MX2009007006A - Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana. - Google Patents
Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana.Info
- Publication number
- MX2009007006A MX2009007006A MX2009007006A MX2009007006A MX2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A MX 2009007006 A MX2009007006 A MX 2009007006A
- Authority
- MX
- Mexico
- Prior art keywords
- 6alkyl
- 6alkyloxy
- cyano
- polyhaloc1
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Se describen inhibidores de la duplicación del VIH de la fórmula: (ver fórmula (I)) R1 es hidrógeno; arilo; formilo; alquil(C1-6)carbonilo, alquilo de C1-6; alquil(C1-6)oxicarbonilo; R2 R3, R7 y R8 son hidrógeno; hidroxi; halógeno; cicloalquilo de C3-7; alquiloxi de C1-6; carboxilo; alquil(C1-6)oxicarbonilo; ciano; nitro; amino; mono- o di-alquil(C1-6)amino; polihalo-alquilo de C1-6; polihalo-alquiloxi de C1-6;-C(=O)R10; alquilo de C1-6 sustituido opcionalmente con halógeno, ciano o -C(=O)R10; alquilo de C1-6 sustituido opcionalmente, alquenilo de C2-6, o alquinilo de C2-6; R4 y R9 son hidroxi; halógeno; cilcoalquilo de C3-7; alquiloxi de C1-6; carboxilo; alquil(1-6)oxicarbonilo; formilo; ciano; nitro; amino; mono- o di-alquil(C1-6)amino; polihalo-alquilo de C1-6; polihalo-alquiloxi de C1-6; -C(=O)R10, ciano; -S(=O)rR10; -NH-S(=O)2R10; -NHC(=O)H; -C(=O)NHNH2; -NHC(=O)R10; -Het; -Y-Het; alquilo de C1-6 sustituido opcionalmente, alquenilo de C2-6 o alquinilo de C2-6; R5 es alquenilo de C2-6; o alquinilo de C2-6, ambos sustituidos con ciano; aminocarbonilo, mono- y di-alquil(C1-6)aminocarbonilo, arilo, piridilo, tienilo, furanilo, o con uno o dos grupos alquiloxi de C1-6; Het; -C(=O)NR5aR5b; -CH(OR5c)R5d; X es -NR1-, -O-, -CH2-, o -S-; composiciones farmacéuticas que contienen estos compuestos como ingredientes activos, y procedimientos de preparación de dichos compuestos y composiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06127328 | 2006-12-29 | ||
PCT/EP2007/064606 WO2008080965A2 (en) | 2006-12-29 | 2007-12-28 | Hiv inhibiting 5,6-substituted pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009007006A true MX2009007006A (es) | 2009-07-09 |
Family
ID=39310923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009007006A MX2009007006A (es) | 2006-12-29 | 2007-12-28 | Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana. |
Country Status (12)
Country | Link |
---|---|
US (1) | US8318736B2 (es) |
EP (2) | EP2781510B1 (es) |
JP (1) | JP5283633B2 (es) |
KR (1) | KR20090094084A (es) |
CN (2) | CN106045965A (es) |
AU (1) | AU2007341228B2 (es) |
BR (1) | BRPI0722079B8 (es) |
CA (2) | CA2674185C (es) |
EA (1) | EA020749B1 (es) |
ES (2) | ES2523863T3 (es) |
MX (1) | MX2009007006A (es) |
WO (1) | WO2008080965A2 (es) |
Families Citing this family (42)
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BRPI0516746A (pt) | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
RU2410379C2 (ru) * | 2004-09-30 | 2011-01-27 | Тиботек Фармасьютикалз Лтд. | 5-замещенные пиримидины, ингибирующие вич |
KR20080066069A (ko) * | 2005-11-03 | 2008-07-15 | 버텍스 파마슈티칼스 인코포레이티드 | 키나제 억제제로서 유용한 아미노피리미딘 |
AU2007233737B2 (en) | 2006-03-30 | 2012-11-29 | Janssen Sciences Ireland Uc | HIV inhibiting 5-amido substituted pyrimidines |
DK2114901T3 (da) * | 2006-12-29 | 2014-06-30 | Janssen R & D Ireland | Hiv-inhiberende 6-substituerede pyrimidiner |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
NZ589315A (en) | 2008-04-16 | 2012-11-30 | Portola Pharm Inc | 2,6-diamino-pyrimidin-5-yl-carboxamides as Spleen tryosine kinase (syk) or Janus kinase (JAK) inhibitors |
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US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
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US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
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UY33199A (es) | 2010-01-26 | 2011-08-31 | Boehringer Ingelheim Int | 5-alquinil-pirimidinas. |
UY33198A (es) | 2010-01-26 | 2011-08-31 | Boehringer Ingelheim Int | 5-alquinil-pirimidinas. |
CA2807051A1 (en) | 2010-08-10 | 2012-02-16 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
ES2635713T3 (es) | 2010-11-01 | 2017-10-04 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
TWI545115B (zh) | 2010-11-01 | 2016-08-11 | 阿維拉製藥公司 | 雜環化合物及其用途 |
JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | 変異体選択的egfr阻害剤およびその使用 |
EP2702044B1 (en) | 2011-04-25 | 2017-03-22 | Hetero Research Foundation | Process for rilpivirine |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
EP2770830A4 (en) | 2011-10-28 | 2015-05-27 | Celgene Avilomics Res Inc | METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE) |
EP2782579B1 (en) | 2011-11-23 | 2019-01-02 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
JP6317320B2 (ja) | 2012-03-15 | 2018-04-25 | セルジーン シーエーアール エルエルシー | 上皮成長因子受容体キナーゼ阻害剤の塩 |
CN108658873B (zh) | 2012-03-15 | 2021-09-14 | 西建卡尔有限责任公司 | 表皮生长因子受体激酶抑制剂的固体形式 |
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CN106967047A (zh) * | 2017-03-29 | 2017-07-21 | 山东大学 | 一种取代二芳基烟酰胺类衍生物及其制备方法与应用 |
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CN111560013B (zh) * | 2020-06-08 | 2023-04-07 | 中山大学 | 一种自噬抑制剂及其应用 |
CN111875548A (zh) * | 2020-07-16 | 2020-11-03 | 山东大学 | 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用 |
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BRPI0516746A (pt) | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
EP2388249A1 (en) * | 2005-01-27 | 2011-11-23 | Tibotec Pharmaceuticals | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives |
AU2007233737B2 (en) | 2006-03-30 | 2012-11-29 | Janssen Sciences Ireland Uc | HIV inhibiting 5-amido substituted pyrimidines |
DK2114901T3 (da) | 2006-12-29 | 2014-06-30 | Janssen R & D Ireland | Hiv-inhiberende 6-substituerede pyrimidiner |
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2007
- 2007-12-28 EA EA200970656A patent/EA020749B1/ru not_active IP Right Cessation
- 2007-12-28 MX MX2009007006A patent/MX2009007006A/es active IP Right Grant
- 2007-12-28 EP EP14170114.4A patent/EP2781510B1/en active Active
- 2007-12-28 JP JP2009543477A patent/JP5283633B2/ja active Active
- 2007-12-28 WO PCT/EP2007/064606 patent/WO2008080965A2/en active Application Filing
- 2007-12-28 ES ES07858202.0T patent/ES2523863T3/es active Active
- 2007-12-28 BR BRPI0722079A patent/BRPI0722079B8/pt active IP Right Grant
- 2007-12-28 US US12/521,379 patent/US8318736B2/en active Active
- 2007-12-28 KR KR1020097011042A patent/KR20090094084A/ko not_active Application Discontinuation
- 2007-12-28 CA CA2674185A patent/CA2674185C/en active Active
- 2007-12-28 AU AU2007341228A patent/AU2007341228B2/en active Active
- 2007-12-28 EP EP07858202.0A patent/EP2114902B1/en active Active
- 2007-12-28 CN CN201610109305.5A patent/CN106045965A/zh active Pending
- 2007-12-28 CN CNA2007800486111A patent/CN101573342A/zh active Pending
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CN106045965A (zh) | 2016-10-26 |
US8318736B2 (en) | 2012-11-27 |
EP2114902B1 (en) | 2014-09-17 |
BRPI0722079B1 (pt) | 2020-01-14 |
CA2674185C (en) | 2017-02-28 |
WO2008080965A2 (en) | 2008-07-10 |
KR20090094084A (ko) | 2009-09-03 |
EP2781510B1 (en) | 2016-12-14 |
EP2114902A2 (en) | 2009-11-11 |
WO2008080965A3 (en) | 2008-09-04 |
CA2923637A1 (en) | 2008-07-10 |
BRPI0722079A2 (pt) | 2014-04-08 |
CN101573342A (zh) | 2009-11-04 |
JP2010514736A (ja) | 2010-05-06 |
ES2523863T3 (es) | 2014-12-02 |
US20100261722A1 (en) | 2010-10-14 |
EP2781510A1 (en) | 2014-09-24 |
JP5283633B2 (ja) | 2013-09-04 |
BRPI0722079B8 (pt) | 2021-05-25 |
EA200970656A1 (ru) | 2009-12-30 |
CA2923637C (en) | 2018-10-02 |
ES2618057T3 (es) | 2017-06-20 |
AU2007341228B2 (en) | 2013-04-18 |
AU2007341228A1 (en) | 2008-07-10 |
CA2674185A1 (en) | 2008-07-10 |
EA020749B1 (ru) | 2015-01-30 |
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