MA39840B1 - Dérivés indolés destinés à être utilisés dans le domaine de la médecine - Google Patents

Dérivés indolés destinés à être utilisés dans le domaine de la médecine

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Publication number
MA39840B1
MA39840B1 MA39840A MA39840A MA39840B1 MA 39840 B1 MA39840 B1 MA 39840B1 MA 39840 A MA39840 A MA 39840A MA 39840 A MA39840 A MA 39840A MA 39840 B1 MA39840 B1 MA 39840B1
Authority
MA
Morocco
Prior art keywords
atom
present
medicine
maintained
groups
Prior art date
Application number
MA39840A
Other languages
English (en)
Other versions
MA39840A (fr
Inventor
Phillip Cowley
Alan Wise
Susan Davis
Michael Kiczun
Original Assignee
Iomet Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201406154A external-priority patent/GB201406154D0/en
Priority claimed from GB201502156A external-priority patent/GB201502156D0/en
Application filed by Iomet Pharma Ltd filed Critical Iomet Pharma Ltd
Publication of MA39840A publication Critical patent/MA39840A/fr
Publication of MA39840B1 publication Critical patent/MA39840B1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

L'invention concerne un composé inhibiteur de la tryptophane-2,3-dioxygénase (tdo) et/ou de l'indoléamine-2,3-dioxygénase (ido) destiné à être utilisé dans le domaine de la médecine, ledit composé ayant la formule suivante : dans laquelle x1, x2, x3, x4 et x5 peuvent être identiques ou différents et chacun est indépendamment choisi parmi c, n et o; chaque atome ayant une ligne en pointillé pouvant indépendamment avoir une liaison double ou une liaison simple, à condition que les valences au niveau de chaque atome soient maintenues; chaque r1, r2, r3, r4, r5 et r7 pouvant être présent ou absent et pouvant être identique ou différent et étant choisi parmi h et un groupe organique substitué ou non substitué, à condition que le nombre de tels groupes r présents soit tel que les valences de x1, x2, x3, x4 et x5 soient maintenues; un ou deux groupes r6 pouvant être présents et étant choisis parmi h et un groupe organique substitué ou non substitué, à condition que le nombre de groupes r6 présents soit tel que la valence de l'atome de carbone auquel ils sont attachés est maintenue, et à condition qu'au moins un r6 soit un groupe organique comprenant un atome ayant une double liaison à un atome d'oxygène (de préférence un groupe carbonyle ou un groupe sulphonyle) en une position a, ß ou ? à l'atome de carbone auquel le r6 est attaché et dans lequel l'atome ayant une double liaison à un atome d'oxygène est également lié à un hétéro-atome.
MA39840A 2014-04-04 2015-03-19 Dérivés indolés destinés à être utilisés dans le domaine de la médecine MA39840B1 (fr)

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GB201406154A GB201406154D0 (en) 2014-04-04 2014-04-04 Pharmaceutical compound
GB201502156A GB201502156D0 (en) 2015-02-10 2015-02-10 Pharmaceutical compound
PCT/EP2015/055823 WO2015150097A1 (fr) 2014-04-04 2015-03-19 Dérivés indolés destinés à être utilisés dans le domaine de la médecine

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MA39840A MA39840A (fr) 2017-02-08
MA39840B1 true MA39840B1 (fr) 2020-10-28

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