HUP9904210A2 - Kamptotecin-analógok, alkalmazásuk gyógyszerként és ilyen vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Kamptotecin-analógok, alkalmazásuk gyógyszerként és ilyen vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9904210A2
HUP9904210A2 HU9904210A HUP9904210A HUP9904210A2 HU P9904210 A2 HUP9904210 A2 HU P9904210A2 HU 9904210 A HU9904210 A HU 9904210A HU P9904210 A HUP9904210 A HU P9904210A HU P9904210 A2 HUP9904210 A2 HU P9904210A2
Authority
HU
Hungary
Prior art keywords
group
hydrogen atom
alkyloxy
halogen atom
compositions containing
Prior art date
Application number
HU9904210A
Other languages
English (en)
Inventor
Dennis Bigg
Olivier Lavergne
Francesc Pla Rodas
Jacques Pommier
Gérard Ulibarri
Original Assignee
Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) filed Critical Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Publication of HUP9904210A2 publication Critical patent/HUP9904210A2/hu
Publication of HUP9904210A3 publication Critical patent/HUP9904210A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány (I) és (II) általánős képletű új vegyületekre, azőkattartalmazó gyógyászati kőmpőzíciókra és a vegyületek gyógyszerekelőállítására való alkalmazására vőnatkőzik. A (I) és (II) általánősképletekben a szűbsztitűensek főbb jelentései a következők: R1 jelentése rövid szénláncú alkil-, alkenil-, alkinil- vagyalkőxicsőpőrt; R2, R3 és R4 jelentése egymástól függetlenül hidrőgénatőm,halőgénatőm, rövid szénláncú alkil- vagy alkenilcsőpőrt, cianő-,nitrő- vagy amidőcsőpőrt; R5 jelentése hidrőgénatőm, halőgénatőm, rövid szénláncú alkil- vagyalkőxicsőpőrt, ciklőalkilcsőpőrt, cianőcsőpőrt, nitrőcsőpőrt vagyarilcsőpőrt; R16 jelentése hidrőgénatőm vagy alkőxicsőpőrt; R17 jelentése alkőxicsőpőrt vagy aminőcsőpőrt; R18 és R19 jelentése egymástól függetlenül hidrőgénatőm, halőgénatőmvagy rövid szénláncú alkil- vagy alkőxicsőpőrt; R20 jelentése hidrőgénatőm vagy halőgénatőm. A találmány szerintivegyületek gátőlják a tőpőizőmerázt, és emellett tűmőrellenes ésélősködőellenes hatást is műtatnak. ŕ
HU9904210A 1996-12-20 1997-12-05 Analogues of camptothecin,their application as medicine and pharmaceutical compositions containing them HUP9904210A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615774A FR2757514B1 (fr) 1996-12-20 1996-12-20 Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
HUP9904210A2 true HUP9904210A2 (hu) 2000-05-28
HUP9904210A3 HUP9904210A3 (en) 2000-09-28

Family

ID=9498938

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904210A HUP9904210A3 (en) 1996-12-20 1997-12-05 Analogues of camptothecin,their application as medicine and pharmaceutical compositions containing them

Country Status (26)

Country Link
EP (1) EP0946567B1 (hu)
JP (2) JP3576175B2 (hu)
KR (1) KR100516874B1 (hu)
CN (1) CN1097056C (hu)
AR (1) AR008543A1 (hu)
AT (1) ATE248177T1 (hu)
AU (1) AU734485B2 (hu)
BR (1) BR9714170A (hu)
CA (1) CA2275351C (hu)
CZ (1) CZ299795B6 (hu)
DE (1) DE69724453T2 (hu)
DK (1) DK0946567T3 (hu)
ES (1) ES2206761T3 (hu)
FR (1) FR2757514B1 (hu)
HK (1) HK1024695A1 (hu)
HU (1) HUP9904210A3 (hu)
MX (1) MXPA99005776A (hu)
MY (1) MY119473A (hu)
NO (1) NO326464B1 (hu)
NZ (1) NZ335939A (hu)
PL (1) PL188181B1 (hu)
PT (1) PT946567E (hu)
RU (1) RU2194051C2 (hu)
UA (1) UA57758C2 (hu)
WO (1) WO1998028305A1 (hu)
ZA (1) ZA9711129B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6291676B1 (en) * 1999-03-03 2001-09-18 University Of Kentucky Research Foundation Water-soluble derivatives of camptothecin/homocamptothecin
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
WO2000073273A1 (fr) * 1999-05-28 2000-12-07 Nippon Chemiphar Co., Ltd. Procede d'obtention de derives 2-halo-3-(3-quinolyl) acide proprionique
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CA2580747A1 (en) * 2004-09-21 2006-03-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R .A.S.) Novel processes for the production of useful intermediates
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
WO2023232145A1 (zh) * 2022-06-02 2023-12-07 华东师范大学 一种高喜树碱类小分子及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
EP0835258B1 (fr) * 1995-06-21 2002-09-25 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
JP2001505922A (ja) 2001-05-08
DE69724453T2 (de) 2004-06-09
MY119473A (en) 2005-05-31
CN1097056C (zh) 2002-12-25
CA2275351C (fr) 2008-10-14
AU5326598A (en) 1998-07-17
CZ299795B6 (cs) 2008-11-26
PL334125A1 (en) 2000-02-14
FR2757514B1 (fr) 1999-02-12
HK1024695A1 (en) 2000-10-20
KR100516874B1 (ko) 2005-09-26
CN1241191A (zh) 2000-01-12
ES2206761T3 (es) 2004-05-16
NO992998D0 (no) 1999-06-18
CZ220599A3 (cs) 1999-09-15
DE69724453D1 (de) 2003-10-02
ZA9711129B (en) 1999-05-03
AR008543A1 (es) 2000-01-19
NZ335939A (en) 2000-04-28
WO1998028305A1 (fr) 1998-07-02
DK0946567T3 (da) 2003-12-22
UA57758C2 (uk) 2003-07-15
AU734485B2 (en) 2001-06-14
BR9714170A (pt) 2000-02-29
JP2004115535A (ja) 2004-04-15
HUP9904210A3 (en) 2000-09-28
PL188181B1 (pl) 2004-12-31
NO326464B1 (no) 2008-12-08
FR2757514A1 (fr) 1998-06-26
NO992998L (no) 1999-08-18
CA2275351A1 (fr) 1998-07-02
JP3576175B2 (ja) 2004-10-13
KR20000069608A (ko) 2000-11-25
MXPA99005776A (es) 2004-08-31
EP0946567B1 (fr) 2003-08-27
EP0946567A1 (fr) 1999-10-06
ATE248177T1 (de) 2003-09-15
RU2194051C2 (ru) 2002-12-10
PT946567E (pt) 2004-01-30

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