MD3672965T2 - Compusi ai pirimidinei ca inhibitori ai kinazei JAK - Google Patents

Compusi ai pirimidinei ca inhibitori ai kinazei JAK

Info

Publication number
MD3672965T2
MD3672965T2 MDE20200681T MDE20200681T MD3672965T2 MD 3672965 T2 MD3672965 T2 MD 3672965T2 MD E20200681 T MDE20200681 T MD E20200681T MD E20200681 T MDE20200681 T MD E20200681T MD 3672965 T2 MD3672965 T2 MD 3672965T2
Authority
MD
Moldova
Prior art keywords
compound
kinase inhibitor
jak kinase
pyrimidine compound
diseases
Prior art date
Application number
MDE20200681T
Other languages
English (en)
Inventor
Jennifer Kozak
Ryan Hudson
Gary E L Brandt
Robert Murray Mckinnell
Marta Dabros
Jerry Nzerem
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of MD3672965T2 publication Critical patent/MD3672965T2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Invenţia furnizează un compus cu formula (I):sau o sare a acestuia acceptabilă farmaceutic, care este un inhibitor al kinazei JAK. Invenţia furnizează, de asemenea, compoziţii farmaceutice care cuprind un asemenea compus, o formă cristalină, metode de folosire a unui asemenea compus pentru a trata bolile inflamatorii ale pielii şi alte boli, şi procedee şi intermediari utili pentru prepararea unui asemenea compus.
MDE20200681T 2017-10-27 2018-10-26 Compusi ai pirimidinei ca inhibitori ai kinazei JAK MD3672965T2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762577852P 2017-10-27 2017-10-27
PCT/US2018/057682 WO2019084383A1 (en) 2017-10-27 2018-10-26 PYRIMIDINE COMPOUNDS AS JAK KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
MD3672965T2 true MD3672965T2 (ro) 2022-12-31

Family

ID=64277858

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20200681T MD3672965T2 (ro) 2017-10-27 2018-10-26 Compusi ai pirimidinei ca inhibitori ai kinazei JAK

Country Status (37)

Country Link
US (7) US10308646B2 (ro)
EP (1) EP3672965B1 (ro)
JP (1) JP7218364B2 (ro)
KR (1) KR102613503B1 (ro)
CN (1) CN111247142B (ro)
AR (1) AR113803A1 (ro)
AU (1) AU2018354370B2 (ro)
BR (1) BR112020008015A2 (ro)
CA (1) CA3074034A1 (ro)
CL (1) CL2020001090A1 (ro)
CR (1) CR20200180A (ro)
CU (1) CU24671B1 (ro)
DK (1) DK3672965T3 (ro)
DO (1) DOP2020000083A (ro)
EA (1) EA202091016A1 (ro)
EC (1) ECSP20023795A (ro)
ES (1) ES2932526T3 (ro)
GE (1) GEP20227344B (ro)
HR (1) HRP20221221T1 (ro)
HU (1) HUE060401T2 (ro)
IL (1) IL274037B2 (ro)
LT (1) LT3672965T (ro)
MA (1) MA49956B1 (ro)
MD (1) MD3672965T2 (ro)
MX (1) MX2020004255A (ro)
NI (1) NI202000032A (ro)
PE (1) PE20201495A1 (ro)
PH (1) PH12020500528A1 (ro)
PL (1) PL3672965T3 (ro)
PT (1) PT3672965T (ro)
RS (1) RS63608B1 (ro)
SG (1) SG11202001706RA (ro)
SI (1) SI3672965T1 (ro)
TW (1) TWI789446B (ro)
UA (1) UA125130C2 (ro)
WO (1) WO2019084383A1 (ro)
ZA (1) ZA202001641B (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7218364B2 (ja) 2017-10-27 2023-02-06 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋキナーゼ阻害剤としてのピリミジン化合物
CN115925705A (zh) * 2018-11-30 2023-04-07 江苏豪森药业集团有限公司 杂芳类衍生物调节剂、其制备方法和应用
JP7482152B2 (ja) 2019-04-24 2024-05-13 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 皮膚疾患の処置のためのピリミジンｊａｋ阻害剤 発明の背景
CA3135383A1 (en) 2019-04-24 2020-10-29 Theravance Biopharma R&D Ip, Llc Ester and carbonate pyrimidine compounds as jak kinase inhibitors
KR20230054682A (ko) * 2020-07-28 2023-04-25 아큐티스 바이오테라퓨틱스, 인크. Jak 저해제 및 라우레스-4를 함유하는 국소 제형
JP2023543670A (ja) * 2020-08-26 2023-10-18 ナロ・セラピューティクス Ｍｙｃファミリー癌原遺伝子タンパク質のモジュレーター
EP4225438A1 (en) * 2020-10-08 2023-08-16 Icahn School of Medicine at Mount Sinai Compositions for treatment alopecia areata, biomarkers for treatment success, and methods of use thereof
CA3236262A1 (en) 2021-10-25 2023-05-04 Isaac Marx Tyk2 degraders and uses thereof
CN114246938A (zh) * 2022-01-25 2022-03-29 中山大学中山眼科中心 Il-4在制备用于治疗视网膜变性疾病药物中的应用
CN115487301B (zh) * 2022-11-08 2023-07-07 四川大学华西医院 Il-13抑制剂在制备延缓或治疗视网膜色素变性的药物中的用途

Family Cites Families (18)

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US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
HUP0302173A2 (hu) 2000-09-15 2003-09-29 Vertex Pharmaceuticals Incorporated Protein kináz inhibitorokként alkalmazható pirazolvegyületek
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ES2265452T3 (es) 2000-12-21 2007-02-16 Vertex Pharmaceuticals Incorporated Compuestos de pirazol utiles como inhibidores de la proteina quinasa.
EP1831216A2 (en) 2004-12-23 2007-09-12 Pfizer Products Inc. Heteroaromatic derivatives useful as anticancer agents
WO2007059299A1 (en) 2005-11-16 2007-05-24 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
MX2008016523A (es) 2006-06-30 2009-01-19 Astrazeneca Ab Derivados de pirimidina utiles en el tratamiento de cancer.
CA2656290A1 (en) 2006-07-05 2008-01-10 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
BR112014015549A8 (pt) 2011-12-22 2017-07-04 Hoffmann La Roche composto, método de inibição da atividade pak1, método para o tratamento, processo, composição, utilização de um composto e invenção
WO2015094803A1 (en) * 2013-12-16 2015-06-25 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
NO2721710T3 (ro) * 2014-08-21 2018-03-31
JP2017535520A (ja) * 2014-09-30 2017-11-30 ハンミ・ファイン・ケミカル・カンパニー・リミテッドＨａｎｍｉ Ｆｉｎｅ Ｃｈｅｍｉｃａｌ Ｃｏ．， Ｌｔｄ． 高純度の（ｒ）−９−［２−（ホスホノメトキシ）プロピル］アデニンの製造方法
EP3303348B1 (en) * 2015-05-28 2019-08-07 Theravance Biopharma R&D IP, LLC Naphthyridine compounds as jak kinase inhibitors
WO2017044434A1 (en) 2015-09-11 2017-03-16 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
EA035226B1 (ru) 2016-04-28 2020-05-19 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Пиримидиновые соединения в качестве ингибиторов jak киназы
JP7218364B2 (ja) * 2017-10-27 2023-02-06 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋキナーゼ阻害剤としてのピリミジン化合物
JP7482152B2 (ja) 2019-04-24 2024-05-13 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 皮膚疾患の処置のためのピリミジンｊａｋ阻害剤 発明の背景
CA3135383A1 (en) 2019-04-24 2020-10-29 Theravance Biopharma R&D Ip, Llc Ester and carbonate pyrimidine compounds as jak kinase inhibitors

Also Published As

Publication number Publication date
SG11202001706RA (en) 2020-03-30
US20220396573A1 (en) 2022-12-15
US10308646B2 (en) 2019-06-04
DOP2020000083A (es) 2020-08-15
US20240158389A1 (en) 2024-05-16
IL274037B1 (en) 2023-07-01
MX2020004255A (es) 2020-07-29
KR20200078517A (ko) 2020-07-01
AU2018354370B2 (en) 2023-04-27
US11420965B2 (en) 2022-08-23
PT3672965T (pt) 2022-09-29
HRP20221221T1 (hr) 2022-12-09
CA3074034A1 (en) 2019-05-02
LT3672965T (lt) 2022-10-10
AR113803A1 (es) 2020-06-10
IL274037A (en) 2020-06-30
PE20201495A1 (es) 2020-12-29
BR112020008015A2 (pt) 2020-10-27
JP7218364B2 (ja) 2023-02-06
TWI789446B (zh) 2023-01-11
WO2019084383A1 (en) 2019-05-02
KR102613503B1 (ko) 2023-12-13
IL274037B2 (en) 2023-11-01
MA49956A (fr) 2020-07-01
JP2021501151A (ja) 2021-01-14
US20200369660A1 (en) 2020-11-26
ECSP20023795A (es) 2020-06-30
MA49956B1 (fr) 2022-11-30
SI3672965T1 (sl) 2022-11-30
CU20200053A7 (es) 2021-03-11
US11814377B2 (en) 2023-11-14
DK3672965T3 (da) 2022-10-03
ES2932526T3 (es) 2023-01-20
CN111247142A (zh) 2020-06-05
CN111247142B (zh) 2022-12-02
TW201930304A (zh) 2019-08-01
EP3672965B1 (en) 2022-09-07
US20200140430A1 (en) 2020-05-07
EA202091016A1 (ru) 2020-07-17
PL3672965T3 (pl) 2023-01-16
UA125130C2 (uk) 2022-01-12
US10562894B2 (en) 2020-02-18
ZA202001641B (en) 2021-04-28
CL2020001090A1 (es) 2020-08-21
CU24671B1 (es) 2023-07-12
PH12020500528A1 (en) 2021-06-07
AU2018354370A1 (en) 2020-04-09
NI202000032A (es) 2020-10-09
EP3672965A1 (en) 2020-07-01
US20190241555A1 (en) 2019-08-08
HUE060401T2 (hu) 2023-02-28
RS63608B1 (sr) 2022-10-31
US10988470B2 (en) 2021-04-27
US20190127364A1 (en) 2019-05-02
CR20200180A (es) 2020-08-12
GEP20227344B (en) 2022-01-25
US20210214349A1 (en) 2021-07-15
US10774080B2 (en) 2020-09-15

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