PL3424920T3 - Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK - Google Patents

Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK

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Publication number
PL3424920T3
PL3424920T3 PL18188034T PL18188034T PL3424920T3 PL 3424920 T3 PL3424920 T3 PL 3424920T3 PL 18188034 T PL18188034 T PL 18188034T PL 18188034 T PL18188034 T PL 18188034T PL 3424920 T3 PL3424920 T3 PL 3424920T3
Authority
PL
Poland
Prior art keywords
methyl
bipyrimidin
propan
carboxamide
quinoline
Prior art date
Application number
PL18188034T
Other languages
English (en)
Inventor
Kwame Wiredu NTI-ADDAE
Simon Adam O'neil
Yuegang Zhang
Praveen Mudunuri
John Gregg Van Alsten
Bin Song
Kathy Stavropoulos
Mark STROHMEIER
Michael Waldo
Mettachit Navamal
Irina Nikolaevna Kadiyala
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of PL3424920T3 publication Critical patent/PL3424920T3/pl

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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PL18188034T 2013-10-17 2014-10-17 Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK PL3424920T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361892002P 2013-10-17 2013-10-17
EP18188034.5A EP3424920B1 (en) 2013-10-17 2014-10-17 Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
PCT/US2014/061102 WO2015058067A1 (en) 2013-10-17 2014-10-17 Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
EP14799578.1A EP3057953B1 (en) 2013-10-17 2014-10-17 Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors

Publications (1)

Publication Number Publication Date
PL3424920T3 true PL3424920T3 (pl) 2020-11-16

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PL18188034T PL3424920T3 (pl) 2013-10-17 2014-10-17 Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK
PL14799578T PL3057953T3 (pl) 2013-10-17 2014-10-17 Kokryształy (S)-N-metylo-8-(1-((2'-metylo-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK

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PL14799578T PL3057953T3 (pl) 2013-10-17 2014-10-17 Kokryształy (S)-N-metylo-8-(1-((2'-metylo-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK

Country Status (26)

Country Link
US (2) US10039761B2 (pl)
EP (2) EP3424920B1 (pl)
JP (2) JP6408569B2 (pl)
KR (1) KR102411227B1 (pl)
CN (2) CN105814036B (pl)
AU (2) AU2014337154B2 (pl)
BR (1) BR112016008452B1 (pl)
CA (1) CA2927631C (pl)
CL (1) CL2016000916A1 (pl)
DK (2) DK3057953T3 (pl)
ES (2) ES2705342T3 (pl)
HR (2) HRP20181841T1 (pl)
HU (2) HUE051275T2 (pl)
IL (1) IL245117B (pl)
LT (2) LT3424920T (pl)
MX (1) MX361488B (pl)
PE (1) PE20161022A1 (pl)
PL (2) PL3424920T3 (pl)
PT (2) PT3057953T (pl)
RS (2) RS60426B1 (pl)
RU (1) RU2675270C2 (pl)
SG (1) SG11201602962PA (pl)
SI (2) SI3057953T1 (pl)
UA (1) UA120915C2 (pl)
WO (1) WO2015058067A1 (pl)
ZA (1) ZA201602777B (pl)

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SG11201602962PA (en) * 2013-10-17 2016-05-30 Vertex Pharma Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
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EP3297636B1 (en) 2015-06-19 2021-02-17 Syn-Nat Products Enterprise LLC Pharmaceutical composition of carboplatin based co-crystals and use thereof
CN116854745A (zh) 2015-06-25 2023-10-10 新纳特产品公司 药物共晶组合物及其用途
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FI3468944T3 (fi) * 2016-06-13 2023-01-31 Natriumbentsoaatin yhteiskiteitä ja niiden käyttöjä
US11124805B2 (en) 2016-07-13 2021-09-21 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
AU2017325870B2 (en) 2016-09-16 2021-07-22 Research Traingle Institute Tetrahydroisoquinoline kappa opioid antagonists
KR20190062485A (ko) * 2016-09-27 2019-06-05 버텍스 파마슈티칼스 인코포레이티드 Dna-손상제 및 dna-pk 저해제의 조합을 사용한 암 치료 방법
MX2019004214A (es) 2016-10-12 2019-06-10 Res Triangle Inst Agonistas heterociclicos del receptor de apelina (apj) y usos de los mismos.
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CN112300126A (zh) * 2019-07-31 2021-02-02 山东轩竹医药科技有限公司 杂环类dna-pk抑制剂
CN112574179B (zh) * 2019-09-29 2022-05-10 山东轩竹医药科技有限公司 Dna-pk抑制剂
CN114478399A (zh) * 2020-10-27 2022-05-13 华东理工大学 嘧菌酯低共熔混合物及其制备方法和应用

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