BR112015024621A2 - c. novyi para o tratamento de tumores sólidos em seres humanos - Google Patents
c. novyi para o tratamento de tumores sólidos em seres humanosInfo
- Publication number
- BR112015024621A2 BR112015024621A2 BR112015024621A BR112015024621A BR112015024621A2 BR 112015024621 A2 BR112015024621 A2 BR 112015024621A2 BR 112015024621 A BR112015024621 A BR 112015024621A BR 112015024621 A BR112015024621 A BR 112015024621A BR 112015024621 A2 BR112015024621 A2 BR 112015024621A2
- Authority
- BR
- Brazil
- Prior art keywords
- human
- novyi
- methods
- solid tumor
- present
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Pregnancy & Childbirth (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
Abstract
abstract the present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. these methods include administering intratumorally to the human a unit dose of c. novyi, preferably c. novyi nt, colony forming units (cfus), which contains about 1 x 103-1 x 107 cfus suspended in a pharmaceutically acceptable carrier or solution. methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of c. novyi, preferably c. novyi nt, cfus, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided. tradução do resumo resumo patente de invenção: "c. novyi para o tratamento de tumores sólidos em seres humanos". a presente invenção proporciona, inter alia, métodos para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano. esses métodos incluem administrar de modo intratumoral ao ser humano uma dose de unidade de unidades formadoras de colônias (cfus) de c. novyi, preferivelmente c. novyi nt, que contém cerca de 1 x 103-1 x 107 cfus suspensa em um veículo ou solução farmaceuticamente aceitável. são também proporcionados métodos para diminuir o volume de um tumor sólido presente em um ser humano, métodos para remover um tumor sólido presente em um ser humano, um método para a excisão microscopicamente exata de células de tumor em um ser humano, métodos para tratar ou atenuar um efeito de um tumor sólido que tenha se espalhado por metástase para um ou mais locais em um ser humano, doses de unidades de cfus de c. novyi, preferivelmente c. novyi nt, e kits para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122020006408-0A BR122020006408B1 (pt) | 2013-03-29 | 2014-03-28 | Dose unitária de unidades formadoras de colônia de c. novyi, composição farmacêutica e uso de c. novyi nt para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361806497P | 2013-03-29 | 2013-03-29 | |
| US61/806,497 | 2013-03-29 | ||
| PCT/US2014/032196 WO2014160950A1 (en) | 2013-03-29 | 2014-03-28 | C. novyi for the treatment of solid tumors in humans |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112015024621A2 true BR112015024621A2 (pt) | 2017-07-18 |
| BR112015024621A8 BR112015024621A8 (pt) | 2019-12-10 |
| BR112015024621B1 BR112015024621B1 (pt) | 2021-09-28 |
Family
ID=51625539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015024621-4A BR112015024621B1 (pt) | 2013-03-29 | 2014-03-28 | Usos de dose unitária de unidades formadoras de colônia de c. novyi e de dose unitária de esporos de c. novyi nt e kit para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano |
| BR122020006408-0A BR122020006408B1 (pt) | 2013-03-29 | 2014-03-28 | Dose unitária de unidades formadoras de colônia de c. novyi, composição farmacêutica e uso de c. novyi nt para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122020006408-0A BR122020006408B1 (pt) | 2013-03-29 | 2014-03-28 | Dose unitária de unidades formadoras de colônia de c. novyi, composição farmacêutica e uso de c. novyi nt para tratar ou atenuar um efeito de um tumor sólido presente em um ser humano |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10617723B2 (pt) |
| EP (3) | EP4108248A1 (pt) |
| JP (6) | JP6756609B2 (pt) |
| KR (1) | KR20160021084A (pt) |
| CN (2) | CN116570628A (pt) |
| AU (2) | AU2014240872A1 (pt) |
| BR (2) | BR112015024621B1 (pt) |
| CA (2) | CA2908508C (pt) |
| DK (1) | DK2988760T3 (pt) |
| ES (2) | ES2922378T3 (pt) |
| HK (1) | HK1222134A1 (pt) |
| IL (1) | IL241823B (pt) |
| MX (1) | MX2015013784A (pt) |
| NZ (1) | NZ712691A (pt) |
| PH (1) | PH12015502260A1 (pt) |
| RU (1) | RU2718670C2 (pt) |
| SG (2) | SG11201508071VA (pt) |
| UA (1) | UA120036C2 (pt) |
| WO (1) | WO2014160950A1 (pt) |
| ZA (2) | ZA201507412B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015240884B2 (en) * | 2014-03-31 | 2020-06-18 | Biomed Valley Discoveries, Inc. | Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-CTLA-4 and/or anti-PD-1 antibodies to treat solid tumor malignancies |
| CN105912930B (zh) * | 2016-04-11 | 2019-02-01 | 北京奇虎科技有限公司 | 移动终端及其系统资源安全控制方法 |
| WO2018039185A1 (en) * | 2016-08-23 | 2018-03-01 | Mayo Foundation For Medical Education And Research | Methods and materials for treating estrogen receptor positive breast cancer |
| AU2018269982A1 (en) * | 2017-05-16 | 2020-01-02 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical BRAF mutations |
| CN109985039A (zh) * | 2017-12-29 | 2019-07-09 | 深圳微芯生物科技股份有限公司 | 用于治疗白血病的联合用药物及其在制备用于治疗急性髓性白血病的药物中的用途 |
| WO2021231611A1 (en) * | 2020-05-12 | 2021-11-18 | Splash Pharmaceuticals, Inc. | Methods for treating cancer using spl-108 polypeptide based on tp53 mutational status |
| US11717787B2 (en) * | 2021-01-04 | 2023-08-08 | Saudi Arabian Oil Company | High free volume membrane for gas separation |
| CN113855710B (zh) * | 2021-10-09 | 2024-02-20 | 施慧达药业集团(吉林)有限公司 | 戈氏梭菌联合肿瘤血管生成抑制剂的应用 |
| CN115350145A (zh) * | 2022-09-06 | 2022-11-18 | 华中科技大学同济医学院附属协和医院 | 细菌介导负载二甲双胍的多肽水凝胶在肿瘤免疫治疗中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599331A (en) | 1984-12-24 | 1986-07-08 | Syntex (U.S.A.) Inc. | Etianic acids as antiangiogenics |
| JP2545522B2 (ja) | 1985-10-23 | 1996-10-23 | アルコン・ラボラトーリーズ，インコーポレイテッド | テトラヒドロ脈管形成抑制ステロイド |
| US4771042A (en) | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
| JPH04506066A (ja) | 1989-06-16 | 1992-10-22 | ジ・アップジョン・カンパニー | 脈管形成を抑制するためのスラミン・タイプの化合物および脈管形成抑止ステロイド類 |
| ATE232540T1 (de) | 1991-11-22 | 2003-02-15 | Alcon Lab Inc | Angiostatische steroide |
| WO2002067796A1 (en) | 2001-02-28 | 2002-09-06 | Rex Medical, L.P. | Apparatus for delivering ablation fluid to treat neoplasms |
| US7344710B2 (en) | 2001-11-21 | 2008-03-18 | The Johns Hopkins University | Combination bacteriolytic therapy for the treatment of tumors |
| WO2005018332A1 (en) * | 2003-08-13 | 2005-03-03 | The General Hospital Corporation | Modified microorganisms for anti-cancer therapy |
| DE602004025834D1 (de) | 2003-10-22 | 2010-04-15 | Univ Johns Hopkins | Die behandlung von tumoren |
| US20070015738A1 (en) * | 2005-07-15 | 2007-01-18 | Walker Stephen G | Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells |
| TW200819540A (en) * | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| US9163091B2 (en) * | 2007-05-30 | 2015-10-20 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
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2014
- 2014-03-28 EP EP22171112.0A patent/EP4108248A1/en active Pending
- 2014-03-28 AU AU2014240872A patent/AU2014240872A1/en not_active Abandoned
- 2014-03-28 SG SG11201508071VA patent/SG11201508071VA/en unknown
- 2014-03-28 KR KR1020157031284A patent/KR20160021084A/ko not_active Application Discontinuation
- 2014-03-28 US US14/781,273 patent/US10617723B2/en active Active
- 2014-03-28 JP JP2016505594A patent/JP6756609B2/ja active Active
- 2014-03-28 CA CA2908508A patent/CA2908508C/en active Active
- 2014-03-28 BR BR112015024621-4A patent/BR112015024621B1/pt active IP Right Grant
- 2014-03-28 NZ NZ712691A patent/NZ712691A/en unknown
- 2014-03-28 CA CA3206655A patent/CA3206655A1/en active Pending
- 2014-03-28 EP EP14774988.1A patent/EP2988760B1/en active Active
- 2014-03-28 UA UAA201510523A patent/UA120036C2/uk unknown
- 2014-03-28 ES ES20167187T patent/ES2922378T3/es active Active
- 2014-03-28 EP EP20167187.2A patent/EP3730146B1/en active Active
- 2014-03-28 BR BR122020006408-0A patent/BR122020006408B1/pt active IP Right Grant
- 2014-03-28 CN CN202310166182.9A patent/CN116570628A/zh active Pending
- 2014-03-28 WO PCT/US2014/032196 patent/WO2014160950A1/en active Application Filing
- 2014-03-28 DK DK14774988.1T patent/DK2988760T3/da active
- 2014-03-28 CN CN201480028119.8A patent/CN105451750B/zh active Active
- 2014-03-28 RU RU2015146199A patent/RU2718670C2/ru active
- 2014-03-28 ES ES14774988T patent/ES2815564T3/es active Active
- 2014-03-28 SG SG10201902765VA patent/SG10201902765VA/en unknown
- 2014-03-28 MX MX2015013784A patent/MX2015013784A/es active IP Right Grant
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2015
- 2015-09-24 IL IL241823A patent/IL241823B/en active IP Right Grant
- 2015-09-29 PH PH12015502260A patent/PH12015502260A1/en unknown
- 2015-10-06 ZA ZA2015/07412A patent/ZA201507412B/en unknown
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2016
- 2016-09-01 HK HK16110438.1A patent/HK1222134A1/zh unknown
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2017
- 2017-02-14 JP JP2017025263A patent/JP2017088619A/ja active Pending
- 2017-09-21 ZA ZA2017/06402A patent/ZA201706402B/en unknown
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2018
- 2018-10-26 JP JP2018201792A patent/JP2019011376A/ja active Pending
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2019
- 2019-01-17 AU AU2019200276A patent/AU2019200276B2/en active Active
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2020
- 2020-03-31 US US16/836,003 patent/US11439669B2/en active Active
- 2020-06-25 JP JP2020109387A patent/JP7445893B2/ja active Active
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2021
- 2021-12-09 JP JP2021199949A patent/JP2022022392A/ja active Pending
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2022
- 2022-08-02 US US17/816,924 patent/US20220378852A1/en active Pending
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2024
- 2024-03-06 JP JP2024034039A patent/JP2024056012A/ja active Pending
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Legal Events
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/03/2014, OBSERVADAS AS CONDICOES LEGAIS. |