JP4234435B2 - プロテインキナーゼインヒビターとして有用なピラゾール化合物 - Google Patents
プロテインキナーゼインヒビターとして有用なピラゾール化合物 Download PDFInfo
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- JP4234435B2 JP4234435B2 JP2002567928A JP2002567928A JP4234435B2 JP 4234435 B2 JP4234435 B2 JP 4234435B2 JP 2002567928 A JP2002567928 A JP 2002567928A JP 2002567928 A JP2002567928 A JP 2002567928A JP 4234435 B2 JP4234435 B2 JP 4234435B2
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- 0 *c1ccccc1 Chemical compound *c1ccccc1 0.000 description 47
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Nc1ccccc1 Chemical compound Nc1ccccc1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 5
- QSNSCYSYFYORTR-UHFFFAOYSA-N Nc(cc1)ccc1Cl Chemical compound Nc(cc1)ccc1Cl QSNSCYSYFYORTR-UHFFFAOYSA-N 0.000 description 3
- JWYUFVNJZUSCSM-UHFFFAOYSA-N Nc1nc(cccc2)c2[nH]1 Chemical compound Nc1nc(cccc2)c2[nH]1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 description 3
- PAFZNILMFXTMIY-UHFFFAOYSA-N NC1CCCCC1 Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
- OXWWFVMJRHLDFK-UHFFFAOYSA-N CC(C)C(c1cnccc1N)N Chemical compound CC(C)C(c1cnccc1N)N OXWWFVMJRHLDFK-UHFFFAOYSA-N 0.000 description 1
- WXCCHFFMVWKMDK-UHFFFAOYSA-N CC(C1)C(CN)C=C1Nc1n[nH]c2ccccc12 Chemical compound CC(C1)C(CN)C=C1Nc1n[nH]c2ccccc12 WXCCHFFMVWKMDK-UHFFFAOYSA-N 0.000 description 1
- RHTWKRPBLSOPBF-UHFFFAOYSA-N CC(C1)Cc2c1ccc(N)c2 Chemical compound CC(C1)Cc2c1ccc(N)c2 RHTWKRPBLSOPBF-UHFFFAOYSA-N 0.000 description 1
- GRGBRBUVPYYBBF-UHFFFAOYSA-N CC(C=C(C)C)NC1=NNC2C=CC=CC12 Chemical compound CC(C=C(C)C)NC1=NNC2C=CC=CC12 GRGBRBUVPYYBBF-UHFFFAOYSA-N 0.000 description 1
- BWIFYADJEYPYSB-VUILVKNBSA-N CC(CC1)C=CC1NC1NNC2C=CC(C3)C3[C@@H]12 Chemical compound CC(CC1)C=CC1NC1NNC2C=CC(C3)C3[C@@H]12 BWIFYADJEYPYSB-VUILVKNBSA-N 0.000 description 1
- KYLQQHWXYMTWTA-UHFFFAOYSA-N CC(CNC(C1CC1)=C1)=C1Nc1cc(N2CCOCC2)nc(C(C2)C2c2cc(cccc3)c3cc2)n1 Chemical compound CC(CNC(C1CC1)=C1)=C1Nc1cc(N2CCOCC2)nc(C(C2)C2c2cc(cccc3)c3cc2)n1 KYLQQHWXYMTWTA-UHFFFAOYSA-N 0.000 description 1
- HDETUEUNBBMOCD-UHFFFAOYSA-N CC1=CC(Nc2n[nH]c(COC)c2)=N1 Chemical compound CC1=CC(Nc2n[nH]c(COC)c2)=N1 HDETUEUNBBMOCD-UHFFFAOYSA-N 0.000 description 1
- MLWPCSYRGJNJTA-UHFFFAOYSA-N CCC1C(c2ccc[o]2)=CC(Nc2nc(Nc3ccccc3)nc(-c3ccccc3)c2)=C(C)C1 Chemical compound CCC1C(c2ccc[o]2)=CC(Nc2nc(Nc3ccccc3)nc(-c3ccccc3)c2)=C(C)C1 MLWPCSYRGJNJTA-UHFFFAOYSA-N 0.000 description 1
- FEBCFHGPBNPCTR-UHFFFAOYSA-N NC1=CC2OCCOC2C=C1 Chemical compound NC1=CC2OCCOC2C=C1 FEBCFHGPBNPCTR-UHFFFAOYSA-N 0.000 description 1
- CQQDGDZAZOHAAW-UHFFFAOYSA-N NCC(CC1)C(N)=CC1NC(C(C=CCC1)=C1N)=N Chemical compound NCC(CC1)C(N)=CC1NC(C(C=CCC1)=C1N)=N CQQDGDZAZOHAAW-UHFFFAOYSA-N 0.000 description 1
- LNPMZQXEPNWCMG-UHFFFAOYSA-N NCCc(cc1)ccc1N Chemical compound NCCc(cc1)ccc1N LNPMZQXEPNWCMG-UHFFFAOYSA-N 0.000 description 1
- OJZQOQNSUZLSMV-UHFFFAOYSA-N Nc1cccc(CO)c1 Chemical compound Nc1cccc(CO)c1 OJZQOQNSUZLSMV-UHFFFAOYSA-N 0.000 description 1
- PNPCRKVUWYDDST-UHFFFAOYSA-N Nc1cccc(Cl)c1 Chemical compound Nc1cccc(Cl)c1 PNPCRKVUWYDDST-UHFFFAOYSA-N 0.000 description 1
- CUYKNJBYIJFRCU-UHFFFAOYSA-N Nc1cnccc1 Chemical compound Nc1cnccc1 CUYKNJBYIJFRCU-UHFFFAOYSA-N 0.000 description 1
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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| JP2013213068A (ja) * | 2000-12-21 | 2013-10-17 | Vertex Pharmaceuticals Inc | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013213068A (ja) * | 2000-12-21 | 2013-10-17 | Vertex Pharmaceuticals Inc | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
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