MX2016004992A - Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il ) amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteínas cinasa dependientes de adn (adn-pk). - Google Patents

Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il ) amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteínas cinasa dependientes de adn (adn-pk).

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Publication number
MX2016004992A
MX2016004992A MX2016004992A MX2016004992A MX2016004992A MX 2016004992 A MX2016004992 A MX 2016004992A MX 2016004992 A MX2016004992 A MX 2016004992A MX 2016004992 A MX2016004992 A MX 2016004992A MX 2016004992 A MX2016004992 A MX 2016004992A
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MX
Mexico
Prior art keywords
methyl
crystals
bipyrimidin
propan
carboxamide
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MX2016004992A
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English (en)
Other versions
MX361488B (es
Inventor
Kwame Wiredu Nti-Addae
Simon Adam O'neil
Yuegang Zhang
Michael Waldo
Praveen Mudunuri
Bin Song
John Gregg Van Alsten
Mark Strohmeier
Kathy Stavropoulos
Irina Nikolaevna Kadiyala
Mettachit Navamal
Original Assignee
Vertex Pharma
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Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2016004992A publication Critical patent/MX2016004992A/es
Publication of MX361488B publication Critical patent/MX361488B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

La presente invención hace referencia a composiciones y cocristales; cada uno comprende un compuesto de la fórmula I que tiene la estructura en donde cada R1 y R2 es H o 2H y un formador de cocristales seleccionado a partir de ácido adípico, ácido cítrico, ácido fumárico, ácido maleico, ácido succínico o ácido benzoico. Además, el alcance de esta invención también abarca los métodos de preparación y uso.
MX2016004992A 2013-10-17 2014-10-17 Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il ) amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteínas cinasa dependientes de adn (adn-pk). MX361488B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361892002P 2013-10-17 2013-10-17
PCT/US2014/061102 WO2015058067A1 (en) 2013-10-17 2014-10-17 Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors

Publications (2)

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MX2016004992A true MX2016004992A (es) 2016-07-19
MX361488B MX361488B (es) 2018-12-07

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MX2016004992A MX361488B (es) 2013-10-17 2014-10-17 Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il ) amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteínas cinasa dependientes de adn (adn-pk).

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US (2) US10039761B2 (es)
EP (2) EP3424920B1 (es)
JP (2) JP6408569B2 (es)
KR (1) KR102411227B1 (es)
CN (2) CN108771681B (es)
AU (2) AU2014337154B2 (es)
BR (1) BR112016008452B1 (es)
CA (1) CA2927631C (es)
CL (1) CL2016000916A1 (es)
DK (2) DK3424920T3 (es)
ES (2) ES2802296T3 (es)
HR (2) HRP20181841T1 (es)
HU (2) HUE041877T2 (es)
IL (1) IL245117B (es)
LT (2) LT3424920T (es)
MX (1) MX361488B (es)
PE (1) PE20161022A1 (es)
PL (2) PL3424920T3 (es)
PT (2) PT3424920T (es)
RS (2) RS57969B1 (es)
RU (2) RU2675270C2 (es)
SG (1) SG11201602962PA (es)
SI (2) SI3057953T1 (es)
UA (1) UA120915C2 (es)
WO (1) WO2015058067A1 (es)
ZA (1) ZA201602777B (es)

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