AR042398A1 - Compuestos de pirazol utiles como inhibidores de proteinquinasa - Google Patents
Compuestos de pirazol utiles como inhibidores de proteinquinasaInfo
- Publication number
- AR042398A1 AR042398A1 ARP010105961A ARP010105961A AR042398A1 AR 042398 A1 AR042398 A1 AR 042398A1 AR P010105961 A ARP010105961 A AR P010105961A AR P010105961 A ARP010105961 A AR P010105961A AR 042398 A1 AR042398 A1 AR 042398A1
- Authority
- AR
- Argentina
- Prior art keywords
- ring
- so2n
- con
- nitrogen
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 14
- 229910052757 nitrogen Chemical group 0.000 abstract 10
- 125000001931 aliphatic group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000004429 atom Chemical group 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 239000011593 sulfur Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 1
- -1 pyrazole compound Chemical class 0.000 abstract 1
Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00Â -Â C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00Â -Â C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00Â -Â C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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| ARP010105963A AR040925A1 (es) | 2000-12-21 | 2001-12-20 | Compuestos de pirazol utiles como inhibidores de proteinquinasa |
| ARP010105962A AR042169A1 (es) | 2000-12-21 | 2001-12-20 | Compuestos de pirazol utiles como inhibidores de proteinquinasa |
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Families Citing this family (379)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982260B1 (en) | 1999-11-22 | 2006-01-03 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
| US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2001296871A1 (en) * | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ES2307667T3 (es) * | 2000-12-05 | 2008-12-01 | Vertex Pharmaceuticals Incorporated | Inhibidires de quinasas terminales c-jun(jnk) y otras proteinas quinasas. |
| HUP0400639A3 (en) * | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| MXPA03008658A (es) * | 2001-03-23 | 2005-04-11 | Bayer Ag | Inhibidores de rho-cinasa. |
| ATE400274T1 (de) | 2001-04-10 | 2008-07-15 | Merck & Co Inc | Hemmstoffe der akt aktivitÀt |
| US7105667B2 (en) * | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| US7138404B2 (en) * | 2001-05-23 | 2006-11-21 | Hoffmann-La Roche Inc. | 4-aminopyrimidine derivatives |
| US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| WO2003026666A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors |
| DE60238999D1 (de) * | 2001-09-26 | 2011-03-03 | Pfizer Italia Srl | Aminoindazolderivate mit kinaseinhibierender wirkung, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
| SE0104140D0 (sv) * | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| AU2002361846A1 (en) * | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| EP1465610B1 (en) * | 2002-01-10 | 2008-12-31 | F. Hoffmann-La Roche Ag | Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| JP4656838B2 (ja) * | 2002-02-06 | 2011-03-23 | ăăŒăăăŻăč ăăĄăŒăă·ă„ăŒăăŁă«ă«ăș ă€ăłăłăŒăăŹă€ăăă | ïœïœâïŒăźé»ćźłć€ăšăăŠæçšăȘăăăăąăȘăŒă«ććç© |
| WO2003078426A1 (en) * | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazine as inhibitors of protein kinases |
| EP1485100B1 (en) * | 2002-03-15 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Azinylaminoazoles as inhibitors of protein kinases |
| EP1485380B1 (en) | 2002-03-15 | 2010-05-19 | Vertex Pharmaceuticals Incorporated | Azolylaminoazines as inhibitors of protein kinases |
| WO2003086394A1 (en) | 2002-04-08 | 2003-10-23 | Merck & Co., Inc. | Inhibitors of akt activity |
| WO2003104230A1 (ja) | 2002-06-07 | 2003-12-18 | ććé±é ”ć·„æ„æ ȘćŒäŒç€Ÿ | äșç°æ§ăăȘăăžăłèȘć°äœ |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| AU2003261204A1 (en) * | 2002-07-23 | 2004-02-09 | Smithkline Beecham Corporation | Pyrazolopyrimidines as kinase inhibitors |
| CN103169708B (zh) | 2002-07-29 | 2018-02-02 | éæ Œć°èŻćèĄä»œæéć Źćž | çš2,4âć§ć¶äșèșććç©æČ»çæè éąéČèȘäœć ç«æ§çŸç çæčæł |
| PL374967A1 (en) | 2002-08-02 | 2005-11-14 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| SI1532145T1 (sl) * | 2002-08-02 | 2007-02-28 | Vertex Pharma | Pirazolni sestavki, koristni kot inhibitorji GSK-3 |
| AU2003278249B8 (en) | 2002-09-05 | 2010-11-18 | Aventis Pharma S.A. | Novel aminoindazole derivatives as medicines and pharmaceutical compositions containing same |
| FR2844267B1 (fr) * | 2002-09-05 | 2008-02-15 | Aventis Pharma Sa | Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant |
| AU2003255482A1 (en) * | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
| KR101122782B1 (ko) * | 2002-10-04 | 2012-04-12 | íëŒë ë°ìŽì€í íŹëëĄì§ 늏믞í°ë | ì êČœ íì± íí©ëŹŒ |
| KR100490893B1 (ko) * | 2002-10-11 | 2005-05-23 | (ìŁŒ) ëčììšë°ìŽì€í | 2-ë©íĄì-1,3,5-ížëŠŹìì§ ì ëìČŽ, ê·ž ì ìĄ°ë°©ëČ ë° ìŽë„Œ íŹíšíë íë°ìŽëŹì€ì© ìœíì ìĄ°ì±ëŹŒ |
| GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
| US7309701B2 (en) | 2002-11-19 | 2007-12-18 | Sanofi-Aventis Deutschland Gmbh | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
| US7462613B2 (en) | 2002-11-19 | 2008-12-09 | Sanofi-Aventis Deutschland Gmbh | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
| FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
| PT2316831E (pt) | 2002-11-21 | 2013-06-06 | Novartis Ag | 2-(morfolin-4-il)pirimidinas como inibidores da fosfatidilinositol (pi) quinase e a sua utilização no tratamento do cancro |
| WO2004072029A2 (en) * | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
| US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
| EP1644338A1 (en) * | 2003-04-01 | 2006-04-12 | Aponetics AG | 2, 4, 6-trisubstituted pyrimidine derivatives useful for the treatment of neoplastic and autoimmune diseases |
| EP1635837B1 (en) * | 2003-06-02 | 2008-07-16 | AstraZeneca AB | (3-((quinazolin-4-yl)amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
| WO2004112719A2 (en) * | 2003-06-19 | 2004-12-29 | Smithkline Beecham Corporation | Chemical compounds |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| AU2004253967B2 (en) * | 2003-07-03 | 2010-02-18 | Cytovia, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| CA2532965C (en) | 2003-07-22 | 2013-05-14 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| WO2005012262A1 (en) * | 2003-07-30 | 2005-02-10 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| US7122542B2 (en) | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
| US20050221357A1 (en) * | 2003-09-19 | 2005-10-06 | Mark Shannon | Normalization of gene expression data |
| US20060024690A1 (en) * | 2003-09-19 | 2006-02-02 | Kao H P | Normalization of data using controls |
| WO2005030131A2 (en) * | 2003-09-23 | 2005-04-07 | Replidyne, Inc | Bis-quinazoline compounds for the treatment of bacterial infections |
| CA2542522A1 (en) | 2003-10-17 | 2005-05-06 | Astrazeneca Ab | 4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer |
| CA2548172A1 (en) * | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| RU2006124559A (ru) * | 2003-12-09 | 2008-01-20 | ĐĐ”ŃŃĐ”ĐșŃ Đ€Đ°ŃĐŒĐ°ŃŃŃŃĐžĐșалз ĐĐœĐșĐŸŃĐżĐŸŃĐ”ĐčŃДЎ (Us) | ĐŃĐŸĐžĐ·ĐČĐŸĐŽĐœŃĐ” ĐœĐ°ŃŃĐžŃĐžĐŽĐžĐœĐ° Đž ĐżŃĐžĐŒĐ”ĐœĐ”ĐœĐžĐ” ŃĐșĐ°Đ·Đ°ĐœĐœŃŃ ĐżŃĐŸĐžĐ·ĐČĐŸĐŽĐœŃŃ ŃŃ ĐČ ĐșаŃĐ”ŃŃĐČĐ” ĐŒĐŸĐŽŃĐ»ŃŃĐŸŃĐŸĐČ ĐŒŃŃĐșаŃĐžĐœĐŸĐČŃŃ ŃĐ”ŃДпŃĐŸŃĐŸĐČ |
| EP1694686A1 (en) * | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
| TW200530235A (en) | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| AU2005212438A1 (en) | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| US20080050314A1 (en) * | 2004-02-26 | 2008-02-28 | Bayer Healthcare Ag | Diagnostics and Therapeutics for Diseases Associated With Glycogen Synthase Kinase 3 Beta (Gsk3b) |
| EP1726580A4 (en) * | 2004-03-15 | 2008-02-13 | Takeda Pharmaceutical | AMINOPHNYLPROPANO ACID DERIVATIVE |
| JP4790703B2 (ja) * | 2004-04-07 | 2011-10-12 | æŠç°èŹćć·„æ„æ ȘćŒäŒç€Ÿ | ç°ćŒććç© |
| JP2007533717A (ja) * | 2004-04-21 | 2007-11-22 | ăąăčăă©ăŒăă« ăąăŻăăă©ă° | ććç© |
| WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
| EP1751136B1 (en) * | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| US7793137B2 (en) | 2004-10-07 | 2010-09-07 | Cisco Technology, Inc. | Redundant power and data in a wired data telecommunincations network |
| AU2012200416B2 (en) * | 2004-05-14 | 2014-07-31 | Millennium Pharmaceuticals, Inc. | "Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase" |
| US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
| MXPA06013208A (es) * | 2004-05-14 | 2007-01-16 | Vertex Pharma | Profarmacos de pirrolipirimidina como inhibidotes de la proteina cinasa erk. |
| SI1771450T1 (sl) * | 2004-05-14 | 2008-06-30 | Millennium Pharm Inc | Spojine in postopki za inhibiranje mitotiÄne progresije z inhibicijo kinaze Aurora |
| ES2299080T3 (es) * | 2004-05-14 | 2008-05-16 | Millennium Pharmaceuticals, Inc. | Compuestos y metodos para inhibir la progresion mitotica mediante la inhibicion de quinasas aurora. |
| EP1750698A4 (en) * | 2004-05-20 | 2010-06-02 | Bayer Pharmaceuticals Corp | 5-ANILINO-4-HETEROARYLPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES |
| US20050282094A1 (en) * | 2004-05-27 | 2005-12-22 | Kim Young H | Developer for a photopolymer protective layer |
| JP4990766B2 (ja) * | 2004-07-01 | 2012-08-01 | ă·ăłăż ăăĄăŒăă·ă„ăŒăăŁă«ă«ăș ăłăŒăăŹăŒă·ă§ăł | äșçœźæćăăăăąăȘăŒă«ććç© |
| JP2008505907A (ja) * | 2004-07-06 | 2008-02-28 | ăąăłăžăȘăł ăă€ăȘăĄăăŁă« ăłăŒăăŹă€ă·ă§ăł | çæČ»çăçźçăšăăŠè现èćąæźć ćăăăłïœâïœïœ ïœæŽ»æ§ăèȘżæŽăăăăăŸăȘăłăąăžă„ăŹăŒăżăŒ |
| JP2008510734A (ja) | 2004-08-18 | 2008-04-10 | ăżă±ă ă”ăł ăăŁăšăŽ ă€ăłăłăŒăăŹă€ăăă | ăăăŒăŒé»ćźłć€ |
| US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
| AR050948A1 (es) | 2004-09-24 | 2006-12-06 | Hoffmann La Roche | Derivados de ftalazinona; su obtencion y su utilizacion en la fabricacion de medicamentos para el tratamiento del cancer. |
| AU2005288865B2 (en) * | 2004-09-30 | 2012-07-19 | Janssen Sciences Ireland Uc | HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines |
| WO2006035067A2 (en) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-heterocyclyl pyrimidines |
| ES2380631T3 (es) * | 2004-09-30 | 2012-05-17 | Tibotec Pharmaceuticals | Pirimidinas sustituidas en posiciĂłn 5 inhibidoras de VIH |
| EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US7491720B2 (en) | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
| US20080027042A1 (en) * | 2004-10-29 | 2008-01-31 | Mitsuru Ohkubo | Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action |
| JP2008519034A (ja) | 2004-11-03 | 2008-06-05 | ăăŒăăăŻăč ăăĄăŒăă·ă„ăŒăăŁă«ă«ăș ă€ăłăłăŒăăŹă€ăăă | ă€ăȘăłăăŁăă«èȘżçŻć€ăšăăŠăźăăȘăăžăłèȘć°äœăăăłäœżçšæčæł |
| WO2006055831A2 (en) | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
| ATE540035T1 (de) | 2004-11-24 | 2012-01-15 | Rigel Pharmaceuticals Inc | Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
| WO2006067614A2 (en) * | 2004-12-23 | 2006-06-29 | Pfizer Products Inc. | Heteroaromatic derivatives useful as anticancer agents |
| US8110573B2 (en) * | 2004-12-30 | 2012-02-07 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases |
| US8211929B2 (en) | 2004-12-30 | 2012-07-03 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| AR054425A1 (es) * | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| JP4804480B2 (ja) * | 2005-01-26 | 2011-11-02 | ă·ă§ăŒăȘăłă° ăłăŒăăŹă€ă·ă§ăł | çăźćŠçœźăźăăăźăăăă€ăłăăăŒăŒă€ăłăăăżăŒăšăăŠăźăïŒâïŒă€ăłăăŸăŒă«âïŒâă€ă«ïŒâïŒïŒïŒïŒïŒïŒïŒăăȘăąăžăłèȘć°äœăăăăłéąéŁăăććç© |
| PT1846394E (pt) | 2005-02-04 | 2012-01-05 | Astrazeneca Ab | Derivados de pirazolilaminopiridina Ășteis como inibidores da quinase |
| AU2006215394B2 (en) * | 2005-02-16 | 2009-10-08 | Astrazeneca Ab | Chemical compounds |
| ES2308731T3 (es) * | 2005-02-16 | 2008-12-01 | Astrazeneca Ab | Compuestos quimicos. |
| BRPI0608513A2 (pt) * | 2005-03-15 | 2010-01-05 | Irm Llc | compostos e composiçÔes como inibidores da proteÏna quinase |
| JP2008534481A (ja) * | 2005-03-23 | 2008-08-28 | ăąăčăă©ăŒăă« ăąăŻăăă©ă° | ă€ăłăčăȘăłæ§ćąæźć ćâïŒććźčäœæŽ»æ§ăźé»ćźłć€ăšăăŠăźïŒâăąăŒăăžăă«âïŒâïŒïŒïœâăă©ăŸăŒă«âïŒâă€ă«ăąăăïŒăăȘăăžăł |
| US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| JP2008534662A (ja) * | 2005-04-05 | 2008-08-28 | ăąăčăă©ăŒăă« ăąăŻăăă©ă° | æçć€ăšăăŠäœżçšăăăăăȘăăžăłèȘć°äœ |
| GB0507347D0 (en) * | 2005-04-12 | 2005-05-18 | Astrazeneca Ab | Chemical compounds |
| US7462639B2 (en) | 2005-04-14 | 2008-12-09 | Hoffmann-La Roche Inc. | Aminopyrazole derivatives |
| WO2006115452A1 (en) * | 2005-04-27 | 2006-11-02 | Astrazeneca Ab | Use of pyrazolyl-pyrimidine derivatives in the treatment of pain |
| WO2006118231A1 (ja) | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | ă·ăąăăăȘăžăłèȘć°äœćăłăăźć»èŹăšăăŠăźçšé |
| WO2006117212A2 (en) | 2005-05-04 | 2006-11-09 | Develogen Aktiengesellschaft | Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders |
| WO2006119504A2 (en) | 2005-05-04 | 2006-11-09 | Renovis, Inc. | Fused heterocyclic compounds, and compositions and uses thereof |
| JP2008540391A (ja) * | 2005-05-05 | 2008-11-20 | ăąăčăă©ăŒăă« ăąăŻăăă©ă° | ăă©ăŸăȘă«ăąăăçœźæăăȘăăžăłăăăăłçăźćŠçœźă«ăăăăăăăźäœżçš |
| AU2006248780B2 (en) * | 2005-05-16 | 2010-06-03 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
| RU2485106C2 (ru) | 2005-06-08 | 2013-06-20 | РаĐčЎжДл Đ€Đ°ĐŒŃŃŃŃŃĐžĐșŃлз, ĐĐœĐș. | ĐĄĐŸĐ”ĐŽĐžĐœĐ”ĐœĐžŃ, ĐżŃĐŸŃĐČĐ»ŃŃŃОД аĐșŃĐžĐČĐœĐŸŃŃŃ ĐČ ĐŸŃĐœĐŸŃĐ”ĐœĐžĐž jak-ĐșĐžĐœĐ°Đ·Ń (ĐČаŃĐžĐ°ĐœŃŃ), ŃĐżĐŸŃĐŸĐ± лДŃĐ”ĐœĐžŃ Đ·Đ°Đ±ĐŸĐ»Đ”ĐČĐ°ĐœĐžĐč, ĐŸĐżĐŸŃŃĐ”ĐŽĐŸĐČĐ°ĐœĐœŃŃ jak-ĐșĐžĐœĐ°Đ·ĐŸĐč, ŃĐżĐŸŃĐŸĐ± ĐžĐœĐłĐžĐ±ĐžŃĐŸĐČĐ°ĐœĐžŃ Đ°ĐșŃĐžĐČĐœĐŸŃŃĐž jak-ĐșĐžĐœĐ°Đ·Ń (ĐČаŃĐžĐ°ĐœŃŃ), ŃаŃĐŒĐ°ŃĐ”ĐČŃĐžŃĐ”ŃĐșĐ°Ń ĐșĐŸĐŒĐżĐŸĐ·ĐžŃĐžŃ ĐœĐ° ĐŸŃĐœĐŸĐČĐ” ŃĐșĐ°Đ·Đ°ĐœĐœŃŃ ŃĐŸĐ”ĐŽĐžĐœĐ”ĐœĐžĐč |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
| EP1890703B1 (en) | 2005-06-14 | 2016-05-11 | Taigen Biotechnology | Pyrimidine compounds as chemokine receptors inhibitors |
| EP1746096A1 (en) | 2005-07-15 | 2007-01-24 | 4Sc Ag | 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer |
| EP1917259B1 (en) * | 2005-08-18 | 2012-01-25 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
| WO2007023382A2 (en) * | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| ES2535854T3 (es) * | 2005-09-30 | 2015-05-18 | Miikana Therapeutics, Inc. | Compuestos de pirazol sustituidos |
| UA96427C2 (en) * | 2005-09-30 | 2011-11-10 | ĐĐžĐčĐșĐ°ĐœĐ° йДŃапŃŃŃĐžĐșŃ, ĐĐœĐș. | Substituted pyrazole compounds |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ăăŹă€ăłă»ă«ăčïŒă€ăłăłăŒăăŹă€ăăŁă | ïœïœ é»ćźłă«ăăç„ç”æ°çăźèȘżçŻ |
| WO2007049041A1 (en) * | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| AU2006309173B2 (en) * | 2005-11-01 | 2011-08-18 | Array Biopharma Inc. | Glucokinase activators |
| CN101316597B (zh) * | 2005-11-03 | 2013-04-17 | 饶çčć»èŻćć Źćž | çšäœæżé ¶æć¶ćçæ°šćșć§ć¶ |
| DE602006021776D1 (de) * | 2005-11-16 | 2011-06-16 | Vertex Pharma | Als kinaseinhibitoren geeignete aminopyrimidine |
| US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| US7572809B2 (en) | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
| EP1968579A1 (en) | 2005-12-30 | 2008-09-17 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US20080058312A1 (en) * | 2006-01-11 | 2008-03-06 | Angion Biomedica Corporation | Modulators of hepatocyte growth factor/c-Met activity |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | ÙÙÙۧ۱ŰȘÙŰł ۧÙÙ ŰŹÙ | Pi-3 inhibitors and methods of use |
| ES2353437T3 (es) * | 2006-02-16 | 2011-03-02 | Schering Corporation | Derivados de pirrolidina como inhibidores de erk. |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| PE20080145A1 (es) * | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| WO2007113254A1 (en) * | 2006-03-30 | 2007-10-11 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-amido substituted pyrimidines |
| EP2001480A4 (en) * | 2006-03-31 | 2011-06-15 | Abbott Lab | Indazole CONNECTIONS |
| US20090286803A1 (en) | 2006-04-07 | 2009-11-19 | Manley Paul W | Combination comprising a) a pyrimidylaminobenzamide compound, and b) a thr315lle kinase inhibitor |
| BRPI0710737A2 (pt) | 2006-04-14 | 2011-05-10 | Prana Biotechnology Ltd | uso de compostos pb-10 33 Ă©teis para o tratamento de degeneraĂço macular relacionada Ă idade (amd), assim como referidos compostos |
| EP2017279B1 (en) * | 2006-04-27 | 2013-09-04 | Msd K.K. | Aminopyrimidine derivatives having aurora-a-selective inhibitory activity |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2838448A1 (en) | 2006-06-27 | 2008-01-03 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds |
| JP2009542608A (ja) * | 2006-06-29 | 2009-12-03 | ăąăčăăăŻăčă»ă»ă©ăă„ăŒăăŁăŻăčă»ăȘăăăă | ć»èŹç”ćă〠|
| JP5523829B2 (ja) | 2006-06-29 | 2014-06-18 | ăąăčăăăŻăčăă»ă©ăă„ăŒăăŁăăŻăčăăȘăăăă | è€ćèŹć€ |
| WO2008001886A1 (en) * | 2006-06-30 | 2008-01-03 | Kyowa Hakko Kirin Co., Ltd. | Aurora inhibitor |
| UY30444A1 (es) * | 2006-06-30 | 2008-01-31 | Astrazeneca Ab | Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos. |
| CA2656290A1 (en) | 2006-07-05 | 2008-01-10 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
| EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
| EP2054413A2 (en) * | 2006-08-09 | 2009-05-06 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
| US7832809B2 (en) * | 2006-08-11 | 2010-11-16 | Schlumberger Technology Corporation | Degradation assembly shield |
| JP2008081492A (ja) * | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | ăȘăŒăă©ïœéžæçé»ćźłäœçšăæăăæ°èŠăąăăăăȘăžăłèȘć°äœ |
| JP2010502722A (ja) * | 2006-09-08 | 2010-01-28 | ăăŹă€ăłă»ă«ăčïŒă€ăłăłăŒăăŹă€ăăŁă | ïŒâăąă·ă«ăąăăăăȘăžăłèȘć°äœăć«ăç”ăżćăă |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | æŠç°èŹćć·„æ„æ ȘćŒäŒç€Ÿ | ăăăŒăŒé»ćźłć€ |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | ăąăčăăăŻăčăă»ă©ăă„ăŒăăŁăăŻăčăăȘăăăă | è€ćèŹć€ |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008053812A1 (en) * | 2006-10-27 | 2008-05-08 | Mitsubishi Tanabe Pharma Corporation | Cyanopyridine derivative and medicinal use thereof |
| EP2086965B1 (en) | 2006-11-02 | 2010-02-10 | Vertex Pharmaceuticals, Inc. | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| AU2007333650A1 (en) | 2006-12-19 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
| WO2008080965A2 (en) * | 2006-12-29 | 2008-07-10 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5,6-substituted pyrimidines |
| JP5185283B2 (ja) * | 2006-12-29 | 2013-04-17 | ăă€ăăăŻă»ăăąăŒăă·ăŠăŒăă«ă«ăș | ïœïœé»ćźłïŒâçœźæăăȘăăžăł |
| EP2118087B1 (en) | 2007-02-06 | 2012-03-28 | Novartis AG | Pi 3-kinase inhibitors and methods of their use |
| WO2008111441A1 (ja) | 2007-03-05 | 2008-09-18 | Kyowa Hakko Kirin Co., Ltd. | ć»èŹç”æç© |
| JP5393489B2 (ja) * | 2007-03-09 | 2014-01-22 | ăăŒăăăŻăč ăăĄăŒăă·ă„ăŒăăŁă«ă«ăș ă€ăłăłăŒăăŹă€ăăă | èçœăăăŒăŒăźé»ćźłć€ăšăăŠæçšăȘăąăăăăȘăăžăł |
| JP2010520887A (ja) | 2007-03-09 | 2010-06-17 | ăăŒăăăŻăč ăăĄăŒăă·ă„ăŒăăŁă«ă«ăș ă€ăłăłăŒăăŹă€ăăă | èçœăăăŒăŒăźé»ćźłć€ăšăăŠæçšăȘăąăăăăȘăžăł |
| MX2009009590A (es) | 2007-03-09 | 2009-11-10 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de proteinas cinasas. |
| MX2009010037A (es) * | 2007-03-20 | 2009-11-05 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasas. |
| WO2008117050A1 (en) * | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer |
| CA2683785A1 (en) | 2007-04-13 | 2008-10-23 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| CN101679429A (zh) * | 2007-04-18 | 2010-03-24 | éżæŻć©ćș·(çć ž)æéć Źćž | 5-æ°šćșćĄć-3-ćș-3h-ćȘććč¶[4,5-b]ćĄć¶èĄçç©ćć ¶æČ»ççççšé |
| JP4782239B2 (ja) | 2007-04-18 | 2011-09-28 | ăăĄă€ă¶ăŒă»ăăăăŻăă»ă€ăłăŻ | ç°ćžžçްèćąæźæČ»çăźăăăźăčă«ăăă«ăąăăèȘć°äœ |
| JP5389785B2 (ja) * | 2007-05-02 | 2014-01-15 | ăăŒăăăŻăč ăăĄăŒăă·ă„ăŒăăŁă«ă«ăș ă€ăłăłăŒăăŹă€ăăă | ăăăŒăŒé»ćźłć€ăšăăŠæçšăȘăăąăŸăŒă«ăăăłăă©ăŸăŒă« |
| CA2694381A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| MX2009011811A (es) * | 2007-05-02 | 2010-01-14 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
| UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | ĐŃŃŃĐ°Đ·Đ”ĐœĐ”Đșа Đб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
| ATE521609T1 (de) * | 2007-05-04 | 2011-09-15 | Astrazeneca Ab | Aminothiazolylpyrimidinderivate und ihre verwendung bei der behandlung von krebs |
| CN101687852A (zh) * | 2007-05-24 | 2010-03-31 | æČæł°ć æŻèŻç©èĄä»œæéć Źćž | ćŻçšäœæżé ¶æć¶ćçć»ćç±»ććĄćç±»ććç© |
| KR101294731B1 (ko) * | 2007-06-04 | 2013-08-16 | ìŒì±ëì€íë ìŽ ìŁŒìíìŹ | ìŽë ìŽ êž°í, ìŽë„Œ ê°ë íìíšë ë° ìŽì ì ìĄ°ë°©ëČ |
| CA2683152A1 (en) * | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
| JP2010532756A (ja) * | 2007-07-06 | 2010-10-14 | ăȘăŒăšăčăąă€ă»ăăĄăŒăăčăŒăăŁă«ă«ășă»ă€ăłăłăŒăăŹăŒăăă | ïœïŒŽïŒŻïŒČïŒŁïŒćăłïœïŒŽïŒŻïŒČïŒŁïŒăźäžĄæčăźé»ćźłć€ăć«ăç”ăżćăăæççæł |
| WO2009007753A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | 4- (3-aminopyrazole) -pyrimidine derivativee and their use as tyrosine kinase inhibitors for the treatment of cancer |
| KR20100038108A (ko) * | 2007-07-25 | 2010-04-12 | ëžëŠŹì€íš-ë§ìŽìŽì€ ì€í 컎íŒë | ížëŠŹìì§ í€ëì ì”ì ì |
| WO2009013545A2 (en) * | 2007-07-26 | 2009-01-29 | Astrazeneca Ab | Chemical compounds |
| CN101790532B (zh) * | 2007-07-31 | 2013-11-20 | æČæł°ć æŻèŻç©èĄä»œæéć Źćž | 5-æ°-1H-ćĄććč¶[3ïŒ4-b]ćĄć¶-3-èșćć ¶èĄçç©çć¶ć€æčæł |
| TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009027736A2 (en) * | 2007-08-27 | 2009-03-05 | Astrazeneca Ab | 2,4 diaminopyrimid'lnes for the treatment of myeloproliferative disorders and cancer |
| BRPI0816881A2 (pt) | 2007-09-21 | 2015-03-17 | Array Biopharma Inc | Composto, composição farmacĂȘutica, uso de um composto, e, mĂ©todos para tratar doenças ou distĂșrbios e para preparar um composto. |
| CA2702265C (en) | 2007-10-11 | 2014-12-02 | Smithkline Beecham Corporation | Novel seh inhibitors and their use |
| US8288397B2 (en) | 2007-12-17 | 2012-10-16 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
| US20090270418A1 (en) * | 2008-01-09 | 2009-10-29 | Marianne Sloss | Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith |
| WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| SG188179A1 (en) * | 2008-02-21 | 2013-03-28 | Merck Sharp & Dohme | Compounds that are erk inhibitors |
| WO2009104802A1 (en) * | 2008-02-22 | 2009-08-27 | Banyu Pharmaceutical Co., Ltd. | Novel aminopyridine derivatives having aurora a selective inhibitory action |
| PL2268635T3 (pl) | 2008-04-21 | 2015-11-30 | Taigen Biotechnology Co Ltd | ZwiÄ zki heterocykliczne |
| WO2010011411A1 (en) | 2008-05-27 | 2010-01-28 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and media for detecting network anomalies |
| AU2009259026B2 (en) * | 2008-06-11 | 2012-10-04 | Astrazeneca Ab | Tricyclic 2,4-diamin0-L,3,5-triazine derivatives useful for the treatment of cancer and myeloproliferative disorders |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| KR20110046514A (ko) * | 2008-07-31 | 2011-05-04 | ì ëší íŹ, ìžíŹ. | íŒëŠŹëŻžë íí©ëŹŒ, ìĄ°ì±ëŹŒ ë° ìŹì© ë°©ëČ |
| WO2010027921A1 (en) * | 2008-09-03 | 2010-03-11 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
| CN105574346A (zh) * | 2008-09-05 | 2016-05-11 | æ°ćșéżç»Žçœç±łć æŻç ç©¶ć Źćž | ć€èœć¶èç©äžäžćŻéæć¶ćçèźŸèźĄæčæłćæŁæ”æčæł |
| WO2010031056A2 (en) * | 2008-09-15 | 2010-03-18 | The Regents Of The University Of California | Methods and compositions for modulating ire1, src, and abl activity |
| KR20110071098A (ko) * | 2008-09-30 | 2011-06-28 | ìì€ížëŒì ë€ìčŽ ìëČ | ëł”ìí ïœïœïœ í€ëì ì”ì ì |
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| WO2010056758A1 (en) * | 2008-11-12 | 2010-05-20 | Yangbo Feng | Quinazoline derivatives as kinase inhibitors |
| TW201021855A (en) | 2008-11-13 | 2010-06-16 | Taigen Biotechnology Co Ltd | Lyophilization formulation |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| PA8851101A1 (es) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
| EP2373664B1 (en) * | 2008-12-19 | 2013-06-12 | Nerviano Medical Sciences S.r.l. | Bicyclic pyrazoles as protein kinase inhibitors |
| WO2010074724A1 (en) | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
| US8809343B2 (en) | 2008-12-26 | 2014-08-19 | Fudan University | Pyrimidine derivative, preparation method and use thereof |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| RU2529019C2 (ru) * | 2009-02-27 | 2014-09-27 | ĐĐŒĐ±ĐžŃ ĐаĐčĐŸŃаĐčĐ”ĐœŃОз ĐĐŸŃĐżĐŸŃĐ”ĐčŃĐœ | ĐĐŸĐŽŃлОŃŃŃŃОД jak ĐșĐžĐœĐ°Đ·Ń Ń ĐžĐœĐ°Đ·ĐŸĐ»ĐžĐœĐŸĐČŃĐ” ĐżŃĐŸĐžĐ·ĐČĐŸĐŽĐœŃĐ” Đž ŃĐżĐŸŃĐŸĐ±Ń ĐžŃ ĐżŃĐžĐŒĐ”ĐœĐ”ĐœĐžŃ |
| CA2660962A1 (en) | 2009-03-31 | 2010-09-30 | Astellas Pharma Inc. | Novel pharmaceutical composition for treatment of schizophrenia |
| US8399663B2 (en) | 2009-04-03 | 2013-03-19 | Astellas Pharma Inc. | Salt of 1,3,5-triazine-2,4,6-triamine derivative |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | Ù Ű±ÙۚۧŰȘ Ű”ÙŰŻÙۧÙÙŰ© Ű”Ùۚ۩ ÙŰ·Ű±Ù ÙۧÙŰȘۧۏÙۧ |
| AU2010259002B2 (en) * | 2009-06-08 | 2014-03-20 | Nantbio, Inc. | Triazine derivatives and their therapeutical applications |
| EP2440052A4 (en) * | 2009-06-08 | 2013-01-23 | Abraxis Bioscience Llc | TRIAZINE DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF |
| BRPI1011319A2 (pt) * | 2009-06-09 | 2016-06-21 | California Capital Equity Llc | derivados de triazina benzil-substituĂdos e suas aplicaçÔes terapĂȘuticas |
| AU2010258853B2 (en) * | 2009-06-09 | 2014-07-31 | Nantbio, Inc. | Triazine derivatives and their therapeutical applications |
| KR20120026613A (ko) * | 2009-06-09 | 2012-03-19 | ìëžëœìì€ ë°ìŽì€ìŹìŽìžì€, ìììš | ì€í°ëŠŽ-ížëŠŹìì§ ì ëìČŽì ìŽë€ì ìčëŁì ì©ë |
| US20120202818A1 (en) * | 2009-06-09 | 2012-08-09 | California Capital Equity, Llc | Ureidophenyl substituted triazine derivatives and their therapeutical applications |
| US20120172384A1 (en) * | 2009-06-18 | 2012-07-05 | Mihiro Sunose | Heterocyclylaminopyrimidines as kinase inhibitors |
| US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| TWI468402B (zh) * | 2009-07-31 | 2015-01-11 | ćż æČ»ćŠ„çŸé ćČè°·æŻć Źćž | éäœÎČïŒéĄæŸ±çČçæäčććç© |
| CN102482312A (zh) | 2009-08-26 | 2012-05-30 | è”èŻșèČ | æ°éąçæèłææ°ä»Łçłè·ç»æ¶æ°Žćç©ă㫿èżäșććç©çèŻç©ććźä»Źççšé |
| US9556426B2 (en) | 2009-09-16 | 2017-01-31 | Celgene Avilomics Research, Inc. | Protein kinase conjugates and inhibitors |
| US8876857B2 (en) * | 2009-11-13 | 2014-11-04 | Intuitive Surgical Operations, Inc. | End effector with redundant closing mechanisms |
| CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| CN102812167A (zh) | 2009-12-30 | 2012-12-05 | éżç»Žæć¶èŻć Źćž | èçœçé äœ-ä»ćŻŒçć ±ä»·äżźé„° |
| SA111320200B1 (ar) * | 2010-02-17 | 2014-02-16 | ŰŻÙŰšÙÙÙŰ§Ű±Ù Ű§Űł ۧÙÙ | Ù Ű±ÙۚۧŰȘ Ű«ÙۧۊÙŰ© ۧÙŰÙÙŰ© Ùۧ۳ŰȘŰźŰŻŰ§Ù Ű§ŰȘÙۧ ÙÙ Ű«ŰšŰ·Ű§ŰȘ c-src/jak Ù ŰČŰŻÙŰŹŰ© |
| US8653064B2 (en) | 2010-02-19 | 2014-02-18 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-D][2]benzazepin-2-yl]amino}-2-methoxybenzoate |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2571359A4 (en) * | 2010-05-20 | 2013-10-23 | Merck Sharp & Dohme | NOVEL PROLYLCARBOXYPEPTIDASE HEMMER |
| WO2011144742A1 (en) | 2010-05-21 | 2011-11-24 | Chemilia Ab | Novel pyrimidine derivatives |
| MX2012014158A (es) | 2010-06-04 | 2013-02-07 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de proteina cinasa rica repeticiones leucina 2 (lrrk2). |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012013728A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use |
| US20130225615A1 (en) * | 2010-09-01 | 2013-08-29 | Ambit Biosciences Corporation | 2-cycloquinazoline derivatives and methods of use thereof |
| JP5872558B2 (ja) * | 2010-09-01 | 2016-03-01 | ăąă ăă ăăȘăčă·ăšăłă»ăč ăłă«ăă©ăăȘăł | ăă©ăŸăȘă«ăąăăăăăŸăȘăłăźèćæ°ŽçŽ é žćĄ© |
| WO2012030918A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Adenosine a3 receptor modulating compounds and methods of use thereof |
| EP2611794A1 (en) * | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | 4-azolylaminoquinazoline derivatives and methods of use thereof |
| CA2810024A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
| US20130296363A1 (en) * | 2010-09-01 | 2013-11-07 | Ambit Biosciences Corporation | Quinoline and isoquinoline derivatives for use as jak modulators |
| EP2611796B1 (en) | 2010-09-01 | 2016-04-20 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| ES2653967T3 (es) | 2010-11-10 | 2018-02-09 | Genentech, Inc. | Derivados de pirazol aminopirimidina como moduladores de LRRK2 |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2688883B1 (en) | 2011-03-24 | 2016-05-18 | Noviga Research AB | Pyrimidine derivatives |
| EP2748159A1 (en) * | 2011-08-25 | 2014-07-02 | F.Hoffmann-La Roche Ag | Serine/threonine pak1 inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN103814030A (zh) * | 2011-09-22 | 2014-05-21 | èŸç性èŻć | ćĄćŻćč¶ć§ć¶ććć€èĄçç© |
| JP6026544B2 (ja) | 2011-09-27 | 2016-11-16 | ăăă«ăăŁăč ăąăŒăČăŒ | ć€ç°äœïœïœïœăźé»ćźłć€ăšăăŠăźïŒâăăȘăăžăłâïŒâă€ă«âăȘăă”ăŸăȘăžăłâïŒâăȘăłéĄ |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
| US8815877B2 (en) | 2011-12-22 | 2014-08-26 | Genentech, Inc. | Serine/threonine kinase inhibitors |
| JP6141334B2 (ja) * | 2012-02-17 | 2017-06-07 | ăąăăŽăŁă»ă€ăłăłăŒăăŹă€ăăă | ăăćŒćžćšć€æ žäœăŠă€ă«ăčïŒïœïœïœïŒăźé»ćźłć€ăšăăŠæçšăȘăžăąăăăăȘăăžăł |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
| SG11201405761WA (en) | 2012-03-16 | 2014-10-30 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| EP2841428B1 (en) | 2012-04-24 | 2018-08-22 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| CA2875990A1 (en) * | 2012-05-24 | 2013-11-28 | Cellzome Limited | Heterocyclyl pyrimidine analogues as tyk2 inhibitors |
| AU2013280644B2 (en) | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| US9216991B2 (en) * | 2012-07-10 | 2015-12-22 | Ares Trading S.A. | Pyrimidine pyrazolyl derivatives |
| CA2884731C (en) * | 2012-09-19 | 2016-11-01 | Taiho Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral administration with improved dissolution and/or absorption |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| CN103191120B (zh) * | 2012-12-31 | 2015-11-25 | ććŒș | äžç§ć§ć¶èĄçç©ćšć¶ć€éąéČć/ææČ»çć/æèŸ 㩿Ȼçèżç€çèŻç©äžççšé |
| CN103059002B (zh) * | 2012-12-31 | 2015-04-22 | äžć±±ć€§ćŠ | ć ·æAuroraæżé ¶æć¶æŽ»æ§çć§ć¶èĄçç©ćć ¶ć¶ć€æčæłä»„ććșçš |
| CN103202843B (zh) * | 2012-12-31 | 2015-04-29 | ććŒș | äžç§ć§ć¶èĄçç©ćšć¶ć€éąéČć/ææČ»çć/æèŸ 㩿ȻççççèŻç©äžççšé |
| CN103910716A (zh) * | 2013-01-07 | 2014-07-09 | ćäžçć·„ć€§ćŠ | 2,4-äșć代-çŻç·ćș[d]ć§ć¶ç±»ććç©ćć ¶çšé |
| WO2014159690A1 (en) | 2013-03-12 | 2014-10-02 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| HK1213251A1 (zh) | 2013-03-14 | 2016-06-30 | Novartis Ag | äœäžșçȘćidhæć¶ćç3-ć§ć¶-4-ćș-æ¶ćç·-2-é źććç© |
| EP3842424B1 (en) | 2013-03-15 | 2024-12-11 | The Trustees of Columbia University in the City of New York | Map kinase modulators and uses thereof in the tretament of tauopathies |
| US9724354B2 (en) | 2013-03-22 | 2017-08-08 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase |
| WO2015003355A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| WO2015028848A1 (en) * | 2013-09-02 | 2015-03-05 | Piramal Enterprises Limited | Bicyclic heterocyclic compounds as multi-kinase inhibitors |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| PL3424920T3 (pl) | 2013-10-17 | 2020-11-16 | Vertex Pharmaceuticals Incorporated | KokrysztaĆy (S)-N-metylo-8-(1-((2'-metylo-4â,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK |
| CA2927917C (en) | 2013-10-18 | 2022-08-09 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
| JP6491202B2 (ja) | 2013-10-18 | 2019-03-27 | ăă€ă ăăĄăŒăăŒ ăăŁăłă”ăŒ ă€ăłăčăăŁăă„ăŒăïŒă€ăłăłăŒăăŹă€ăăă | ă”ă€ăŻăȘăłäŸćæ§ăăăŒăŒïŒïŒïœïœïœïŒïŒăźć€ç°é»ćźłć€ |
| CA2935392C (en) | 2014-01-01 | 2022-07-26 | Medivation Technologies, Inc. | Amino pyridine derivatives for the treatment of conditions associated with excessive tgf.beta activity |
| PT3116475T (pt) | 2014-03-13 | 2020-12-15 | Neuroderm Ltd | ComposiçÔes de inibidores de dopa-descarboxilase |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| WO2015148868A1 (en) * | 2014-03-28 | 2015-10-01 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| CA2944240A1 (en) | 2014-04-04 | 2015-10-08 | Iomet Pharma Ltd | Indole derivatives as ido/tdo inhibitors |
| WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| CN105367555B (zh) * | 2014-08-07 | 2019-06-25 | ćčżäžäžéłć èŻäžæéć Źćž | ć代çæèłćșććç©ćć ¶ç»ćç©ćçšé |
| TWI730331B (zh) | 2014-10-13 | 2021-06-11 | ćéćæłéæŽèĄèĄä»œæéć Źćž | çšæŒèȘżçŻïœ ïœïœïœçȘèźćæżé ¶æŽ»æ§çććç©ćç”æç© |
| HUE049801T2 (hu) | 2014-12-23 | 2020-10-28 | Sma Therapeutics Inc | 3,5-diaminopirazol kinĂĄz inhibitorok |
| EP3236959B1 (en) | 2014-12-23 | 2025-09-24 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| WO2016123627A1 (en) * | 2015-01-30 | 2016-08-04 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction |
| CA2978518C (en) | 2015-03-27 | 2023-11-21 | Nathanael S. Gray | Inhibitors of cyclin-dependent kinases |
| EP3283482B1 (en) | 2015-04-17 | 2022-04-06 | Ludwig Institute for Cancer Research Ltd | Plk4 inhibitors |
| PL3303348T3 (pl) | 2015-05-28 | 2020-02-28 | Theravance Biopharma R&D Ip, Llc | ZwiÄ zki naftyrydyny jako inhibitory kinazy JAK |
| JP2018135268A (ja) * | 2015-06-05 | 2018-08-30 | ć€§æ„æŹäœćèŁœèŹæ ȘćŒäŒç€Ÿ | æ°èŠăăăăąăȘăŒă«ăąăăâïŒâăă©ăŸăŒă«èȘć°äœăăăłăăźèŹçćŠäžèš±ćźčăăă楩 |
| JP2018524292A (ja) | 2015-07-21 | 2018-08-30 | ăăŹăăąă ăăĄăŒăă·ă„ăŒăăŁă«ă«ășïŒ ă€ăłăłăŒăăŹă€ăăăïŒïœïœïœïœ ïœïœïœïœïœ ïœïœïœïœïœïœïœ ïœïœïœïœïœïœïœïŒ ïœïœïŒ | ăȘăŒăă©ăăăŒăŒă€ăłăăăżăŒăšććŠçæłć€ăźæäž |
| JP7028766B2 (ja) | 2015-09-09 | 2022-03-02 | ăăïŒăăĄăŒăăŒ ăăŁăłă”ăŒ ă€ăłăčăăŁăă„ăŒăïŒ ă€ăłăłăŒăăŹă€ăăă | ă”ă€ăŻăȘăłäŸćæ§ăăăŒăŒăźé»ćźłć€ |
| WO2017044434A1 (en) | 2015-09-11 | 2017-03-16 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| CN108697709A (zh) * | 2015-12-10 | 2018-10-23 | Ptcć»çć Źćž | çšäșæČ»çäșšć»·éĄżç çæčæł |
| CN105384702B (zh) * | 2015-12-11 | 2018-04-10 | æ”æ±ć€§ćŠ | äžć代ćäžćȘç±»ććç©ćć ¶ć¶ć€æčæł |
| CN105503754B (zh) * | 2015-12-11 | 2017-11-17 | æ”æ±ć€§ćŠ | 2âæ°šćșâ4âèćșâ6âććâ1,3,5âäžćȘćć ¶ć¶ć€ććșçš |
| CN105399695B (zh) * | 2015-12-11 | 2019-04-19 | æ”æ±ć€§ćŠ | äžćȘç±»ććç©ćć ¶ć¶ć€æčæłćçšé |
| WO2017102091A1 (en) | 2015-12-18 | 2017-06-22 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| AU2017233841B9 (en) | 2016-03-14 | 2021-09-09 | Afferent Pharmaceuticals Inc. | Pyrimidines and variants thereof, and uses therefor |
| CA3018180C (en) * | 2016-03-25 | 2024-02-20 | Ronald Charles Hawley | Pyrimidines and variants thereof, and uses therefor |
| CN109071529B (zh) | 2016-04-28 | 2021-08-06 | æœäžçç©ć¶èŻç ćIpæéèŽŁä»»ć Źćž | äœäžșjakæżé ¶æć¶ćçć§ć¶ććç© |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| WO2018064092A1 (en) | 2016-09-27 | 2018-04-05 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors |
| US10858319B2 (en) | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
| US10968227B2 (en) * | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| CN108239071B (zh) * | 2016-12-27 | 2020-12-04 | æČéłèŻç§ć€§ćŠ | é °èșćçĄ«ä»Łé °èșç±»èĄçç©ćć ¶ć¶ć€æčæłććșçš |
| FR3064275B1 (fr) | 2017-03-21 | 2019-06-07 | Arkema France | Procede de chauffage et/ou climatisation d'un vehicule |
| IL270873B2 (en) | 2017-05-30 | 2023-04-01 | Basf Se | "The history of pyridine and pyrazine compounds, a preparation containing them and their use as fungicides |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptcć»çć Źćž | çšäșæČ»çäșšć»·éĄżæ°ç çæčæł |
| EP3421465B1 (en) * | 2017-06-30 | 2022-10-26 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof |
| JP7311228B2 (ja) | 2017-06-30 | 2023-07-19 | ăă€ăžăł ăżă€ă ăăĄăŒăă·ă„ăŒăăŁă«ă« ă«ăłăăăŒ ăȘăăăă | ïŒČïœïœïŒéąéŁăăăă€ăłăăăŒăŒé»ćźłć€ăăăăć«ăć»èŹç”æç©äžŠăłă«ăăźèȘżèŁœæčæłćăłäœżçš |
| WO2019000683A1 (zh) | 2017-06-30 | 2019-01-03 | ćäșŹæł°ćŸ·ć¶èŻèĄä»œæéć Źćž | Rhoçžć łèçœæżé ¶æć¶ćăć ć«ć ¶çèŻç©ç»ćç©ćć ¶ć¶ć€æčæłćçšé |
| EP3676264A1 (en) * | 2017-08-28 | 2020-07-08 | Acurastem Inc. | Pikfyve kinase inhibitors |
| US11440904B2 (en) * | 2017-08-28 | 2022-09-13 | Zhihong Chen | Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof |
| CA3074034A1 (en) | 2017-10-27 | 2019-05-02 | Theravance Biopharma R&D Ip, Llc | Pyrimidine compound as jak kinase inhibitor |
| EP3672957A1 (en) * | 2017-11-23 | 2020-07-01 | BioMed X GmbH | Pyrimidine derivatives as tropomyosin receptor kinase a (trka) inhibitors |
| WO2019113311A1 (en) * | 2017-12-06 | 2019-06-13 | Ludwig Institute For Cancer Research Ltd | Methods of treating cancer with plk4 inhibitors |
| CA3093802A1 (en) | 2018-03-13 | 2019-09-19 | Shire Human Genetic Therapies, Inc. | Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof |
| BR112020019373A2 (pt) | 2018-03-27 | 2020-12-29 | Ptc Therapeutics, Inc. | Compostos para o tratamento da doença de hutington |
| WO2020005807A1 (en) * | 2018-06-25 | 2020-01-02 | Dana-Farber Cancer Institute, Inc. | Taire family kinase inhibitors and uses thereof |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CA3121408A1 (en) * | 2018-11-30 | 2020-06-04 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Heteroaromatic derivatives for use as regulator, preparation method therefor and use thereof |
| EP3902542A4 (en) | 2018-12-28 | 2022-09-07 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 and uses thereof |
| JP7470713B2 (ja) | 2019-04-24 | 2024-04-18 | ă»ă©ăŽăĄăłăč ăă€ăȘăăĄăŒă ăąăŒă«ïŒăăŁăŒ ăąă€ăăŒïŒ ăšă«ăšă«ă·ăŒ | ïŒȘïœïœăăăŒăŒé»ćźłć€ăšăăŠăźăšăčăă«ăăăłă«ă«ăăăŒăăăȘăăžăłććç© |
| PL3959213T3 (pl) | 2019-04-24 | 2024-11-04 | Theravance Biopharma R&D Ip, Llc | Pirymidynowe inhibitory JAK w leczeniu chorĂłb skĂłry |
| KR20220042159A (ko) | 2019-08-01 | 2022-04-04 | ìží ê·žë ë°ìŽì€ìŹìŽìžì€ íŒëžìŽí°. ìí°ë. | í€ëì ì”ì ì ëĄìì í€í ëĄìŹìŽíŽëŠ íí©ëŹŒ ë° ìŽì ì©ë |
| PL4031547T3 (pl) | 2019-09-18 | 2024-10-07 | Takeda Pharmaceutical Company Limited | Inhibitory kalikreiny osoczowej i ich zastosowania |
| US11370803B2 (en) | 2019-09-18 | 2022-06-28 | Takeda Pharmaceutical Company Limited | Heteroaryl plasma kallikrein inhibitors |
| CN110483493A (zh) * | 2019-09-19 | 2019-11-22 | ćčżäžć·„äžć€§ćŠ | äžç§äșćç±»èĄçç©ćć ¶ć¶ć€æčæłććșçš |
| MX2022008627A (es) | 2020-01-13 | 2022-11-08 | Verge Analytics Inc | Pirazolo-pirimidinas sustituidas y usos de las mismas. |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| TW202237119A (zh) | 2020-12-10 | 2022-10-01 | çŸćäœćèŁœè„è «ç€ć Źćž | ïŒĄïœïœïčïŒæć¶ćććœŒäčçšé |
| EP4308564A1 (en) * | 2021-03-17 | 2024-01-24 | Takeda Pharmaceutical Company Limited | Polycyclic inhibitors of plasma kallikrein |
| US20240197729A1 (en) * | 2021-03-26 | 2024-06-20 | Sumitomo Pharma Oncology, Inc. | ALK-5 Inhibitors and Uses Thereof |
| WO2022240876A1 (en) | 2021-05-11 | 2022-11-17 | Oric Pharmaceuticals, Inc. | Polo like kinase 4 inhibitors |
| TW202317574A (zh) | 2021-06-28 | 2023-05-01 | çŸćçșćè„ćć Źćž | ïŒŁïœïœïŒæć¶ć |
| KR102692529B1 (ko) * | 2021-07-01 | 2024-08-08 | íê”ììë „ìíì | Mastl-pp2a넌 íì ííë ìì ìë°© ëë ìčëŁì© ìœíì ìĄ°ì±ëŹŒ |
| CN116354938B (zh) * | 2021-12-28 | 2024-02-20 | æČéłèŻç§ć€§ćŠ | äžç±»ćčććèĄçç©äžć ¶ç±»äŒŒç©çć¶ć€æčæłććșçš |
| CN114276302B (zh) * | 2022-01-11 | 2023-07-25 | ć±±äžçŸćŻçç©ć»èŻæéć Źćž | äžç§ć¶ć€2,4-äșæ°šćșćčććèĄçç©çæčæł |
| CN116813595B (zh) * | 2022-03-28 | 2025-07-18 | äžæ”·ć»èŻć·„äžç ç©¶éąæéć Źćž | ćčććç±»èĄçç©ăć ¶ć¶ć€æčæłăèŻç©ç»ćç©ććșçš |
| WO2024003773A1 (en) | 2022-07-01 | 2024-01-04 | Pfizer Inc. | 2,7-naphthyridine compounds as mastl inhibitors |
| CN115403568B (zh) * | 2022-09-21 | 2023-09-29 | äžć±±ć€§ćŠ | äžç§ćčććç±»Aurora A㠱价æć¶ććć ¶ć¶ć€æčæłććșçš |
| CN117736198A (zh) * | 2022-09-21 | 2024-03-22 | ç§èŸæșèŻçç©ç§æ(æ·±ćł)æéć Źćž | 性çŻć«æ°źć éććç©ćć ¶äœäžșèçœæżé ¶æć¶ćçćșçš |
| CN121001717A (zh) * | 2023-02-23 | 2025-11-21 | ć°æŽČçłçç©ç§æć Źćž | äœäžșcdk2æć¶ćçæ°ćć€§çŻæ°šćșćĄćććç© |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133081A (en) | 1964-05-12 | J-aminoindazole derivatives | ||
| US18436A (en) * | 1857-10-20 | And saml | ||
| US2585906A (en) | 1952-02-12 | Quaternary salts of pyrimdjines | ||
| US3935183A (en) | 1970-01-26 | 1976-01-27 | Imperial Chemical Industries Limited | Indazole-azo phenyl compounds |
| BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
| US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
| US3998951A (en) | 1974-03-13 | 1976-12-21 | Fmc Corporation | Substituted 2-arylquinazolines as fungicides |
| DE2458965C3 (de) | 1974-12-13 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | 3-Amino-indazol-N-carbonsÀure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel |
| MA18829A1 (fr) | 1979-05-18 | 1980-12-31 | Ciba Geigy Ag | Derives de la pyrimidine,procedes pour leur preparation,compositions pharmaceutiques contenant ces composes et leur utilisation therapeutique |
| DOP1981004033A (es) * | 1980-12-23 | 1990-12-29 | Ciba Geigy Ag | Procedimiento para proteger plantas de cultivo de la accion fitotoxica de herbicidas. |
| SE8102193L (sv) | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och dess anvendning |
| SE8102194L (sv) | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
| JPS58124773A (ja) | 1982-01-20 | 1983-07-25 | Mitsui Toatsu Chem Inc | ïŒâăĄăă«ăăȘăăȘăăžăłèȘć°äœăšăăźèŁœé æłăšèŸČćèžçšæźșè〠|
| EP0136976A3 (de) | 1983-08-23 | 1985-05-15 | Ciba-Geigy Ag | Verwendung von Phenylpyrimidinen als Pflanzenregulatoren |
| DE3725638A1 (de) | 1987-08-03 | 1989-02-16 | Bayer Ag | Neue aryloxy (bzw. thio)aminopyrimidine |
| JPH0532662A (ja) | 1990-11-09 | 1993-02-09 | Nissan Chem Ind Ltd | çœźæăă©ăŸăŒă«èȘć°äœăăăłèŸČćèžçšæźșè〠|
| US5714493A (en) * | 1991-05-10 | 1998-02-03 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5597920A (en) | 1992-04-30 | 1997-01-28 | Neurogen Corporation | Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes |
| JPH0665237A (ja) | 1992-05-07 | 1994-03-08 | Nissan Chem Ind Ltd | çœźæăă©ăŸăŒă«èȘć°äœăăăłèŸČćèžçšæźșè〠|
| ATE325113T1 (de) | 1993-10-01 | 2006-06-15 | Novartis Pharma Gmbh | Pharmacologisch wirksame pyrimidinderivate und verfahren zu deren herstellung |
| JPH10509708A (ja) | 1994-11-10 | 1998-09-22 | ăłăą ă»ă©ăă„ăŒăăŁăŻăčïŒă€ăłăłăŒăăŹă€ăăŁă | ăăăă€ăłă»ăăăŒăŒăźă€ăłăăăżăŒăšăăŠæçšăȘć»èŹăă©ăŸăŒă«ç”æç© |
| IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
| US5935966A (en) | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| WO1997009325A1 (en) | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| JPH10130150A (ja) | 1996-09-05 | 1998-05-19 | Dainippon Pharmaceut Co Ltd | é ąé žăąăăèȘć°äœăăăȘăć»èŹ |
| GB9619284D0 (en) | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| JP4205168B2 (ja) | 1996-10-02 | 2009-01-07 | ăăă«ăăŁăč ăąăŻăăšăłăČăŒă«ă·ă€ăă | ăăȘăăžăłèȘć°äœăăăłăăźèŁœé æł |
| WO1998016502A1 (en) | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1ÎČ CONVERTING ENZYME |
| DE19710435A1 (de) * | 1997-03-13 | 1998-09-17 | Hoechst Ag | Verwendung von Pyrimidinderivaten zur PrĂ€vention von Krebs allein oder in Kombination mit anderen therapeutischen MaĂnahmen |
| EA200000409A1 (ru) | 1997-10-10 | 2000-10-30 | ХаĐčŃĐŸĐČĐžŃ, ĐĐœĐș. | ĐĄĐŸĐ”ĐŽĐžĐœĐ”ĐœĐžĐ”, ŃаŃĐŒĐ°ŃĐ”ĐČŃĐžŃĐ”ŃĐșĐ°Ń ĐșĐŸĐŒĐżĐŸĐ·ĐžŃĐžŃ, ŃĐżĐŸŃĐŸĐ± ĐžĐœĐłĐžĐ±ĐžŃĐŸĐČĐ°ĐœĐžŃ ĐłĐžĐ±Đ”Đ»Đž ĐșлДŃĐșĐž ĐČ ĐŸĐŽĐœĐŸĐč ĐșлДŃĐșĐ” ОлО ŃĐșĐ°ĐœĐž, ŃĐżĐŸŃĐŸĐ± лДŃĐ”ĐœĐžŃ ĐžĐ»Đž ŃĐœĐžĐ¶Đ”ĐœĐžŃ ĐșлДŃĐŸŃĐœĐŸĐč ŃĐŒĐ”ŃŃĐž, ŃĐżĐŸŃĐŸĐ± лДŃĐ”ĐœĐžŃ ĐžĐ»Đž ĐżŃĐŸŃОлаĐșŃĐžĐșĐž ĐżĐŸĐ»ĐžĐșĐžŃŃĐŸĐ·ĐœĐŸĐłĐŸ Đ·Đ°Đ±ĐŸĐ»Đ”ĐČĐ°ĐœĐžŃ ĐżĐŸŃĐ”Đș ОлО Đ°ĐœĐ”ĐŒĐžĐž/ŃŃĐžŃŃĐŸĐżĐŸŃза Ń Đ¶ĐžĐČĐŸŃĐœŃŃ , ŃĐżĐŸŃĐŸĐ± заŃĐžŃŃ ĐŸŃĐłĐ°ĐœĐ° ОлО ŃĐșĐ°ĐœĐž ĐŒĐ»Đ”ĐșĐŸĐżĐžŃаŃŃĐ”ĐłĐŸ ĐŸŃ ĐłĐžĐ±Đ”Đ»Đž ĐșлДŃĐŸĐș, ŃĐżĐŸŃĐŸĐ± ŃĐœĐžĐ¶Đ”ĐœĐžŃ ĐžĐ»Đž ĐżŃĐŸŃОлаĐșŃĐžĐșĐž гОбДлО ĐșлДŃĐŸĐș ĐČ ĐŸŃĐłĐ°ĐœĐ” ОлО ŃĐșĐ°ĐœĐž ĐŽĐŸĐœĐŸŃа ĐżĐŸŃлД ĐžŃ ŃŃĐ°ĐœŃĐżĐ»Đ°ĐœŃаŃОО, ŃĐżĐŸŃĐŸĐ± ŃĐœĐžĐ¶Đ”ĐœĐžŃ ĐžĐ»Đž ĐżŃĐ”ĐŽĐŸŃĐČŃаŃĐ”ĐœĐžŃ ĐłĐžĐ±Đ”Đ»Đž ŃпДŃĐŒŃ ĐžĐ»Đž ŃĐčŃĐ”ĐșлДŃĐŸĐș |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| JP2000026421A (ja) | 1998-01-29 | 2000-01-25 | Kumiai Chem Ind Co Ltd | ăžăąăȘâă«ăčă«ăăŁăèȘć°äœćăłæćźłçç©éČé€ć€ |
| CA2321153A1 (en) | 1998-02-17 | 1999-08-19 | Timothy D. Cushing | Anti-viral pyrimidine derivatives |
| KR20010041905A (ko) | 1998-03-16 | 2001-05-25 | ìí ëčì ìžíŹ. | ëí©í°ë ìčŽì€íì ì”ì ì ë° ìŽì ì©ë |
| JP4611524B2 (ja) | 1998-06-02 | 2011-01-12 | ăȘăŒăšăčăąă€ă»ăăĄăŒăăčăŒăăŁă«ă«ășă»ă€ăłăłăŒăăŹăŒăăă | ăăăïŒïŒïŒïœïŒœăăȘăăžăłç”æç©ăăăłăăźäœżçš |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ăăă«ăăŁăč ăăŻă·ăłăș ăąăłă ăă€ăąă°ăăčăăŁăăŻăčïŒă€ăłăłăŒăăŹăŒăăă | ă°ăȘăłăŒăČăłă·ăłăżăŒăŒăăăŒăŒïŒăźă€ăłăăăżăŒ |
| WO2000003901A1 (de) * | 1998-07-16 | 2000-01-27 | Continental Teves Ag & Co. Ohg | Verfahren und vorrichtung zum ermitteln von kritischen fahrzustÀnden bei im fahrbetrieb befindlichen fahrzeugen |
| WO2000011003A1 (en) | 1998-08-21 | 2000-03-02 | Du Pont Pharmaceuticals Company | ISOXAZOLO[4,5-d]PYRIMIDINES AS CRF ANTAGONISTS |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| HK1039126B (en) * | 1998-10-08 | 2005-09-30 | éżæŻçčææŸć°ŒćĄæéć Źćž | Quinazoline derivatives |
| GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| GB9828511D0 (en) * | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| AP2001002225A0 (en) | 1999-01-13 | 2001-09-30 | Warner Lambert Co | 1-heterocycle substituted diarylamines. |
| GB9905075D0 (en) * | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| EP1165085B1 (en) | 1999-03-30 | 2006-06-14 | Novartis AG | Phthalazine derivatives for treating inflammatory diseases |
| WO2000078757A1 (en) | 1999-06-17 | 2000-12-28 | Shionogi Bioresearch Corp. | Inhibitors of il-12 production |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| CZ2002534A3 (cs) | 1999-08-13 | 2002-07-17 | Vertex Pharmaceuticals Incorporated | Inhibitory protein-kinĂĄz, farmaceutickĂ© prostĆedky, kterĂ© je obsahujĂ, a jejich pouÄŸitĂ |
| ES2306671T3 (es) | 1999-10-07 | 2008-11-16 | Amgen Inc. | Inhibidores de triazina quinasa. |
| TR200201431T2 (tr) | 1999-11-30 | 2002-09-23 | Pfizer Products Inc. | İmĂŒnosupresanlar olarak faydalı 2,4-diaminopirimidin bileĆikleri |
| DK1246623T3 (da) | 1999-12-02 | 2006-11-13 | Osi Pharm Inc | Forbindelser, som er specifikke for adenosin A1-, A2a- og A3-receptor og anvendelser deraf |
| US6376489B1 (en) | 1999-12-23 | 2002-04-23 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| MY125768A (en) | 1999-12-15 | 2006-08-30 | Bristol Myers Squibb Co | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| DE60043397D1 (de) | 1999-12-28 | 2010-01-07 | Pharmacopeia Inc | Cytokine, insbesondere tnf-alpha, hemmer |
| CZ20013540A3 (cs) | 2000-02-05 | 2002-03-13 | Vertex Pharmaceuticals Incorporated | DerivĂĄty pyrazolu jako inhibitory ERK a farmaceutickĂœ prostĆedek, kterĂœ je obsahuje |
| AU2001237041B9 (en) | 2000-02-17 | 2005-07-28 | Amgen Inc. | Kinase inhibitors |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| ATE297946T1 (de) | 2000-04-03 | 2005-07-15 | Vertex Pharma | Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease |
| CA2398446A1 (en) | 2000-04-18 | 2001-10-25 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinases |
| JP3890184B2 (ja) * | 2000-05-15 | 2007-03-07 | ïŒźïœ ïœăăŒăœăă«ăăăăŻăæ ȘćŒäŒç€Ÿ | 黿șèŁ çœźćăłăăźé»ćć¶ćŸĄæčæłăæ ć ±ćŠçæ©ćš |
| IL153246A0 (en) | 2000-06-28 | 2003-07-06 | Astrazeneca Ab | Substituted quinazoline derivatives and their use as inhibitors |
| CN1498224A (zh) | 2000-07-21 | 2004-05-19 | ïżœïżœïżœéč«ËŸ | çšäœäžćèçç æŻns3-äžæ°šé žèçœé ¶æć¶ćçæ°ćèœ |
| CZ2003468A3 (cs) | 2000-08-31 | 2004-05-12 | PfizerĂĄproductsĂĄinc | DerivĂĄty pyrazolu a jejich pouĆŸitĂ jako inhibitorĆŻ proteinkinĂĄzy |
| DE60122176T2 (de) | 2000-09-15 | 2007-07-05 | Vertex Pharmaceuticals Inc., Cambridge | Isoxazole und ihre verwendung als erk-inhibitoren |
| US6610677B2 (en) | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2001296871A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6613776B2 (en) | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| JP2004509876A (ja) | 2000-09-20 | 2004-04-02 | ăĄă«ăŻăăăăłăăăČăŒă«ă·ăŁăăăăăăăăă·ă„ăŹăłăŻăă«ăăăăăłă° | ïŒâăąăăâăăăŸăȘăł |
| US6641579B1 (en) * | 2000-09-29 | 2003-11-04 | Spectrasonics Imaging, Inc. | Apparatus and method for ablating cardiac tissue |
| US6716851B2 (en) | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
| EP1351691A4 (en) | 2000-12-12 | 2005-06-22 | Cytovia Inc | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS, AND USE THEREOF |
| DE10061863A1 (de) | 2000-12-12 | 2002-06-13 | Basf Ag | Verfahren zur Herstellung von Triethylendiamin (TEDA) |
| HUP0400639A3 (en) | 2000-12-21 | 2010-03-29 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them |
| MY130778A (en) | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
| CA2441733A1 (en) | 2001-03-29 | 2002-10-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| JP2004535381A (ja) | 2001-04-13 | 2004-11-25 | ăăŒăăăŻăčăăăĄăŒăă·ă„ăŒăăŁă«ă«ășăă€ăłăłăŒăăŹă€ăăă | ïœâïŒȘïœïœïŒźæ«ç«ŻăăăŒăŒïŒïŒȘïŒźïŒ«ïŒăăăłä»ăźăăăă€ăłăăăŒăŒăźă€ăłăăăżăŒ |
| US20030096813A1 (en) | 2001-04-20 | 2003-05-22 | Jingrong Cao | Compositions useful as inhibitors of GSK-3 |
| AU2002308748A1 (en) | 2001-05-16 | 2002-11-25 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
| EP1399440B1 (en) | 2001-06-15 | 2009-06-03 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl)benzisoxazoles as protein kinase inhibitors |
| DE60214198T2 (de) | 2001-07-03 | 2007-08-09 | Vertex Pharmaceuticals Inc., Cambridge | Isoxazolyl-pyrimidines als inhibitoren von src- und lck-protein-kinasen |
| WO2003026666A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors |
| US6569499B2 (en) * | 2001-10-02 | 2003-05-27 | Xerox Corporation | Apparatus and method for coating photoreceptor substrates |
| MXPA04005510A (es) | 2001-12-07 | 2006-02-24 | Vertex Pharma | Compuestos basados en pirimidina utiles como inhibidores de gsk-3. |
| EP1485100B1 (en) | 2002-03-15 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Azinylaminoazoles as inhibitors of protein kinases |
| WO2003078426A1 (en) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazine as inhibitors of protein kinases |
| EP1485380B1 (en) | 2002-03-15 | 2010-05-19 | Vertex Pharmaceuticals Incorporated | Azolylaminoazines as inhibitors of protein kinases |
| ATE365733T1 (de) | 2002-03-15 | 2007-07-15 | Vertex Pharma | Zusammensetzungen brauchbar als protein-kinase- inhibitoren |
| US20030207873A1 (en) | 2002-04-10 | 2003-11-06 | Edmund Harrington | Inhibitors of Src and other protein kinases |
| WO2003091246A1 (en) | 2002-04-26 | 2003-11-06 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| CA2491895C (en) | 2002-07-09 | 2011-01-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| PL374967A1 (en) | 2002-08-02 | 2005-11-14 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| ES2535854T3 (es) | 2005-09-30 | 2015-05-18 | Miikana Therapeutics, Inc. | Compuestos de pirazol sustituidos |
| AU2007333650A1 (en) | 2006-12-19 | 2008-06-26 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
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