|
US4911920A
(en)
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
JPH0832707B2
(ja)
|
1986-02-05 |
1996-03-29 |
富山化学工業株式会社 |
新規なセフアロスポリン類およびその塩
|
|
JP2594486B2
(ja)
|
1991-01-15 |
1997-03-26 |
アルコン ラボラトリーズ インコーポレイテッド |
局所的眼薬組成物
|
|
US5212162A
(en)
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
ATE216247T1
(de)
|
1991-05-20 |
2002-05-15 |
Rhone Poulenc Rorer Internat H |
Aromatische oligomere verbindungen als imitatoren bioaktives makromoleküle
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
EP0891334A1
(en)
|
1996-04-03 |
1999-01-20 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
JP2000256286A
(ja)
|
1999-03-11 |
2000-09-19 |
Kaken Pharmaceut Co Ltd |
アルキルアミン誘導体
|
|
IL148718A0
(en)
|
1999-09-17 |
2002-09-12 |
Abbott Gmbh & Co Kg |
Pyrazolopyrimidines as therapeutic agents
|
|
US6887870B1
(en)
|
1999-10-12 |
2005-05-03 |
Bristol-Myers Squibb Company |
Heterocyclic sodium/proton exchange inhibitors and method
|
|
AU2001273040A1
(en)
|
2000-06-27 |
2002-01-08 |
Du Pont Pharmaceuticals Company |
Factor xa inhibitors
|
|
HUP0400639A3
(en)
|
2000-12-21 |
2010-03-29 |
Vertex Pharma |
Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them
|
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
|
MY139563A
(en)
|
2002-09-04 |
2009-10-30 |
Bristol Myers Squibb Co |
Heterocyclic aromatic compounds useful as growth hormone secretagogues
|
|
BRPI0412360A
(pt)
|
2003-07-09 |
2006-09-05 |
Paradigm Therapeutics Ltd |
compostos de organossilìcio e seu uso
|
|
US8022063B2
(en)
|
2004-05-29 |
2011-09-20 |
7Tm Pharma A/S |
CRTH2 receptor ligands for medicinal uses
|
|
WO2006091898A2
(en)
|
2005-02-25 |
2006-08-31 |
Adenosine Therapeutics, Llc |
Pyrazolyl substituted xanthines
|
|
CA2615045A1
(en)
|
2005-07-20 |
2007-01-25 |
Merck Frosst Canada Ltd. |
Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
|
|
WO2007064797A2
(en)
|
2005-11-30 |
2007-06-07 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-met and uses thereof
|
|
PT1981519T
(pt)
|
2005-12-29 |
2018-02-23 |
Dyax Corp |
Inibição de protéases
|
|
EP1849781A1
(en)
|
2006-04-28 |
2007-10-31 |
Laboratorios del Dr. Esteve S.A. |
Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments
|
|
AU2007281220B2
(en)
|
2006-07-31 |
2013-08-15 |
Activesite Pharmaceuticals, Inc. |
Inhibitors of plasma kallikrein
|
|
EP1908471A1
(en)
|
2006-10-04 |
2008-04-09 |
Speedel Experimenta AG |
Tetrahydropyridines as renin inhibitors
|
|
EP1908762A2
(en)
|
2006-10-04 |
2008-04-09 |
Speedel Experimenta AG |
Organic compounds
|
|
WO2008059854A1
(en)
|
2006-11-16 |
2008-05-22 |
Astellas Pharma Inc. |
Piperidine derivatives or salts thereof
|
|
EP1974729A1
(en)
|
2007-03-28 |
2008-10-01 |
Santhera Pharmaceuticals (Schweiz) AG |
Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
|
|
JP5539864B2
(ja)
|
2007-06-12 |
2014-07-02 |
アカオゲン,インコーポレーテッド |
抗菌剤
|
|
US20090176778A1
(en)
|
2007-08-10 |
2009-07-09 |
Franz Ulrich Schmitz |
Certain nitrogen containing bicyclic chemical entities for treating viral infections
|
|
KR100994115B1
(ko)
|
2008-08-18 |
2010-11-15 |
삼성모바일디스플레이주식회사 |
광효율 개선층을 구비한 유기 발광 소자
|
|
EP2370438A1
(en)
|
2008-12-04 |
2011-10-05 |
Exelixis, Inc. |
Imidazo [1,2a]pyridine derivatives, their use as s1p1 agonists and methods for their production
|
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
|
CA2759547A1
(en)
|
2009-04-22 |
2010-10-28 |
Janssen Pharmaceutica Nv |
Azetidinyl diamides as monoacylglycerol lipase inhibitors
|
|
WO2010132598A1
(en)
|
2009-05-13 |
2010-11-18 |
Amgen Inc. |
Heteroaryl compounds as pikk inhibitors
|
|
US9206173B2
(en)
|
2009-05-28 |
2015-12-08 |
Otsuka Pharmaceutical Co., Ltd. |
Heterocyclic compounds for the treatment of stress-related conditions
|
|
US8937150B2
(en)
|
2009-06-11 |
2015-01-20 |
Abbvie Inc. |
Anti-viral compounds
|
|
US9394279B2
(en)
|
2009-06-11 |
2016-07-19 |
Abbvie Inc. |
Anti-viral compounds
|
|
GB201007187D0
(en)
|
2010-04-29 |
2010-06-09 |
Iti Scotland Ltd |
Ubiquitination modulators
|
|
WO2012016133A2
(en)
|
2010-07-29 |
2012-02-02 |
President And Fellows Of Harvard College |
Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
|
|
US8927559B2
(en)
|
2010-10-11 |
2015-01-06 |
Merck Sharp & Dohme Corp. |
Quinazolinone-type compounds as CRTH2 antagonists
|
|
US9273028B2
(en)
|
2010-10-29 |
2016-03-01 |
Biogen Ma Inc. |
Heterocyclic tyrosine kinase inhibitors
|
|
JP2012111731A
(ja)
|
2010-11-26 |
2012-06-14 |
Otsuka Pharmaceut Co Ltd |
医薬
|
|
JP5868996B2
(ja)
|
2010-12-13 |
2016-02-24 |
アレイ バイオファーマ、インコーポレイテッド |
III型受容体チロシンキナーゼ阻害剤としての置換N−(1H−インダゾール−4−イル)イミダゾ[1,2−a]ピリジン−3−カルボキサミド化合物
|
|
WO2012092471A2
(en)
|
2010-12-29 |
2012-07-05 |
Development Center For Biotechnology |
Novel tubulin inhibitors and methods of using the same
|
|
US9464065B2
(en)
|
2011-03-24 |
2016-10-11 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
RU2013150349A
(ru)
|
2011-04-13 |
2015-05-20 |
Мерк Шарп И Доум Корп. |
5-замещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов васе, содержащие их композиции и их применение
|
|
US8691861B2
(en)
|
2011-04-13 |
2014-04-08 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
GB2494851A
(en)
|
2011-07-07 |
2013-03-27 |
Kalvista Pharmaceuticals Ltd |
Plasma kallikrein inhibitors
|
|
EP2763533B1
(en)
|
2011-10-06 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Triazolyl pde10 inhibitors
|
|
JPWO2013081094A1
(ja)
|
2011-11-30 |
2015-04-27 |
東レ株式会社 |
イミダゾ[1,2−a]ピリジン誘導体及びその医薬用途
|
|
USRE47689E1
(en)
|
2011-12-30 |
2019-11-05 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
ES2620668T3
(es)
|
2012-03-02 |
2017-06-29 |
Genentech, Inc. |
Derivados de amidas y sulfonamidas amido espirocíclicas
|
|
CA2880896C
(en)
|
2012-06-26 |
2021-11-16 |
Del Mar Pharmaceuticals |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
|
|
AR096393A1
(es)
|
2013-05-23 |
2015-12-30 |
Bayer Cropscience Ag |
Compuestos heterocíclicos pesticidas
|
|
HUE14755117T2
(hu)
|
2013-08-14 |
2018-12-28 |
Kalvista Pharmaceuticals Ltd |
Plazma-kallikrein inhibitorok
|
|
WO2015063093A1
(de)
|
2013-10-30 |
2015-05-07 |
Bayer Pharma Aktiengesellschaft |
Substituierte oxopyridin-derivate
|
|
WO2015095449A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount rna transcripts
|
|
JP6454349B2
(ja)
|
2013-12-26 |
2019-01-16 |
武田薬品工業株式会社 |
モノアシルグリセロールリパーゼ(magl)阻害剤としての4−(ピペラジン−1−イル)−ピロリジン−2−オン化合物
|
|
US9611252B2
(en)
|
2013-12-30 |
2017-04-04 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2015103317A1
(en)
|
2013-12-30 |
2015-07-09 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2015188051A1
(en)
|
2014-06-06 |
2015-12-10 |
Biogen Ma Inc. |
Atx modulating agents
|
|
MX381342B
(es)
|
2014-07-16 |
2025-03-12 |
Lifesci Pharmaceuticals Inc |
Compuestos terapeuticos inhibidores.
|
|
WO2016029146A1
(en)
|
2014-08-22 |
2016-02-25 |
University Of Washington |
Specific inhibitors of methionyl-trna synthetase
|
|
GB201421085D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
GB201421083D0
(en)
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
Enzyme inhibitors
|
|
GB201421088D0
(en)
*
|
2014-11-27 |
2015-01-14 |
Kalvista Pharmaceuticals Ltd |
New enzyme inhibitors
|
|
CN105777632A
(zh)
|
2015-01-09 |
2016-07-20 |
成都贝斯凯瑞生物科技有限公司 |
芳环并氮杂环衍生物及其应用
|
|
MX2017012646A
(es)
|
2015-04-17 |
2018-01-24 |
Dow Agrosciences Llc |
Moleculas que tienen utilidad plaguicida, e intermediarios, composiciones y procesos, relacionados con ellas.
|
|
EP3317241A4
(en)
|
2015-07-01 |
2019-01-23 |
Lifesci Pharmaceuticals, Inc. |
THERAPEUTIC INHIBITING COMPOUNDS
|
|
CA2991171A1
(en)
|
2015-07-01 |
2017-01-05 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2017098328A2
(en)
|
2015-12-11 |
2017-06-15 |
Lifesci Phamaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
BR112018068703B1
(pt)
|
2016-03-16 |
2024-02-06 |
Kura Oncology, Inc. |
Inibidores substituídos de menin-mll e métodos de uso
|
|
RS60600B1
(sr)
|
2016-05-31 |
2020-08-31 |
Kalvista Pharmaceuticals Ltd |
Derivati pirazola kao inhibitori kalikreina plazme
|
|
GB201609519D0
(en)
|
2016-05-31 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of n-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyr idin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
GB201609607D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
|
|
GB201609603D0
(en)
|
2016-06-01 |
2016-07-13 |
Kalvista Pharmaceuticals Ltd |
Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
|
|
WO2018011628A1
(en)
|
2016-07-11 |
2018-01-18 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
US20190292155A1
(en)
|
2016-07-15 |
2019-09-26 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
WO2018064510A1
(en)
|
2016-09-29 |
2018-04-05 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3577116B1
(en)
|
2017-02-01 |
2025-04-23 |
Changzhou Qianhong Bio-Pharma Co., Ltd |
Derivatives of n-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents
|
|
WO2018161033A1
(en)
|
2017-03-02 |
2018-09-07 |
Wright, Adrian |
Small molecule ire1-alpha inhibitors
|
|
US10407424B2
(en)
|
2017-03-30 |
2019-09-10 |
Genentech, Inc. |
Naphthyridines as inhibitors of HPK1
|
|
WO2018229543A2
(en)
|
2017-06-14 |
2018-12-20 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
CN111132972B
(zh)
|
2017-06-22 |
2024-07-12 |
克拉德夫制药有限公司 |
人sting的小分子调节剂
|
|
AU2018311976B2
(en)
|
2017-08-04 |
2022-10-13 |
Takeda Pharmaceutical Company Limited |
Inhibitors of Plasma Kallikrein and uses thereof
|
|
GB201719881D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of plasma kallikrein inhibitor and salts thereof
|
|
GB201719882D0
(en)
|
2017-11-29 |
2018-01-10 |
Kalvista Pharmaceuticals Ltd |
Solid forms of a plasma kallikrein inhibitor and salts thereof
|
|
KR20200143376A
(ko)
|
2018-03-13 |
2020-12-23 |
샤이어 휴먼 지네틱 테라피즈 인크. |
혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도
|
|
TW202116753A
(zh)
|
2019-07-11 |
2021-05-01 |
大陸商南京征祥醫藥有限公司 |
以噌啉作為hpk1的抑制劑
|
|
WO2021055589A1
(en)
|
2019-09-18 |
2021-03-25 |
Shire Human Genetic Therapies, Inc. |
Heteroaryl plasma kallikrein inhibitors
|
|
ES2987744T3
(es)
|
2019-09-18 |
2024-11-18 |
Takeda Pharmaceuticals Co |
Inhibidores de calicreína plasmática y usos de los mismos
|
|
CN114605401B
(zh)
|
2020-04-28 |
2023-08-22 |
江南大学 |
一类含氧五元杂环化合物、合成方法、药物组合物及用途
|
|
US20230416227A1
(en)
|
2020-09-10 |
2023-12-28 |
Merck Sharp & Dohme Llc |
Plasma kallikrein inhibitors
|
|
WO2022197756A1
(en)
|
2021-03-17 |
2022-09-22 |
Shire Human Genetic Therapies, Inc. |
Plasma kallikrein inhibitors
|
|
EP4308564A1
(en)
|
2021-03-17 |
2024-01-24 |
Takeda Pharmaceutical Company Limited |
Polycyclic inhibitors of plasma kallikrein
|
|
EP4308229A1
(en)
|
2021-03-17 |
2024-01-24 |
Takeda Pharmaceutical Company Limited |
Inhibitors of plasma kallikrein
|
|
EP4308230A1
(en)
|
2021-03-17 |
2024-01-24 |
Takeda Pharmaceutical Company Limited |
Heteroaryl inhibitors of plasma kallikrein
|
|
CN117396473A
(zh)
|
2021-03-17 |
2024-01-12 |
武田药品工业株式会社 |
血浆激肽释放酶的咪唑并吡啶基抑制剂
|