SG11202104017VA - Tyk2 inhibitors and uses thereof - Google Patents

Tyk2 inhibitors and uses thereof

Info

Publication number
SG11202104017VA
SG11202104017VA SG11202104017VA SG11202104017VA SG11202104017VA SG 11202104017V A SG11202104017V A SG 11202104017VA SG 11202104017V A SG11202104017V A SG 11202104017VA SG 11202104017V A SG11202104017V A SG 11202104017VA SG 11202104017V A SG11202104017V A SG 11202104017VA
Authority
SG
Singapore
Prior art keywords
tyk2 inhibitors
tyk2
inhibitors
Prior art date
Application number
SG11202104017VA
Inventor
Bohan Jin
Qing Dong
Gene Hung
Stephen W Kaldor
Original Assignee
Esker Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esker Therapeutics Inc filed Critical Esker Therapeutics Inc
Publication of SG11202104017VA publication Critical patent/SG11202104017VA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
SG11202104017VA 2018-10-22 2019-10-22 Tyk2 inhibitors and uses thereof SG11202104017VA (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862749003P 2018-10-22 2018-10-22
US201862756942P 2018-11-07 2018-11-07
US201962839459P 2019-04-26 2019-04-26
US201962875449P 2019-07-17 2019-07-17
US201962893721P 2019-08-29 2019-08-29
US201962907354P 2019-09-27 2019-09-27
PCT/US2019/057485 WO2020086616A1 (en) 2018-10-22 2019-10-22 Tyk2 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
SG11202104017VA true SG11202104017VA (en) 2021-05-28

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US (4) US11053219B2 (en)
EP (1) EP3870579A4 (en)
JP (1) JP2022505987A (en)
KR (1) KR20210095634A (en)
CN (1) CN113490664A (en)
AU (1) AU2019364336B2 (en)
BR (1) BR112021007679A2 (en)
CA (1) CA3117200A1 (en)
CL (1) CL2021000989A1 (en)
IL (1) IL282487A (en)
MX (1) MX2021004538A (en)
SG (1) SG11202104017VA (en)
WO (1) WO2020086616A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3870579A4 (en) 2018-10-22 2022-10-19 Alumis Inc. Tyk2 inhibitors and uses thereof
CN111484480B (en) * 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 Polycyclic derivative inhibitor, preparation method and application thereof
BR112021014709A2 (en) * 2019-01-30 2021-09-28 Bristol-Myers Squibb Company amide-replaced pyridine or pyridazine compounds
WO2021011513A1 (en) * 2019-07-16 2021-01-21 Bristol-Myers Squibb Company Prodrugs in the modulation of interleukin
MX2022003490A (en) 2019-09-27 2022-04-25 Takeda Pharmaceuticals Co 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors.
CA3170773A1 (en) * 2020-03-11 2021-09-16 Xiangyang Chen Heterocyclic compounds for inhibiting tyk2 activities
WO2021202652A1 (en) * 2020-04-01 2021-10-07 Eternity Bioscience Inc. Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
EP4136073A1 (en) * 2020-04-14 2023-02-22 Gossamer Bio Services, Inc. Substituted pyridines for the treatment of inflammatory diseases
CN113563309A (en) * 2020-04-28 2021-10-29 浙江海正药业股份有限公司 Pyridine derivative and preparation method and application thereof
CN113735837B (en) * 2020-05-28 2023-09-01 江苏先声药业有限公司 Pyridazine compound and use thereof
CN113735836B (en) * 2020-05-28 2023-05-30 江苏先声药业有限公司 Pyridazine compound and application thereof
CN113773262A (en) * 2020-06-09 2021-12-10 江苏先声药业有限公司 Pyridazine compound
BR112022025946A2 (en) * 2020-06-22 2023-01-24 Beigene Ltd COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF A DISEASE
WO2022032484A1 (en) * 2020-08-11 2022-02-17 北京诺诚健华医药科技有限公司 Pyridazine-3-formamide compound, and preparation method therefor and medical use thereof
US20230339977A1 (en) * 2020-08-13 2023-10-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compound, and composition and application thereof
TW202227430A (en) * 2020-11-17 2022-07-16 大陸商江蘇恆瑞醫藥股份有限公司 Nitrogen-containing derivatives, their preparation method and their medical use
MX2023006504A (en) * 2020-12-02 2023-06-21 Shenzhen Chipscreen Biosciences Co Ltd Hydroxamate compound, preparation method therefor and application thereof.
CN116547276A (en) * 2020-12-08 2023-08-04 正大天晴药业集团股份有限公司 TYK2 inhibitor compounds containing an amide group and a heterocycloalkyl group
CN115160297B (en) * 2020-12-22 2023-03-31 益方生物科技(上海)股份有限公司 Heteroaryl compounds, their preparation and use
BR112023016590A2 (en) 2021-02-19 2023-11-14 Sudo Biosciences Ltd TYK2 INHIBITORS AND THEIR USES
WO2022179578A1 (en) * 2021-02-24 2022-09-01 南京明德新药研发有限公司 Compound containing sulfinylpyridine structure and applications
CN112920103A (en) * 2021-03-02 2021-06-08 康化（上海）新药研发有限公司 Method for mild preparation of 2-azaspiro [3.3] heptane hydrochloride
EP4308556A1 (en) * 2021-03-16 2024-01-24 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Amino heteroaryl compounds and compositions
CN115197196A (en) * 2021-04-06 2022-10-18 扬子江药业集团有限公司 TYK2 inhibitor and application thereof
TWI804266B (en) * 2021-04-07 2023-06-01 大陸商上海齊魯製藥研究中心有限公司 Tyk2 inhibitors and use thereof
JP2024517453A (en) * 2021-05-04 2024-04-22 シャンハイ ゼイ バイオテクノロジー カンパニー リミテッド Nitrogen-containing heterocyclic pyridine compounds
WO2022241174A1 (en) 2021-05-14 2022-11-17 Bristol-Myers Squibb Company Substituted heterocyclic compounds
WO2022253335A1 (en) * 2021-06-02 2022-12-08 南京明德新药研发有限公司 Sulfonyl-containing aryl compound and application thereof
WO2022253333A1 (en) * 2021-06-02 2022-12-08 南京明德新药研发有限公司 Amide compounds and application thereof
TWI825800B (en) * 2021-06-22 2023-12-11 大陸商南京明德新藥研發有限公司 Sulfinimine compounds and their applications
WO2023284869A1 (en) * 2021-07-15 2023-01-19 南京明德新药研发有限公司 Sulfur/phosphorus-containing aryl compound and application thereof
US20230122670A1 (en) * 2021-08-10 2023-04-20 Revela, Inc. Compositions, formulations, and methods for hair treatment
CN115724830A (en) * 2021-08-31 2023-03-03 浙江文达医药科技有限公司 Compounds as TYK2/JAK1 pseudokinase domain (JH 2) inhibitors and methods of synthesis and use
WO2023054549A1 (en) * 2021-09-30 2023-04-06 あすか製薬株式会社 Degradation inducer
WO2023064223A1 (en) * 2021-10-11 2023-04-20 Gossamer Bio Services, Inc. Tri-substituted pyridines
WO2023076161A1 (en) 2021-10-25 2023-05-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
WO2023109954A1 (en) * 2021-12-16 2023-06-22 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof
WO2023116748A1 (en) * 2021-12-23 2023-06-29 广东东阳光药业有限公司 Substituted heteroaryl compound, and composition and use thereof
WO2023116822A1 (en) * 2021-12-23 2023-06-29 Beigene, Ltd. Solid forms of a tyk2 inhibitor, method of preparation, and use thereof
CN116693449A (en) * 2022-03-04 2023-09-05 上海致根医药科技有限公司 Compounds useful as TYK2 inhibitors, preparation method and application thereof in medicine
WO2023192351A1 (en) 2022-03-29 2023-10-05 Alumis Inc. Tyk2 inhibitors and uses thereof
WO2023220338A1 (en) * 2022-05-13 2023-11-16 Alumis Inc. Crystalline forms of a tyk2 inhibitor and uses thereof
WO2023236945A1 (en) * 2022-06-07 2023-12-14 广州费米子科技有限责任公司 Pyridazin-3-carboxamide compound as tyk2 inhibitor
WO2024059529A1 (en) * 2022-09-12 2024-03-21 Alumis Inc. Crystalline forms of a tyk2 inhibitor and uses thereof
WO2024081603A1 (en) * 2022-10-10 2024-04-18 Alumis Inc. Crystalline forms of a tyk2 inhibitor and uses thereof
CN116284040A (en) * 2023-01-05 2023-06-23 华润医药研究院（深圳）有限公司 Nitrogen-containing heterocyclic compound and medical application thereof

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002047690A1 (en) 2000-12-12 2002-06-20 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof
JP4741948B2 (en) 2002-08-14 2011-08-10 バーテックス ファーマシューティカルズ インコーポレイテッド Protein kinase inhibitors and their use
WO2006105222A2 (en) * 2005-03-25 2006-10-05 Scios Inc. Carboxamide inhibitors of tgfb
KR20170051521A (en) * 2008-04-16 2017-05-11 포톨라 파마슈티컬스, 인코포레이티드 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
WO2010058846A1 (en) * 2008-11-21 2010-05-27 アステラス製薬株式会社 4,6-diaminonicotinamide compound
PL2428508T3 (en) * 2009-05-08 2016-05-31 Astellas Pharma Inc Diamino heterocyclic carboxamide compound
MX365251B (en) 2010-05-20 2019-05-28 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors.
EP2635557A2 (en) * 2010-11-01 2013-09-11 Portola Pharmaceuticals, Inc. Nicotinamides as jak kinase modulators
US8846928B2 (en) * 2010-11-01 2014-09-30 Portola Pharmaceuticals, Inc. Benzamides and nicotinamides as Syk modulators
CN102250065B (en) 2011-05-20 2015-05-13 浙江海正药业股份有限公司 Substituted triazine phenyl urea derivatives and application thereof
WO2013001310A1 (en) 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
HUE029728T2 (en) 2011-09-30 2017-03-28 Ipsen Pharma Sas Macrocyclic lrrk2 kinase inhibitors
JP6109192B2 (en) * 2012-01-10 2017-04-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Pyridazine amide compounds and their use as SYK inhibitors
EP4071144A1 (en) * 2012-11-08 2022-10-12 Bristol-Myers Squibb Company Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
WO2014084330A1 (en) 2012-11-30 2014-06-05 協和発酵キリン株式会社 Nitrogen-containing heterocyclic compound
US20160024114A1 (en) 2013-03-15 2016-01-28 Oncodesign S.A. Macrocyclic rip2 kinase inhibitors
CA2922716C (en) * 2013-08-29 2021-10-12 Kyoto Pharmaceutical Industries, Ltd. Aromatic compound and use thereof in the treatment of disorders associated with bone metabolism
AR094537A1 (en) * 2013-11-07 2015-08-12 Bristol Myers Squibb Co PIRIDIL COMPOUNDS REPLACED WITH USEFUL ALQUILAMIDE AS MODULATORS OF THE ANSWERS OF IL-12, IL-23 AND / OR IFNa
WO2015084998A1 (en) * 2013-12-05 2015-06-11 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
US9714258B2 (en) 2014-01-24 2017-07-25 Tp Therapeutics, Inc. Diaryl macrocycles as modulators of protein kinases
WO2015123453A1 (en) * 2014-02-14 2015-08-20 Portola Pharmaceuticals, Inc. Pyridazine compounds as jak inhibitors
CN105111151B (en) 2015-04-17 2018-09-28 成都理工大学 Aminopyridine derivative as PPAR- gamma modulators
KR20180021740A (en) * 2015-06-02 2018-03-05 파마싸이클릭스 엘엘씨 Inhibitor of bruton tyrosine kinase
JP6871903B2 (en) 2015-07-02 2021-05-19 ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Chiral diallyl macrocyclic molecule as a modulator of protein kinase
EP3319969B1 (en) 2015-07-06 2024-04-03 Turning Point Therapeutics, Inc. Diaryl macrocycle polymorph
EP3325488B1 (en) 2015-07-21 2020-06-24 Turning Point Therapeutics, Inc. Chiral diaryl macrocycle and use thereof in the treatment of cancer
CA3003153A1 (en) 2015-10-26 2017-05-04 Loxo Oncology, Inc. Point mutations in trk inhibitor-resistant cancer and methods relating to the same
KR20180081584A (en) 2015-11-18 2018-07-16 브리스톨-마이어스 스큅 컴퍼니 Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and / or IFN alpha responses
AU2017208555B2 (en) 2016-01-22 2021-03-18 Janssen Pharmaceutica Nv New 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors
AU2017302019A1 (en) 2016-07-28 2019-02-07 Turning Point Therapeutics, Inc. Macrocycle kinase inhibitors
EP3523305B1 (en) 2016-10-07 2021-12-08 Bristol-Myers Squibb Company Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
WO2018112027A1 (en) 2016-12-14 2018-06-21 Development Center For Biotechnology Antibody-drug conjugates and uses thereof
TWI808958B (en) 2017-01-25 2023-07-21 美商特普醫葯公司 Combination therapy involving diaryl macrocyclic compounds
CN106866660B (en) 2017-02-15 2019-05-17 上海天马有机发光显示技术有限公司 Electron transport material, OLED display panel and electronic equipment comprising it
TWI783978B (en) * 2017-03-08 2022-11-21 美商林伯士拉克許米公司 Tyk2 inhibitors, uses, and methods for production thereof
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
CA3058880A1 (en) 2017-04-03 2018-10-11 Kyoto Pharmaceutical Industries, Ltd. Novel cyclin-dependent kinase 8 and/or 19 inhibitor
EP3642204A1 (en) 2017-06-21 2020-04-29 H. Hoffnabb-La Roche Ag PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
UA126158C2 (en) 2017-07-28 2022-08-25 Тьорнінґ Поінт Терапьютикс, Інк. Macrocyclic compounds and uses thereof
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
CA3071032A1 (en) 2017-08-23 2019-02-28 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
WO2019049891A1 (en) 2017-09-06 2019-03-14 小野薬品工業株式会社 METHOD FOR TREATING CANCER BY COMBINATION OF Trk INHIBITOR AND KINASE INHIBITOR
US20190247398A1 (en) 2017-10-26 2019-08-15 Array Biopharma Inc. Formulations of a macrocyclic trk kinase inhibitor
EP3700516B1 (en) 2017-10-27 2024-01-24 Sonic Master Limited Inhibitors of dux4 induction for regulation of muscle function
WO2019094143A1 (en) 2017-11-10 2019-05-16 Angex Pharmaceutical, Inc. Macrocyclic compounds as trk kinase inhibitors and uses thereof
PL3728271T3 (en) 2017-12-19 2023-01-23 Turning Point Therapeutics, Inc. Macrocyclic compounds for treating diseases
WO2019144885A1 (en) 2018-01-23 2019-08-01 深圳市塔吉瑞生物医药有限公司 Substituted pyrazolo[1,5-a]pyrimidine macrocyclic compound
EP3760632B1 (en) 2018-02-28 2023-07-19 Simcere Pharmaceutical Co. Ltd. Pyrazolopyrimidine derivative and use thereof
US20210023086A1 (en) 2018-03-29 2021-01-28 Loxo Oncology, Inc. Treatment of trk-associated cancers
EP3870579A4 (en) 2018-10-22 2022-10-19 Alumis Inc. Tyk2 inhibitors and uses thereof
CN113348021A (en) 2019-01-23 2021-09-03 林伯士拉克许米公司 TYK2 inhibitors and uses thereof
JP2022524279A (en) 2019-01-28 2022-05-02 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 Pyridazine derivative inhibitor, its production method and use
CN113677347A (en) 2019-02-07 2021-11-19 温缇克斯生物科学公司 TYK2 pseudokinase ligands
BR112021017996A2 (en) 2019-03-11 2021-11-16 Esker Therapeutics Inc Tyk2 inhibitors and their uses
EA202192625A1 (en) 2019-03-26 2022-03-21 Вентикс Байосайенсес, Инк. PSEUDOKINASE TYK2 LIGANDS

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