DK2308420T3 - Flowcytometrisk system til tilvejebringelse af kønssorteret dyresperma - Google Patents
Flowcytometrisk system til tilvejebringelse af kønssorteret dyresperma Download PDFInfo
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- DK2308420T3 DK2308420T3 DK10184826.5T DK10184826T DK2308420T3 DK 2308420 T3 DK2308420 T3 DK 2308420T3 DK 10184826 T DK10184826 T DK 10184826T DK 2308420 T3 DK2308420 T3 DK 2308420T3
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Claims (17)
1. Flowcytometrisk system til sortering af spermatozoer med en egenskab A og med en egenskab B, hvor egenskab A er tegn på en levende X-spermatozo, og egenskab B er tegn på andet end en levende X-celle (~X), hvor systemet indbefatter et væskefremføringssystem til fremføring af en væske, der indeholder spermatozoerne, et flowcytometriapparat til modtagelse af væsken, formning af denne til en strøm og anvendelse af flowcytometri til klassificering af spermatozoerne i henhold til egenskaberne og et sorteringssystem til sortering af spermatozoerne i henhold til klassifikationen og i henhold til en sorteringsstrategi til tilvejebringelse af mindst én population, der indeholder ønskede spermatozoer, hvilket system er kendetegnet ved, at det indbefatter: en analog-til-digital-omformer til synkron sampling af et over tid varierende analogt output fra flowcytometriapparatet ved en samplinghastighed på 105 MHz eller højere og tilvejebringelse af et output, der indbefatter digital information svarende til det over tid varierende analoge output, hvor det over tid varierende analoge output og den tilsvarende digitale information er tegn på egenskab A eller egenskab B; og en eller flere digitale signalprocessorer til analyse og klassificering af den digitale information og tilvejebringelse af et sorteringssignal til sorteringssystemet som en funktion af den analyserede og klassificerede digitale information, hvor den ene eller de flere digitale signalprocessorer sammen indbefatter anvisninger i påvisning af impulser, der svarer til den digitale information, anvisninger i ekstraktion af træk i de påviste impulser og anvisninger i at skelne de påviste impulser som en funktion af deres ekstraherede træk.
2. System ifølge krav 1, der er kendetegnet ved, at det over tid varierende analoge output indbefatter en serie af bølgeformede impulser, der hver repræsenterer en egenskab for en spermatozo, og ved, at den ene eller de flere digitale signalprocessorer er til påvisning af dele af den digitale information, der svarer til de bølgeformede impulser, og til klassificering af de påviste dele, og ved, at den ene eller de flere digitale signalprocessorer er til tilvejebringelse af sorteringssignalet som en funktion af de påviste og klassificerede dele.
3. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at strømmen indeholder spermatozoer, der følger den ene efter den anden i en serie, som indbefatter sekventielle sæt af spermatozoer, der indbefatter første spermatozosæt, der hver indbefatter en eller flere spermatozoer med egenskab A, andet spermatozosæt, der hver indbefatter en eller flere spermatozoer med egenskab B, og tredje spermatozosæt, der hver indbefatter to eller flere, tæt placerede spermatozoer, hvoraf mindst én har egenskab A, og hvoraf mindst én har egenskab B.
4. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at sorteringssystemet er et dråbesorteringssystem eller et fotoskade-sorteringssystem eller et væskeomskiftnings-sorteringssystem.
5. System ifølge krav 1, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter anvisninger i definering af en beslutningsgrænse, der skelner mellem de ekstraherede træk, der repræsenterer egenskab A, og de ekstraherede træk, der repræsenterer egenskab B.
6. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en databehandlingsprocessor til samling af den digitale information til en fortløbende strøm.
7. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en impulsdetektionprocessor til påvisning af bølgeformede impulser, der repræsenteres af den digitale information, og ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information som en funktion af de påviste bølgeformede impulser.
8. System ifølge krav 7, der er kendetegnet ved, at systemet yderligere indbefatter et filter til filtrering af det analoge output ved en frekvens, der er lig med eller mindre end halvdelen af den fortløbende samplinghastighed for omformeren, og ved, at omformeren er til omformning af det filtrerede analoge output til tilsvarende digital information, og ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information som en funktion af en beslutningsgrænse.
9. System ifølge krav 1, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer omfatter en impulsdetektionsprocessor til påvisning af bølgeformede impulser, der repræsenteres af den digitale information, og hvor den ene eller de flere digitale processorer er til klassificering af den digitale information som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab A eller som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab B.
10. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en processor til ekstraktion og skelnen af træk til definering af en beslutningsgrænse, der skelner mellem ekstraherede træk, der repræsenterer egenskab A, og ekstraherede træk, der repræsenterer egenskab B, og ved, at processoren til ekstraktion og skelnen af træk er til ekstraktion af træk, der repræsenteres af den digitale information, og klassificering af trækkene som en funktion af beslutningsgrænsen.
11. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en processor til ekstraktion og skelnen af træk til definering af en beslutningsgrænse, der skelner mellem ekstraherede træk, der repræsenterer egenskab A, og ekstraherede træk, der repræsenterer egenskab B, og ved, at processoren til ekstraktion og skelnen af træk er til ekstrahering af træk, der repræsenteres af den digitale information, og klassificering af trækkene som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab A eller som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab B.
12. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en sorteringsprocessor, der reagerer på klassificeringen til tilvejebringelse af sorteringssignalerne til sorteringssystemet.
13. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer er til optælling af antallet af klassificerede spermatozoer med egenskab A eller med egenskab B.
14. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information som en funktion af reducering af en variationskoefficient for en population af spermatozoerne med egenskab A, så den er lig med eller mindre end en forvalgt værdi, eller som en funktion af minimering af en variationskoefficient for en population of spermatozoerne med egenskab B, så den er lig med eller mindre end en forvalgt værdi.
15. System ifølge krav 14, der er kendetegnet ved, at den forvalgte værdi er enten 1,5 % eller mindre eller er 1,3 % eller mindre.
16. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information, således at en population of spermatozoerne med egenskab A og en population of spermatozoerne med egenskab B svarer til en computermodel af tre populationer, der indbefatter en første modelpopulation af spermatozoer med egenskab A, en anden modelpopulation af spermatozoer med egenskab B og en tredje modelpopulation af ikke-indpassede spermatozoer, hvilken model er til estimering af populationstatistik for hver af den første, anden og tredje modelpopulation.
17. System ifølge krav 16, der er kendetegnet ved, at den tredje modelpopulation indbefatter to populationer af ikke-indpassede spermatozoer, og ved, at modellen er til estimering af populationsstatistik for de to populationer.
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