EA201790563A1 - Применение реслизумаба для лечения эозинофильной астмы со степенью тяжести от умеренной до тяжелой - Google Patents

Применение реслизумаба для лечения эозинофильной астмы со степенью тяжести от умеренной до тяжелой

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Publication number
EA201790563A1
EA201790563A1 EA201790563A EA201790563A EA201790563A1 EA 201790563 A1 EA201790563 A1 EA 201790563A1 EA 201790563 A EA201790563 A EA 201790563A EA 201790563 A EA201790563 A EA 201790563A EA 201790563 A1 EA201790563 A1 EA 201790563A1
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EA
Eurasian Patent Office
Prior art keywords
patient
woodlizumab
heavy
degree
treatment
Prior art date
Application number
EA201790563A
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English (en)
Other versions
EA201790563A8 (ru
EA034864B1 (ru
Inventor
Ги Брюссель
Кристофер О'Брайен
Джеймс Зангрилли
Тушар Шах
Original Assignee
Сефалон, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Сефалон, Инк. filed Critical Сефалон, Инк.
Publication of EA201790563A1 publication Critical patent/EA201790563A1/ru
Publication of EA201790563A8 publication Critical patent/EA201790563A8/ru
Publication of EA034864B1 publication Critical patent/EA034864B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

В настоящем документе раскрыты способы лечения эозинофильной астмы со степенью тяжести от умеренной до тяжелой у пациента, включающие: 1) идентификацию пациента, имеющего эозинофильную астму со степенью тяжести от умеренной до тяжелой, при этом симптомы пациента недостаточно контролируются текущим лекарственным средством против астмы и уровень эозинофилов в крови у пациента составляет 400/мкл или более; и 2) введение указанному пациенту терапевтически эффективной дозы реслизумаба.
EA201790563A 2014-09-08 2015-08-28 Способ лечения эозинофильной астмы со степенью тяжести от умеренной до тяжёлой EA034864B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462047248P 2014-09-08 2014-09-08
US201462091150P 2014-12-12 2014-12-12
US201562168007P 2015-05-29 2015-05-29
US201562191690P 2015-07-13 2015-07-13
PCT/US2015/047357 WO2016040007A1 (en) 2014-09-08 2015-08-28 Use of reslizumab to treat moderate to severe eosinophilic asthma

Publications (3)

Publication Number Publication Date
EA201790563A1 true EA201790563A1 (ru) 2017-08-31
EA201790563A8 EA201790563A8 (ru) 2017-11-30
EA034864B1 EA034864B1 (ru) 2020-03-31

Family

ID=54066234

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790563A EA034864B1 (ru) 2014-09-08 2015-08-28 Способ лечения эозинофильной астмы со степенью тяжести от умеренной до тяжёлой

Country Status (19)

Country Link
US (2) US9815894B2 (ru)
EP (1) EP3191513B1 (ru)
KR (1) KR102495432B1 (ru)
CN (1) CN107073114B (ru)
AU (1) AU2015315628A1 (ru)
CA (1) CA2962944A1 (ru)
CY (1) CY1123501T1 (ru)
DK (1) DK3191513T3 (ru)
EA (1) EA034864B1 (ru)
ES (1) ES2811124T3 (ru)
HR (1) HRP20201307T1 (ru)
HU (1) HUE050202T2 (ru)
PL (1) PL3191513T3 (ru)
PT (1) PT3191513T (ru)
RS (1) RS60701B1 (ru)
SI (1) SI3191513T1 (ru)
UA (1) UA122670C2 (ru)
WO (1) WO2016040007A1 (ru)
ZA (1) ZA201702247B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180056018A1 (en) * 2016-08-31 2018-03-01 Cephalon, Inc. Inhalation Systems, Devices and Methods
US20200332344A1 (en) * 2017-05-12 2020-10-22 The Regents Of The University Of California Treating and detecting dysbiosis
EP3689906A4 (en) 2017-09-29 2021-04-07 Jiangsu Hengrui Medicine Co., Ltd. IL-5 ANTIBODIES, ANTIGIBINDING FRAGMENT THEREOF, AND MEDICAL USES THEREOF
WO2020200099A1 (zh) 2019-03-29 2020-10-08 江苏恒瑞医药股份有限公司 包含抗il-5抗体的药物组合物及其用途
CN113966229A (zh) 2019-05-10 2022-01-21 爱沐疗法公司 用于改善花生过敏患者的生活质量的方法
TW202126688A (zh) * 2019-09-27 2021-07-16 瑞典商阿斯特捷利康公司 使用貝那利珠單抗治療遲發性氣喘之方法
EP3957308A1 (en) * 2020-08-21 2022-02-23 Palobiofarma, S.L. (1r,3s)-3-((5-cyano-4-phenylthiazol-2-yl)carbamoyl)cyclopentane-1-carboxylic acid and derivatives thereof for use in the treatment of airway diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU683836B2 (en) 1992-02-06 1997-11-27 Schering Corporation Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
USRE39548E1 (en) 1994-06-17 2007-04-03 Celltech R&D Limited Interleukin-5 specific recombinant antibodies
US6056957A (en) 1994-08-04 2000-05-02 Schering Corporation Humanized monoclonal antibodies against human interleukin-5
MX2010010667A (es) * 2008-03-28 2010-11-09 Glaxosmithkline Llc Metodos de tratamiento.
WO2011156000A2 (en) * 2010-06-07 2011-12-15 Aerovance, Inc. Use of il-4/il-13 antagonists to treat eosinophilic disorders
CN105175542B (zh) * 2010-12-16 2018-12-18 弗·哈夫曼-拉罗切有限公司 与th2抑制相关的诊断和治疗

Also Published As

Publication number Publication date
DK3191513T3 (da) 2020-08-24
RS60701B1 (sr) 2020-09-30
CN107073114B (zh) 2022-01-14
ZA201702247B (en) 2018-08-29
EP3191513B1 (en) 2020-06-24
NZ730541A (en) 2023-10-27
KR102495432B1 (ko) 2023-02-03
SI3191513T1 (sl) 2020-12-31
US10577414B2 (en) 2020-03-03
US20160102144A1 (en) 2016-04-14
US9815894B2 (en) 2017-11-14
EA201790563A8 (ru) 2017-11-30
UA122670C2 (uk) 2020-12-28
CY1123501T1 (el) 2022-03-24
CN107073114A (zh) 2017-08-18
PL3191513T3 (pl) 2021-02-08
EA034864B1 (ru) 2020-03-31
US20180030131A1 (en) 2018-02-01
HRP20201307T1 (hr) 2020-11-27
ES2811124T3 (es) 2021-03-10
HUE050202T2 (hu) 2020-11-30
AU2015315628A1 (en) 2017-04-20
PT3191513T (pt) 2020-07-31
EP3191513A1 (en) 2017-07-19
WO2016040007A1 (en) 2016-03-17
CA2962944A1 (en) 2016-03-17
KR20170072197A (ko) 2017-06-26

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