HK1258275A1 - 用於調節血管緊張素原表達的化合物和方法 - Google Patents

用於調節血管緊張素原表達的化合物和方法

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Publication number
HK1258275A1
HK1258275A1 HK19100639.6A HK19100639A HK1258275A1 HK 1258275 A1 HK1258275 A1 HK 1258275A1 HK 19100639 A HK19100639 A HK 19100639A HK 1258275 A1 HK1258275 A1 HK 1258275A1
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HK
Hong Kong
Prior art keywords
modulating
compounds
methods
angiotensinogen expression
angiotensinogen
Prior art date
Application number
HK19100639.6A
Other languages
English (en)
Inventor
Mullick Adam
J Graham Mark
P Seth Punit
M Freier Susan
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of HK1258275A1 publication Critical patent/HK1258275A1/zh

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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • AHUMAN NECESSITIES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK19100639.6A 2015-10-08 2019-01-15 用於調節血管緊張素原表達的化合物和方法 HK1258275A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562238831P 2015-10-08 2015-10-08
PCT/US2016/056068 WO2017062816A2 (en) 2015-10-08 2016-10-07 Compounds and methods for modulating angiotensinogen expression

Publications (1)

Publication Number Publication Date
HK1258275A1 true HK1258275A1 (zh) 2019-11-08

Family

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Country Status (17)

Country Link
US (2) US10912792B2 (zh)
EP (2) EP3960183A1 (zh)
JP (3) JP2018530325A (zh)
KR (2) KR20180055898A (zh)
CN (2) CN108271351B (zh)
AU (2) AU2016334114B2 (zh)
BR (2) BR122020023854B1 (zh)
CA (1) CA2998898A1 (zh)
CL (2) CL2018000899A1 (zh)
CO (1) CO2018002598A2 (zh)
HK (1) HK1258275A1 (zh)
IL (2) IL295971A (zh)
MX (2) MX2018004307A (zh)
PE (1) PE20181085A1 (zh)
SG (1) SG10202003148VA (zh)
WO (1) WO2017062816A2 (zh)
ZA (1) ZA201801600B (zh)

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US20220243210A1 (en) * 2019-05-17 2022-08-04 Ionis Pharmaceuticals, Inc. Angiotensin ii type 1 receptor targeted oligonucleotides and uses thereof
KR20220115946A (ko) * 2019-11-13 2022-08-19 알닐람 파마슈티칼스 인코포레이티드 안지오텐시노겐 (agt) 관련 장애를 치료하기 위한 방법 및 조성물
US11649458B2 (en) * 2020-05-05 2023-05-16 University Of Kentucky Research Foundation Inhibiting angiotensinogen to attenuate aortic pathology in Marfan syndrome
JP2023549563A (ja) 2020-11-18 2023-11-27 アイオーニス ファーマシューティカルズ, インコーポレーテッド アンジオテンシノーゲン発現を調節するための化合物及び方法
CN114763547A (zh) * 2021-01-14 2022-07-19 施能康生物科技有限公司 靶向血管紧张素原的核酸及其用途
WO2022232650A1 (en) * 2021-04-30 2022-11-03 Ionis Pharmaceuticals, Inc. Methods for reducing agt expression
WO2023056446A1 (en) * 2021-10-01 2023-04-06 Adarx Pharmaceuticals, Inc. Angiotensinogen-modulating compositions and methods of use thereof
CN113862268A (zh) * 2021-10-20 2021-12-31 厦门甘宝利生物医药有限公司 Agt抑制剂及其用途
CN116940682A (zh) * 2021-11-16 2023-10-24 上海舶望制药有限公司 抑制血管紧张素原(agt)蛋白表达的组合物和方法
TW202344687A (zh) * 2021-11-19 2023-11-16 大陸商上海拓界生物醫藥科技有限公司 靶向血管緊張素原的siRNA及其醫藥用途
WO2023138650A1 (zh) * 2022-01-20 2023-07-27 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
CN117264948B (zh) * 2022-06-14 2024-05-10 广州必贝特医药股份有限公司 抑制血管紧张素原基因表达的RNAi抑制剂及其应用
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