JP5214883B2 - 三次元分光的符号化撮像のための方法と装置 - Google Patents
三次元分光的符号化撮像のための方法と装置 Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
- G01B11/2441—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures using interferometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
- G01B11/25—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures by projecting a pattern, e.g. one or more lines, moiré fringes on the object
- G01B11/2509—Color coding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
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- G01B9/02015—Interferometers characterised by the beam path configuration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/042—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by a proximal camera, e.g. a CCD camera
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
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Description
ここにおいて、E(ω)=A(ω)exp(iφ(ω))およびE0(ω)=A0(ω)exp(iφ0(ω))はそれぞれ、サンプルおよび基準アームから反射されたスペクトルである。簡略化のため、サンプルおよび基準アームからのスペクトル振幅は実数で等しく、A(ω)=A0(ω)とする。連続かつ滑らかな位相を有する二波の間のスペクトル干渉信号から位相差を抽出するアルゴリズムはよく知られている。スペクトル位相測定は、広帯域ソースおよび白色光を使用する分散測定のために主に実行された。基準および信号フィールド間の与えられた遅延τを有するフーリエ限界基準フィールド(φ0(ω)=0)を使用すると、式(1)における干渉項は、単にcos[φ(ω)−ωτ]となる。端的なアルゴリズムを使用すると、スペクトル位相は、干渉パターンI(ω)から明瞭に抽出することができる。一つの構成においては、各点における深度または表面の高さhは、h=c・φ(ω)/(2ω)により与えられ、ここにおいてcは光の速度である。
ここにおいて、Nはx軸に沿う解像可能な点の数(波長)であり、Δωは、ソース帯域幅の合計である。コヒーレンス長が、CL=c/Δωで与えられ、数ミクロンと短くてもよい白色干渉法と異なり、各分光的符号化スポットのスペクトル幅によってのみ決定されるので、ここではコヒーレンス長はN倍長い。この作業を通して、コヒーレンス長(310μm)は、共焦点パラメータ(2.7mm)よりも小さく、従って、軸方向の解像度を決定していた。焦点の大きな深度により、基準アームの光学経路長を走査するだけで、共焦点パラメータと等価な範囲に渡る撮像が可能になる。
Claims (36)
- 試料の少なくとも1つの部分に関係する情報を提供する方法であって、
試料上に提供される少なくとも1つの特定の電磁放射の少なくとも2つの波長をスペクトル的に分散し、前記少なくとも1つの部分の複数の横方向の位置のうちの少なくとも1つの横方向の位置を決定するのに前記少なくとも2つの波長のそれぞれを、利用すること、
前記試料から戻った少なくとも1つの第1の電磁放射と基準から戻った少なくとも1つの第2の電磁放射の間の少なくとも1つの相対位相を取得して、前記少なくとも1つの部分の少なくとも1つの相対深さ位置を決定すること、および
前記横方向の位置のそれぞれおよび前記少なくとも1つの相対深さ位置に基づいて、前記少なくとも1つの部分の情報を提供すること、を備える方法。 - 前記少なくとも1つの第1の電磁放射を、前記試料の前記少なくとも1つの部分を横切って1次元で走査して、前記少なくとも1つの横方向の位置に基づいて3次元データを取得することを、さらに備える請求項1に記載の方法。
- 前記情報は、前記2次元データの関数として提供される請求項1に記載の方法。
- 前記情報は、前記2次元データに基づいて取得された前記少なくとも1つの部分の3次元情報である請求項3に記載の方法。
- 前記情報は、前記少なくとも1つの部分の3次元情報である請求項1に記載の方法。
- 前記少なくとも1つの第1の電磁放射および前記少なくとも1つの第2の電磁放射は、第1の位相関係を有し、前記少なくとも1つの相対位相は、
前記第1の位相関係を有する前記第1および第2の電磁放射の位相差の干渉により生成される第1の干渉信号を検出すること、
前記基準の位相長を第2の位相関係になるように変更し、前記試料からの少なくとも1つの第3の電磁放射、および少なくとも1つの第4の電磁放射を受けること、
前記第2の位相関係を有する前記第3および第4電磁放射の位相差の干渉により生成される第2の干渉信号を検出すること、および
前記第1および第2の干渉信号を処理して干渉データを提供すること、により決定される請求項1に記載の方法。 - 前記情報は、前記干渉データに基づいて提供される請求項6に記載の方法。
- 前記情報は、前記少なくとも1つの部分の深さ情報を含む請求項7に記載の方法。
- 前記深さ情報は、前記第1の干渉信号を測定することにより決定される請求項8に記載の方法。
- 前記深さ情報は、前記第2の干渉信号を測定することによりさらに決定される請求項9に記載の方法。
- 前記第2および第4の電磁放射は、異なる位相を有する請求項8に記載の方法。
- 前記情報は、前記少なくとも1つの部分上の複数の横方向の位置における前記少なくとも1つの部分の高さ情報を含む請求項7に記載の方法。
- 前記基準の経路の長さにおいて個別の変化を行わせて、前記少なくとも1つの相対位相を発生させること、をさらに備える請求項1に記載の方法。
- 前記少なくとも1つの横方向の位置は、複数の横方向の位置である請求項1に記載の方法。
- 試料に関係する3次元情報を取得するための方法であって、
前記試料を含むサンプルアームから、前記試料に提供された横方向にスペクトル的に分散された電磁放射に基づいて、少なくとも1つの第1の電磁放射を受けること、
基準アームから、互いに異なる第1経路長と第2経路長に基づいて、少なくとも1つの第2の電磁放射を受けること、
前記第1および第2電磁放射に基づいて干渉情報を発生すること、および
前記試料に関係する前記3次元情報を、前記干渉情報の関数として提供すること、を備える方法。 - 前記第2経路長は、前記基準アーム内の反射表面を、前記基準アームの前記第1経路長の位置から移動することにより生成される請求項15に記載の方法。
- 前記干渉情報は、前記第1および第2電磁放射を、散乱配置を使用して、結合および空間的に散乱させることにより、発生される請求項15に記載の方法。
- 前記散乱された電磁放射を、画像化システムに提供して、3次元情報を発生させることを、さらに備える請求項17に記載の方法。
- 前記散乱された電磁放射は、電荷結合素子(CCD)上に提供される請求項18に記載の方法。
- 試料の少なくとも1つの部分に関係する3次元画像化情報を提供する装置であって、
試料上に提供される少なくとも1つの特定の電磁放射の少なくとも2つの波長を提供して、前記少なくとも1つの部分の複数の横方向の位置のうちの少なくとも1つの横方向の位置を、前記少なくとも2つの波長のそれぞれを使用して、決定するように構成された少なくとも1つの第1の手段、
試料から戻った少なくとも1つの第1の電磁放射と、基準から戻った少なくとも1つの第2の電磁放射の間の少なくとも1つの相対位相を取得して、前記部分の相対深さ位置を決定するように構成された少なくとも1つの第2の手段、および
前記横方向の位置および前記相対深さ位置に基づいて、前記部分の情報を提供するように構成された少なくとも1つの第3の手段、を備える装置。 - 前記少なくとも1つの第1の電磁放射を、前記試料の前記少なくとも1つの部分を横切って1次元で走査して、前記横方向の位置に基づいて3次元データを取得するように構成された少なくとも1つの第4の手段を、さらに備える請求項20に記載の装置。
- 前記情報は、前記2次元データの関数として提供される請求項21に記載の装置。
- 前記情報は、前記2次元データに基づいて取得された前記少なくとも1つの部分の3次元情報である請求項22に記載の装置。
- 前記情報は、前記少なくとも1つの部分の3次元情報である請求項20に記載の装置。
- 前記第1および第2の電磁放射を、結合および横方向に空間的に散乱させて前記情報を発生させるように構成された散乱手段をさらに備える請求項20に記載の装置。
- 前記基準の経路の長さにおいて個別の変化を行わせて、前記少なくとも1つの相対位相を発生させるように構成された少なくとも1つの第5の手段を、さらに備える請求項20に記載の装置。
- 前記少なくとも1つの横方向の位置は、複数の横方向の位置である請求項20に記載の装置。
- 試料に関係する3次元情報を取得するための装置であって、
前記試料を含むサンプルアームから、前記試料に提供された横方向にスペクトル的に分散された電磁放射に基づいて、少なくとも1つの第1の電磁放射、および基準アームから、互いに異なる第1経路長と第2経路長に基づいて、少なくとも1つの第2の電磁放射、を受けるように構成された少なくとも1つの第1の手段、
前記第1および第2電磁放射に基づいて干渉情報を発生するように構成された少なくとも1つの第2の手段、および
前記試料に関係する前記3次元情報を、前記干渉情報の関数として提供するように構成された少なくとも1つの第3の手段、を備える装置。 - 前記第1および第2電磁放射を結合および横方向に空間的に散乱させることにより、前記3次元情報を発生するように構成された散乱手段をさらに備える請求項28に記載の装置。
- 前記散乱された電磁放射を受けるように構成された電荷結合素子(CCD)をさらに備える請求項29に記載の装置。
- 前記少なくとも1つの位置は、複数の位置を含む請求項1に記載の方法。
- 前記波長のそれぞれは、前記位置のそれぞれの位置に関係している請求項31に記載の方法。
- 前記少なくとも1つの位置は、複数の位置を含む請求項20に記載の装置。
- 前記波長のそれぞれは、前記位置のそれぞれの位置に関係している請求項33に記載の装置。
- 前記少なくとも1つの特定の電磁放射は、前記試料上の少なくとも2つの離れた位置に照射される請求項1に記載の方法。
- 前記少なくとも1つの特定の電磁放射は、前記試料上の少なくとも2つの離れた位置に照射される請求項20に記載の装置。
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AT503309B1 (de) | 2001-05-01 | 2011-08-15 | Gen Hospital Corp | Vorrichtung zur bestimmung von atherosklerotischem belag durch messung von optischen gewebeeigenschaften |
US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
EP1426411A1 (en) * | 2002-12-06 | 2004-06-09 | KRATON Polymers Research B.V. | Styrenic block copolymer compositions to be used for the manufacture of transparent, gel free films |
US8054468B2 (en) | 2003-01-24 | 2011-11-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US7567349B2 (en) | 2003-03-31 | 2009-07-28 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
JP2006516739A (ja) | 2003-01-24 | 2006-07-06 | ザ・ジェネラル・ホスピタル・コーポレイション | 低コヒーレンス干渉計を用いて組織を識別するためのシステムおよび方法 |
KR101546024B1 (ko) | 2003-06-06 | 2015-08-20 | 더 제너럴 하스피탈 코포레이션 | 파장 동조 소스용 방법 및 장치 |
KR101384553B1 (ko) | 2003-10-27 | 2014-04-11 | 더 제너럴 하스피탈 코포레이션 | 주파수 영역 간섭법을 이용하여 광 영상화를 수행하는 방법 및 장치 |
EP1754016B1 (en) * | 2004-05-29 | 2016-05-18 | The General Hospital Corporation | Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging |
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EP1687587A1 (en) | 2006-08-09 |
JP2007512541A (ja) | 2007-05-17 |
EP1687587B1 (en) | 2020-01-08 |
US7551293B2 (en) | 2009-06-23 |
JP2013068636A (ja) | 2013-04-18 |
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