PT3604294T - Compostos e composições para modular atividades da cinase do mutante de egfr - Google Patents

Compostos e composições para modular atividades da cinase do mutante de egfr

Info

Publication number
PT3604294T
PT3604294T PT191967132T PT19196713T PT3604294T PT 3604294 T PT3604294 T PT 3604294T PT 191967132 T PT191967132 T PT 191967132T PT 19196713 T PT19196713 T PT 19196713T PT 3604294 T PT3604294 T PT 3604294T
Authority
PT
Portugal
Prior art keywords
compositions
compounds
kinase activities
egfr mutant
mutant kinase
Prior art date
Application number
PT191967132T
Other languages
English (en)
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55654993&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3604294(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of PT3604294T publication Critical patent/PT3604294T/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
PT191967132T 2014-10-13 2015-10-13 Compostos e composições para modular atividades da cinase do mutante de egfr PT3604294T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462063394P 2014-10-13 2014-10-13

Publications (1)

Publication Number Publication Date
PT3604294T true PT3604294T (pt) 2021-07-29

Family

ID=55654993

Family Applications (2)

Application Number Title Priority Date Filing Date
PT158503144T PT3207035T (pt) 2014-10-13 2015-10-13 Compostos e composições para modular actividades da cinase do mutante de egfr
PT191967132T PT3604294T (pt) 2014-10-13 2015-10-13 Compostos e composições para modular atividades da cinase do mutante de egfr

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT158503144T PT3207035T (pt) 2014-10-13 2015-10-13 Compostos e composições para modular actividades da cinase do mutante de egfr

Country Status (25)

Country Link
US (1) US9593098B2 (pt)
EP (3) EP3604294B1 (pt)
JP (3) JP6524221B2 (pt)
KR (4) KR102208775B1 (pt)
CN (2) CN106795144B (pt)
AU (1) AU2015331166B2 (pt)
BR (1) BR112017007769B1 (pt)
CA (1) CA2962914C (pt)
CY (2) CY1122737T1 (pt)
DK (2) DK3207035T3 (pt)
ES (2) ES2879474T3 (pt)
HR (2) HRP20200201T1 (pt)
HU (2) HUE048006T2 (pt)
LT (2) LT3604294T (pt)
MX (3) MX2017003181A (pt)
NZ (1) NZ730012A (pt)
PH (1) PH12017500488A1 (pt)
PL (2) PL3207035T3 (pt)
PT (2) PT3207035T (pt)
RS (2) RS61865B1 (pt)
RU (2) RU2727700C2 (pt)
SG (1) SG11201701960XA (pt)
SI (2) SI3604294T1 (pt)
TW (2) TWI664173B (pt)
WO (1) WO2016060443A2 (pt)

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AR111469A1 (es) * 2017-04-21 2019-07-17 Yuhan Corp Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma
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MA49703A (fr) * 2017-07-28 2021-04-21 Yuhan Corp Nouveaux intermédiaires utiles pour la synthèse de dérivés d'aminopyrimidine, leur procédé de préparation et procédé de préparation de dérivés d'aminopyrimidine à l'aide de ceux-ci
RS64654B1 (sr) * 2017-07-28 2023-10-31 Yuhan Corp Proces za pripremu n-(5-((4-(4-((dimetilamino)metil)-3-fenil-1h-pirazol-1-il)pirimidin-2-il)amino)-4-metoksi-2- morfolinofenil)akrilamida reakcijom odgovarajućeg amina sa 3-halo-propionil hloridom
SG11201913556SA (en) * 2017-07-28 2020-02-27 Yuhan Corp Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same
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TW202207940A (zh) 2020-04-14 2022-03-01 美商健生生物科技公司 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物
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TW202227425A (zh) * 2020-09-18 2022-07-16 南韓商沃若諾伊生物公司 雜芳基衍生物、彼之製法、及包含彼作為活性成份之藥學組成物
WO2022131741A1 (ko) * 2020-12-14 2022-06-23 보로노이바이오 주식회사 아이소옥사졸리딘 유도체 화합물 및 이의 용도
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TW202342057A (zh) 2022-02-07 2023-11-01 美商健生生物科技公司 用於減少用egfr/met雙特異性抗體治療之患者的輸注相關反應之方法
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Publication number Publication date
CN106795144A (zh) 2017-05-31
AU2015331166A1 (en) 2017-03-30
PL3604294T3 (pl) 2021-11-02
CN111686110A (zh) 2020-09-22
PT3207035T (pt) 2020-02-19
RS61865B1 (sr) 2021-06-30
RU2727700C2 (ru) 2020-07-23
JP2019163277A (ja) 2019-09-26
ES2879474T3 (es) 2021-11-22
CA2962914A1 (en) 2016-04-21
AU2015331166B2 (en) 2018-04-26
EP3604294A1 (en) 2020-02-05
TW201619150A (zh) 2016-06-01
KR102487451B1 (ko) 2023-01-11
JP2017530999A (ja) 2017-10-19
ES2770058T3 (es) 2020-06-30
KR20210011068A (ko) 2021-01-29
CY1124359T1 (el) 2022-07-22
KR20170066650A (ko) 2017-06-14
RS59900B1 (sr) 2020-03-31
MX2021010761A (es) 2022-06-09
RU2017116598A (ru) 2018-11-21
JP2020196740A (ja) 2020-12-10
US9593098B2 (en) 2017-03-14
TWI664173B (zh) 2019-07-01
MX2020002168A (es) 2021-09-07
HRP20210949T1 (hr) 2021-09-03
US20160102076A1 (en) 2016-04-14
KR20230010836A (ko) 2023-01-19
EP3604294B1 (en) 2021-05-05
CA2962914C (en) 2018-10-23
LT3207035T (lt) 2020-02-25
HRP20200201T1 (hr) 2020-05-15
KR102073854B1 (ko) 2020-02-05
KR20200014944A (ko) 2020-02-11
HUE048006T2 (hu) 2020-05-28
CN106795144B (zh) 2020-06-16
TW201938553A (zh) 2019-10-01
RU2017116598A3 (pt) 2018-11-21
LT3604294T (lt) 2021-07-26
CN111686110B (zh) 2023-06-16
SG11201701960XA (en) 2017-04-27
SI3207035T1 (sl) 2020-04-30
BR112017007769A2 (pt) 2018-01-16
DK3207035T3 (da) 2020-01-27
NZ730012A (en) 2019-06-28
MX2017003181A (es) 2017-07-20
SI3604294T1 (sl) 2021-08-31
EP3929190A1 (en) 2021-12-29
EP3207035A2 (en) 2017-08-23
PH12017500488A1 (en) 2017-07-31
PL3207035T3 (pl) 2020-06-01
BR112017007769B1 (pt) 2023-10-10
JP6524221B2 (ja) 2019-06-05
WO2016060443A2 (en) 2016-04-21
CY1122737T1 (el) 2021-03-12
WO2016060443A3 (en) 2016-06-23
RU2020123547A (ru) 2020-08-18
HUE054848T2 (hu) 2021-09-28
DK3604294T3 (da) 2021-06-28
JP6754864B2 (ja) 2020-09-16
EP3207035B1 (en) 2019-11-20
EP3207035A4 (en) 2018-03-14
KR102208775B1 (ko) 2021-01-28
TWI730331B (zh) 2021-06-11
KR102662358B1 (ko) 2024-04-30

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