HK1244790A1 - Bace1抑制劑 - Google Patents

Bace1抑制劑

Info

Publication number
HK1244790A1
HK1244790A1 HK18103983.3A HK18103983A HK1244790A1 HK 1244790 A1 HK1244790 A1 HK 1244790A1 HK 18103983 A HK18103983 A HK 18103983A HK 1244790 A1 HK1244790 A1 HK 1244790A1
Authority
HK
Hong Kong
Prior art keywords
bace1 inhibitors
bace1
inhibitors
Prior art date
Application number
HK18103983.3A
Other languages
English (en)
Inventor
比約恩．巴特爾斯
科西莫．多倫特
沃爾夫岡．古帕
沃爾夫岡．哈普
烏爾麗克．奧布斯特．森德
延斯-烏韋‧彼得斯
托馬斯．沃爾特林
Original Assignee
豪夫邁．羅氏有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 豪夫邁．羅氏有限公司 filed Critical 豪夫邁．羅氏有限公司
Publication of HK1244790A1 publication Critical patent/HK1244790A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HK18103983.3A 2015-03-20 2018-03-22 Bace1抑制劑 HK1244790A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15160101 2015-03-20
PCT/EP2016/055649 WO2016150785A1 (en) 2015-03-20 2016-03-16 Bace1 inhibitors

Publications (1)

Publication Number Publication Date
HK1244790A1 true HK1244790A1 (zh) 2018-08-17

Family

ID=52780400

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103983.3A HK1244790A1 (zh) 2015-03-20 2018-03-22 Bace1抑制劑

Country Status (19)

Country Link
US (4) US10047081B2 (zh)
EP (1) EP3271355B1 (zh)
JP (1) JP6674960B2 (zh)
KR (1) KR20170129745A (zh)
CN (1) CN107406440B (zh)
AU (1) AU2016236402B2 (zh)
BR (1) BR112017015474A2 (zh)
CA (1) CA2979113A1 (zh)
CL (1) CL2017002229A1 (zh)
CO (1) CO2017007691A2 (zh)
CR (1) CR20170426A (zh)
HK (1) HK1244790A1 (zh)
IL (1) IL253322A0 (zh)
MX (1) MX2017012188A (zh)
PE (1) PE20171349A1 (zh)
PH (1) PH12017501668A1 (zh)
RU (1) RU2712272C2 (zh)
SG (1) SG11201707050VA (zh)
WO (1) WO2016150785A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3271355B1 (en) * 2015-03-20 2020-07-29 H. Hoffnabb-La Roche Ag Bace1 inhibitors
CN110467611B (zh) * 2018-05-11 2022-09-27 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途
AR115495A1 (es) 2018-06-06 2021-01-27 Syngenta Crop Protection Ag Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
ES2398017T3 (es) 2008-02-18 2013-03-13 F. Hoffmann-La Roche Ag Derivados de 4,5-dihidro-oxazol-2-il-amina
US8461160B2 (en) 2009-05-08 2013-06-11 Hoffmann-La Roche, Inc. Dihydropyrimidinones
US8188079B2 (en) 2009-08-19 2012-05-29 Hoffman-La Roche Inc. 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
US7964594B1 (en) 2009-12-10 2011-06-21 Hoffmann-La Roche Inc. Amino oxazine derivatives
UA103272C2 (uk) 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
US8673894B2 (en) 2010-05-07 2014-03-18 Hoffmann-La Roche Inc. 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds
US8815881B2 (en) 2010-08-09 2014-08-26 Hoffmann-La Roche Inc. 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds
US20120053200A1 (en) 2010-09-01 2012-03-01 Harald Mauser Bace 2 inhibitors
US9242943B2 (en) 2011-01-18 2016-01-26 Siena Biotech S.P.A. 1,4 oxazines as BACE1 and/or BACE2 inhibitors
US8399459B2 (en) 2011-02-02 2013-03-19 Hoffmann-La Roche Inc. 1,4 oxazines as BACE1 and/or BACE2 inhibitors
US8404680B2 (en) 2011-02-08 2013-03-26 Hoffmann-La Roche Inc. N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors
US8815841B2 (en) 2011-02-18 2014-08-26 Hoffmann-La Roche Inc. 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors
US9067924B2 (en) 2011-03-04 2015-06-30 Hoffmann-La Roche Inc. 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
US8748418B2 (en) 2011-03-18 2014-06-10 Hoffmann-La Roche Inc. 1,4-oxazepines as BACE1 and/or BACE2 inhibitors
US8877744B2 (en) 2011-04-04 2014-11-04 Hoffmann-La Roche Inc. 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors
US8754075B2 (en) 2011-04-11 2014-06-17 Hoffmann-La Roche Inc. 1,3-oxazines as BACE1 and/or BACE2 inhibitors
CN103596939A (zh) * 2011-04-13 2014-02-19 默沙东公司 作为bace抑制剂的5-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其应用
CA2832473A1 (en) * 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 5-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions, and their use
US8785436B2 (en) 2011-05-16 2014-07-22 Hoffmann-La Roche Inc. 1,3-oxazines as BACE 1 and/or BACE2 inhibitors
US9079919B2 (en) 2011-05-27 2015-07-14 Hoffmann-La Roche Inc. Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors
AU2012266544A1 (en) 2011-06-07 2013-11-21 F. Hoffmann-La Roche Ag Halogen-alkyl-1,3 oxazines as BACE1 and/or BACE2 inhibitors
MX2013014007A (es) 2011-06-07 2014-03-12 Hoffmann La Roche [1,3] oxazinas.
US8927535B2 (en) 2011-07-06 2015-01-06 Hoffman-La Roche Inc. Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
RU2014111055A (ru) * 2011-08-22 2015-09-27 Мерк Шарп И Доум Корп. 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение
US8476264B2 (en) 2011-09-21 2013-07-02 Hoffmann-La Roche Inc. N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors
SG11201403956VA (en) 2012-01-26 2014-10-30 Hoffmann La Roche Fluoromethyl-5,6-dihydro-4h-[1,3]oxazines
AU2013265376B2 (en) 2012-05-24 2017-07-20 F. Hoffmann-La Roche Ag 5-amino[1,4]thiazines as BACE 1 inhibitors
AU2013283524B2 (en) 2012-06-26 2017-03-30 F. Hoffmann-La Roche Ag Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as BACE1 inhibitors
WO2014062549A1 (en) * 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
BR112015016315A2 (pt) * 2013-01-22 2017-07-11 Hoffmann La Roche fluoro-[1,3]oxazinas como inibidores de bace1
WO2014150331A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use
US9453034B2 (en) 2013-03-15 2016-09-27 Merck Sharp & Dohme Corp. C2-azaspiro iminothiazine dioxides as BACE inhibitors, compositions, and their use
US9428476B2 (en) 2013-03-15 2016-08-30 Merck Sharp & Dohme Corp. S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use
EP3271355B1 (en) * 2015-03-20 2020-07-29 H. Hoffnabb-La Roche Ag Bace1 inhibitors

Also Published As

Publication number Publication date
EP3271355A1 (en) 2018-01-24
US20180319787A1 (en) 2018-11-08
US11034687B2 (en) 2021-06-15
CN107406440B (zh) 2021-05-07
WO2016150785A1 (en) 2016-09-29
JP6674960B2 (ja) 2020-04-01
RU2017134884A3 (zh) 2019-07-17
AU2016236402A1 (en) 2017-07-27
CR20170426A (es) 2017-10-23
MX2017012188A (es) 2017-12-15
CN107406440A (zh) 2017-11-28
US10047081B2 (en) 2018-08-14
US20190337936A1 (en) 2019-11-07
US10723729B2 (en) 2020-07-28
CL2017002229A1 (es) 2018-04-13
IL253322A0 (en) 2017-09-28
AU2016236402B2 (en) 2019-08-01
RU2712272C2 (ru) 2020-01-28
CO2017007691A2 (es) 2017-10-20
CA2979113A1 (en) 2016-09-29
EP3271355B1 (en) 2020-07-29
US20200308166A1 (en) 2020-10-01
US20180057485A1 (en) 2018-03-01
PE20171349A1 (es) 2017-09-13
RU2017134884A (ru) 2019-04-22
JP2018507879A (ja) 2018-03-22
US10399969B2 (en) 2019-09-03
KR20170129745A (ko) 2017-11-27
SG11201707050VA (en) 2017-10-30
BR112017015474A2 (pt) 2018-01-30
PH12017501668A1 (en) 2018-03-19

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