WO2014153056A2 (pt)

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Publication number Priority date Publication date Assignee Title
SG11201507563SA (en) 2013-03-14 2015-10-29 Parkash Gill Cancer treatment using antibodies that bind cell surface grp78
US20180360799A1 (en) * 2015-05-08 2018-12-20 Oklahoma Medical Research Foundation Nitrofuran Derivatives That Induce Apoptosis in Breast Cancer Cells by Activating Protein Expression
EP3387441A1 (en) * 2015-12-11 2018-10-17 Sanford Health Reagents and methods for monitoring breast cancer therapy
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