JP6512756B2 - 光源装置およびこれを用いた情報取得装置 - Google Patents
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Description
Δβ=β2(Δω)2+β4(Δω)4/12 数式(2)
β2は非線形光学媒質の励起光の周波数における群速度分散、β4は群速度分散β2の2次導関数である。なお、群速度分散β2は、励起光の伝搬定数βcの2次導関数である。
λc<λ0のとき β2>0かつβ4<0
λc≧λ0のとき β2≦0 数式(8)
λc≦λ0のとき β2≦0
λc>λ0のとき β2>0かつβ4<0 数式(9)
以下、本発明にかかる光源装置および情報取得装置の実施形態について図面を用いて説明するが、本発明は実施形態の構成等に何ら限定されるものではない。各図面において、同じ符号を付した部材は、同じ部材もしくは対応する部材を意味している。また、各実施例において共通する内容については、記載を省略する場合がある。
図1は本実施形態に係る光源装置を示す模式図である。光源装置100は、励起光であるパルス光を発する励起用光源101と、数式(8)または(9)の条件を満たす非線形光学媒質102と、光出力部103とを備えている。励起用光源101で発せられる励起光を非線形光学媒質102へ入射させて励起光とは異なる波長の光を発生させ、光出射部103を介して発生した光を取り出す構成となっている。
図2に、本実施形態に係る光源装置の別の構成例を示す。光源装置100は、パルス光を発する励起用光源101と、光合波器104と、非線形光学媒質102と、バンドパスフィルタ105と、光取出しカップラ(光出力部)103とを有している。
励起用光源101から射出される励起光の中心波長λcが、非線形光学媒質106の零分散波長λ0より長い第2モードでは、励起光が非線形光学媒質102を伝搬する間に、中心波長λiのスペクトル幅の広いブロードバンド光を発生し、出力する。
本実施形態では、本発明に係る光源装置を用いた情報取得装置として、誘導ラマン散乱イメージング(SRSイメージング)を取得する第1測定系とSD−OCTである第2測定系とを組み合わせたマルチモダリティ装置を例に挙げて説明する。
本発明にかかる第4の実施形態として、第1の実施形態の光源装置を用いた、二光子励起蛍光顕微鏡である第1測定系と、SD−OCTである第2測定系とを組み合わせたマルチモダリティ装置を説明する。
101 励起用光源
102 非線形光学媒質
106 共振器
123、133 情報取得部
121 同期検出器
Claims (12)
- 第1のパルス光を発する光源と、前記第1のパルス光の入射により前記第1のパルス光とは異なる波長の第2のパルス光を発生させる非線形光学媒質と、を備えており、前記光源が、前記第1のパルス光として、前記非線形光学媒質の零分散波長より短波長のパルス光と、前記零分散波長より長波長のパルス光とを切替えて射出するように構成され、
前記非線形光学媒質の零分散波長をλ 0 、前記第1のパルス光の中心波長をλ c とし、前記中心波長λ c における前記非線形光学媒質の群速度分散をβ 2 、前記群速度分散β 2 の2次導関数をβ 4 とするとき、前記非線形光学媒質が、
β 2 >0かつβ 4 <0(λ c <λ 0 のとき)β 2 ≦0(λ c ≧λ 0 のとき)の関係を満たすことを特徴とする光源装置。 - 前記第1のパルス光の中心波長を、前記非線形光学媒質における零分散波長よりも短波長もしくは長波長として、スペクトル幅が10nm以下の光を出力する第1モードと、
前記第1のパルス光の中心波長を、前記非線形光学媒質における零分散波長に対して前記第1モードと反対の関係に変えて、スペクトル幅が100nm以上の光を出力する第2モードと、を有することを特徴とする請求項1に記載の光源装置。 - 前記非線形光学媒質を含み、前記第2のパルス光を発振させる共振器を有しており、前記第1のパルス光のパルスレートが、前記第2のパルス光の中心波長における前記共振器の自由スペクトル間隔の整数倍であることを特徴とする請求項1または2に記載の光源装置。
- 前記非線形光学媒質がフォトニック結晶ファイバまたはテーパーファイバを含んでいることを特徴とする請求項1乃至3のいずれか1項に記載の光源装置。
- 前記第1のパルス光および前記第2のパルス光のパルス幅は、1ns以下であることを特徴とする請求項1乃至4のいずれか1項に記載の光源装置。
- 前記第1のパルス光のスペクトル幅は、1nm以下であることを特徴とする請求項1乃至5のいずれか1項に記載の光源装置。
- 光源装置と、
前記光源装置から出力される光を被検体に照射し、該被検体にて反射または散乱または透過する光、あるいは該被検体において発光する光を検出し、該被検体の情報を取得する情報取得部と、を備える第1測定系と、
前記光源装置から出力される光を測定光と参照光に分割し、被検体を経由した前記測定光と前記参照光との干渉光を検出する検出部と、前記検出部で検出された情報に基づいて、前記被検体の断層情報を得る情報取得部と、を備える第2測定系と、
を備える情報取得装置であって、
前記光源装置が請求項1乃至6のいずれか1項に記載の光源装置を含むことを特徴とする情報取得装置。 - 前記情報取得部が、前記被検体に存在する分子の分子振動に基づく誘導ラマン散乱またはコヒーレントアンチストークスラマン散乱に基づく光を検出する顕微鏡であることを特徴とする請求項7に記載の情報取得装置。
- 前記第1測定系が、前記被検体に存在する分子の分子振動に基づく誘導ラマン散乱またはコヒーレントアンチストークスラマン散乱に基づく光を検出する同期検出器を含むことを特徴とする請求項8に記載の情報取得装置。
- 前記情報取得装置が、内視鏡装置を構成していることを特徴とする請求項7に記載の情報取得装置。
- 前記第1のパルス光および前記第2のパルス光のパルスレートが、1MHz以上1GHz以下であることを特徴とする請求項7乃至10のいずれか1項に記載の情報取得装置。
- 前記第2測定系が、SD−OCTであることを特徴とする請求項7乃至11のいずれか1項に記載の情報取得装置。
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JP6711600B2 (ja) * | 2015-12-09 | 2020-06-17 | キヤノン株式会社 | 光源装置及び情報取得装置 |
JP6746371B2 (ja) * | 2016-05-13 | 2020-08-26 | キヤノン株式会社 | 光源装置及び情報取得装置 |
WO2017213712A2 (en) * | 2016-06-08 | 2017-12-14 | Massachusetts Institute Of Technology | Systems and methods for dual-more imaging using optical coherence tomography and fluorescence imaging |
US10302561B2 (en) | 2016-09-12 | 2019-05-28 | Canon Kabushiki Kaisha | Light source apparatus, and information acquisition apparatus using the same |
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