MX2019006141A - Metodos para tratar trastornos inflamatorios con compuestos de fc multivalentes. - Google Patents
Metodos para tratar trastornos inflamatorios con compuestos de fc multivalentes.Info
- Publication number
- MX2019006141A MX2019006141A MX2019006141A MX2019006141A MX2019006141A MX 2019006141 A MX2019006141 A MX 2019006141A MX 2019006141 A MX2019006141 A MX 2019006141A MX 2019006141 A MX2019006141 A MX 2019006141A MX 2019006141 A MX2019006141 A MX 2019006141A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- multivalent
- compounds
- inflammatory disorders
- treating inflammatory
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención provee métodos para la identificación de pacientes con una enfermedad autoinmunitaria o inflamatoria que demuestran una respuesta inadecuada al tratamiento con un agente terapéutico multi-Fc y la determinación de una dosis óptima de un agente terapéutico multi-Fc para dicho paciente con base en los niveles en circulación del paciente de C3b inactivado (iC3b) y/o componentes del complemento adicionales que se pueden emplear como un sustituto para iC3b con base en una respuesta análoga a los agentes terapéuticos multi-Fc. La presente invención provee además mejoras en el uso de tales agentes terapéuticos multi-Fc en el tratamiento de enfermedades autoinmunitarias e inflamatorias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662432407P | 2016-12-09 | 2016-12-09 | |
PCT/US2017/065400 WO2018107082A1 (en) | 2016-12-09 | 2017-12-08 | Methods of treating inflammatory disorders with multivalent fc compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019006141A true MX2019006141A (es) | 2019-08-14 |
Family
ID=62491402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006141A MX2019006141A (es) | 2016-12-09 | 2017-12-08 | Metodos para tratar trastornos inflamatorios con compuestos de fc multivalentes. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11331372B2 (es) |
EP (1) | EP3551227A4 (es) |
JP (2) | JP2020500856A (es) |
KR (1) | KR20190093186A (es) |
CN (1) | CN110022898B (es) |
AU (1) | AU2017371182B2 (es) |
BR (1) | BR112019009495A2 (es) |
CA (1) | CA3043251A1 (es) |
IL (1) | IL266988A (es) |
MX (1) | MX2019006141A (es) |
WO (1) | WO2018107082A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3551227A4 (en) | 2016-12-09 | 2020-07-29 | Gliknik Inc. | METHOD FOR TREATING INFLAMMABLE DISEASES WITH MULTI-VALUE FC COMPOUNDS |
BR112019009484A2 (pt) | 2016-12-09 | 2019-07-30 | Gliknik Inc | otimização de fabricação de gl-2045, um stradomer multimerizador |
CN113194990A (zh) * | 2018-07-11 | 2021-07-30 | 动量制药公司 | 与靶向CD38的工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
BR112021000415A2 (pt) * | 2018-07-11 | 2021-04-06 | Momenta Pharmaceuticals, Inc. | Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulados |
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BR112019009484A2 (pt) | 2016-12-09 | 2019-07-30 | Gliknik Inc | otimização de fabricação de gl-2045, um stradomer multimerizador |
EP3551227A4 (en) | 2016-12-09 | 2020-07-29 | Gliknik Inc. | METHOD FOR TREATING INFLAMMABLE DISEASES WITH MULTI-VALUE FC COMPOUNDS |
-
2017
- 2017-12-08 EP EP17879309.7A patent/EP3551227A4/en active Pending
- 2017-12-08 US US16/467,859 patent/US11331372B2/en active Active
- 2017-12-08 CA CA3043251A patent/CA3043251A1/en active Pending
- 2017-12-08 MX MX2019006141A patent/MX2019006141A/es unknown
- 2017-12-08 BR BR112019009495A patent/BR112019009495A2/pt unknown
- 2017-12-08 WO PCT/US2017/065400 patent/WO2018107082A1/en unknown
- 2017-12-08 JP JP2019527452A patent/JP2020500856A/ja active Pending
- 2017-12-08 KR KR1020197014713A patent/KR20190093186A/ko not_active IP Right Cessation
- 2017-12-08 AU AU2017371182A patent/AU2017371182B2/en active Active
- 2017-12-08 CN CN201780073552.7A patent/CN110022898B/zh active Active
-
2019
- 2019-05-29 IL IL266988A patent/IL266988A/en unknown
-
2022
- 2022-04-12 US US17/718,822 patent/US20220241372A1/en active Pending
-
2023
- 2023-02-02 JP JP2023014745A patent/JP2023063293A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3551227A4 (en) | 2020-07-29 |
KR20190093186A (ko) | 2019-08-08 |
EP3551227A1 (en) | 2019-10-16 |
US20200069769A1 (en) | 2020-03-05 |
AU2017371182B2 (en) | 2024-03-28 |
JP2020500856A (ja) | 2020-01-16 |
CA3043251A1 (en) | 2018-06-14 |
WO2018107082A1 (en) | 2018-06-14 |
AU2017371182A1 (en) | 2019-05-23 |
RU2019117789A3 (es) | 2021-01-29 |
CN110022898B (zh) | 2023-07-04 |
US20220241372A1 (en) | 2022-08-04 |
CN110022898A (zh) | 2019-07-16 |
RU2019117789A (ru) | 2020-12-07 |
JP2023063293A (ja) | 2023-05-09 |
US11331372B2 (en) | 2022-05-17 |
BR112019009495A2 (pt) | 2019-08-06 |
IL266988A (en) | 2019-07-31 |
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