AR016416A1 - Fenil-alquil-imidazoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento - Google Patents
Fenil-alquil-imidazoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamentoInfo
- Publication number
- AR016416A1 AR016416A1 ARP980105621A ARP980105621A AR016416A1 AR 016416 A1 AR016416 A1 AR 016416A1 AR P980105621 A ARP980105621 A AR P980105621A AR P980105621 A ARP980105621 A AR P980105621A AR 016416 A1 AR016416 A1 AR 016416A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- trihalomethyl
- independently selected
- hydrogen
- minor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la formula(I) o su sal o solvato farmacéuticamente aceptable donde:el doble enlace (a)es E o Z;cada R1 se selecciona independientemente delgrupo formado por hidrogeno, alquilo menor, trihalometilo, fenilo y bencilo; cada R7 seselecci ona independientemente del grupo formado por hidrogeno, alquilomenor, halogeno, trihalometilo, NR10R11 o un grupo OR10 donde R10 y R11 se seleccionan independientemente de hidrogeno, alquilo menor o trihalometilo; X es-CONR5-; -SO2; -S-;-CO-; -COO-; -CN(OR5)NR5; -C(NR5)NR5-, -SONR5-; -SO2NR5 y, si p no es cero, X también puede ser -O-; -NR5-; -NR5CONR5-; -OCONR5-; -O-CO- o-NR5CO; Y es alquilo de C1-3, opcionalmente sustituido con cualquier átomo de carbono del grupo por unsustituyente R5, A es C(R1)2; donde no más que dosgrupos R1 son diferentes de hidrogeno; n es 1 o 2; m es 0 o 1; p es 0 o1; q es 0 o 1; R se selecciona de un (1) cicloalquilo de C3-C7, (2) gruposheterocíclicos, (3) arilo, (4) heteroarilo, (5)cicloalquilo de C3 a C7 sust ituido que tiene 1-3 sustituyentes independientemente seleccionados del grupoformado por alquilo menor, trihalometilo y NR10R11, donde R10 y R11 se seleccionan independientemente de hidrogeno, alquilo menor otrihalometilo, (6) unheterociclico sustit uido que tiene 1-3 sustituyentes independientemente seleccionados del grupo formado por un alquilo menor, trihalometilo, y NR10R11 dondeR10 y R11 son como definimos anteriormente, dichos sustituyentes estánenlazados a los átomos de carbono en el ani llo de manera tal que la cantidad total desustituyentes en el anillo es entre 1 y 3; y donde dicho anillo heterocíclico contiene átomos de nitrogeno sustituibles, dichos átomos de nitrogenoestánopcionalmente sustituidos con un alquilo menor; (7) el arilo sustituido que tiene 1-3 sustituyentes independientemente seleccionados del grupo formado poralquilo menor, halogeno, trihalometilo, CN, NO2, OR10R11, donde R10 y R11 son comodefinimos anteriormente; (8) heteroarilo sustituido que tienen 1-3su stituyentes independientemente seleccionados del grupo formado por un alquilo menor, halogeno, trihalometilo, CH, NO2, OR10 o NR10R11, donde R10 y R11 son
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96626497A | 1997-11-07 | 1997-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016416A1 true AR016416A1 (es) | 2001-07-04 |
Family
ID=25511129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980105621A AR016416A1 (es) | 1997-11-07 | 1998-11-06 | Fenil-alquil-imidazoles, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de un medicamento |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1028948B1 (es) |
JP (1) | JP2001522836A (es) |
CN (1) | CN1285823A (es) |
AR (1) | AR016416A1 (es) |
AT (1) | ATE231841T1 (es) |
AU (1) | AU1296899A (es) |
CA (1) | CA2309121A1 (es) |
DE (1) | DE69811110T2 (es) |
ES (1) | ES2188029T3 (es) |
PE (1) | PE130799A1 (es) |
WO (1) | WO1999024406A1 (es) |
ZA (1) | ZA9810184B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR025976A1 (es) * | 1999-10-08 | 2002-12-26 | Affinium Pharm Inc | Inhibidores de fab i. |
WO2004066960A2 (en) * | 2003-01-28 | 2004-08-12 | Schering Corporation | Combination of h1, h3 and h4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
CN1902177A (zh) * | 2003-09-22 | 2007-01-24 | 万有制药株式会社 | 新哌啶衍生物 |
US7423149B2 (en) * | 2003-12-23 | 2008-09-09 | Schering Corporation | Substituted n-aryl amidines as selective D1 dopamine receptor antagonists for the treatment of obesity and CNS disorders |
WO2006076706A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ, インク. | Fabiインヒビターとしてのアクリルアミド誘導体 |
EP3255045A1 (en) | 2007-02-16 | 2017-12-13 | Debiopharm International SA | Salts, prodrugs and polymorphs of fab i inhibitors |
TR201909016T4 (tr) | 2012-06-19 | 2019-07-22 | Debiopharm Int Sa | (E)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamidin ön ilaç türevleri. |
AU2017223037B2 (en) | 2016-02-26 | 2022-04-14 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
AU693142B2 (en) * | 1993-11-15 | 1998-06-25 | Schering Corporation | Phenyl-alkyl imidazoles as H3-receptor antagonists |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
ATE314071T1 (de) * | 1996-08-16 | 2006-01-15 | Schering Corp | Behandlung von allergischen reaktionen im oberen respirationstrakt mit einer kombination von histamin-rezeptor-antagonisten |
-
1998
- 1998-11-05 AT AT98956444T patent/ATE231841T1/de not_active IP Right Cessation
- 1998-11-05 CN CN98812982A patent/CN1285823A/zh active Pending
- 1998-11-05 CA CA002309121A patent/CA2309121A1/en not_active Abandoned
- 1998-11-05 ES ES98956444T patent/ES2188029T3/es not_active Expired - Lifetime
- 1998-11-05 EP EP98956444A patent/EP1028948B1/en not_active Expired - Lifetime
- 1998-11-05 DE DE69811110T patent/DE69811110T2/de not_active Expired - Fee Related
- 1998-11-05 JP JP2000520420A patent/JP2001522836A/ja active Pending
- 1998-11-05 WO PCT/US1998/023225 patent/WO1999024406A1/en active IP Right Grant
- 1998-11-05 AU AU12968/99A patent/AU1296899A/en not_active Abandoned
- 1998-11-06 ZA ZA9810184A patent/ZA9810184B/xx unknown
- 1998-11-06 PE PE1998001071A patent/PE130799A1/es not_active Application Discontinuation
- 1998-11-06 AR ARP980105621A patent/AR016416A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1028948A1 (en) | 2000-08-23 |
WO1999024406A1 (en) | 1999-05-20 |
DE69811110D1 (de) | 2003-03-06 |
CN1285823A (zh) | 2001-02-28 |
JP2001522836A (ja) | 2001-11-20 |
DE69811110T2 (de) | 2003-11-27 |
ZA9810184B (en) | 1999-05-06 |
PE130799A1 (es) | 1999-12-16 |
EP1028948B1 (en) | 2003-01-29 |
ES2188029T3 (es) | 2003-06-16 |
AU1296899A (en) | 1999-05-31 |
CA2309121A1 (en) | 1999-05-20 |
ATE231841T1 (de) | 2003-02-15 |
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