AR008543A1 - Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y el uso del compuesto. - Google Patents

Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y el uso del compuesto.

Info

Publication number
AR008543A1
AR008543A1 ARP970106043A ARP970106043A AR008543A1 AR 008543 A1 AR008543 A1 AR 008543A1 AR P970106043 A ARP970106043 A AR P970106043A AR P970106043 A ARP970106043 A AR P970106043A AR 008543 A1 AR008543 A1 AR 008543A1
Authority
AR
Argentina
Prior art keywords
compound
methyl
camptotecine
understands
pharmaceutical composition
Prior art date
Application number
ARP970106043A
Other languages
English (en)
Original Assignee
Ipsen Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas
Publication of AR008543A1 publication Critical patent/AR008543A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos análogos de camptotecina de formulas (I) y (II) en las cuales R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18,R19, R20, R21, m, n, q y [N=X] tienen los significados dados en las páginas 4 a 8 de la memoriade scriptiva y reivindicacion 1 del juego reivindicatorio, yparticularmente con los siguientes compuestos: 5-etil-9,10-difluoro-4,5- -dihidro-5-hidroxi-12-(4-metilpiperidinometil)-1H-oxepino[3, 4:6,7]--indolizino[1,2-b] quinolina-3,15(4H,13H)-di ona; 5-metil-12-dietilamminometil- -9-fluoro-4,5-dihidro-5-hidroxi-10-metil-1H-oxepino-[3,4:6,7]indolizino[1,2-b]quinolina-3-15(4H, 13H)-diona; y 5-metil-9-fluoro-4,5-dihidro-5-hidroxi- -10-metil-12-(4-metilpiperidinometil)-1H-oxepino-[3,4:6,7]indoz ilo[1,2-b]quinolina-3,15(4H, 13H)-diona. También se refiere a medicamentos y composiciones farmacéuticas que los contienen y a la aplicacion de dichosanálogos para la preparacion de drogas con accion terapéutica.
ARP970106043A 1996-12-20 1997-12-19 Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y el uso del compuesto. AR008543A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615774A FR2757514B1 (fr) 1996-12-20 1996-12-20 Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AR008543A1 true AR008543A1 (es) 2000-01-19

Family

ID=9498938

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970106043A AR008543A1 (es) 1996-12-20 1997-12-19 Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y el uso del compuesto.

Country Status (26)

Country Link
EP (1) EP0946567B1 (es)
JP (2) JP3576175B2 (es)
KR (1) KR100516874B1 (es)
CN (1) CN1097056C (es)
AR (1) AR008543A1 (es)
AT (1) ATE248177T1 (es)
AU (1) AU734485B2 (es)
BR (1) BR9714170A (es)
CA (1) CA2275351C (es)
CZ (1) CZ299795B6 (es)
DE (1) DE69724453T2 (es)
DK (1) DK0946567T3 (es)
ES (1) ES2206761T3 (es)
FR (1) FR2757514B1 (es)
HK (1) HK1024695A1 (es)
HU (1) HUP9904210A3 (es)
MX (1) MXPA99005776A (es)
MY (1) MY119473A (es)
NO (1) NO326464B1 (es)
NZ (1) NZ335939A (es)
PL (1) PL188181B1 (es)
PT (1) PT946567E (es)
RU (1) RU2194051C2 (es)
UA (1) UA57758C2 (es)
WO (1) WO1998028305A1 (es)
ZA (1) ZA9711129B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6291676B1 (en) * 1999-03-03 2001-09-18 University Of Kentucky Research Foundation Water-soluble derivatives of camptothecin/homocamptothecin
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
WO2000073273A1 (fr) * 1999-05-28 2000-12-07 Nippon Chemiphar Co., Ltd. Procede d'obtention de derives 2-halo-3-(3-quinolyl) acide proprionique
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CA2580747A1 (en) * 2004-09-21 2006-03-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R .A.S.) Novel processes for the production of useful intermediates
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
WO2023232145A1 (zh) * 2022-06-02 2023-12-07 华东师范大学 一种高喜树碱类小分子及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
PT835258E (pt) * 1995-06-21 2003-02-28 Sod Conseils Rech Applic Novos analogos de camptotecina, processos para a sua preparacao, sua utilizacao como farmacos e composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
CN1241191A (zh) 2000-01-12
KR100516874B1 (ko) 2005-09-26
HUP9904210A3 (en) 2000-09-28
AU5326598A (en) 1998-07-17
BR9714170A (pt) 2000-02-29
DE69724453D1 (de) 2003-10-02
UA57758C2 (uk) 2003-07-15
CA2275351A1 (fr) 1998-07-02
AU734485B2 (en) 2001-06-14
NO326464B1 (no) 2008-12-08
CZ299795B6 (cs) 2008-11-26
JP2001505922A (ja) 2001-05-08
NZ335939A (en) 2000-04-28
RU2194051C2 (ru) 2002-12-10
PL188181B1 (pl) 2004-12-31
CA2275351C (fr) 2008-10-14
MY119473A (en) 2005-05-31
HUP9904210A2 (hu) 2000-05-28
EP0946567B1 (fr) 2003-08-27
PL334125A1 (en) 2000-02-14
JP2004115535A (ja) 2004-04-15
ZA9711129B (en) 1999-05-03
DK0946567T3 (da) 2003-12-22
MXPA99005776A (es) 2004-08-31
KR20000069608A (ko) 2000-11-25
ATE248177T1 (de) 2003-09-15
CZ220599A3 (cs) 1999-09-15
JP3576175B2 (ja) 2004-10-13
EP0946567A1 (fr) 1999-10-06
NO992998D0 (no) 1999-06-18
WO1998028305A1 (fr) 1998-07-02
FR2757514B1 (fr) 1999-02-12
NO992998L (no) 1999-08-18
ES2206761T3 (es) 2004-05-16
PT946567E (pt) 2004-01-30
CN1097056C (zh) 2002-12-25
FR2757514A1 (fr) 1998-06-26
DE69724453T2 (de) 2004-06-09
HK1024695A1 (en) 2000-10-20

Similar Documents

Publication Publication Date Title
AR005849A1 (es) Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion del compuesto
AR037517A1 (es) Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
ES2173074T3 (es) Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico.
AR017796A1 (es) DERIVADOS DE 2-ARIL-8-OXODIHIDROPURINA, PROCEDIMIENTOS PARA PREPARARLOS, COMPUESTOS INTERMEDIARIOS DE APLICACIoN EN DICHOS PROCEDIMIENTOS, COMPOSICIONES FARMACEUTICAS, Y SU USO PARA LA PREPARACIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ESTADOS DE ANSIEDAD.
AR025959A1 (es) DERIVADOS DE TER.-BUTIL-(7-METIL-IMIDAZO[1,2,a]PIRIDIN-3-IL)-AMINA, PROCEDIMIENTO PARA SU PREPARACION, MEDICAMENTOS QUE LOS CONTIENEN, SU USO PARA LAPREPARACION DE UN MEDICAMENTO PARA LA INHIBICION DE NO-SINTASA Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
YU21803A (sh) Farmaceutski aktivni derivati sulfonamida koji imaju i lipofilne i jonizujuće osobine kao inhibitori protein-junkinaza
YU84791A (sh) Biciklicni 1-aza-cikloalkalni
AR061422A2 (es) Peptidos ciclicos selectivos, procedimiento de preparacion, composicion farmaceutica que los comprende, y uso de los mismos en la preparacion de medicamentos
MXPA02003199A (es) Derivados de sulfonamida farmaceuticamente activos.
AR026593A1 (es) Formulaciones para agentes farmaceuticos ionizables como acidos libres o bases libres
IL94768A0 (en) Pharmaceutical compositions containing aryl-substituted amine derivatives,certain such novel compounds and their preparation
AR008543A1 (es) Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y el uso del compuesto.
AR024969A1 (es) Derivados de 8-fenil-6,9-dihidro-[1,2,4]triazol[3,4-i]purin-5-ona
MX9305379A (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene.
HUP0004076A2 (hu) C-4"-Szubsztituált-makrolid-származékok
AR045040A1 (es) Derivados de compuestos espiroazabiciclicos, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos
PA8542701A1 (es) Composición parenteral reconstituible
SI1320526T1 (sl) Farmacevtsko aktivni derivati benzsulfonamida kotinhibitorji protein jun kinaz
AR008291A1 (es) Derivados de tetrahidroisoquinolina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su uso para la preparacionde un medicamento.
PT92303A (pt) Processo para a preparacao de derivados de xantina
ES2029254T3 (es) Procedimiento para la preparacion de una sal de diclofenac con una base organica ciclica.
AR029618A1 (es) Compuestos de amida , procedimientos para prepararlos, las composiciones farmaceuticas que los contienen y el uso de dichos compuestos para la fabricacion de medicamentos
FR2521998B1 (fr) Pyrido (3,4-c) psoralenes, obtention, applications en cosmetologie et a titre de medicaments et compositions cosmetiques et pharmaceutiques les contenant
FR2617476B1 (fr) Nouveaux derives polycycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique
AR027454A1 (es) Derivados de beta-alanina, utiles como antagonistas de receptores, las composiciones farmaceuticas que las contienen y el uso de los mismos para lapreparacion de medicamentos

Legal Events

Date Code Title Description
FG Grant, registration