JP6046325B2 - 漸次的に解像度を増加させて1以上の生物学的サンプルの観察及び分析のための方法及びその方法のための装置 - Google Patents
漸次的に解像度を増加させて1以上の生物学的サンプルの観察及び分析のための方法及びその方法のための装置 Download PDFInfo
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Description
本出願は、2005年9月29日に出願された米国仮特許出願第60/721,802号に基いており、そして当該出願の優先権を主張する。当該出願の全ての開示は本明細書に援用される。
本発明のさらなる対象、特徴、及び利点は、本発明の図による実施態様を示す添付の図面と合わせて上記の詳細な説明から明らかとなるであろう。
Claims (25)
- 解剖学的構造を分析又は図示のうちの少なくとも1を行う方法であって、以下の:
解剖学的構造上に又は解剖学的構造内にあてられた光から得られた解剖学的構造に関連する第一情報を処理する工程、ここで当該第一情報は、顕微鏡情報であり、前記解剖学的構造の画像を伴っており、そして表示用の画像の解像度よりも高い解像度を含み;
前記第一情報に基いて前記解剖学的構造の少なくとも1の領域を選択する工程;
前記選択された領域に基づき、前記第一情報の少なくとも一部である第二情報を作成する工程;
前記第二情報に基づいて、前記解剖学的構造の表示の倍率を漸次的に変更する工程、ここで前記第一情報が、光学コヒーレンス断層撮影法又は共焦点顕微鏡方法のうちの少なくとも1を使用して行われ;そして
1秒当たり60,000,000ピクセルを超える速度で、前記解剖学的構造の画像を作成し、そして前記解剖学的構造の画像を処理して、前記解剖学的構造の画像を拡大する工程
を含む、前記方法。 - 前記変更工程が、前記解剖学的構造の位置の表示を変更することを含む、請求項1に記載の方法。
- 前記変更工程が、前記解剖学的構造内の深さの表示を変更することを含む、請求項1に記載の方法。
- 前記第二情報が、前記解剖学的構造の中に提供される領域に関連する、請求項1に記載の方法。
- 前記第二情報が、ユーザーが前記領域を選択することにより得られる、請求項4に記載の方法。
- 前記選択が、ユーザーからの入力を伴わずに処理要素により自動的に行なわれる、請求項1に記載の方法。
- 前記解剖学的構造の中の異常領域を決定することをさらに含み、そして処理要素が、当該異常領域の少なくとも1の領域を表示するために、選択、作成、及び変更工程を行なう、請求項1に記載の方法。
- 処理要素を用いて前記第一情報から前記解剖学的構造内の異常領域を決定して、当該異常領域に関わる第三情報を作成することをさらに含み、そして当該選択工程が、前記第一情報の代わりに当該第三情報に基づいてユーザーにより行なわれる、請求項1に記載の方法。
- 処理要素を用いて前記第一情報から前記解剖学的構造内の異常領域を決定して、当該異常領域に関わる第三情報を作成することをさらに含み、そして当該選択工程が、前記第一情報の代わりに当該第三情報に基づいて処理要素により行なわれる、請求項1に記載の方法。
- 前記第一情報が、前記解剖学的構造の二次元表示に関連する、請求項1に記載の方法。
- 前記第一情報が、前記解剖学的構造の三次元表示に関連する、請求項1に記載の方法。
- 前記第一情報が、3次元超を有する前記解剖学的構造の表示と関連する、請求項1に記載の方法。
- 前記解剖学的構造が、1mm2より大きい領域を有する、請求項1に記載の方法。
- 前記解剖学的構造が、10mm2より大きい領域を有する、請求項1に記載の方法。
- 前記解剖学的構造の表示された領域が、1cm2未満である領域を有する、請求項1に記載の方法。
- 前記解剖学的構造の表示された領域が、1mm2未満である領域を有する、請求項1に記載の方法。
- 前記解剖学的構造の表示された領域が、100μm2未満である領域を有する、請求項1に記載の方法。
- 前記第一情報が、光周波数ドメイン干渉分光法と関連する、請求項1に記載の方法。
- 解剖学的構造の分析又は図示のうちの少なくとも1を行なうための装置であって、以下の:
解剖学的構造を含む対象内に配置され、そして解剖学的構造に光りを進めて、前記解剖学的構造に関する第一情報を作成するように構成された
少なくとも1の第一作成要素、ここで当該第一情報が、顕微鏡情報であり、前記解剖学的構造の画像を伴い、そして表示用の画像よりも高い解像度を含んでおり;
上記解剖学的構造から受容された第一情報に基づいて、上記解剖学的構造の少なくとも1の領域を選択して、上記第一情報の少なくとも一部である第二情報を作成する少なくとも1の第二処理要素;そして
上記第二情報に基づいて上記解剖学的構造の表示倍率を漸次的に変更するように構成される少なくとも1の第三処理要素
を含み、ここで当該第一情報の作成は、光学的コヒーレンス断層撮影法又は共焦点顕微鏡法のうちの少なくとも1を使用することで行われ、前記少なくとも1の第三処理要素が、1秒当たり60,000,000ピクセルを超える速度で、前記解剖学的構造の画像を作成し、そして前記解剖学的構造の画像を処理して、前記解剖学的構造の画像を拡大するように構成される、前記装置。 - 処理要素に解剖学的構造の分析又は図示のうちの少なくとも1を行なわせるためのプログラムであって、以下の:
処理要素により実行される場合に、解剖学的構造を含む対象内に配置された作成要素により前記解剖学的構造に進められた光に対して作成された前記解剖学的構造に関する第一情報を処理要素が受容するように設定する第一指令セット、ここで、当該第一情報が、顕微鏡情報であり、前記解剖学的構造の画像を伴い、かつ表示用の画像の解像度よりも高い解像度を含んでおり;
前記処理要素により実行される場合に、当該処理要素が、第一情報を受容するように設定し、そして処理要素又はユーザーのうちの少なくとも1が当該第一情報に基づいて解剖学的構造の少なくとも1の領域を選択して、当該第一情報の少なくとも一部である第二情報を作成することを可能にする第二指令セット;
前記処理要素により実行される場合に、前記処理要素が上記第二情報に基づいて上記解剖学的構造の表示倍率を漸次的に変更するように設定する第三指令セット
を含み、ここで当該第一情報が、光学的コヒーレンス断層撮影方法又は共焦点顕微鏡法のうちの少なくとも1を使用して行われ、そしてここで前記処理要素が、1秒当たり60,000,000ピクセルを超える速度で、前記解剖学的構造の画像を作成し、そして前記解剖学的構造の画像を処理して、前記解剖学的構造の画像を拡大するように構成される、前記プログラム。 - 前記解剖学的構造が血管である、請求項1に記載の方法。
- 前記解剖学的構造が血管である、請求項19に記載の装置。
- 前記解剖学的構造が血管である、請求項20に記載のプログラム。
- 前記第一作成要素が、解剖学的構造の内腔又は開口部に位置する、請求項19に記載の装置。
- 前記作成要素が、解剖学的構造の内腔又は開口部に位置する、請求項20に記載のプログラム。
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