DK2308420T3 - Flowcytometrisk system til tilvejebringelse af kønssorteret dyresperma - Google Patents
Flowcytometrisk system til tilvejebringelse af kønssorteret dyresperma Download PDFInfo
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- DK2308420T3 DK2308420T3 DK10184826.5T DK10184826T DK2308420T3 DK 2308420 T3 DK2308420 T3 DK 2308420T3 DK 10184826 T DK10184826 T DK 10184826T DK 2308420 T3 DK2308420 T3 DK 2308420T3
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Claims (17)
1. Flowcytometrisk system til sortering af spermatozoer med en egenskab A og med en egenskab B, hvor egenskab A er tegn på en levende X-spermatozo, og egenskab B er tegn på andet end en levende X-celle (~X), hvor systemet indbefatter et væskefremføringssystem til fremføring af en væske, der indeholder spermatozoerne, et flowcytometriapparat til modtagelse af væsken, formning af denne til en strøm og anvendelse af flowcytometri til klassificering af spermatozoerne i henhold til egenskaberne og et sorteringssystem til sortering af spermatozoerne i henhold til klassifikationen og i henhold til en sorteringsstrategi til tilvejebringelse af mindst én population, der indeholder ønskede spermatozoer, hvilket system er kendetegnet ved, at det indbefatter: en analog-til-digital-omformer til synkron sampling af et over tid varierende analogt output fra flowcytometriapparatet ved en samplinghastighed på 105 MHz eller højere og tilvejebringelse af et output, der indbefatter digital information svarende til det over tid varierende analoge output, hvor det over tid varierende analoge output og den tilsvarende digitale information er tegn på egenskab A eller egenskab B; og en eller flere digitale signalprocessorer til analyse og klassificering af den digitale information og tilvejebringelse af et sorteringssignal til sorteringssystemet som en funktion af den analyserede og klassificerede digitale information, hvor den ene eller de flere digitale signalprocessorer sammen indbefatter anvisninger i påvisning af impulser, der svarer til den digitale information, anvisninger i ekstraktion af træk i de påviste impulser og anvisninger i at skelne de påviste impulser som en funktion af deres ekstraherede træk.
2. System ifølge krav 1, der er kendetegnet ved, at det over tid varierende analoge output indbefatter en serie af bølgeformede impulser, der hver repræsenterer en egenskab for en spermatozo, og ved, at den ene eller de flere digitale signalprocessorer er til påvisning af dele af den digitale information, der svarer til de bølgeformede impulser, og til klassificering af de påviste dele, og ved, at den ene eller de flere digitale signalprocessorer er til tilvejebringelse af sorteringssignalet som en funktion af de påviste og klassificerede dele.
3. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at strømmen indeholder spermatozoer, der følger den ene efter den anden i en serie, som indbefatter sekventielle sæt af spermatozoer, der indbefatter første spermatozosæt, der hver indbefatter en eller flere spermatozoer med egenskab A, andet spermatozosæt, der hver indbefatter en eller flere spermatozoer med egenskab B, og tredje spermatozosæt, der hver indbefatter to eller flere, tæt placerede spermatozoer, hvoraf mindst én har egenskab A, og hvoraf mindst én har egenskab B.
4. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at sorteringssystemet er et dråbesorteringssystem eller et fotoskade-sorteringssystem eller et væskeomskiftnings-sorteringssystem.
5. System ifølge krav 1, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter anvisninger i definering af en beslutningsgrænse, der skelner mellem de ekstraherede træk, der repræsenterer egenskab A, og de ekstraherede træk, der repræsenterer egenskab B.
6. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en databehandlingsprocessor til samling af den digitale information til en fortløbende strøm.
7. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en impulsdetektionprocessor til påvisning af bølgeformede impulser, der repræsenteres af den digitale information, og ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information som en funktion af de påviste bølgeformede impulser.
8. System ifølge krav 7, der er kendetegnet ved, at systemet yderligere indbefatter et filter til filtrering af det analoge output ved en frekvens, der er lig med eller mindre end halvdelen af den fortløbende samplinghastighed for omformeren, og ved, at omformeren er til omformning af det filtrerede analoge output til tilsvarende digital information, og ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information som en funktion af en beslutningsgrænse.
9. System ifølge krav 1, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer omfatter en impulsdetektionsprocessor til påvisning af bølgeformede impulser, der repræsenteres af den digitale information, og hvor den ene eller de flere digitale processorer er til klassificering af den digitale information som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab A eller som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab B.
10. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en processor til ekstraktion og skelnen af træk til definering af en beslutningsgrænse, der skelner mellem ekstraherede træk, der repræsenterer egenskab A, og ekstraherede træk, der repræsenterer egenskab B, og ved, at processoren til ekstraktion og skelnen af træk er til ekstraktion af træk, der repræsenteres af den digitale information, og klassificering af trækkene som en funktion af beslutningsgrænsen.
11. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en processor til ekstraktion og skelnen af træk til definering af en beslutningsgrænse, der skelner mellem ekstraherede træk, der repræsenterer egenskab A, og ekstraherede træk, der repræsenterer egenskab B, og ved, at processoren til ekstraktion og skelnen af træk er til ekstrahering af træk, der repræsenteres af den digitale information, og klassificering af trækkene som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab A eller som en funktion af en variationskoefficient for en population af spermatozoerne med egenskab B.
12. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer indbefatter en sorteringsprocessor, der reagerer på klassificeringen til tilvejebringelse af sorteringssignalerne til sorteringssystemet.
13. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer er til optælling af antallet af klassificerede spermatozoer med egenskab A eller med egenskab B.
14. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information som en funktion af reducering af en variationskoefficient for en population af spermatozoerne med egenskab A, så den er lig med eller mindre end en forvalgt værdi, eller som en funktion af minimering af en variationskoefficient for en population of spermatozoerne med egenskab B, så den er lig med eller mindre end en forvalgt værdi.
15. System ifølge krav 14, der er kendetegnet ved, at den forvalgte værdi er enten 1,5 % eller mindre eller er 1,3 % eller mindre.
16. System ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den ene eller de flere digitale signalprocessorer er til klassificering af den digitale information, således at en population of spermatozoerne med egenskab A og en population of spermatozoerne med egenskab B svarer til en computermodel af tre populationer, der indbefatter en første modelpopulation af spermatozoer med egenskab A, en anden modelpopulation af spermatozoer med egenskab B og en tredje modelpopulation af ikke-indpassede spermatozoer, hvilken model er til estimering af populationstatistik for hver af den første, anden og tredje modelpopulation.
17. System ifølge krav 16, der er kendetegnet ved, at den tredje modelpopulation indbefatter to populationer af ikke-indpassede spermatozoer, og ved, at modellen er til estimering af populationsstatistik for de to populationer.
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EP09014407.2A EP2194379B1 (en) | 2003-03-28 | 2004-03-29 | Apparatus and methods for providing sex-sorted animal sperm |
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DK10184321.7T DK2308418T3 (da) | 2003-03-28 | 2004-03-29 | Flowcytometridyse for tilvejebringelse af kønssorteret dyresæd |
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DK10183913.2T DK2309244T3 (da) | 2003-03-28 | 2004-03-29 | Apparatur og fremgangsmåder til tilvejebringelse af kønssorteret dyresperm |
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Families Citing this family (398)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1562035B1 (en) | 1997-01-31 | 2017-01-25 | Xy, Llc | Optical apparatus and method |
US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
JP2002521043A (ja) | 1998-07-30 | 2002-07-16 | エックスワイ,インコーポレイテッド | 非外科的人工授精のためのウマシステム |
US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
NZ551401A (en) * | 2000-05-09 | 2009-12-24 | Xy Inc | A particle differentiation apparatus which differentiates between X-chromosome bearing and Y-chromosome bearing populations of spermatozoa |
EP1294293A4 (en) * | 2000-06-12 | 2009-11-04 | Xy Inc | INTEGRATED FLUID MANAGEMENT SYSTEM USING ISOLATED POPULATIONS OF X- AND Y-CHROMOSOME-CARRYING SPERMATOZOES |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
AU2002220018A1 (en) | 2000-11-29 | 2002-06-11 | Colorado State University | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
US20060199260A1 (en) * | 2002-05-01 | 2006-09-07 | Zhiyu Zhang | Microbioreactor for continuous cell culture |
US7699767B2 (en) * | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
CA2532376C (en) | 2002-08-01 | 2015-05-12 | Colorado State University Research Foundation | Low pressure sperm cell separation system |
US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
BRPI0313476B1 (pt) | 2002-08-15 | 2015-06-23 | Xy Llc | Citômetro de fluxo de alta resolução |
US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
EP1608382B1 (en) | 2003-03-28 | 2007-08-15 | Monsanto Technology LLC | Process for the staining of sperm |
MX345105B (es) | 2003-03-28 | 2017-01-16 | Inguran Llc * | Método de fotodaño para separar partículas. |
AU2004242121B2 (en) * | 2003-05-15 | 2010-06-24 | Xy, Llc. | Efficient haploid cell sorting for flow cytometer systems |
KR101149880B1 (ko) * | 2003-08-13 | 2012-05-24 | 루미넥스 코포레이션 | 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법 |
EP1682438B1 (en) | 2003-10-30 | 2013-05-08 | Cytonome/ST, LLC | Multilayer hydrodynamic sheath flow structure |
DE602005018907D1 (de) * | 2004-03-29 | 2010-03-04 | Inguran Llc | Verwendung einer oxidations-/reduktionsreaktionen intrazellulär und/oder extrazellulär regulierenden zusammensetzung in einem anfärbe- oder sortierungsverfahren für spermatozoen |
AU2005228893B2 (en) | 2004-03-29 | 2010-08-19 | Inguran, Llc | Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations |
WO2005103642A1 (ja) * | 2004-04-23 | 2005-11-03 | The Furukawa Electric Co., Ltd. | 検体の分離と識別と分注方法とその装置及び解析装置 |
US8232962B2 (en) | 2004-06-21 | 2012-07-31 | Trading Technologies International, Inc. | System and method for display management based on user attention inputs |
JP2008507287A (ja) | 2004-07-22 | 2008-03-13 | モンサント テクノロジー エルエルシー | 精子細胞の集団を富化する方法 |
USRE46559E1 (en) * | 2004-07-27 | 2017-09-26 | Beckman Coulter, Inc. | Enhancing flow cytometry discrimination with geometric transformation |
US7340957B2 (en) | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
US7355696B2 (en) * | 2005-02-01 | 2008-04-08 | Arryx, Inc | Method and apparatus for sorting cells |
US7113266B1 (en) * | 2005-03-30 | 2006-09-26 | Beckman Coulter, Inc. | Flow cytometer for differentiating small particles in suspension |
ITBO20050481A1 (it) | 2005-07-19 | 2007-01-20 | Silicon Biosystems S R L | Metodo ed apparato per la manipolazione e/o l'individuazione di particelle |
US20070025879A1 (en) * | 2005-07-27 | 2007-02-01 | Dakocytomation Denmark A/S | Method and apparatus for syringe-based sample introduction within a flow cytometer |
US7518723B2 (en) * | 2005-09-19 | 2009-04-14 | Jmar Technologies, Inc. | Systems and methods for detecting radiation, biotoxin, chemical, and biological warfare agents using a multiple angle light scattering (MALS) instrument |
ITBO20050646A1 (it) | 2005-10-26 | 2007-04-27 | Silicon Biosystem S R L | Metodo ed apparato per la caratterizzazione ed il conteggio di particelle |
WO2007051170A2 (en) | 2005-10-28 | 2007-05-03 | The Regents Of The University Of California | Apparatus and method for improved optical detection of particles in fluid |
US7299135B2 (en) * | 2005-11-10 | 2007-11-20 | Idexx Laboratories, Inc. | Methods for identifying discrete populations (e.g., clusters) of data within a flow cytometer multi-dimensional data set |
US7595874B1 (en) | 2006-02-08 | 2009-09-29 | Sciperio, Inc. | Method of condensed cell slide preparation and detection of rarely occurring cells on microscope slides |
ITCN20060005A1 (it) * | 2006-03-22 | 2007-09-23 | Amc Italy Srl | Procedimento e apparecchiatura per rilevare il contenuto cromosomico di spermatozoo animali, in particolare ai fini del sessaggio di tali spermatozoi |
ITTO20060226A1 (it) | 2006-03-27 | 2007-09-28 | Silicon Biosystem S P A | Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche |
CN101611323B (zh) * | 2006-09-29 | 2013-02-20 | 密理博公司 | 流式细胞术脉冲的区分和应用 |
US7835000B2 (en) | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
US20130056398A1 (en) * | 2006-12-08 | 2013-03-07 | Visys Nv | Apparatus and method for inspecting and sorting a stream of products |
BE1017422A3 (nl) * | 2006-12-08 | 2008-09-02 | Visys Nv | Werkwijze en inrichting voor het inspecteren en sorteren van een productstroom. |
US8202733B1 (en) * | 2006-12-18 | 2012-06-19 | Shervin Javadi | System and method for obtaining a differential flow rate |
DE202007002350U1 (de) * | 2007-01-19 | 2008-05-29 | Liebherr-Hausgeräte Ochsenhausen GmbH | Kühl- und/oder Gefriergerät |
BRPI0700624A (pt) * | 2007-02-28 | 2008-10-14 | Pedrazzi Cesar Augusto Ferraz | processo de manipulação de sêmen |
US8101426B2 (en) * | 2007-03-02 | 2012-01-24 | Icyt Mission Technology, Inc. | System and method for the measurement of multiple fluorescence emissions in a flow cytometry system |
EP2122327B1 (en) * | 2007-03-13 | 2013-12-25 | Advanced Liquid Logic, Inc. | Method for improving absorbance detection of a droplet |
JP5936808B2 (ja) * | 2007-03-22 | 2016-06-22 | シンセティック ジェノミクス インコーポレーテッド | 嫌気性環境における微生物の区画化された培養のためのシステムおよび方法 |
EP2479552B1 (en) * | 2007-04-02 | 2015-09-02 | Acoustic Cytometry Systems, Inc. | Methods for enhanced analysis of acoustic field focused cells and particles |
US8290625B2 (en) | 2007-04-04 | 2012-10-16 | Beckman Coulter, Inc. | Flow cytometer sorter |
US8083068B2 (en) | 2007-04-09 | 2011-12-27 | Los Alamos National Security, Llc | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
US7837040B2 (en) * | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
JP5178069B2 (ja) * | 2007-06-29 | 2013-04-10 | ベックマン コールター, インコーポレイテッド | Mtシステムによる凝集像自動判定方法、装置、プログラムおよび記録媒体 |
AU2008293652B2 (en) * | 2007-08-24 | 2013-02-21 | Advanced Liquid Logic, Inc. | Bead manipulations on a droplet actuator |
KR100864138B1 (ko) * | 2007-09-04 | 2008-10-16 | 주식회사 노아바이오텍 | 정자의 고순도 성 분리방법 |
US7787197B2 (en) * | 2007-09-14 | 2010-08-31 | Becton, Dickinson And Company | Beam-adjusting optics |
CA2699319A1 (en) | 2007-09-17 | 2009-03-26 | Luminex Corporation | Systems, storage mediums, and methods for identifying particles in flow |
CA2701170A1 (en) * | 2007-09-29 | 2009-08-27 | Timothy James Williams | Composition and method to modify sperm function and increase male gender ratio in mammals |
US20100081862A1 (en) * | 2008-10-01 | 2010-04-01 | Timothy James Williams | Composition and method to modify sperm function and increase male gender ratio in mammals |
US8528406B2 (en) * | 2007-10-24 | 2013-09-10 | Los Alamos National Security, LLP | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8263407B2 (en) | 2007-10-24 | 2012-09-11 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
JP5378228B2 (ja) | 2007-10-29 | 2013-12-25 | シスメックス株式会社 | 細胞分析装置及び細胞分析方法 |
ITTO20070771A1 (it) * | 2007-10-29 | 2009-04-30 | Silicon Biosystems Spa | Metodo e apparato per la identificazione e manipolazione di particelle |
CN101873893B (zh) * | 2007-11-27 | 2013-09-04 | Ei频谱有限责任公司 | 基于荧光的移液器仪器 |
US8266950B2 (en) | 2007-12-19 | 2012-09-18 | Los Alamos National Security, LLP | Particle analysis in an acoustic cytometer |
US9594071B2 (en) * | 2007-12-21 | 2017-03-14 | Colin G. Hebert | Device and method for laser analysis and separation (LAS) of particles |
US10281385B2 (en) * | 2007-12-21 | 2019-05-07 | The United States Of America, As Represented By The Secretary Of The Navy | Device for laser analysis and separation (LAS) of particles |
CN105181407B (zh) * | 2008-03-31 | 2020-06-30 | 希森美康株式会社 | 制样装置与制样方法以及细胞分析装置与细胞分析方法 |
WO2009151624A1 (en) * | 2008-06-13 | 2009-12-17 | Xy, Inc. | Lubricious microfluidic flow path system |
PL2304020T3 (pl) | 2008-06-30 | 2019-06-28 | Microbix Biosystems Inc. | Sposób i urządzenie do sortowania komórek |
AU2009269054A1 (en) * | 2008-07-11 | 2010-01-14 | Intellicyt | Multi-sample particle analyzer system and method for high throughput screening |
US8105499B2 (en) * | 2008-07-14 | 2012-01-31 | International Business Macines Corporation | Transmission electron microscopy sample etching fixture |
US7844726B2 (en) | 2008-07-28 | 2010-11-30 | Trading Technologies International, Inc. | System and method for dynamically managing message flow |
BRPI0823085B8 (pt) * | 2008-08-21 | 2021-07-27 | Xy Llc | aparelho de análise de célula e método de retroassentamento de citômetro de fluxo |
WO2011120020A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet transport system for detection |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9598725B2 (en) * | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US8633015B2 (en) * | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
US9399215B2 (en) | 2012-04-13 | 2016-07-26 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
US10895575B2 (en) | 2008-11-04 | 2021-01-19 | Menarini Silicon Biosystems S.P.A. | Method for identification, selection and analysis of tumour cells |
EP2199956A1 (en) * | 2008-12-18 | 2010-06-23 | Siemens Aktiengesellschaft | Method and system for managing results of an analysis process on objects handled along a technical process line |
US8557587B2 (en) * | 2009-01-07 | 2013-10-15 | Xy, Llc | Self-tuning, biologically modeled sorter |
US9645010B2 (en) | 2009-03-10 | 2017-05-09 | The Regents Of The University Of California | Fluidic flow cytometry devices and methods |
US9134221B2 (en) | 2009-03-10 | 2015-09-15 | The Regents Of The University Of California | Fluidic flow cytometry devices and particle sensing based on signal-encoding |
ES2945686T3 (es) | 2009-05-13 | 2023-07-05 | Sartorius Bioanalytical Instr Inc | Medición y control de flujo para cuantificación mejorada de partículas en citometría de flujo |
EP2432869B1 (en) * | 2009-05-21 | 2020-08-12 | Essen Instruments, Inc. d/b/a Essen BioScience, Inc. | System and method for separating samples in a continuous flow |
EP2267430A1 (de) * | 2009-06-24 | 2010-12-29 | Masterrind GmbH | Vorrichtung und Verfahren zur Selektion von Partikeln |
US8665439B2 (en) * | 2009-06-30 | 2014-03-04 | Microbix Biosystems, Inc. | Method and apparatus for limiting effects of refraction in cytometry |
US20110001963A1 (en) * | 2009-07-02 | 2011-01-06 | Durack Gary P | System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system |
CN102472701A (zh) * | 2009-07-06 | 2012-05-23 | 索尼公司 | 微流体装置 |
CN102472709B (zh) * | 2009-07-06 | 2015-07-15 | 索尼公司 | 具有处理机载组织或细胞样品的能力的微流体装置 |
WO2011005757A1 (en) * | 2009-07-07 | 2011-01-13 | Sony Corporation | Microfluidic device adapted for post-centrifugation use with selective sample extraction and methods for its use |
US8891084B2 (en) * | 2009-07-07 | 2014-11-18 | Sony Corporation | Microfluidic device |
WO2011005754A1 (en) * | 2009-07-08 | 2011-01-13 | Sony Corporation | Microfluidic device having a flow channel within a gain medium |
US20110020855A1 (en) * | 2009-07-21 | 2011-01-27 | Masataka Shinoda | Method and apparatus for performing cytometry |
JP5446563B2 (ja) * | 2009-08-06 | 2014-03-19 | ソニー株式会社 | 微小粒子分取装置、および該微小粒子分取装置を用いたフローサイトメーター |
WO2011028539A1 (en) | 2009-09-02 | 2011-03-10 | Quantalife, Inc. | System for mixing fluids by coalescence of multiple emulsions |
EP2494036A4 (en) * | 2009-10-30 | 2013-08-28 | Inguran Llc | METHOD AND SYSTEMS FOR REDUCING DNA FRAGMENTATION IN A POPULATION OF SPERM CELLS |
US9057676B2 (en) | 2010-02-05 | 2015-06-16 | Cytonome/St, Llc | Multiple flow channel particle analysis system |
US20110223587A1 (en) * | 2010-03-11 | 2011-09-15 | Schulman Joseph D | Optical particle characterization system |
US20110223586A1 (en) * | 2010-03-11 | 2011-09-15 | David Karabinus | Optical particle characterization system |
EP2550351A4 (en) | 2010-03-25 | 2014-07-09 | Quantalife Inc | DETECTION SYSTEM FOR DROPLET-BASED ANALYZES |
CA2767182C (en) | 2010-03-25 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
JP5646196B2 (ja) | 2010-03-30 | 2014-12-24 | 武蔵エンジニアリング株式会社 | 吐出装置および液体分注装置並びに液体分注方法 |
BR112012025022A2 (pt) | 2010-04-01 | 2015-09-22 | Inguran Llc | "método de redução da fragmentação de dna em uma amostra de espermatozoides separados" |
US9470617B2 (en) * | 2010-04-07 | 2016-10-18 | Sony Corporation | Flow cytometry apparatus |
JP5437148B2 (ja) * | 2010-04-23 | 2014-03-12 | ベイバイオサイエンス株式会社 | フローサイトメータおよびセルソータ |
JP5841315B2 (ja) | 2010-04-28 | 2016-01-13 | ソニー株式会社 | 微小粒子分析装置 |
NZ603807A (en) | 2010-06-09 | 2014-09-26 | Xy Llc | A heterogeneous inseminate system |
CN105342553B (zh) * | 2010-06-30 | 2019-05-07 | 安派科生物医学科技有限公司 | 疾病检测仪 |
WO2012018410A1 (en) | 2010-08-05 | 2012-02-09 | St Reproductive Technologies Llc | Shipping containers and methods of transporting livestock |
US8720379B2 (en) | 2010-08-12 | 2014-05-13 | St Reproductive Technologies, Llc | Shipping containers for livestock |
US9102258B2 (en) | 2010-08-05 | 2015-08-11 | St Reproductive Technologies, Llc | Floating partition, loft and troughs for a livestock shipping container |
US9340762B2 (en) | 2010-08-20 | 2016-05-17 | Yu Sun | Method for automated sperm manipulation and device for holding sperm and oocytes |
IE20110394A1 (en) * | 2010-09-07 | 2013-01-02 | Univ Limerick | A liquid droplet dispenser |
KR101885936B1 (ko) | 2010-10-21 | 2018-09-10 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 무선 전력이 공급되는 전자 회로를 포함하는 미세 유체 |
DE202011110979U1 (de) | 2010-11-01 | 2017-12-04 | Bio-Rad Laboratories, Inc. | System zum Bilden von Emulsionen |
WO2012063687A1 (ja) * | 2010-11-09 | 2012-05-18 | 国立大学法人広島大学 | ヒト凍結精子用希釈液、ヒト凍結精子の希釈方法、及び、ヒトの体外受精用精液又は人工授精用精液の調整方法 |
US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
US8941062B2 (en) | 2010-11-16 | 2015-01-27 | 1087 Systems, Inc. | System for identifying and sorting living cells |
EP2640844B1 (en) * | 2010-11-16 | 2021-03-24 | 1087 Systems, Inc. | System for identifying and sorting living cells |
US20120225475A1 (en) | 2010-11-16 | 2012-09-06 | 1087 Systems, Inc. | Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells |
US8797395B2 (en) * | 2010-12-17 | 2014-08-05 | General Electric Company | Optical system for inspecting porous substrates |
EP2661614A2 (en) * | 2011-01-03 | 2013-11-13 | Cytonome/ST, LLC | Method and apparatus for monitoring and optimizing particle sorting |
US8618510B2 (en) * | 2011-01-28 | 2013-12-31 | The Regents Of The University Of Colorado | Optically integrated microfluidic cytometers for high throughput screening of photophysical properties of cells or particles |
EP2671065B1 (en) | 2011-02-04 | 2019-07-10 | Cytonome/ST, LLC | Particle sorting apparatus and method |
RU2586406C2 (ru) | 2011-02-15 | 2016-06-10 | Микробикс Байосистемз Инк. | Способ, система и устройство для осуществления проточной цитометрии |
SG193283A1 (en) | 2011-03-03 | 2013-10-30 | Life Technologies Corp | Sampling probes, systems, apparatuses, and methods |
CA2830443C (en) | 2011-03-18 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
US8990047B2 (en) | 2011-03-21 | 2015-03-24 | Becton, Dickinson And Company | Neighborhood thresholding in mixed model density gating |
WO2012132148A1 (ja) * | 2011-03-28 | 2012-10-04 | 三洋電機株式会社 | 分注装置および分注システム |
WO2012129591A1 (en) * | 2011-03-30 | 2012-10-04 | Empire Technology Development Llc | Material sorting system and method of sorting material |
CN103717749A (zh) | 2011-04-25 | 2014-04-09 | 伯乐生命医学产品有限公司 | 用于核酸分析的方法和组合物 |
BR112013027173B1 (pt) | 2011-04-29 | 2019-08-06 | Becton, Dickinson And Company | Sistema de classificador de célula, método para calibrar um sistema de classificador de célula, e sistema de controle de retardo de carga para um citômetro de fluxo |
EP2702132B1 (en) | 2011-04-29 | 2018-11-21 | Becton Dickinson and Company | Multi-way sorter system and method |
CN103608682B (zh) * | 2011-05-05 | 2017-01-18 | 安派科生物医学科技有限公司 | 肿瘤细胞检测仪 |
US20120301869A1 (en) * | 2011-05-25 | 2012-11-29 | Inguran, Llc | Particle separation devices, methods and systems |
US9781919B2 (en) | 2011-06-01 | 2017-10-10 | Inguran, Llc | Compositions and methods for improving the quality of processed sperm |
NZ764002A (en) | 2011-06-01 | 2022-12-23 | Inguran Llc | Compositions and methods for improving the quality of processed sperm |
JP2012251881A (ja) * | 2011-06-03 | 2012-12-20 | Bay Bioscience Kk | 液体フローに含まれる生物学的粒子を分析するシステム |
US9095414B2 (en) | 2011-06-24 | 2015-08-04 | The Regents Of The University Of California | Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea |
JP2013024629A (ja) * | 2011-07-19 | 2013-02-04 | Sysmex Corp | フローサイトメータ |
EP2737089B1 (en) | 2011-07-29 | 2017-09-06 | Bio-rad Laboratories, Inc. | Library characterization by digital assay |
US8514067B2 (en) | 2011-08-16 | 2013-08-20 | Elwha Llc | Systematic distillation of status data relating to regimen compliance |
US20140220621A1 (en) | 2011-08-25 | 2014-08-07 | Sony Corporation Of America | Characterization of motion-related error in a stream of moving micro-entities |
EP2761275B1 (en) | 2011-09-30 | 2017-06-21 | Inguran, LLC | Sperm staining and sorting methods |
DE102011115467A1 (de) * | 2011-10-10 | 2013-04-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung und Verfahren zur Druck-Kryokonservierung einer biologischen Probe |
US9568423B2 (en) | 2011-10-21 | 2017-02-14 | Acea Biosciences, Inc. | System and method for detecting multiple-excitation-induced light in a flow channel |
ITTO20110990A1 (it) | 2011-10-28 | 2013-04-29 | Silicon Biosystems Spa | Metodo ed apparato per l'analisi ottica di particelle a basse temperature |
CN103998915B (zh) * | 2011-12-20 | 2016-10-26 | 贝克顿·迪金森公司 | 用于改进分选颗粒的产量的系统和方法 |
ITBO20110766A1 (it) | 2011-12-28 | 2013-06-29 | Silicon Biosystems Spa | Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico |
WO2013111130A1 (en) * | 2012-01-23 | 2013-08-01 | Estar Technologies Ltd | A system and method for obtaining a cellular sample enriched with defined cells such as platelet rich plasma(prp) |
US20130199298A1 (en) * | 2012-02-03 | 2013-08-08 | Microsonic Systems Inc. | Apparatus for automation of fluid sample processing using ultrasonic waves |
JP2015508657A (ja) * | 2012-02-15 | 2015-03-23 | ザ・トランスレーショナル・ジェノミクス・リサーチ・インスティチュート | ゲノムプロファイリングのシステムおよび方法 |
EP3285062B1 (en) | 2012-02-29 | 2019-08-07 | Fluidigm Corporation | Methods, systems, and devices for multiple single-cell capturing and processing using microfluidics |
EP2827701B1 (en) | 2012-03-19 | 2020-11-18 | Malaysian Palm Oil Board | Gene controlling shell phenotype in palm |
JP5924077B2 (ja) | 2012-03-30 | 2016-05-25 | ソニー株式会社 | 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法 |
JP5601424B2 (ja) | 2012-03-30 | 2014-10-08 | ソニー株式会社 | 微小粒子分取装置及び該装置における流体ストリーム最適化方法 |
US9888990B2 (en) | 2012-06-06 | 2018-02-13 | Inguran, Llc | Methods for use of sex sorted semen to improve genetic management in swine |
US9433195B2 (en) * | 2012-06-06 | 2016-09-06 | Inguran, Llc | Methods for increasing genetic progress in a line or breed of swine using sex-selected sperm cells |
JP2013255447A (ja) * | 2012-06-12 | 2013-12-26 | Nippon Koden Corp | 細胞単離装置 |
WO2013188770A1 (en) | 2012-06-14 | 2013-12-19 | Bio-Rad Laboratories, Inc. | Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry |
WO2013192401A1 (en) * | 2012-06-22 | 2013-12-27 | Bio-Rad Laboratories, Inc. | Fluid mixing and rinsing system for a flow cytometer |
US9222874B2 (en) * | 2012-06-27 | 2015-12-29 | The United States Of America As Represented By The Secretary Of The Army | Systems and methods for individually trapping particles from air and measuring the optical spectra or other properties of individual trapped particles |
US9911572B2 (en) * | 2012-07-06 | 2018-03-06 | Eth Zurich | Method for controlling an interaction between droplet targets and a laser and apparatus for conducting said method |
JP2014020918A (ja) * | 2012-07-18 | 2014-02-03 | Sony Corp | 微小粒子測定装置及び微小粒子分析方法 |
EP3845885A1 (en) | 2012-07-27 | 2021-07-07 | Engender Technologies Limited | Method and system for microfluidic particle orientation and/or sorting |
US10379026B2 (en) | 2012-08-29 | 2019-08-13 | Inguran, Llc | Cell processing using magnetic particles |
ES2914373T3 (es) | 2012-08-29 | 2022-06-10 | Inguran Llc | Eliminación magnética o identificación de células o de estructuras celulares dañadas o comprometidas |
DK2898057T3 (da) | 2012-09-19 | 2022-10-10 | Inguran Llc | Strømningscytometersystem med en affaset dysespids |
US11668640B2 (en) * | 2015-03-06 | 2023-06-06 | Inguran, Llc | Nozzle assembly for a flow cytometry system and methods of manufacture |
EP2898325B1 (en) | 2012-09-19 | 2023-05-03 | Inguran, LLC | Nozzle assembly for a flow cytometer system |
JP6016547B2 (ja) * | 2012-09-19 | 2016-10-26 | 株式会社日立製作所 | 付着物検査装置 |
PL2903432T3 (pl) * | 2012-10-05 | 2019-10-31 | Inguran Llc | Sposoby traktowania plemników do sortowania ze względu na płeć |
US10620213B2 (en) | 2012-10-05 | 2020-04-14 | Inguran, Llc | High pressure sperm sorting and flow cytometer methods |
US8760658B2 (en) | 2012-10-12 | 2014-06-24 | Perkinelmer Health Sciences, Inc. | Flow cell modules and liquid sample analyzers and methods including same |
JP6396911B2 (ja) | 2012-10-15 | 2018-09-26 | ナノセレクト バイオメディカル, インコーポレイテッド | 粒子を選別するためのシステム、装置、および、方法 |
JP6065527B2 (ja) * | 2012-11-08 | 2017-01-25 | ソニー株式会社 | 微小粒子分取装置及び微小粒子分取方法 |
US20150168297A1 (en) * | 2013-12-15 | 2015-06-18 | Satish Deshpande | System to Distinguish between X Sperm and Y Sperm |
US10184929B2 (en) | 2012-12-16 | 2019-01-22 | Satish Deshpande | System to distinguish between X sperm and Y sperm |
US10467691B2 (en) | 2012-12-31 | 2019-11-05 | Trading Technologies International, Inc. | User definable prioritization of market information |
CN104169708B (zh) | 2013-01-28 | 2016-08-24 | 索尼公司 | 微粒分选装置和微粒分选方法 |
WO2014120985A1 (en) * | 2013-01-30 | 2014-08-07 | Kla-Tencor Corporation | Euv light source using cryogenic droplet targets in mask inspection |
US9207166B2 (en) * | 2013-01-31 | 2015-12-08 | Honeywell International Inc. | Micro-molded cytometer cartridge with integrated optics |
US10190963B2 (en) | 2013-02-01 | 2019-01-29 | Becton, Dickinson And Company | Methods and systems for assessing sample behavior in a flow cytometer |
CN105073262B (zh) * | 2013-03-14 | 2017-08-25 | 英格朗公司 | 用于高通过量精子分选的设备和方法 |
US9964968B2 (en) | 2013-03-14 | 2018-05-08 | Cytonome/St, Llc | Operatorless particle processing systems and methods |
US10662408B2 (en) * | 2013-03-14 | 2020-05-26 | Inguran, Llc | Methods for high throughput sperm sorting |
US9757726B2 (en) | 2013-03-14 | 2017-09-12 | Inguran, Llc | System for high throughput sperm sorting |
EP2972207B1 (en) | 2013-03-14 | 2022-09-21 | Cytonome/ST, LLC | Assemblies and methods for reducing optical crosstalk in particle processing systems |
US10190960B2 (en) | 2013-03-14 | 2019-01-29 | Cytonome/St, Llc | Micro-lens systems for particle processing systems |
NZ711384A (en) | 2013-03-14 | 2018-06-29 | Cytonome St Llc | Hydrodynamic focusing apparatus and methods |
US10371622B2 (en) | 2013-03-14 | 2019-08-06 | Inguran, Llc | Device for high throughput sperm sorting |
US9857361B2 (en) * | 2013-03-15 | 2018-01-02 | Iris International, Inc. | Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples |
CN105492887A (zh) * | 2013-03-15 | 2016-04-13 | 理查德·哈理·特纳 | 用于体液中的颗粒和可溶性化学实体的体外检测的系统和方法 |
JP5892967B2 (ja) * | 2013-03-29 | 2016-03-23 | シスメックス株式会社 | 細胞分析装置、細胞測定装置の管理方法およびコンピュータプログラム |
US8975595B2 (en) * | 2013-04-12 | 2015-03-10 | Becton, Dickinson And Company | Automated set-up for cell sorting |
JP6433982B2 (ja) * | 2013-04-19 | 2018-12-05 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. | 無接触微小滴ディスペンサおよび方法 |
JP6281193B2 (ja) * | 2013-05-30 | 2018-02-21 | ソニー株式会社 | レーザー走査型顕微鏡システム |
US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
FR3009084B1 (fr) * | 2013-07-23 | 2015-08-07 | Commissariat Energie Atomique | Procede pour trier des cellules et dispositif associe. |
CN105579829B (zh) | 2013-08-16 | 2019-02-19 | 生物辐射实验室股份有限公司 | 来自流式细胞器中的流体流的液滴的分离和/或充电的定时和/或相位调整 |
EP3042178B1 (en) | 2013-09-05 | 2019-08-21 | Bio-rad Laboratories, Inc. | Method of isolating a particle from a fluid sample |
US10343165B2 (en) | 2013-09-05 | 2019-07-09 | Bio-Rad Laboratories, Inc. | On-demand particle dispensing system |
CN103529036A (zh) * | 2013-10-08 | 2014-01-22 | 南京师范大学 | 一种鉴别杂交黄颡鱼幼鱼性别的方法 |
US10309891B2 (en) | 2013-10-16 | 2019-06-04 | Sony Corporation | Particle sorting apparatus, particle sorting method, and program |
JP6136843B2 (ja) * | 2013-10-17 | 2017-05-31 | ソニー株式会社 | 粒子分取装置、粒子分取方法及びプログラム |
CN105874316B (zh) | 2013-10-30 | 2022-06-28 | Abs全球公司 | 具有聚焦能量装置的微流体系统和方法 |
US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
EP3071951B1 (en) | 2013-11-19 | 2019-10-30 | ACEA Biosciences, Inc. | Optical engine for flow cytometer, flow cytometer system and methods of use |
US10261080B2 (en) | 2013-11-19 | 2019-04-16 | Acea Biosciences, Inc. | Optical detection system for flow cytometer, flow cytometer system and methods of use |
US10460387B2 (en) | 2013-12-18 | 2019-10-29 | Trading Technologies International, Inc. | Dynamic information configuration and display |
CN104749086B (zh) * | 2013-12-31 | 2018-12-18 | 深圳迈瑞生物医疗电子股份有限公司 | 多参考通道脉冲识别方法、装置及粒子分析仪 |
US10309892B2 (en) | 2014-02-13 | 2019-06-04 | Sony Corporation | Particle sorting device, particle sorting method, program, and particle sorting system |
JP6102783B2 (ja) * | 2014-02-14 | 2017-03-29 | ソニー株式会社 | 粒子分取装置、粒子分取方法及びプログラム |
JP2015161719A (ja) * | 2014-02-26 | 2015-09-07 | ソニー株式会社 | レーザー走査型顕微鏡システム及びサンプリング装置 |
US9880085B2 (en) | 2014-03-21 | 2018-01-30 | Intellicyt Corporation | Flow cytometer system including flow cytometer, autosampler and system integration structure |
CR20160513A (es) | 2014-05-02 | 2017-05-16 | Malaysian Palm Oil Board | Deteccion de fenotipo de cobertor en palma |
JP6313123B2 (ja) * | 2014-05-28 | 2018-04-18 | 東京エレクトロン株式会社 | 測定装置及び測定方法 |
JP6328493B2 (ja) * | 2014-05-28 | 2018-05-23 | 東京エレクトロン株式会社 | 測定装置及び測定方法 |
WO2015187783A1 (en) * | 2014-06-05 | 2015-12-10 | Virocyt, Inc. | Flow cytometer signal peak identification employing dynamic thresholding |
US9869628B2 (en) | 2014-06-25 | 2018-01-16 | Acea Biosciences, Inc. | Methods of collecting cells from multi-well plates for use in flow cytometry |
FR3022998B1 (fr) * | 2014-06-30 | 2016-07-15 | Alain Rousseau Techniques & Innovations Arteion | Systeme et ensemble de cytometrie en flux, dispositif d’analyse comprenant un tel ensemble de cytometrie et ensemble comprenant un tel systeme de cytometrie |
US9816626B1 (en) | 2014-07-15 | 2017-11-14 | Davis & Davis Company | Method and device for adapting an actuator to a valve |
FR3024738B1 (fr) * | 2014-08-11 | 2018-06-15 | Genes Diffusion | Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique |
WO2016028907A1 (en) * | 2014-08-20 | 2016-02-25 | Bio-Rad Laboratories, Inc. | Optofluidic sorter |
JP6657625B2 (ja) | 2014-09-05 | 2020-03-04 | ソニー株式会社 | 液滴分取装置、液滴分取方法及びプログラム |
CA2905670A1 (en) | 2014-09-26 | 2016-03-26 | Inguran, Llc | Sex sorted sperm demonstrating a dose response and methods of producing sex sorted sperm demonstrating a dose response |
US11965812B2 (en) | 2014-10-09 | 2024-04-23 | Kinetic River Corp. | Apparatus and methods for particle analysis and autofluorescence discrimination |
US11740174B2 (en) | 2014-10-09 | 2023-08-29 | Kinetic River Corp. | Apparatus and methods for particle analysis and autofluorescence discrimination |
US10564088B2 (en) | 2014-10-09 | 2020-02-18 | Kinetic River Corp. | Particle analysis and sorting apparatus and methods |
JP6832848B2 (ja) * | 2014-10-20 | 2021-02-24 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | 組織試料処理システム及びそれに関連する方法 |
JP6367351B2 (ja) * | 2014-10-22 | 2018-08-08 | 株式会社日立ハイテクノロジーズ | 細胞計測機構及びそれを有する細胞培養装置並びに細胞計測方法 |
CA2968414C (en) | 2014-11-20 | 2023-10-03 | Inguran, Llc | Low sugar sperm media and compositions |
WO2016090310A1 (en) | 2014-12-05 | 2016-06-09 | Inguran, Llc | Cell processing using magnetic particles |
JP6692834B2 (ja) | 2015-02-09 | 2020-05-13 | スリングショット バイオサイエンシーズ, インコーポレイテッド | 調整可能な光学特性を有するヒドロゲル粒子およびその使用の方法 |
WO2016132222A2 (en) | 2015-02-19 | 2016-08-25 | Premium Genetics (Uk) Ltd. | Scanning infrared measurement system |
WO2016142785A1 (en) * | 2015-03-10 | 2016-09-15 | Microbix Biosystems Inc. | Methods, systems and apparatus for sorting and processing analytes |
JP6397992B2 (ja) * | 2015-03-27 | 2018-09-26 | 東京エレクトロン株式会社 | 微粒子計測装置 |
WO2016161109A1 (en) * | 2015-03-31 | 2016-10-06 | The Regents Of The University Of California | System and method for tunable patterning and assembly of particles via acoustophoresis |
WO2016161292A1 (en) * | 2015-04-02 | 2016-10-06 | Particle Measuring Systems, Inc. | Laser noise detection and mitigation in particle counting instruments |
US10444141B2 (en) * | 2015-04-02 | 2019-10-15 | Carefusion 303, Inc. | Systems and methods for tracking particles in a fluid flow |
US10145776B2 (en) | 2015-04-13 | 2018-12-04 | Massachusetts Institute Of Technology | Fluid analysis using digital imagery |
EP3304040B1 (en) * | 2015-05-28 | 2023-04-19 | Accellix Ltd | System and apparatus for blind deconvolution of flow cytometer particle emission |
US10591474B2 (en) * | 2015-06-03 | 2020-03-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Point-of-care fluorescent immunoassay for identifying biomarkers in patient biofluid samples |
AU2016284332B2 (en) * | 2015-06-22 | 2019-05-09 | The Brigham And Women's Hospital, Inc | Home evaluation of the quality of semen samples |
WO2017033809A1 (ja) * | 2015-08-26 | 2017-03-02 | 倉敷紡績株式会社 | 細胞測定方法 |
JP5943366B1 (ja) * | 2015-08-28 | 2016-07-05 | 株式会社サタケ | 光学ユニットを備えた装置 |
JP6790490B2 (ja) | 2015-09-18 | 2020-11-25 | ソニー株式会社 | 情報処理装置、情報処理方法及び情報処理システム |
WO2017046988A1 (en) | 2015-09-18 | 2017-03-23 | Sony Corporation | Information processing apparatus, information processing method, and information processing system |
US10302545B2 (en) | 2015-10-05 | 2019-05-28 | Becton, Dickinson And Company | Automated drop delay calculation |
US9573038B1 (en) * | 2015-10-08 | 2017-02-21 | Waterway Plastics | Variable speed swim spa system |
ITUB20154668A1 (it) * | 2015-10-14 | 2017-04-14 | Mario Goisis | Dispositivo per la filtrazione del grasso estratto con procedure chirurgiche di liposuzione |
US10605714B2 (en) | 2015-10-19 | 2020-03-31 | Sony Corporation | Image processing device, fine particle sorting device, and image processing method |
USD793473S1 (en) | 2015-12-18 | 2017-08-01 | Abbott Laboratories | Print tape cartridge |
USD782695S1 (en) | 2015-12-18 | 2017-03-28 | Abbott Laboratories | Slide carrier |
USD802787S1 (en) | 2015-12-18 | 2017-11-14 | Abbott Laboratories | Slide carrier |
USD799055S1 (en) | 2015-12-18 | 2017-10-03 | Abbott Laboratories | Smear tape cartridge |
USD812244S1 (en) | 2015-12-18 | 2018-03-06 | Abbott Laboratories | Tube rack |
USD782064S1 (en) | 2015-12-18 | 2017-03-21 | Abbott Laboratories | Tube rack |
USD811616S1 (en) | 2015-12-18 | 2018-02-27 | Abbott Laboratories | Tube rack |
USD799057S1 (en) | 2015-12-18 | 2017-10-03 | Abbott Laboratories | Slide rack |
EP3362777B1 (de) * | 2015-12-23 | 2023-02-22 | Siemens Healthcare GmbH | Fliesszelle zur analyse von partikeln in einer zu untersuchenden flüssigkeit, verfahren und verwendung |
CN108474730A (zh) * | 2016-01-22 | 2018-08-31 | 索尼公司 | 微粒测量设备、信息处理设备、以及信息处理方法 |
AU2017212067A1 (en) | 2016-01-26 | 2018-08-02 | Ricoh Company, Ltd. | Droplet forming device and dispensing device |
USD799058S1 (en) | 2016-02-18 | 2017-10-03 | Abbott Laboratories | Slide caddy |
TWI601947B (zh) * | 2016-04-14 | 2017-10-11 | Ce Biotechnology Inc | Biological particle capture and capture system and method |
EP3443323B1 (en) | 2016-04-15 | 2023-11-29 | Becton, Dickinson and Company | Enclosed droplet sorter, methods of using the same, and kit |
CN109863384B (zh) | 2016-06-10 | 2022-10-28 | 加利福尼亚大学董事会 | 基于图像的细胞分选系统和方法 |
CN109313119B (zh) * | 2016-06-20 | 2021-11-02 | 普莱尔股份公司 | 用于检测和/或表征流体携带的颗粒的装置和方法 |
DE102016211038A1 (de) | 2016-06-21 | 2017-12-21 | Cytena Gmbh | Vorrichtung und Verfahren zum Detektieren von Zellen oder Partikeln in einem Fluidbehälter |
JP6686800B2 (ja) * | 2016-08-31 | 2020-04-22 | ウシオ電機株式会社 | 光学測定器 |
CN107884319B (zh) * | 2016-09-30 | 2023-05-02 | 日本电气株式会社 | 用于对粉尘传感器进行标定的系统和方法 |
CN115254210A (zh) * | 2016-11-14 | 2022-11-01 | 浩康生物系统公司 | 用于分选目标颗粒的方法和装置 |
US11577366B2 (en) | 2016-12-12 | 2023-02-14 | Omax Corporation | Recirculation of wet abrasive material in abrasive waterjet systems and related technology |
CN108205337A (zh) * | 2016-12-19 | 2018-06-26 | 广州康昕瑞基因健康科技有限公司 | 混匀仪的保温结构 |
WO2018123343A1 (ja) * | 2016-12-28 | 2018-07-05 | 株式会社日立製作所 | 超音波計測装置及び超音波計測方法 |
FR3061910A1 (fr) | 2017-01-18 | 2018-07-20 | Genes Diffusion | Dispostif et procede de discrimination de spermatozoides |
EP3351926A1 (en) * | 2017-01-18 | 2018-07-25 | Hifibio | Method for analyzing and selecting a specific droplet among a plurality of droplets and associated apparatus |
CN114732007B (zh) * | 2017-01-20 | 2024-04-12 | 英格朗公司 | 精子处理方法、装置和有关介质组合物 |
US11982611B2 (en) | 2017-03-20 | 2024-05-14 | Nanocellect Biomedical, Inc. | Systems, apparatuses, and methods for cell sorting and flow cytometry |
USD868991S1 (en) * | 2017-03-28 | 2019-12-03 | Becton, Dickinson And Company | Register block |
USD869676S1 (en) * | 2017-03-28 | 2019-12-10 | Becton, Dickinson And Company | Particle sorting module |
EP3602003A1 (en) * | 2017-03-31 | 2020-02-05 | Life Technologies Corporation | Apparatuses, systems and methods for imaging flow cytometry |
CN107063977A (zh) * | 2017-04-23 | 2017-08-18 | 湖南乾康科技有限公司 | 一种多通道计数池 |
WO2018213643A1 (en) | 2017-05-18 | 2018-11-22 | 10X Genomics, Inc. | Methods and systems for sorting droplets and beads |
US10544413B2 (en) | 2017-05-18 | 2020-01-28 | 10X Genomics, Inc. | Methods and systems for sorting droplets and beads |
US11525767B2 (en) | 2017-05-24 | 2022-12-13 | Sony Corporation | Optimizing method of suction condition of microparticle and microparticle fractionating device |
RU177494U1 (ru) * | 2017-07-14 | 2018-02-28 | Общество с ограниченной ответственностью "Фармпласт" | Пистолет-дозатор для искусственного осеменения птиц и домашних животных |
RU2727679C2 (ru) * | 2017-07-17 | 2020-07-22 | Ингуран, Ллк | Установка и способы для высокопроизводительной сортировки спермы |
BR112020000896A2 (pt) * | 2017-07-19 | 2020-07-21 | Inguran, Llc | método e sistema que incorporam os elementos ópticos de modelagem do feixe e a estabilização do feixe. |
US10558001B2 (en) * | 2017-07-25 | 2020-02-11 | Canon U.S.A., Inc. | Optical alignment of fiber-optic rotary joint assembly |
CN107276330A (zh) * | 2017-08-01 | 2017-10-20 | 安徽达来电机有限公司 | 一种电机组装用模具 |
EP3667290A4 (en) * | 2017-08-08 | 2020-07-29 | Sony Corporation | INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING PROCESS AND PROGRAM |
US10821442B2 (en) | 2017-08-22 | 2020-11-03 | 10X Genomics, Inc. | Devices, systems, and kits for forming droplets |
US10069027B1 (en) * | 2017-09-15 | 2018-09-04 | Premium Genetics (Uk) Ltd | Cytometer sperm sex sensing apparatus with an avalanche photodiode |
US11204310B2 (en) | 2017-09-21 | 2021-12-21 | Bit Group France | Optical flow cytometer for epi fluorescence measurement |
EP3687416A1 (en) | 2017-09-29 | 2020-08-05 | Nanovare SAS | Devices and methods for analysis of male infertility |
WO2019083852A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING |
GB201721824D0 (en) * | 2017-12-22 | 2018-02-07 | Asymptote Ltd | Apparatus and methods relating to freezing at least part of a biological sample |
USD882817S1 (en) | 2018-01-30 | 2020-04-28 | Becton, Dickinson And Company | Sample container |
USD864415S1 (en) | 2018-01-30 | 2019-10-22 | Becton, Dickinson And Company | Particle sorting system |
USD876668S1 (en) | 2018-01-30 | 2020-02-25 | Becton, Dickinson And Company | Particle sorting module mount |
USD872296S1 (en) * | 2018-01-30 | 2020-01-07 | Becton, Dickinson And Company | Particle sorting module |
US11561162B2 (en) * | 2018-03-19 | 2023-01-24 | Sony Corporation | Information processing device, information processing system, and information processing method |
US10591400B2 (en) | 2018-03-29 | 2020-03-17 | Sony Corporation | Micro particle analyzer and micro particle analysis method |
US11441997B2 (en) | 2018-03-30 | 2022-09-13 | Idexx Laboratories, Inc. | Quality control for point-of-care diagnostic systems |
US20190310243A1 (en) | 2018-04-09 | 2019-10-10 | Inguran, Llc | Methods and compositions for determining the presence or absence of dna aberrations |
AU2019300685A1 (en) * | 2018-04-25 | 2020-11-26 | Engender Technologies Ltd. | Systems, devices and methods associated with microfluidic systems |
EP3785015B1 (en) | 2018-04-27 | 2024-06-26 | Becton, Dickinson and Company | Flow cytometers having enclosed droplet sorters with controlled aerosol content and methods of using the same |
EP3785017A4 (en) * | 2018-04-27 | 2022-01-26 | Becton, Dickinson and Company | COLLECTION SYSTEMS FOR STREAM CYTOMETRICALLY SORTED SAMPLES AND METHODS OF USE THEREOF |
EP3796998A1 (en) | 2018-05-23 | 2021-03-31 | ABS Global, Inc. | Systems and methods for particle focusing in microchannels |
FR3081292B1 (fr) * | 2018-05-24 | 2020-06-05 | Imv Technologies | Dispositif de collecte de semence animale |
CN108841717B (zh) * | 2018-05-31 | 2021-06-29 | 张艳 | 一种冷冻卵细胞的解冻装置 |
US11427804B2 (en) | 2018-06-15 | 2022-08-30 | Abs Global, Inc. | Apparatus and method for cell kill confirmation |
JP7076300B2 (ja) * | 2018-06-26 | 2022-05-27 | マークテック株式会社 | 紫外線探傷灯 |
US11002915B2 (en) * | 2018-06-29 | 2021-05-11 | Taiwan Semiconductor Manufacturing Co., Ltd. | Fiber-to-chip grating coupler for photonic circuits |
US11911553B2 (en) * | 2018-07-06 | 2024-02-27 | Fenwal, Inc. | Systems and methods for concentrating cells with a syringe and a centrifuge |
CA3106121A1 (en) * | 2018-07-10 | 2020-01-16 | Gerrit Jan Van Den Engh | System, apparatus and method for off-axis illumination in flow cytometry |
GB2576191B (en) * | 2018-08-08 | 2022-11-16 | Sphere Fluidics Ltd | Droplet processing methods and systems |
EP3842771A4 (en) * | 2018-08-22 | 2022-05-11 | Hitachi High-Tech Corporation | AUTOMATIC ANALYZER AND OPTICAL MEASUREMENT PROCEDURE |
JP7338336B2 (ja) * | 2018-09-10 | 2023-09-05 | ソニーグループ株式会社 | 微小粒子分取装置、細胞治療薬製造装置、微小粒子分取方法、及びプログラム |
US10908065B2 (en) | 2018-09-17 | 2021-02-02 | Inguran, Llc | Light collection from objects within a fluid column |
CN113316713A (zh) | 2018-10-17 | 2021-08-27 | 贝克顿·迪金森公司 | 颗粒分析仪的自适应分选 |
US11035776B2 (en) * | 2018-10-30 | 2021-06-15 | Becton, Dickinson And Company | Particle sorting module with alignment window, systems and methods of use thereof |
US11614756B2 (en) * | 2018-11-30 | 2023-03-28 | Halliburton Energy Services, Inc. | Flow rate management for improved recovery |
WO2020128561A1 (en) * | 2018-12-21 | 2020-06-25 | Premium Genetics (Uk) Ltd. | System and methods for sub-population identification |
CN109819955B (zh) * | 2019-01-02 | 2022-03-01 | 北京农业智能装备技术研究中心 | 桨叶组件及航空雾化系统 |
JP2022522263A (ja) | 2019-01-11 | 2022-04-15 | ベクトン・ディキンソン・アンド・カンパニー | 最適化されたソーティングゲート |
US11137337B2 (en) | 2019-01-21 | 2021-10-05 | Essen Instruments, Inc. | Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation |
JP7485682B2 (ja) * | 2019-02-08 | 2024-05-16 | ベクトン・ディキンソン・アンド・カンパニー | 液滴選別決定モジュール、システム、及びその使用方法 |
EP3698871A1 (en) * | 2019-02-19 | 2020-08-26 | Gottfried Wilhelm Leibniz Universität Hannover | Laser based sorting of droplets in microfluidic streams |
WO2020175381A1 (ja) * | 2019-02-27 | 2020-09-03 | 京セラ株式会社 | 粒子分離計測デバイスおよび粒子分離計測装置 |
JP2020148830A (ja) * | 2019-03-11 | 2020-09-17 | ルネサスエレクトロニクス株式会社 | 半導体装置およびその製造方法 |
WO2020191064A1 (en) * | 2019-03-19 | 2020-09-24 | Inguran, Llc | Method for improved sperm cell populations |
US20220404351A1 (en) * | 2019-03-22 | 2022-12-22 | Kaya17 Inc. | System and method for detecting presence of a target bioparticle in a sample via a vertical flow assay |
US10777049B1 (en) * | 2019-03-29 | 2020-09-15 | Honeywell International Inc. | Strobes and speaker-strobes for a mass notification system |
EP3955735B1 (en) | 2019-04-18 | 2024-05-22 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
US20220355295A1 (en) * | 2019-04-24 | 2022-11-10 | Bennubio, Inc. | Positionally Assisted Negative particle Rejection (PANR) to sort and enrich target cells of interest |
CN110231682B (zh) * | 2019-05-09 | 2021-07-27 | 上海大学 | 一种用于神经活动调控的光电光纤及制作方法 |
CN110187126A (zh) * | 2019-05-29 | 2019-08-30 | 中国农业大学 | Scamp1蛋白在鉴定哺乳动物精子性别中的应用 |
US11513114B2 (en) * | 2019-05-29 | 2022-11-29 | Abs Global, Inc. | Kill event optimization |
CN110465339B (zh) * | 2019-09-03 | 2021-02-09 | 浙江大学 | 一种流固两相输运中颗粒定位的方法 |
EP4038371A4 (en) * | 2019-10-04 | 2024-01-10 | Genetirate, Inc. | AUTOMATED ORGANISM SORTING DEVICE AND METHOD OF USE |
CN111080401A (zh) * | 2019-11-25 | 2020-04-28 | 苏宁云计算有限公司 | 一种年龄估计方法及装置 |
CN111010538B (zh) * | 2019-12-06 | 2021-04-23 | 吕衍荣 | 风杯式自洁高空抛物监控摄像头 |
CN111050129B (zh) * | 2019-12-06 | 2021-06-22 | 深圳市智慧仔物联有限公司 | 一种高空抛物监控摄像头 |
CN111037814B (zh) * | 2020-01-07 | 2021-08-03 | 吉林大学 | 一种智能高效硫化压力机及其控制方法 |
US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
WO2021150838A1 (en) * | 2020-01-24 | 2021-07-29 | Slingshot Biosciences, Inc. | Compositions and methods for cell-like calibration particles |
US11709116B2 (en) | 2020-02-04 | 2023-07-25 | Sartorius Bioanalytical Instruments, Inc. | Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods |
WO2021163335A1 (en) * | 2020-02-11 | 2021-08-19 | Tsi Incorporated | Photoelectric sensor for seed dispensing system |
CN111307695B (zh) * | 2020-03-11 | 2022-06-14 | 深圳大学 | 一种用于细胞计数的激光散射分类装置的校验装置及方法 |
US11584662B2 (en) * | 2020-03-16 | 2023-02-21 | Inguran, Llc | Systems and method for correction of positionally dependent electromagnetic radiation detected from objects within a fluid column |
CN111220588B (zh) * | 2020-03-24 | 2023-05-16 | 哈尔滨工业大学(威海) | 一种基于油膜荧光亮度的流场辐聚辐散测量方法 |
CN111500530A (zh) * | 2020-04-30 | 2020-08-07 | 延安大学 | 一种通用型动物精子分选方法及x精子质控方法 |
CA3177834A1 (en) | 2020-05-04 | 2021-11-11 | Jeffrey Kim | Compositions and methods for passive optical barcoding for multiplexed assays |
CN111537697B (zh) * | 2020-05-12 | 2022-03-11 | 西南石油大学 | 一种超临界水与页岩反应的室内模拟装置和方法 |
CN111521547A (zh) * | 2020-05-13 | 2020-08-11 | 洹仪科技(上海)有限公司 | 一种颗粒分析分选装置及方法 |
CN114556086A (zh) * | 2020-05-19 | 2022-05-27 | 生命科技股份有限公司 | 用于流式细胞仪的喷嘴密封和疏通站 |
WO2021257144A1 (en) * | 2020-06-19 | 2021-12-23 | Becton, Dickinson And Company | Flow cytometer with adjustable positional offset sort deflection plates and methods of using the same |
WO2021259903A1 (en) | 2020-06-22 | 2021-12-30 | Westfälische Wilhelms-Universität Münster | Sperm stratification |
WO2021262359A1 (en) * | 2020-06-24 | 2021-12-30 | Becton, Dickinson And Company | Flow cytometric droplet dispensing systems and methods for using the same |
CN111915779B (zh) * | 2020-07-31 | 2022-04-15 | 浙江大华技术股份有限公司 | 一种闸机控制方法、装置、设备和介质 |
CN112099216B (zh) * | 2020-08-18 | 2022-06-21 | 宁波永新光学股份有限公司 | 一种电动荧光显微镜的调焦方法 |
CN111948082B (zh) * | 2020-08-19 | 2022-06-17 | 西南交通大学 | 一种冷热冲击试验装置 |
CN114244998B (zh) * | 2020-08-27 | 2024-01-09 | 南宁富联富桂精密工业有限公司 | 可动式摄像装置及其控制方法 |
CN112112627B (zh) * | 2020-09-05 | 2022-11-04 | 百恒石油装备有限公司 | 一种数字化条件下的油井生产参数检测方法 |
WO2022055656A1 (en) * | 2020-09-10 | 2022-03-17 | Becton, Dickinson And Company | Laser light propagation systems for irradiating a sample in a flow stream and methods for using same |
CN111832845B (zh) * | 2020-09-21 | 2020-12-11 | 武汉元光科技有限公司 | 一种公交线路判定方法、装置、设备和存储介质 |
CN112088838B (zh) * | 2020-09-29 | 2021-12-24 | 邢国兵 | 一种龟鳖孵化系统 |
CN112400862A (zh) * | 2020-11-24 | 2021-02-26 | 长沙医学院 | 一种精原干细胞冷冻保存系统及其保存方法 |
EP4267938A4 (en) * | 2020-12-23 | 2024-06-05 | Engender Technologies Limited | PARTICLE CLASSIFICATION AND SORTING SYSTEMS AND METHODS |
CN112485854B (zh) * | 2020-12-24 | 2022-04-22 | 中国工程物理研究院激光聚变研究中心 | 一种传输反射镜及其在降低背向散射光对激光驱动器损伤风险中的应用 |
CN112782045B (zh) * | 2021-02-05 | 2022-04-12 | 西南石油大学 | 测定高温高压泡沫液膜渗透能力的装置及其使用方法 |
CN113109537B (zh) * | 2021-03-05 | 2023-04-28 | 山东淄博民康药业包装有限公司 | 一种对注射器针头的自动检测装置 |
US11858008B2 (en) | 2021-03-26 | 2024-01-02 | Cytonome/St, Llc | Systems and methods for particle sorting with automated adjustment of operational parameters |
CN113387475B (zh) * | 2021-06-17 | 2022-06-21 | 长沙水老官食品有限公司 | 一种高效抑菌净水装置 |
CN113417613B (zh) * | 2021-06-21 | 2023-03-24 | 中国石油大学(华东) | 一种可定制波形的水力脉冲发生实验装置及其实验方法 |
CN113466408A (zh) * | 2021-06-23 | 2021-10-01 | 新疆生产建设兵团第八师生态环境监测站(石河子市生态环境监测站) | 一种移动式大气臭氧监测和处理装置及方法 |
US20230046207A1 (en) * | 2021-08-10 | 2023-02-16 | Becton, Dickinson And Company | Outlet fittings for reducing bubbles at the interface with a flow cell, and flow cytometers and methods using the same |
CN114062229B (zh) * | 2021-09-07 | 2022-09-23 | 浙江大学 | 一种推断颗粒物化学组分的凝结核粒子计数器 |
CN114113517B (zh) * | 2021-10-28 | 2023-08-29 | 江苏食品药品职业技术学院 | 一种河湖水质巡检装置及方法 |
CN114257800B (zh) * | 2021-12-21 | 2023-08-18 | 重庆杰夫与友文化创意有限公司 | 一种智能投影方法、系统及智能投影设备 |
WO2023235591A1 (en) * | 2022-06-03 | 2023-12-07 | The Jackson Laboratory | Device to improve sorting stream alignment on cell sorter |
CN114878440B (zh) * | 2022-07-08 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | 一种样本分析仪及其堵孔检测方法 |
WO2024020348A2 (en) * | 2022-07-18 | 2024-01-25 | Acoustic Bio Inc. | Submersion transducer with adjustable focus |
TWI828453B (zh) * | 2022-11-30 | 2024-01-01 | 博訊生物科技股份有限公司 | 重力分注裝置、具該重力分注裝置的細胞繼代處理機及細胞繼代處理方法 |
CN115791305B (zh) * | 2023-02-03 | 2023-04-14 | 山西宝辉环保科技有限公司 | 一种用于环境检测的水检测装置 |
CN117721005A (zh) * | 2023-12-23 | 2024-03-19 | 木蕊(上海)医药科技有限公司 | 一种细菌耐药性变化测试装置及其测试方法 |
Family Cites Families (724)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US34782A (en) * | 1862-03-25 | Improvement in lamps | ||
US2217342A (en) | 1938-05-19 | 1940-10-08 | Aaron G Ladrach | Time or speed controlled delayed action relay for strip material classifiers |
US3005756A (en) | 1958-11-14 | 1961-10-24 | Noland L Van Demark | Diluter containing carbon dioxide for preserving semen |
US3299354A (en) * | 1962-07-05 | 1967-01-17 | Coulter Electronics | Aperture tube structure for particle study apparatus |
US3499435A (en) | 1967-06-02 | 1970-03-10 | Paul E Rockwell | Esophageal probe for use in monitoring |
US3547526A (en) | 1967-10-26 | 1970-12-15 | Kollsman Instr Corp | Optical beam cross-section converter |
US3810010A (en) | 1968-11-02 | 1974-05-07 | Telefunken Patent | Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path |
US3829216A (en) | 1968-11-26 | 1974-08-13 | M Persidsky | Optical system and method for counting sperm cells |
DE1815352C3 (de) | 1968-12-18 | 1975-03-20 | Wolfgang Prof. Dr. Dittrich | Automatisches MeB- und Zählgerät für die Teilchen einer Dispersion |
US4327177A (en) | 1969-04-10 | 1982-04-27 | Wallace Shrimpton | Method and means for controlling the sex of mammalian offspring and product therefor |
US3894529A (en) | 1969-04-10 | 1975-07-15 | Bio Controls Inc | Method and means for controlling the sex of mammalian offspring and product therefor |
US4474875A (en) | 1969-04-10 | 1984-10-02 | Wallace Shrimpton | Method and means for controlling the sex of mammalian offspring and product therefor |
DE1919628C3 (de) | 1969-04-18 | 1975-04-10 | Wolfgang Prof. Dr. Dittrich | Anordnung zum automatischen Zählen und/oder Klassifizieren von in einem strömungsfähigen Medium dispergierten Teilchen |
US3687806A (en) | 1969-11-04 | 1972-08-29 | Bio Controls Inc | Method for controlling sex of mammalian offspring |
US3788744A (en) | 1970-01-14 | 1974-01-29 | Bio Physics Systems Inc | Method and apparatus for photoanalysis |
US3661460A (en) | 1970-08-28 | 1972-05-09 | Technicon Instr | Method and apparatus for optical analysis of the contents of a sheathed stream |
US3816249A (en) | 1970-11-23 | 1974-06-11 | B Bhattacharya | Universal medium and method for extending the useful life of semen in vitro |
US3644128A (en) | 1970-12-28 | 1972-02-22 | Stuart Lipner | Method of preparing comminuted meat products |
US3756459A (en) | 1971-01-12 | 1973-09-04 | Damon Corp | Method and apparatus for metering fluid utilizing pressure differentials |
US3916143A (en) | 1971-04-22 | 1975-10-28 | Research Corp | Branding living animals |
US3791384A (en) | 1971-07-15 | 1974-02-12 | Schaumann H | Artificial insemination of sows |
US3833796A (en) | 1971-10-13 | 1974-09-03 | Georgia Tech Res Inst | Method and apparatus for chromosome digitizing |
BE793185A (fr) | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
US3826364A (en) | 1972-05-22 | 1974-07-30 | Univ Leland Stanford Junior | Particle sorting method and apparatus |
US3761941A (en) | 1972-10-13 | 1973-09-25 | Mead Corp | Phase control for a drop generating and charging system |
CA1029833A (en) | 1973-02-23 | 1978-04-18 | Hildegarde Goehde | Apparatus for the automatic counting and measuring of suspended particles |
US3791517A (en) | 1973-03-05 | 1974-02-12 | Bio Physics Systems Inc | Digital fluidic amplifier particle sorter |
US4009260A (en) | 1973-04-19 | 1977-02-22 | Schering Aktiengesellschaft | Fractionation of sperm |
US3893766A (en) | 1973-06-14 | 1975-07-08 | Coulter Electronics | Apparatus for orienting generally flat particles for slit-scan photometry |
USRE29141E (en) | 1973-06-14 | 1977-02-22 | Coulter Electronics, Inc. | Apparatus for orienting generally flat particles for sensing |
US3947093A (en) | 1973-06-28 | 1976-03-30 | Canon Kabushiki Kaisha | Optical device for producing a minute light beam |
US3944917A (en) | 1973-08-13 | 1976-03-16 | Coulter Electronics, Inc. | Electrical sensing circuitry for particle analyzing device |
US3909744A (en) | 1973-09-24 | 1975-09-30 | United Technologies Corp | Unstable resonator system producing a high irradiance beam in the far field |
US3854470A (en) | 1973-11-23 | 1974-12-17 | L Augspurger | Reproduction processes for cellular bodies |
US3906929A (en) | 1973-11-23 | 1975-09-23 | Lynn Lawrence Augspurger | Processes for reproduction of cellular bodies |
FR2254639B1 (da) | 1973-12-18 | 1978-06-02 | Agronomique Inst Nat Rech | |
US4070617A (en) | 1974-05-08 | 1978-01-24 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Device for controlling the particle flow in an apparatus for measuring the properties of particles suspended in liquid |
US3973196A (en) | 1974-05-24 | 1976-08-03 | Coulter Electronics, Inc. | Method and apparatus for ejecting a metered amount of particulate sample |
US3963606A (en) | 1974-06-03 | 1976-06-15 | Coulter Electronics, Inc. | Semi-automatic adjusting delay for an electronic particle separator |
US3877430A (en) | 1974-07-17 | 1975-04-15 | Horst K Wieder | Artificial insemination apparatus |
US4083957A (en) | 1974-07-26 | 1978-04-11 | Lang John L | Process for the alteration of the sex-ratio of mammals |
US4006360A (en) | 1974-08-21 | 1977-02-01 | Block Engineering, Inc. | Method of discriminating between dyed particles and background fluorescence of the dye |
US4092229A (en) | 1975-12-17 | 1978-05-30 | Bhattacharya Bhairab C | Thermal convection counter streaming sedimentation and forced convection galvanization method for controlling the sex of mammalian offspring |
US3976197A (en) | 1974-11-22 | 1976-08-24 | Bhattacharya Bhairab C | Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring |
USRE32350E (en) | 1974-11-22 | 1987-02-10 | Bhairab C. Bhattacharya | Thermal convection counter streaming sedimentation and forced convection galvanization method for controlling the sex of mammalian offspring |
US3940943A (en) | 1975-01-22 | 1976-03-02 | The Curators Of The University Of Missouri | Multistage freezing system for preservation of biological materials |
US4014611A (en) | 1975-04-30 | 1977-03-29 | Coulter Electronics, Inc. | Aperture module for use in particle testing apparatus |
DE2521236C3 (de) | 1975-05-10 | 1978-12-14 | Hildegard Dr. 4400 Muenster Goehde Geb. Kuhl | Einrichtung zum Zählen und Messen von in einer Flüssigkeit suspendierten Teilchen |
US3960449A (en) | 1975-06-05 | 1976-06-01 | The Board Of Trustees Of Leland Stanford Junior University | Measurement of angular dependence of scattered light in a flowing stream |
US4058732A (en) | 1975-06-30 | 1977-11-15 | Analytical Radiation Corporation | Method and apparatus for improved analytical fluorescent spectroscopy |
US4021117A (en) | 1975-08-07 | 1977-05-03 | Hildegard Gohde | Process for automatic counting and measurement of particles |
US4007087A (en) | 1975-10-17 | 1977-02-08 | Gametrics Limited | Sperm fractionation and storage |
US4006380A (en) | 1975-10-31 | 1977-02-01 | Shigeru Suga | Mounting of carbon electrodes on a holder of an arc lamp |
AU2154077A (en) | 1976-01-27 | 1978-07-27 | Univ Edinburgh | Control of sex ratio in mammalian offspring |
US4302166A (en) | 1976-04-22 | 1981-11-24 | Coulter Electronics, Inc. | Droplet forming apparatus for use in producing uniform particles |
US4162282A (en) | 1976-04-22 | 1979-07-24 | Coulter Electronics, Inc. | Method for producing uniform particles |
JPS5319891A (en) | 1976-06-10 | 1978-02-23 | Coulter Electronics | Method and apparatus for folling drop formation and separation |
GB1583150A (en) | 1976-08-02 | 1981-01-21 | Milk Marketing Board | Apparatus for collecting eggs |
US4110604A (en) | 1976-11-04 | 1978-08-29 | Becton, Dickinson And Company | Particle density measuring system |
DE2709399C3 (de) | 1977-03-04 | 1980-07-24 | Goehde, Wolfgang, Dr., 4400 Muenster | Einrichtung zum Messen von Zelleigenschaften |
DE2716095A1 (de) | 1977-04-12 | 1978-10-19 | Zoeld Tibor Dr Phys | Gasgesteuertes verfahren zum sortieren von in einem elektrolyten suspendierten teilchen und vorrichtung zur durchfuehrung des verfahrens |
US4448767A (en) | 1977-10-11 | 1984-05-15 | Sumar Corporation | Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex |
US4191749A (en) | 1977-10-11 | 1980-03-04 | Bryant Bernard J | Method and material for increasing the percentage of mammalian offspring of either sex |
US4189236A (en) | 1978-03-20 | 1980-02-19 | Coulter Electronics, Inc. | Ellipsoid-conic radiation collector and method |
US4179218A (en) | 1978-05-15 | 1979-12-18 | The Boeing Company | Particle size analyzer |
US4251733A (en) * | 1978-06-29 | 1981-02-17 | Hirleman Jr Edwin D | Technique for simultaneous particle size and velocity measurement |
DE2832091A1 (de) | 1978-07-21 | 1980-01-31 | Eidenschink Henning | Optisches verfahren zur bestimmung der teilchengroesse kolloidaler loesungen und messgeraet zur durchfuehrung des verfahrens |
US4276139A (en) | 1978-08-16 | 1981-06-30 | Lawson Rommon L | Process for magnetic separation and collection of viable female and male spermatozoa |
US4225405A (en) | 1978-08-16 | 1980-09-30 | Lawson Rommom L | Process for separation and collection of viable female and male spermatozoa |
US4230558A (en) | 1978-10-02 | 1980-10-28 | Coulter Electronics, Inc. | Single drop separator |
US4355441A (en) | 1978-11-24 | 1982-10-26 | Haell Gunnar B | Rope-lock |
US4341471A (en) | 1979-01-02 | 1982-07-27 | Coulter Electronics, Inc. | Apparatus and method for measuring the distribution of radiant energy produced in particle investigating systems |
US4316985A (en) | 1979-01-16 | 1982-02-23 | Hoffmann-La Roche Inc. | Cyclic compounds |
US4267268A (en) | 1979-03-12 | 1981-05-12 | Nelson Jr Robert A | Spermatozoa extenders |
US4274408A (en) | 1979-03-26 | 1981-06-23 | Beatrice Nimrod | Method for guide-wire placement and novel syringe therefor |
US4200802A (en) | 1979-03-28 | 1980-04-29 | The United States Of America As Represented By The United States Department Of Energy | Parabolic cell analyzer |
US4408877A (en) | 1979-04-10 | 1983-10-11 | Ernst Leitz Wetzlar Gmbh | Device for hydrodynamic focussing of a particle-suspension in a liquid flow cytophotometer |
NO144002C (no) | 1979-04-10 | 1981-05-27 | Norsk Hydro S Inst For Kreftfo | Anordning for anvendelse ved vaeskestroemsfotometri |
US4293221A (en) | 1979-04-17 | 1981-10-06 | Research Corporation | Multidimensional slit-scan flow system |
US4263508A (en) | 1979-04-20 | 1981-04-21 | Research Corporation | Pulse edge measurement for determining particle dimensional characteristics |
US4255021A (en) | 1979-04-20 | 1981-03-10 | The United States Of America As Represented By The United States Department Of Energy | Optical device with conical input and output prism faces |
US4318483A (en) | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system |
US4318482A (en) | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system |
US4325483A (en) | 1979-08-20 | 1982-04-20 | Ortho Diagnostics, Inc. | Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus |
US4317520A (en) | 1979-08-20 | 1982-03-02 | Ortho Diagnostics, Inc. | Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus |
US4318481A (en) | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter |
US4318480A (en) | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device |
DE2943116C2 (de) | 1979-10-25 | 1986-06-19 | Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München | Einrichtung zur durchflußcytometrischen Reaktions- und/oder Diffusionsmessung |
US4284355A (en) | 1979-10-29 | 1981-08-18 | Ortho Diagnostics, Inc. | Automated method for cell volume determination |
US4400764A (en) | 1980-02-05 | 1983-08-23 | The Boeing Company | Low backscatter illumination system |
US4367043A (en) | 1980-05-05 | 1983-01-04 | Leland Stanford Junior University | Method and means for delivering liquid samples to a sample scanning device |
US4362246A (en) | 1980-07-14 | 1982-12-07 | Adair Edwin Lloyd | Method of treating collected mammal semen and separating sperm into X Y components |
US4348107A (en) | 1980-07-18 | 1982-09-07 | Coulter Electronics, Inc. | Orifice inside optical element |
EP0046345A3 (en) | 1980-08-15 | 1982-03-03 | Ortho Diagnostic Systems Inc. | Controlled hydrodynamic flow in flow cytometry systems |
US4350410A (en) | 1980-10-08 | 1982-09-21 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Multiprism collimator |
US4691829A (en) | 1980-11-03 | 1987-09-08 | Coulter Corporation | Method of and apparatus for detecting change in the breakoff point in a droplet generation system |
US4487320A (en) | 1980-11-03 | 1984-12-11 | Coulter Corporation | Method of and apparatus for detecting change in the breakoff point in a droplet generation system |
US4395676A (en) | 1980-11-24 | 1983-07-26 | Coulter Electronics, Inc. | Focused aperture module |
US4361400A (en) | 1980-11-26 | 1982-11-30 | The United States Of America As Represented By The United States Department Of Energy | Fluidic assembly for an ultra-high-speed chromosome flow sorter |
DE8107889U1 (de) | 1981-03-18 | 1981-10-22 | Festo-Maschinenfabrik Gottlieb Stoll, 7300 Esslingen | Pneumatische ventilanordnung |
US4680258A (en) | 1981-03-24 | 1987-07-14 | Sloan-Kettering Institute For Cancer Research | Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen |
US4818103A (en) | 1981-05-15 | 1989-04-04 | Ratcom | Flow cytometry |
US4673288A (en) | 1981-05-15 | 1987-06-16 | Ratcom, Inc. | Flow cytometry |
DE3266669D1 (en) | 1981-06-24 | 1985-11-07 | Becton Dickinson Co | Analyzer for simultaneously determining volume and light emission characteristics of particles |
US4339434A (en) | 1981-08-17 | 1982-07-13 | Gametrics Limited | Method of increasing the incidence of female offspring |
US4395397A (en) | 1981-09-17 | 1983-07-26 | Sidney Farber Cancer Institute, Inc. | Apparatus and method for killing unwanted cells |
US4422761A (en) | 1981-09-28 | 1983-12-27 | Frommer Joseph C | Photo-electric particle sensing system |
US4515274A (en) | 1981-12-02 | 1985-05-07 | Coulter Corporation | Particle analyzing and sorting apparatus |
JPS59500340A (ja) | 1982-03-08 | 1984-03-01 | モトロ−ラ・インコ−ポレ−テツド | 集積回路のリ−ドフレ−ム |
US4511661A (en) | 1982-03-19 | 1985-04-16 | University Patents, Inc. | ATCC HB8116 And its monoclonal anti-H-Y antibody, Hyclonalan |
US4498766A (en) | 1982-03-25 | 1985-02-12 | Becton, Dickinson And Company | Light beam focal spot elongation in flow cytometry devices |
DE3315194A1 (de) | 1982-04-29 | 1983-11-03 | International Remote Imaging Systems Inc., 91311 Chatsworth, Calif. | Verfahren zum trennen von in einer fluidprobe stroemenden teilchen |
DE3315195A1 (de) | 1982-04-29 | 1983-11-03 | International Remote Imaging Systems Inc., 91311 Chatsworth, Calif. | Verfahren zum ausrichten von teilchen in einer fluidprobe |
US4629687A (en) | 1982-07-29 | 1986-12-16 | Board Of Trustees Of Michigan State University | Positive selection sorting of cells |
GB2125181B (en) | 1982-08-11 | 1986-01-29 | Coulter Electronics | Flow cells for particle study |
US4559309A (en) | 1982-09-01 | 1985-12-17 | Memorial Sloan Kettering Cancer Center | Flow cytometry-fluorescence measurements for characterizing sperm |
WO1984001265A1 (en) * | 1982-10-05 | 1984-04-12 | Genetic Engineering Inc | Method of treating collected mammal semen and separating sperm into x and y components |
US4501366A (en) | 1982-12-14 | 1985-02-26 | Adolph Coors Company | Photomultiplier tube assembly |
EP0112188B1 (en) | 1982-12-21 | 1987-06-16 | Crosfield Electronics Limited | Light beam-splitter |
US4492436A (en) | 1983-01-03 | 1985-01-08 | At&T Bell Laboratories | Polarization independent beam splitter |
JPS59143146A (ja) | 1983-02-07 | 1984-08-16 | Nippon Kogaku Kk <Nikon> | ミラ−集光型照明光学系 |
CA1206559A (en) | 1983-03-04 | 1986-06-24 | Robert E. Auer | Method of and apparatus for detecting change in the breakoff point of a droplet generation system |
IT1197570B (it) | 1983-02-11 | 1988-12-06 | Serono Ist Farm | Miscele di fsh e lh da ipofisi porcine in rapporto definito |
CH651930A5 (en) | 1983-03-24 | 1985-10-15 | Coulter Corp | Apparatus for analysis and sorting of particles |
JPS59174742A (ja) | 1983-03-25 | 1984-10-03 | Agency Of Ind Science & Technol | 微小粒子を区分又は選別する方法及びその装置 |
JPS59184841A (ja) | 1983-04-05 | 1984-10-20 | ベクトン・デイツキンソン・アンド・カンパニ− | サンプル中の白血球のサブクラスを識別する方法および装置 |
GB2145112B (en) | 1983-04-27 | 1987-02-18 | Milk Marketing Board | Sorting living spermatozoa |
US4523809A (en) | 1983-08-04 | 1985-06-18 | The United States Of America As Represented By The Secretary Of The Air Force | Method and apparatus for generating a structured light beam array |
NZ207393A (en) | 1983-08-05 | 1987-03-31 | Neal Lloyd First | Staining dna in living cells |
US4538733A (en) | 1983-10-14 | 1985-09-03 | Becton, Dickinson And Company | Particle sorter with neutralized collection wells and method of using same |
US4780406A (en) | 1983-10-18 | 1988-10-25 | The Regents Of The University Of California | Flow cytometric measurement of total DNA and incorporated halodeoxyuridine |
US4585736A (en) | 1983-10-18 | 1986-04-29 | The United States Of America As Represented By The United States Department Of Energy | Flow cytometric measurement of total DNA and incorporated halodeoxyuridine |
US4735504A (en) | 1983-10-31 | 1988-04-05 | Technicon Instruments Corporation | Method and apparatus for determining the volume & index of refraction of particles |
ATE58017T1 (de) | 1983-12-24 | 1990-11-15 | Inotech Ag | Vorrichtung zum fuehren und sammeln von licht in der fotometrie od. dgl. |
US4573796A (en) | 1984-01-06 | 1986-03-04 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for eliminating background interference in fluorescence measurements |
US4631483A (en) | 1984-02-01 | 1986-12-23 | Coulter Electronics, Inc. | Particle analyzing apparatus and method of moving particles in suspension through such apparatus |
US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
EP0172242A1 (en) | 1984-02-29 | 1986-02-26 | Research Corporation | Flow cytometers |
US4545677A (en) | 1984-03-05 | 1985-10-08 | Becton, Dickinson And Company | Prismatic beam expander for light beam shaping in a flow cytometry apparatus |
US4600302A (en) | 1984-03-26 | 1986-07-15 | Becton, Dickinson And Company | Flow cytometry apparatus with uniform incoherent light excitation |
DE3412620A1 (de) | 1984-04-04 | 1985-10-17 | Basf Ag, 6700 Ludwigshafen | Laseroptische anordnung zur messung des dispergiergrades in stroemenden systemen |
US4609286A (en) | 1984-04-16 | 1986-09-02 | Becton, Dickinson And Company | Dispersion prism for separation of wavelengths of spectrally rich light in a flow cytometry apparatus |
US4605558A (en) | 1984-04-20 | 1986-08-12 | Wallace Shrimpton | Process for cell separation |
US4660971A (en) * | 1984-05-03 | 1987-04-28 | Becton, Dickinson And Company | Optical features of flow cytometry apparatus |
FR2563726B1 (fr) | 1984-05-04 | 1986-10-10 | Robert Cassou | Appareil d'insemination artificielle, notamment des carnivores |
FR2566543B1 (fr) | 1984-06-20 | 1988-02-26 | Commissariat Energie Atomique | Dispositif optique a rendement de collection eleve et cytofluorimetre en faisant application |
EP0171676B1 (en) | 1984-07-31 | 1990-11-07 | Hitachi, Ltd. | Free-flow electrophoretic separation method and apparatus therefor |
EP0177718B1 (de) | 1984-09-11 | 1989-12-06 | Partec AG | Verfahren und Vorrichtung zur Sortierung von mikroskopischen Partikeln |
US4661913A (en) | 1984-09-11 | 1987-04-28 | Becton, Dickinson And Company | Apparatus and method for the detection and classification of articles using flow cytometry techniques |
US4598408A (en) | 1984-10-22 | 1986-07-01 | Trw Inc. | High extraction efficiency cylindrical ring resonator |
SU1267231A1 (ru) * | 1984-11-21 | 1986-10-30 | Ленинградский Институт Ядерной Физики Им.Б.П.Константинова | Проточный цитофлуориметр-сортировщик клеток |
JPS61139747A (ja) | 1984-12-12 | 1986-06-27 | Canon Inc | 粒子解析装置 |
JPS61159135A (ja) | 1984-12-31 | 1986-07-18 | Canon Inc | 粒子解析装置 |
US4702598A (en) | 1985-02-25 | 1987-10-27 | Research Corporation | Flow cytometer |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
CA1250808A (en) | 1985-04-29 | 1989-03-07 | David W. Dresser | Semen sexing |
US4662742A (en) | 1985-05-10 | 1987-05-05 | Becton, Dickinson And Company | Scatter/fluorescene beam splitter in a flow cytometry apparatus |
JPS61294334A (ja) | 1985-06-21 | 1986-12-25 | Canon Inc | 粒子解析装置 |
US4877965A (en) | 1985-07-01 | 1989-10-31 | Diatron Corporation | Fluorometer |
USRE34782E (en) | 1985-07-01 | 1994-11-08 | Diatron Corporation | Fluorometer |
US4744090A (en) | 1985-07-08 | 1988-05-10 | Trw Inc. | High-extraction efficiency annular resonator |
NO156916C (no) | 1985-07-10 | 1987-12-16 | Harald B Steen | Stroemningskammer for vaeskestroemsfotometer. |
NO156917C (no) | 1985-07-16 | 1987-12-16 | Harald B Steen | Anordning for maaling av biologiske cellers lysspredning i vaeskestroemsfotometere. |
US4989977A (en) | 1985-07-29 | 1991-02-05 | Becton, Dickinson And Company | Flow cytometry apparatus with improved light beam adjustment |
US4794086A (en) | 1985-11-25 | 1988-12-27 | Liquid Air Corporation | Method for measurement of impurities in liquids |
US4770992A (en) | 1985-11-27 | 1988-09-13 | Den Engh Gerrit J Van | Detection of specific DNA sequences by flow cytometry |
US4999283A (en) | 1986-01-10 | 1991-03-12 | University Of Kentucky Research Foundation | Method for x and y spermatozoa separation |
US5756696A (en) | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
US4710635A (en) | 1986-04-14 | 1987-12-01 | Becton, Dickinson And Company | Dual laser excitation from single laser source |
NL8601000A (nl) | 1986-04-21 | 1987-11-16 | Jan Greve T H Twente Afdeling | Het gebruik van gepolariseerd licht in stromingscytometrie. |
US5336217A (en) | 1986-04-24 | 1994-08-09 | Institut National De La Sante Et De La Recherche Medicale (Insepm) | Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias |
JPS62274238A (ja) | 1986-05-22 | 1987-11-28 | ベクトン・デイツキンソン・アンド・カンパニ− | フロ−サイトメトリ−装置に用いる光学的結合用ゲル |
US4790653A (en) | 1986-05-22 | 1988-12-13 | Becton Dickinson And Company | Housing for a flow cytometry apparatus with particle unclogging feature |
US4786165A (en) | 1986-07-10 | 1988-11-22 | Toa Medical Electronics Co., Ltd. | Flow cytometry and apparatus therefor |
US4896967A (en) | 1986-08-15 | 1990-01-30 | Hamilton-Thorn Research | Motility scanner and method |
US4896966A (en) | 1986-08-15 | 1990-01-30 | Hamilton-Thorn Research | Motility scanner and method |
US4704891A (en) | 1986-08-29 | 1987-11-10 | Becton, Dickinson And Company | Method and materials for calibrating flow cytometers and other analysis instruments |
US4867908A (en) | 1986-08-29 | 1989-09-19 | Becton, Dickinson And Company | Method and materials for calibrating flow cytometers and other analysis instruments |
FR2609885B1 (fr) | 1987-01-22 | 1989-04-14 | Cassou Robert | Instrument pour l'insemination artificielle, le transfert d'embryons ou le prelevement de liquides folliculaires chez les mammiferes |
US5162306A (en) | 1987-01-23 | 1992-11-10 | Donaldson Lloyd E | Composition and method for producing superovulation in mammals |
US4780451B1 (en) | 1987-01-23 | 1995-04-04 | Asua International Inc | Composition and method for producing superovulation in cattle |
ATE91789T1 (de) | 1987-02-17 | 1993-08-15 | Ratcom Inc | Durchflusszytometrie. |
KR970007077B1 (ko) | 1987-03-13 | 1997-05-02 | 코울터 일렉트로닉스 인커퍼레이티드 | 광산란 기술을 이용한 다중-부분식별 분석 방법 |
US4764013A (en) | 1987-03-23 | 1988-08-16 | The United States Of America As Represented By The United States Department Of Energy | Interferometric apparatus and method for detection and characterization of particles using light scattered therefrom |
US4765737A (en) | 1987-03-30 | 1988-08-23 | Cornell Research Foundation | Cell size measurements using light in flow cytometry and cell sorting |
US5021244A (en) | 1988-12-06 | 1991-06-04 | Cytogam, Inc. | Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex |
US5346990A (en) | 1987-04-08 | 1994-09-13 | Cytogam, Inc. | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex |
US4983038A (en) | 1987-04-08 | 1991-01-08 | Hitachi, Ltd. | Sheath flow type flow-cell device |
JPS63262565A (ja) | 1987-04-20 | 1988-10-28 | Hitachi Ltd | フロ−セル |
EP0289200B2 (en) | 1987-04-27 | 1998-07-22 | Fritz K. Preikschat | Apparatus and method for particle analysis |
EP0289677A3 (en) | 1987-04-27 | 1989-05-10 | Fritz K. Preikschat | Apparatus and method for particle analysis |
FR2614626B1 (fr) | 1987-04-30 | 1989-07-21 | Ranoux Claude | Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal |
KR910002210B1 (ko) | 1987-06-25 | 1991-04-08 | 데루모가부시끼가이샤 | 복수내강(內腔)카테테르, 복수내강 카테테르(catheter)조립체 및 이들의 제조방법 |
JP2642632B2 (ja) | 1987-07-03 | 1997-08-20 | 株式会社日立製作所 | 微粒子計測装置および微粒子計測方法 |
GB8716285D0 (en) | 1987-07-10 | 1987-08-19 | Medical Res Council | Light collecting device |
US4979093A (en) | 1987-07-16 | 1990-12-18 | Cavro Scientific Instruments | XYZ positioner |
US4987539A (en) | 1987-08-05 | 1991-01-22 | Stanford University | Apparatus and method for multidimensional characterization of objects in real time |
US4796788A (en) | 1987-08-26 | 1989-01-10 | Liqui-Box Corporation | Bag-in-box packaging and dispensing of substances which will not readily flow by gravity |
US4758729A (en) | 1987-08-28 | 1988-07-19 | Spectra-Physics, Inc. | Apparatus and method for measuring the included angle of a reflective cone |
DE3832901A1 (de) | 1987-10-02 | 1989-04-20 | Hitachi Ltd | Teilchenmessvorrichtung |
US4793705A (en) | 1987-10-07 | 1988-12-27 | The United States Of America As Represented By The United States Department Of Energy | Single molecule tracking |
US4831385A (en) | 1987-10-14 | 1989-05-16 | Burlington Industries, Inc. | Vacuum tray fluid-jet start-up system |
US4980277A (en) | 1987-10-16 | 1990-12-25 | Cultor Ltd. | Cryoprotectant solution and method |
US5712807A (en) | 1987-10-21 | 1998-01-27 | Bangham; James Andrew | Pulse analyzing method and apparatus |
US5789155A (en) | 1987-10-30 | 1998-08-04 | California Institute Of Technology | Process for identifying nucleic acids and triple helices formed thereby |
GB8726304D0 (en) | 1987-11-10 | 1987-12-16 | Secr Defence | Particle asymmetry analyser |
WO1989004470A1 (en) | 1987-11-10 | 1989-05-18 | The Secretary Of State For Defence In Her Britanni | Particle monitoring system |
GB8726305D0 (en) | 1987-11-10 | 1987-12-16 | Secr Defence | Portable particle analysers |
US4845025A (en) | 1987-11-10 | 1989-07-04 | Coulter Corporation | Biological sample mixing apparatus and method |
US5040890A (en) | 1987-11-25 | 1991-08-20 | Becton, Dickinson And Company | Sheathed particle flow controlled by differential pressure |
US4887721A (en) | 1987-11-30 | 1989-12-19 | The United States Of America As Represented By The United States Department Of Energy | Laser particle sorter |
US4988619A (en) * | 1987-11-30 | 1991-01-29 | United States Department Of Energy | Flow cytometry apparatus |
US4936465A (en) | 1987-12-07 | 1990-06-26 | Zoeld Tibor | Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system |
US5219729A (en) | 1988-02-25 | 1993-06-15 | Serono Laboratories, Inc. | Fertility assay |
US4986659A (en) | 1988-02-29 | 1991-01-22 | Aerometrics, Inc. | Method for measuring the size and velocity of spherical particles using the phase and intensity of scattered light |
US5622820A (en) | 1988-03-10 | 1997-04-22 | City Of Hope | Method for amplification and detection of RNA and DNA sequences |
US4836038A (en) | 1988-03-18 | 1989-06-06 | Aim Instruments Ltd. | Automated sampler-injector apparatus and method for sampling a quantity of sample and testing portions of said quantity |
US5057413A (en) | 1988-06-13 | 1991-10-15 | Becton, Dickinson And Company | Method for discriminating between intact and damaged cells in a sample |
JPH0213830A (ja) | 1988-06-30 | 1990-01-18 | Canon Inc | 粒子測定装置 |
JPH0224535A (ja) | 1988-07-12 | 1990-01-26 | Canon Inc | 粒子解析装置 |
US5070080A (en) | 1988-08-10 | 1991-12-03 | Fahim Mostafa S | Method of inhibiting generation, maturation, motility and viability of sperm with minerals in bioavailable form |
US4999513A (en) | 1988-09-09 | 1991-03-12 | Canon Kabushiki Kaisha | Particle measuring apparatus |
JPH0718785B2 (ja) | 1988-09-19 | 1995-03-06 | 株式会社日立製作所 | フローセル装置 |
JP2635126B2 (ja) | 1988-09-30 | 1997-07-30 | 東亜医用電子株式会社 | 核の分葉指数を求めるための粒子分析装置及び方法 |
JP2635125B2 (ja) | 1988-09-30 | 1997-07-30 | 東亜医用電子株式会社 | 核の分葉指数を求めるための粒子分析装置及び方法 |
US5185107A (en) | 1988-10-26 | 1993-02-09 | Iovision, Inc. | Fabrication of an intraocular lens |
JPH02168160A (ja) | 1988-12-22 | 1990-06-28 | Omron Tateisi Electron Co | 細胞選別装置 |
US5976389A (en) | 1988-12-30 | 1999-11-02 | Zavos; Panayiotis M. | Method of semen filtration |
US5726009A (en) | 1989-03-20 | 1998-03-10 | Anticancer, Inc. | Native-state method and system for determining viability and proliferative capacity of tissues in vitro |
JPH02289808A (ja) | 1989-04-28 | 1990-11-29 | Olympus Optical Co Ltd | 照明光学系 |
US4981580A (en) | 1989-05-01 | 1991-01-01 | Coulter Corporation | Coincidence arbitration in a flow cytomery sorting system |
EP0471758B1 (en) | 1989-05-10 | 1996-09-11 | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE | Method to preselect the sex of offspring |
EP0475936B1 (en) * | 1989-05-12 | 1995-09-13 | Cytogam, Inc. | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex |
US4942305A (en) | 1989-05-12 | 1990-07-17 | Pacific Scientific Company | Integrating sphere aerosol particle detector |
US5055393A (en) | 1989-06-13 | 1991-10-08 | Salk Institute Biotechnology/Industrial Associates, Inc. | Prenatal sex determination of bovine cells using male-specific oligonucleotides |
US4954715A (en) | 1989-06-26 | 1990-09-04 | Zoeld Tibor | Method and apparatus for an optimized multiparameter flow-through particle and cell analyzer |
JPH0353164A (ja) | 1989-07-20 | 1991-03-07 | Canon Inc | サンプル供給装置及びこれを用いたサンプル測定装置 |
US5098657A (en) | 1989-08-07 | 1992-03-24 | Tsi Incorporated | Apparatus for measuring impurity concentrations in a liquid |
US5030002A (en) | 1989-08-11 | 1991-07-09 | Becton, Dickinson And Company | Method and apparatus for sorting particles with a moving catcher tube |
US5215376A (en) | 1989-09-08 | 1993-06-01 | Becton, Dickinson And Company | Method for causing vortices in a test tube |
US5005981A (en) | 1989-09-08 | 1991-04-09 | Becton, Dickinson And Company | Apparatus for method for causing vortices in a test tube |
DE69014507T2 (de) | 1989-09-13 | 1995-04-13 | Tiyoda Seisakusho Koushoku Kk | Gerät zur Zellenvorbehandlung für Durchfluss-Zytometrie. |
JP2808321B2 (ja) | 1989-09-19 | 1998-10-08 | 東亜医用電子株式会社 | 細胞分析方法及び装置 |
US5072382A (en) | 1989-10-02 | 1991-12-10 | Kamentsky Louis A | Methods and apparatus for measuring multiple optical properties of biological specimens |
US5275787A (en) | 1989-10-04 | 1994-01-04 | Canon Kabushiki Kaisha | Apparatus for separating or measuring particles to be examined in a sample fluid |
EP0422616B1 (en) * | 1989-10-11 | 1996-02-07 | Canon Kabushiki Kaisha | Apparatus for and method of fractionating particle in particle-suspended liquid in conformity with the properties thereof |
JPH03140840A (ja) | 1989-10-26 | 1991-06-14 | Hitachi Ltd | 流動細胞分析装置 |
FR2653885B1 (fr) | 1989-10-27 | 1994-01-14 | Abx | Appareil pour le comptage et la determination d'au moins une sous-population leucocytaire. |
US5034613A (en) | 1989-11-14 | 1991-07-23 | Cornell Research Foundation, Inc. | Two-photon laser microscopy |
US5101978A (en) | 1989-11-27 | 1992-04-07 | The United States Of America As Represented By The Secretary Of The Army | Fluidic sorting device for two or more materials suspended in a fluid |
AU647741B2 (en) | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
US5274240A (en) | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
DE69118429T2 (de) | 1990-01-26 | 1996-09-12 | Canon Kk | Verfahren zur Messung einer Spezies unter Verwendung von Fluoreszenzlicht |
JP3049254B2 (ja) | 1990-02-08 | 2000-06-05 | シスメックス株式会社 | 2種類の光源を備えた光学式粒子分析装置 |
IL93634A0 (en) | 1990-03-05 | 1990-12-23 | Galai Lab Ltd | Particle size analyzer |
EP0446509A1 (en) * | 1990-03-15 | 1991-09-18 | Panayiotis M. Zavos | Semen filter column |
US5153117A (en) | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
US5492534A (en) | 1990-04-02 | 1996-02-20 | Pharmetrix Corporation | Controlled release portable pump |
US5150313A (en) | 1990-04-12 | 1992-09-22 | Regents Of The University Of California | Parallel pulse processing and data acquisition for high speed, low error flow cytometry |
US5087295A (en) | 1990-06-13 | 1992-02-11 | Becton Dickinson And Company | Cleaning cycle for flow cytometers |
US5076472A (en) | 1990-06-13 | 1991-12-31 | Becton, Dickinson And Company | Cleaning cycle for flow cytometers |
JPH0710226B2 (ja) | 1990-06-20 | 1995-02-08 | 株式会社ピーシーシーテクノロジー | プロトプラスト攪拌装置並びにそれを含む細胞融合装置及びフローサイトメーター装置 |
JPH0716392B2 (ja) | 1990-06-20 | 1995-03-01 | 株式会社ピーシーシーテクノロジー | 細胞融合及び融合細胞選別システム |
JPH04126065A (ja) | 1990-06-25 | 1992-04-27 | Saburo Okonogi | 食品素材の棒状体成型装置 |
US5160974A (en) | 1990-06-25 | 1992-11-03 | Flow Science, Inc. | Closed sample cell for use in flow cytometry |
US5559032A (en) | 1990-06-29 | 1996-09-24 | Pomeroy; Patrick C. | Method and apparatus for post-transfer assaying of material on solid support |
CA2086330A1 (en) | 1990-07-09 | 1992-01-10 | Richard C. Fry | Enhanced implantation, development and maintenance of embryos using leukaemia inhibitory factor |
JP2939647B2 (ja) | 1990-07-24 | 1999-08-25 | シスメックス株式会社 | フローイメージングサイトメータにおける自動焦点調整方法 |
IE76732B1 (en) | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
US5259593A (en) | 1990-08-30 | 1993-11-09 | University Of Southern California | Apparatus for droplet stream manufacturing |
JPH04115136A (ja) | 1990-09-05 | 1992-04-16 | Hitachi Ltd | 粒子計測装置 |
JPH04126064A (ja) | 1990-09-14 | 1992-04-27 | Nitto Shokai:Kk | 二重包餡食品の製造法 |
JPH04126080A (ja) | 1990-09-14 | 1992-04-27 | Juzo Udaka | 耐熱性キシロースイソメラーゼの製造方法 |
JP2957246B2 (ja) | 1990-09-14 | 1999-10-04 | 大和化成株式会社 | 微生物起源カルボキシペプチダーゼb様酵素 |
US5132548A (en) | 1990-09-14 | 1992-07-21 | High Yield Technology | High sensitivity, large detection area particle sensor for vacuum applications |
US5204884A (en) | 1991-03-18 | 1993-04-20 | University Of Rochester | System for high-speed measurement and sorting of particles |
US5108366A (en) | 1990-09-28 | 1992-04-28 | Ovamed Corporation | Delivery catheter |
US5273527A (en) | 1992-05-12 | 1993-12-28 | Ovamed Corporation | Delivery catheter |
US5663048A (en) | 1990-10-04 | 1997-09-02 | University Of Calgary | Y-chromosome specific polynucleotide probes for prenatal sexing |
US5840482A (en) | 1990-10-10 | 1998-11-24 | The Regents Of The University Of California | Y chromosome specific nucleic acid probe and method for determining the Y chromosome in situ |
WO1992008120A1 (en) * | 1990-10-29 | 1992-05-14 | Macquarie University | Pulsed laser flow cytometry |
US5116125A (en) | 1990-10-31 | 1992-05-26 | Biophos Medical Ab | Fertility analyzer |
DE69013366T2 (de) | 1990-10-31 | 1995-04-20 | Biophos Medical Ab | Fruchtbarkeitsanalysegerät. |
JP2874746B2 (ja) | 1990-11-22 | 1999-03-24 | シスメックス株式会社 | フローイメージングサイトメータにおけるフローセル機構 |
US5991028A (en) | 1991-02-22 | 1999-11-23 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for cell classification |
JP3121849B2 (ja) | 1991-02-27 | 2001-01-09 | シスメックス株式会社 | フローイメージサイトメータ |
JPH0734012B2 (ja) | 1991-02-27 | 1995-04-12 | 東亜医用電子株式会社 | フローイメージサイトメータ |
US5144224A (en) | 1991-04-01 | 1992-09-01 | Larsen Lawrence E | Millimeter wave flow cytometer |
US5199576A (en) | 1991-04-05 | 1993-04-06 | University Of Rochester | System for flexibly sorting particles |
EP0515211A3 (en) | 1991-05-23 | 1993-04-07 | Becton Dickinson And Company | Apparatus and method for phase resolved fluorescence lifetimes of independent and varying amplitude pulses |
DE9107792U1 (de) | 1991-06-25 | 1991-09-12 | Labotect-Labor-Technik, Göttingen, GmbH, 3406 Bovenden | Instrumentensatz zum uterinen Embryonentransfer |
FR2678506B1 (fr) | 1991-07-01 | 2000-03-10 | Claude Ranoux | Procede de fecondation en cycle spontane. |
US6071889A (en) | 1991-07-08 | 2000-06-06 | Neurospheres Holdings Ltd. | In vivo genetic modification of growth factor-responsive neural precursor cells |
US5548661A (en) | 1991-07-12 | 1996-08-20 | Price; Jeffrey H. | Operator independent image cytometer |
US5412466A (en) | 1991-07-26 | 1995-05-02 | Toa Medical Electronics Co., Ltd. | Apparatus for forming flattened sample flow for analyzing particles |
FR2680101B1 (fr) | 1991-08-07 | 1993-11-05 | Robert Cassou | Buse d'injection a usage unique pour machine de remplissage de paillettes, notamment pour l'insemination artificielle d'animaux et conservation de produits biologiques. |
US5488469A (en) | 1991-08-30 | 1996-01-30 | Omron Corporation | Cell analyzing apparatus |
DE69230902D1 (de) | 1991-08-30 | 2000-05-18 | Omron Tateisi Electronics Co | Vorrichtung zur Zellenanalyse |
US5548395A (en) | 1991-09-20 | 1996-08-20 | Toa Medical Electronics Co., Ltd. | Particle analyzer |
US5578449A (en) | 1991-10-03 | 1996-11-26 | Hilding Ohlsson, S.A. | Procedure for the sex determination of embryos in mammals especially applied to bovine embryos |
US5919621A (en) | 1991-10-24 | 1999-07-06 | Brown; David B. | Methods for diagnosing human male infertility |
JP3212647B2 (ja) | 1991-10-24 | 2001-09-25 | シスメックス株式会社 | イメージングフローサイトメータ |
IT1253226B (it) | 1991-10-24 | 1995-07-11 | Piero Serra | Catetere per l'introduzione o l'aspirazione di liquidi di diversa natura in animali particolarmente per trattamenti ginecologici in bovini, equini e simili |
US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
GB9125327D0 (en) | 1991-11-28 | 1992-01-29 | Nat Res Dev | Bovine semen sexing |
US5370842A (en) | 1991-11-29 | 1994-12-06 | Canon Kabushiki Kaisha | Sample measuring device and sample measuring system |
JP2593021B2 (ja) | 1991-12-13 | 1997-03-19 | 伊藤ハム株式会社 | ウシ胚の性の識別方法 |
JP3130628B2 (ja) | 1992-01-30 | 2001-01-31 | シスメックス株式会社 | 粒子判定装置 |
US5400179A (en) | 1992-02-18 | 1995-03-21 | Asahi Kogaku Kogyo Kabushiki Kaisha | Optical multilayer thin film and beam splitter |
ATE172791T1 (de) | 1992-02-20 | 1998-11-15 | Canon Kk | Verfahren und messapparatur zur handhabung von teilchen |
CA2130343C (en) | 1992-02-21 | 2003-02-11 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Analysis of particle characteristics |
US5558998A (en) | 1992-02-25 | 1996-09-24 | The Regents Of The Univ. Of California | DNA fragment sizing and sorting by laser-induced fluorescence |
US6120735A (en) | 1992-02-26 | 2000-09-19 | The Ohio States University | Fractional cell sorter |
US5298967A (en) | 1992-06-02 | 1994-03-29 | Pacific Scientific Company | Measurement of concentrations of dissolved solvent |
JP3145486B2 (ja) | 1992-06-12 | 2001-03-12 | シスメックス株式会社 | イメージングフローサイトメータ |
JPH07509153A (ja) | 1992-07-13 | 1995-10-12 | ポール・コーポレーション | 生物学的流体を処理するための自動化されたシステムおよび方法 |
JP3215175B2 (ja) | 1992-08-10 | 2001-10-02 | シスメックス株式会社 | 粒子分析装置 |
US5315122A (en) | 1992-08-25 | 1994-05-24 | Becton, Dickinson And Company | Apparatus and method for fluorescent lifetime measurement |
US5466572A (en) | 1992-09-03 | 1995-11-14 | Systemix, Inc. | High speed flow cytometric separation of viable cells |
WO1994005775A1 (en) | 1992-09-03 | 1994-03-17 | Systemix, Inc. | High speed flow cytometric separation of viable mammalian cells |
US5736410A (en) | 1992-09-14 | 1998-04-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5275933A (en) | 1992-09-25 | 1994-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Triple gradient process for recovering nucleated fetal cells from maternal blood |
US5311290A (en) * | 1992-09-30 | 1994-05-10 | Pulp And Paper Research Institute Of Canada | Imaging apparatus and method of fiber analysis |
US5371585A (en) | 1992-11-10 | 1994-12-06 | Pacific Scientific Company | Particle detecting instrument with sapphire detecting cell defining a rectangular flow path |
US5359907A (en) | 1992-11-12 | 1994-11-01 | Horiba Instruments, Inc. | Method and apparatus for dry particle analysis |
US5395588A (en) | 1992-12-14 | 1995-03-07 | Becton Dickinson And Company | Control of flow cytometer having vacuum fluidics |
JPH06197665A (ja) | 1993-01-07 | 1994-07-19 | Norin Suisansyo Chikusan Shikenjo | 体外受精用培地および体外受精方法 |
EP0679298B1 (en) | 1993-01-16 | 1999-03-31 | BANGHAM, James Andrew | Signal processing system |
JP2525713B2 (ja) | 1993-01-19 | 1996-08-21 | 農林水産省畜産試験場長 | 低分子チオ―ル化合物を用いた牛胚の培養法および輸送法 |
US5467189A (en) | 1993-01-22 | 1995-11-14 | Venturedyne, Ltd. | Improved particle sensor and method for assaying a particle |
JP3052665B2 (ja) | 1993-01-26 | 2000-06-19 | 株式会社日立製作所 | フローセル装置 |
CA2113957A1 (en) | 1993-01-29 | 1994-07-30 | University Of Guelph | Nucleotide sequences for bovine sex determination |
US5453575A (en) | 1993-02-01 | 1995-09-26 | Endosonics Corporation | Apparatus and method for detecting blood flow in intravascular ultrasonic imaging |
JPH08506664A (ja) | 1993-02-01 | 1996-07-16 | セック,リミテッド | Dna配列決定の方法および装置 |
US5367474A (en) | 1993-02-08 | 1994-11-22 | Coulter Corporation | Flow cytometer |
US5556764A (en) | 1993-02-17 | 1996-09-17 | Biometric Imaging, Inc. | Method and apparatus for cell counting and cell classification |
US5547849A (en) | 1993-02-17 | 1996-08-20 | Biometric Imaging, Inc. | Apparatus and method for volumetric capillary cytometry |
US5563059A (en) | 1993-02-23 | 1996-10-08 | Genentech, Inc. | Use of human inhibin and human activin to increase the number of mature primate oocytes |
EP0648348B1 (en) | 1993-03-01 | 1999-04-28 | General Signal Corporation | Variable annular illuminator for photolithographic projection imager. |
NO930980L (no) | 1993-03-18 | 1994-09-19 | Flowtech As | Optisk konfigurasjon for væskeströmcytofotometer |
US5658751A (en) | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
JPH06302897A (ja) * | 1993-04-19 | 1994-10-28 | Sumitomo Electric Ind Ltd | レーザ装置、その運転方法およびその応用 |
US5494795A (en) | 1993-05-05 | 1996-02-27 | The United States Of America As Represented By The Secretary Of The Navy | Specific oligonucleotide primers for detection of pathogenic campylobacter bacteria by polymerase chain reaction |
US5439578A (en) | 1993-06-03 | 1995-08-08 | The Governors Of The University Of Alberta | Multiple capillary biochemical analyzer |
EP0627643B1 (en) | 1993-06-03 | 1999-05-06 | Hamamatsu Photonics K.K. | Laser scanning optical system using axicon |
AU6857094A (en) | 1993-06-04 | 1995-01-03 | Kwahak International Co., Ltd. | Artificial insemination and embryo transfer device |
NO932088L (no) | 1993-06-08 | 1995-01-05 | Oddbjoern Gjelsnes | Anordning for anvendelse ved væskeströmscytometri |
US5483469A (en) * | 1993-08-02 | 1996-01-09 | The Regents Of The University Of California | Multiple sort flow cytometer |
US5464581A (en) | 1993-08-02 | 1995-11-07 | The Regents Of The University Of California | Flow cytometer |
US6328071B1 (en) | 1993-08-06 | 2001-12-11 | Cary Austin | Well pressure tank |
US5596401A (en) | 1993-09-16 | 1997-01-21 | Toa Medical Electronics Co., Ltd. | Particle analyzing apparatus using a coherence lowering device |
JP2826449B2 (ja) * | 1993-09-17 | 1998-11-18 | 株式会社日立製作所 | フロー式粒子画像解析方法およびフロー式粒子画像解析装置 |
US5503994A (en) | 1993-10-08 | 1996-04-02 | The Board Of Trustees Of The Leland Stanford Junior University | System for sample detection with compensation for difference in sensitivity to detection of components moving at different velocities |
US5480774A (en) | 1993-10-14 | 1996-01-02 | A/F Protein, Inc. | Determination of genomic sex in salmonids |
JPH07120375A (ja) | 1993-10-21 | 1995-05-12 | Hitachi Ltd | フロー式粒子画像解析方法及び装置 |
JP3290786B2 (ja) | 1993-11-26 | 2002-06-10 | シスメックス株式会社 | 粒子分析装置 |
GB9324938D0 (en) | 1993-12-04 | 1994-01-26 | Atomic Energy Authority Uk | Aerosol generator |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
FI96452C (fi) | 1994-01-26 | 1996-06-25 | Pekka Haenninen | Menetelmä väriaineiden virittämiseksi |
US5889013A (en) | 1994-02-28 | 1999-03-30 | Sunkyong Industries Co., Inc. | Pyrimidine acyclonucleoside derivatives |
KR100294996B1 (ko) | 1994-03-25 | 2001-09-17 | 오오노 유지 | 에피머라제 |
JPH07286953A (ja) | 1994-04-19 | 1995-10-31 | Toa Medical Electronics Co Ltd | イメージングフローサイトメータ |
US5475487A (en) | 1994-04-20 | 1995-12-12 | The Regents Of The University Of California | Aqueous carrier waveguide in a flow cytometer |
US5608518A (en) | 1994-04-25 | 1997-03-04 | Wilks, Jr.; Paul A. | Multiple internal reflection analyzers not requiring external optics |
DE4414940C2 (de) | 1994-04-28 | 1998-07-02 | Pekka Haenninen | Lumineszenz-Rastermikroskop mit zwei Photonen Anregung |
US5595866A (en) | 1994-05-27 | 1997-01-21 | Methodist Hospital Of Indiana, Inc. | Step-wise method to remove cryoprotectant from sperm |
DE4419894A1 (de) | 1994-06-07 | 1995-12-14 | Gip Medizin Technik Gmbh | Endoskopische Punktionsnadelvorrichtung |
EP0687956B2 (de) | 1994-06-17 | 2005-11-23 | Carl Zeiss SMT AG | Beleuchtungseinrichtung |
US5601234A (en) | 1994-08-01 | 1997-02-11 | Abbott Laboratories | Fluid nozzle and method of introducing a fluid |
US5891734A (en) | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
JP3375203B2 (ja) | 1994-08-08 | 2003-02-10 | シスメックス株式会社 | 細胞分析装置 |
FR2723735B1 (fr) | 1994-08-18 | 1996-10-31 | Abx Sa | Boitier a branchement automatique pour distribution de reactifs dans un appareil notamment un analyseur hematologique. |
US20020186874A1 (en) | 1994-09-07 | 2002-12-12 | Jeffrey H. Price | Method and means for image segmentation in fluorescence scanning cytometry |
US5790692A (en) | 1994-09-07 | 1998-08-04 | Jeffrey H. Price | Method and means of least squares designed filters for image segmentation in scanning cytometry |
US5540020A (en) | 1994-09-26 | 1996-07-30 | Santini; Daniel E. | Building panel |
US5700692A (en) * | 1994-09-27 | 1997-12-23 | Becton Dickinson And Company | Flow sorter with video-regulated droplet spacing |
US5934885A (en) | 1994-10-07 | 1999-08-10 | Bayer Corporation | Reagent pump assembly |
IL115327A (en) | 1994-10-07 | 2000-08-13 | Bayer Ag | Diaphragm pump |
US5643796A (en) | 1994-10-14 | 1997-07-01 | University Of Washington | System for sensing droplet formation time delay in a flow cytometer |
AU698929B2 (en) | 1994-10-14 | 1998-11-12 | University Of Washington | High speed flow cytometer droplet formation system |
US6861265B1 (en) | 1994-10-14 | 2005-03-01 | University Of Washington | Flow cytometer droplet formation system |
US5602349A (en) | 1994-10-14 | 1997-02-11 | The University Of Washington | Sample introduction system for a flow cytometer |
US5602039A (en) * | 1994-10-14 | 1997-02-11 | The University Of Washington | Flow cytometer jet monitor system |
JP3347495B2 (ja) | 1994-11-14 | 2002-11-20 | シスメックス株式会社 | 粒子分析装置 |
US5495719A (en) | 1994-11-14 | 1996-03-05 | Gray, Jr.; Carl O. | Method of preserving spermatozoa |
US5514537A (en) | 1994-11-28 | 1996-05-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Process and apparatus for sorting spermatozoa |
AU3963595A (en) | 1994-12-08 | 1996-06-26 | Molecular Dynamics, Inc. | Fluorescence imaging system employing a macro scanning objective |
US5596157A (en) | 1994-12-12 | 1997-01-21 | Williams; Maschon | Stringed musical instrument with keyboard |
US5632754A (en) | 1994-12-23 | 1997-05-27 | Devices For Vascular Intervention | Universal catheter with interchangeable work element |
US5575914A (en) | 1994-12-23 | 1996-11-19 | Vance Products Incorporated | Sperm filter trap having compressed glass wool filter material |
DE69533469T2 (de) | 1994-12-26 | 2005-09-22 | Sysmex Corp. | Durchflusszytometer |
US5835262A (en) | 1994-12-28 | 1998-11-10 | Research Development Corporation Of Japan | Multi-wavelength optical microscope |
JP3079932B2 (ja) | 1994-12-28 | 2000-08-21 | 株式会社佐竹製作所 | 穀粒色彩選別装置 |
FI98765C (fi) * | 1995-01-16 | 1997-08-11 | Erkki Soini | Virtaussytometrinen menetelmä ja laite |
US5793485A (en) | 1995-03-20 | 1998-08-11 | Sandia Corporation | Resonant-cavity apparatus for cytometry or particle analysis |
US5608519A (en) | 1995-03-20 | 1997-03-04 | Gourley; Paul L. | Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells |
US5598401A (en) | 1995-03-21 | 1997-01-28 | Motorola, Inc. | Apparatus and method for a digital data communications device to operate in an analog mode |
US5620842A (en) | 1995-03-29 | 1997-04-15 | Becton Dickinson And Company | Determination of the number of fluorescent molecules on calibration beads for flow cytometry |
US5786560A (en) | 1995-03-31 | 1998-07-28 | Panasonic Technologies, Inc. | 3-dimensional micromachining with femtosecond laser pulses |
US5699152A (en) * | 1995-04-03 | 1997-12-16 | Alltrista Corporation | Electro-optical inspection system and method |
ATE339680T1 (de) | 1995-04-06 | 2006-10-15 | Delaval Holding Ab | Verfahren und vorrichtung zur quantitativen bestimmung von teilchen in flüssigkeiten |
US5682038A (en) | 1995-04-06 | 1997-10-28 | Becton Dickinson And Company | Fluorescent-particle analyzer with timing alignment for analog pulse subtraction of fluorescent pulses arising from different excitation locations |
US5528045A (en) | 1995-04-06 | 1996-06-18 | Becton Dickinson And Company | Particle analyzer with spatially split wavelength filter |
DE19514955C2 (de) | 1995-04-24 | 1997-07-10 | Buehler Ag | Walzenstuhl für die Vermahlung von Nahrungs- und Futtermittel |
US5641457A (en) | 1995-04-25 | 1997-06-24 | Systemix | Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure |
US5687727A (en) | 1995-05-01 | 1997-11-18 | Danforth Biomedical Incorporated | Catheter adaptor with slitting blade and improved manual control and method of use |
WO1996035384A1 (en) | 1995-05-09 | 1996-11-14 | Curators Of The University Of Missouri | A system for introducing a fluid into the uterus of an animal |
FR2734637B1 (fr) | 1995-05-24 | 1997-08-14 | Abx Sa | Dispositif d'inspection optique d'un fluide, notamment pour analyses hematologiques |
US5798276A (en) | 1995-06-07 | 1998-08-25 | Molecular Probes, Inc. | Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability |
US5650847A (en) | 1995-06-14 | 1997-07-22 | Erkki Soini | Method and device for determination of parameters of individual microparticles |
US6454945B1 (en) | 1995-06-16 | 2002-09-24 | University Of Washington | Microfabricated devices and methods |
US5716852A (en) | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
US5589457A (en) | 1995-07-03 | 1996-12-31 | Ausa International, Inc. | Process for the synchronization of ovulation |
US6411835B1 (en) | 1997-01-13 | 2002-06-25 | Medispectra, Inc. | Spectral volume microprobe arrays |
US5840504A (en) | 1995-08-11 | 1998-11-24 | University Of Guelph | Method for separating sex specific molecules and non-sex specific molecules |
JP2001520637A (ja) | 1995-09-06 | 2001-10-30 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 二光子アップコンバーティング色素および応用 |
DE19533092A1 (de) | 1995-09-07 | 1997-03-13 | Basf Ag | Vorrichtung zur parallelisierten Zweiphotonen-Fluoreszenz-Korrelations-Spektroskopie (TPA-FCS) und deren Verwendung zum Wirkstoff-Screening |
US6329158B1 (en) | 1995-09-15 | 2001-12-11 | Becton Dickinson And Company | Use of dimly fluorescing nucleic acid dyes in the identification of nucleated cells |
US6040139A (en) | 1995-09-19 | 2000-03-21 | Bova; G. Steven | Laser cell purification system |
US5726751A (en) | 1995-09-27 | 1998-03-10 | University Of Washington | Silicon microchannel optical flow cytometer |
US5780230A (en) | 1995-10-06 | 1998-07-14 | Coriell Institute For Medical Research | Compositions and methods for human sperm activation and quantitative assessment of human sperm genome replication |
US5736330A (en) | 1995-10-11 | 1998-04-07 | Luminex Corporation | Method and compositions for flow cytometric determination of DNA sequences |
US6117068A (en) | 1995-10-19 | 2000-09-12 | Elite Genetics, Inc | Artificial insemination system |
AU723170B2 (en) | 1995-10-19 | 2000-08-17 | Bio-Origyn Llc | Methods and compositions to improve germ cell and embryo survival and function |
DK0863700T3 (da) | 1995-11-09 | 2003-06-30 | Applied Research Systems | Anvendelse af CYB-medium til transport og opbevaring af sperm |
DE19549015C1 (de) | 1995-12-28 | 1997-04-03 | Siemens Ag | Verfahren und Anordnung zur Überwachung eines abreißenden Flüssigkeitstrahls |
JP3584108B2 (ja) | 1996-01-08 | 2004-11-04 | キヤノン株式会社 | レンズ鏡筒 |
US6641708B1 (en) | 1996-01-31 | 2003-11-04 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
WO1997029354A1 (de) | 1996-02-05 | 1997-08-14 | Bayer Aktiengesellschaft | Verfahren und vorrichtung zum sortieren und zur gewinnung von planar ausgebrachten biologischen objekten wie biologische zellen bzw. zellorganellen, histologischen schnitten, chromosomenteilchen etc. mit laserstrahlen |
BR9600722A (pt) | 1996-02-14 | 1997-12-30 | Jorge Antonio Rodrigues Claro | Bomba de infusão para contidos em bolsas plásticas flexíveis |
AU1852297A (en) | 1996-02-16 | 1997-09-02 | Inphocyte, Inc. | System and method for rapid analysis of cells using spectral cytometry |
JP3127111B2 (ja) | 1996-02-22 | 2001-01-22 | 株式会社日立製作所 | フロー式粒子画像解析方法および装置 |
US6090947A (en) | 1996-02-26 | 2000-07-18 | California Institute Of Technology | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support |
US6143901A (en) | 1996-07-31 | 2000-11-07 | Genesoft, Inc. | Complex formation between dsDNA and pyrrole imidazole polyamides |
US5895922A (en) | 1996-03-19 | 1999-04-20 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Fluorescent biological particle detection system |
US5701012A (en) | 1996-03-19 | 1997-12-23 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Fluorescent biological particle detection system |
US5747349A (en) | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
JP3640461B2 (ja) | 1996-04-03 | 2005-04-20 | シスメックス株式会社 | 粒子分析装置 |
US5707808A (en) | 1996-04-15 | 1998-01-13 | The Regents Of The University Of California | Optical selection and collection of DNA fragments |
ATE357663T1 (de) | 1996-04-25 | 2007-04-15 | Genicon Sciences Corp | Teilchenförmiges markierungsmittel verwendendes analytassay |
WO1997043620A1 (en) | 1996-05-15 | 1997-11-20 | International Remote Imaging Systems, Inc. | Selectively emphasizing particles of interest from a fluid sample for analysis |
JP2963393B2 (ja) | 1996-06-14 | 1999-10-18 | 浜松ホトニクス株式会社 | 光電子増倍管用電圧分割回路 |
US5846737A (en) | 1996-07-26 | 1998-12-08 | Molecular Probes, Inc. | Conjugates of sulforhodamine fluorophores with enhanced fluorescence |
US5909278A (en) | 1996-07-29 | 1999-06-01 | The Regents Of The University Of California | Time-resolved fluorescence decay measurements for flowing particles |
EP0822401A3 (en) | 1996-07-30 | 1999-05-06 | Bayer Corporation | Hydraulic system for a hematology analytical instrument |
US5844685A (en) | 1996-07-30 | 1998-12-01 | Bayer Corporation | Reference laser beam sampling apparatus |
US5883378A (en) | 1996-07-30 | 1999-03-16 | Bayer Corporation | Apparatus and methods for transmitting electrical signals indicative of optical interactions between a light beam and a flowing suspension of particles |
US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US5872627A (en) | 1996-07-30 | 1999-02-16 | Bayer Corporation | Method and apparatus for detecting scattered light in an analytical instrument |
US5745308A (en) | 1996-07-30 | 1998-04-28 | Bayer Corporation | Methods and apparatus for an optical illuminator assembly and its alignment |
US5719667A (en) | 1996-07-30 | 1998-02-17 | Bayer Corporation | Apparatus for filtering a laser beam in an analytical instrument |
US6042249A (en) | 1996-07-30 | 2000-03-28 | Bayer Corporation | Illuminator optical assembly for an analytical instrument and methods of alignment and manufacture |
DE69739456D1 (de) | 1996-07-30 | 2009-07-30 | Siemens Healthcare Diagnostics | Optisches System für Blutanalysegerät |
US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
US5804436A (en) | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response |
WO1998005853A1 (en) | 1996-08-07 | 1998-02-12 | Cuno, Inc. | Additive dispensing apparatus |
ATE211258T1 (de) | 1996-09-04 | 2002-01-15 | Scandinavian Micro Biodevices | Mikrofliesssystem für die teilchenanalyse und trennung |
US5873254A (en) | 1996-09-06 | 1999-02-23 | Interface Multigrad Technology | Device and methods for multigradient directional cooling and warming of biological samples |
AU721792B2 (en) | 1996-09-06 | 2000-07-13 | Medarex, Inc. | Cyanidin compositions and therapeutic and diagnostic uses therefor |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5759767A (en) | 1996-10-11 | 1998-06-02 | Joseph R. Lakowicz | Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids |
US6002471A (en) | 1996-11-04 | 1999-12-14 | California Institute Of Technology | High resolution scanning raman microscope |
US5799830A (en) | 1996-11-08 | 1998-09-01 | Carroll; David C. | Pressure vessel access port |
US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
EP1562035B1 (en) | 1997-01-31 | 2017-01-25 | Xy, Llc | Optical apparatus and method |
AU6141598A (en) | 1997-02-04 | 1998-08-25 | Hybridon, Inc. | Base protecting groups and process for oligonucleotide synthesis |
US6753161B2 (en) | 1997-03-27 | 2004-06-22 | Oncosis Llc | Optoinjection methods |
US6534308B1 (en) | 1997-03-27 | 2003-03-18 | Oncosis, Llc | Method and apparatus for selectively targeting specific cells within a mixed cell population |
US5874266A (en) | 1997-03-27 | 1999-02-23 | Palsson; Bernhard O. | Targeted system for removing tumor cells from cell populations |
GB9707096D0 (en) | 1997-04-08 | 1997-05-28 | Smithkline Beecham Plc | Novel device |
JP2968231B2 (ja) | 1997-04-11 | 1999-10-25 | 株式会社荏原製作所 | 空調システム |
US6133995A (en) | 1997-05-09 | 2000-10-17 | Sysmex Corporation | Particle measuring apparatus |
US6050935A (en) | 1997-05-09 | 2000-04-18 | Biofertec | Container assembly for intravaginal fertilization and culture and embryo transfer and method of intravaginal fertilization and culture employing such a container |
CA2293426C (en) | 1997-06-09 | 2007-05-15 | Guava Technologies, Inc. | Method and apparatus for detecting microparticles in fluid samples |
WO1998059233A1 (en) | 1997-06-23 | 1998-12-30 | Luminex Corporation | Interlaced lasers for multiple fluorescence measurement |
DE69834527T2 (de) | 1997-07-01 | 2007-05-10 | VLP Watertown Limited Partnership, Watertown | Verfahren zur Geschlechtsbestimmung von Säuger-Nachkommenschaft |
US6111398A (en) | 1997-07-03 | 2000-08-29 | Coulter International Corp. | Method and apparatus for sensing and characterizing particles |
BR9704313A (pt) | 1997-07-08 | 1999-04-06 | Alves Elias Walter | Utilização de ig-y de ovo de galinha associado a anticorpos monoclonais contra antigenos sexo especifico na imunosexagem de espermatozóides de bovinos |
US5899848A (en) | 1997-07-14 | 1999-05-04 | Haubrich; Mark A. | Device and process for artificial insemination of animals |
US5985216A (en) | 1997-07-24 | 1999-11-16 | The United States Of America, As Represented By The Secretary Of Agriculture | Flow cytometry nozzle for high efficiency cell sorting |
US5876942A (en) | 1997-07-24 | 1999-03-02 | National Science Council Of Republic Of China | Process for sexing cow embryos |
US5985538A (en) | 1997-08-01 | 1999-11-16 | Saint Barnabas Medical Center | Cryopreservation and cell culture medium comprising less than 50 mM sodium ions and greater than 100 mM choline salt |
US5819948A (en) | 1997-08-21 | 1998-10-13 | Van Den Engh; Gerrit J. | Particle separating apparatus and method |
US6003678A (en) | 1997-08-21 | 1999-12-21 | University Of Washington | Particle separating apparatus and method |
US5880474A (en) | 1997-08-29 | 1999-03-09 | Becton Dickinson And Company | Multi-illumination-source flow particle analyzer with inter-location emissions crosstalk cancelation |
AU9247598A (en) | 1997-09-22 | 1999-04-12 | University Of Guelph | Reduction of sperm sensitivity to chilling |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US5965321A (en) | 1997-09-25 | 1999-10-12 | E. U. Du Pont De Nemours And Company | Peel-apart photosensitive elements and their process of use |
JP3735190B2 (ja) * | 1997-10-28 | 2006-01-18 | オリンパス株式会社 | 走査型サイトメータ |
US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
WO1999026186A1 (en) | 1997-11-19 | 1999-05-27 | University Of Washington | High throughput optical scanner |
US6086574A (en) | 1997-11-21 | 2000-07-11 | Hyclone Laboratories, Inc. | Fluid delivery systems with diptube connector |
US5895764A (en) | 1997-11-24 | 1999-04-20 | University Of New Mexico | Controlled sheath flow injection cytometry |
US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US5986216A (en) | 1997-12-05 | 1999-11-16 | Hubbell Incorporated | Reinforced insulator |
WO1999031488A1 (en) | 1997-12-12 | 1999-06-24 | Chemunex S.A. | Digital flow cytometer |
US6071689A (en) * | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
WO1999038883A1 (en) | 1998-02-03 | 1999-08-05 | Xy, Inc. | Specific oligonucleotide primers for detection of bovine male chromosome presence by polymerase chain reaction and method |
SE9800360D0 (sv) * | 1998-02-06 | 1998-02-06 | Goeteborg University Science I | Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules |
AU775339B2 (en) | 1998-02-20 | 2004-07-29 | Dako Colorado, Inc. | A vibratory system for a sorting flow cytometer |
US6746873B1 (en) | 1998-02-20 | 2004-06-08 | Xy, Inc. | Vibratory system for a sorting flow cytometer |
US6154276A (en) | 1998-02-23 | 2000-11-28 | The Regents Of The University Of California | Waveguide detection of right-angle-scattered light in flow cytometry |
US6281018B1 (en) | 1998-02-26 | 2001-08-28 | Coulter International Corp. | Selective purification and enrichment sorting of flow cytometer droplets based upon analysis of droplet precursor regions |
US6211477B1 (en) | 1998-02-26 | 2001-04-03 | Becton Dickinson And Company | Electrostatic deceleration system for flow cytometer |
US6248590B1 (en) | 1998-02-27 | 2001-06-19 | Cytomation, Inc. | Method and apparatus for flow cytometry |
US6723290B1 (en) * | 1998-03-07 | 2004-04-20 | Levine Robert A | Container for holding biologic fluid for analysis |
US6042025A (en) * | 1998-03-13 | 2000-03-28 | Smith Et Al. | Two hole dispenser with baffles |
US6371331B1 (en) | 1998-03-16 | 2002-04-16 | Partec Partikelzahlgerate Gmbh | Electronic apparatus for dispensing precise small quantities of fluid |
JP3594794B2 (ja) | 1998-03-24 | 2004-12-02 | 独立行政法人 科学技術振興機構 | ナノ秒時間ゲート分光診断装置 |
US6642018B1 (en) | 1998-03-27 | 2003-11-04 | Oncosis Llc | Method for inducing a response in one or more targeted cells |
AU760291B2 (en) | 1998-03-30 | 2003-05-08 | Bioshaf | Flow cytometer for analysis of general diagnostic factors in cells and body fluids |
US6175409B1 (en) | 1999-04-02 | 2001-01-16 | Symyx Technologies, Inc. | Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers |
JP3350442B2 (ja) | 1998-04-09 | 2002-11-25 | 科学技術振興事業団 | 顕微鏡システム |
CA2640578A1 (en) * | 1998-05-14 | 1999-11-18 | Luminex Corporation | Multi-analyte diagnostic system and computer implemented process for same |
JP3946444B2 (ja) | 1998-05-14 | 2007-07-18 | ルミネックス コーポレイション | フローサイトメータのデッドタイムをゼロにする構成および方法 |
WO1999060397A1 (en) | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
AU763433B2 (en) | 1998-05-22 | 2003-07-24 | California Institute Of Technology | Microfabricated cell sorter |
US6079836A (en) | 1998-07-20 | 2000-06-27 | Coulter International Corp. | Flow cytometer droplet break-off location adjustment mechanism |
JP2002521043A (ja) * | 1998-07-30 | 2002-07-16 | エックスワイ,インコーポレイテッド | 非外科的人工授精のためのウマシステム |
US20040107150A1 (en) | 1998-07-31 | 2004-06-03 | Chata Biosystems, Inc. Of Colorado | Apparatus and method with vessel for containing/transporting a fluent substance |
US6729369B2 (en) | 1998-07-31 | 2004-05-04 | Chata Biosystems, Inc. | Vessel for containing/transporting a fluent substance |
DE29813921U1 (de) | 1998-08-04 | 1998-10-08 | Kisfeld, Alfons, 48691 Vreden | Vorrichtung zur Besamung von Tieren, insbesondere Sauen |
US6309815B1 (en) | 1998-08-07 | 2001-10-30 | University Of Kansas Medical Center | Composition and method for preparation, storage and activation of large populations of immotile sperm |
GB9817795D0 (en) | 1998-08-14 | 1998-10-14 | Genosis Inc | A method and device for separation and detection of spermatozoa in a sample |
US6087352A (en) | 1998-08-17 | 2000-07-11 | Trout; William E. | Use of Zeranol to modulate reproductive cycles |
ATE376175T1 (de) * | 1998-08-21 | 2007-11-15 | Union Biometrica Inc | Instrument zur analyse und selektiven verteilung von objektproben |
US6326144B1 (en) | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6495333B1 (en) | 1998-09-22 | 2002-12-17 | Becton Dickinson And Company | Flow cytometric, whole blood dendritic cell immune function assay |
US6042052A (en) | 1998-09-25 | 2000-03-28 | Smith; Donald E. | Retractable step fairing for amphibian airplane |
US6208411B1 (en) | 1998-09-28 | 2001-03-27 | Kla-Tencor Corporation | Massively parallel inspection and imaging system |
US6707555B1 (en) | 1998-10-15 | 2004-03-16 | Sysmex Corporation | Optical information measuring apparatus |
US6423505B1 (en) | 1998-12-03 | 2002-07-23 | Becton Dickinson And Company | Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells |
US7649153B2 (en) * | 1998-12-11 | 2010-01-19 | International Business Machines Corporation | Method for minimizing sample damage during the ablation of material using a focused ultrashort pulsed laser beam |
WO2000036396A2 (en) | 1998-12-15 | 2000-06-22 | Union Biometrica, Inc. | Axial pattern analysis and sorting instrument for multicellular organisms employing improved light scatter trigger |
US7116407B2 (en) | 1998-12-15 | 2006-10-03 | Union Biometrica, Inc. | System for axial pattern analysis of multicellular organisms |
US6128133A (en) | 1998-12-22 | 2000-10-03 | Lucent Technologies Inc. | Optical beamsplitter |
EP1018644A2 (en) | 1999-01-06 | 2000-07-12 | Bayer Corporation | Variable rate particle counter and method of use |
US6256096B1 (en) | 1999-01-11 | 2001-07-03 | Softray | Flow cytometry apparatus and method |
US20010006416A1 (en) | 1999-01-11 | 2001-07-05 | Johnson Paul E. | Ribbon flow cytometry apparatus and methods |
US6150119A (en) | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system |
US6671044B2 (en) | 1999-01-25 | 2003-12-30 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells in broad flat flow |
US6580504B1 (en) | 1999-01-25 | 2003-06-17 | Amnis Corporation | Multipass cavity for illumination and excitation of moving objects |
US6707551B2 (en) | 2000-01-24 | 2004-03-16 | Amnis Corporation | Multipass cavity for illumination and excitation of moving objects |
US6473176B2 (en) | 1999-01-25 | 2002-10-29 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
DE60034720T2 (de) | 1999-02-02 | 2008-01-17 | Nipro Corp., Osaka | Röhrchen und Verfahren zum Reinigen und Konzentrieren von Sperma |
US6119465A (en) | 1999-02-10 | 2000-09-19 | Mullens; Patrick L. | Shipping container for storing materials at cryogenic temperatures |
FR2789778B1 (fr) | 1999-02-12 | 2001-09-14 | France Telecom | Procede pour associer des references d'acheminement a des paquets de donnees au moyen d'une memoire trie, et routeur de paquets appliquant ce procede |
US6323632B1 (en) | 1999-08-13 | 2001-11-27 | Coulter International Corp. | Solid state RF oscillator-detector for flow cytometer |
CA2329031C (en) | 1999-02-19 | 2003-09-23 | Idexx Laboratories, Inc. | High numerical aperture flow cytometer and method of using same |
EP1161671B1 (en) | 1999-03-05 | 2016-01-20 | Viking Genetics f.m.b.a. | Determination of sperm concentration and viability for artificial insemination |
US6097485A (en) * | 1999-03-08 | 2000-08-01 | Integrated Waveguides, Inc. | Microchip optical transport technology for use in a personal flow cytometer |
US6114857A (en) | 1999-03-08 | 2000-09-05 | Baker Hughes Incorporated | System and method for monitoring corrosion in oilfield wells and pipelines utilizing time-domain-reflectometry |
EP1169122A2 (en) | 1999-03-24 | 2002-01-09 | Torsana Biosensor A/S | Spatially directed interaction on a solid surface |
FR2791645B1 (fr) | 1999-04-02 | 2001-06-15 | Valois Sa | Echantillon de produit fluide destine a la presse |
US6193647B1 (en) | 1999-04-08 | 2001-02-27 | The Board Of Trustees Of The University Of Illinois | Microfluidic embryo and/or oocyte handling device and method |
US6793387B1 (en) | 1999-05-08 | 2004-09-21 | Chata Biosystems, Inc. | Apparatus for automatic preparation of a mixture and method |
FR2793495B1 (fr) | 1999-05-14 | 2001-08-10 | Imv Technologies | Dilueur pour la cryoconservation de spermatozoides de bovins |
AU770678B2 (en) | 1999-05-17 | 2004-02-26 | Caliper Life Sciences, Inc. | Focusing of microparticles in microfluidic systems |
FR2793708B1 (fr) | 1999-05-21 | 2001-08-03 | Valois Sa | Dispositif de distribution de produit fluide |
US6372506B1 (en) | 1999-07-02 | 2002-04-16 | Becton, Dickinson And Company | Apparatus and method for verifying drop delay in a flow cytometer |
IT1307787B1 (it) | 1999-07-26 | 2001-11-19 | Univ Firenze | Processo per incrementare la motilita' degli spermatozoi e spermatozoia motilita' superiore cosi' ottenuti. |
DE19935766A1 (de) | 1999-07-29 | 2001-02-01 | Friedrich Schiller Uni Jena Bu | Verfahren zur optischen Anregung von Fluorophor-markierter DNA und RNA |
US6664550B2 (en) | 1999-08-30 | 2003-12-16 | Sandia National Laboratories | Apparatus to collect, classify, concentrate, and characterize gas-borne particles |
US6495366B1 (en) | 1999-09-03 | 2002-12-17 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
US6813017B1 (en) | 1999-10-20 | 2004-11-02 | Becton, Dickinson And Company | Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer |
JP2003512616A (ja) * | 1999-10-20 | 2003-04-02 | ベクトン・ディキンソン・アンド・カンパニー | フロー血球計において粒子検出光源としてインコヒーレント光放出半導体デバイスを使用する装置及びその方法 |
US7024316B1 (en) * | 1999-10-21 | 2006-04-04 | Dakocytomation Colorado, Inc. | Transiently dynamic flow cytometer analysis system |
CA2387860A1 (en) * | 1999-10-21 | 2001-04-26 | Cytomation, Inc. | Transiently dynamic flow cytometer analysis system |
US6472153B1 (en) | 1999-10-26 | 2002-10-29 | Epoch Biosciences, Inc. | Hybridization-triggered fluorescent detection of nucleic acids |
US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
EP1234026B1 (en) | 1999-11-30 | 2011-08-17 | Cyntellect, Inc. | Method and apparatus for selectively targeting specific cells within a cell population |
US6263745B1 (en) | 1999-12-03 | 2001-07-24 | Xy, Inc. | Flow cytometer nozzle and flow cytometer sample handling methods |
US6558911B1 (en) | 1999-12-10 | 2003-05-06 | Oregon Health Sciences University | Sperm quality assay |
ATE277566T1 (de) | 2000-01-03 | 2004-10-15 | Iberica De Reproduccion Asisti | Vorrichtung zur künstlichen befruchtung von schweinen |
US6465169B2 (en) | 2000-01-14 | 2002-10-15 | Artemis Pharmaceuticals Gmbh | Method for cryoconservation of Zebrafish sperm |
IT1317724B1 (it) | 2000-01-14 | 2003-07-15 | Istituto Sperimentale Italiano | Procedimento per la produzione di embrioni non umani di sessopredeterminato ad alto valore genetico. |
DE60000132T2 (de) | 2000-01-14 | 2002-11-07 | Artemis Pharmaceuticals Gmbh | Verfahren zur Kryokonservierung von Zebrafisch-Samen |
AU2001234608A1 (en) | 2000-01-28 | 2001-08-07 | Genetrace Systems, Inc. | Methods for analysis of gene expression |
US6587203B2 (en) | 2000-02-17 | 2003-07-01 | Cornell Research Foundation, Inc. | Sort stream stabilizer for flow cytometer |
US6618143B2 (en) | 2000-02-18 | 2003-09-09 | Idexx Laboratories, Inc. | High numerical aperture flow cytometer and method of using same |
US6646742B1 (en) | 2000-02-19 | 2003-11-11 | Mwi, Inc. | Optical device and method for multi-angle laser light scatter |
GB2360360B (en) | 2000-03-14 | 2002-03-20 | Univ Bristol | A method of sorting cells |
JP3587755B2 (ja) | 2000-03-14 | 2004-11-10 | シスメックス株式会社 | 粒子測定装置およびその方法 |
US6482652B2 (en) | 2000-03-23 | 2002-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Biological particle sorter |
WO2001075161A2 (en) | 2000-03-30 | 2001-10-11 | Iowa State University Research Foundation | Genetic markers for improved meat characteristics in animals |
AU2001249820A1 (en) | 2000-04-04 | 2001-10-15 | California Institute Of Technology | Methods and systems for molecular fingerprinting |
EP1290427B1 (en) | 2000-04-11 | 2017-08-23 | ChemoMetec A/S | Method and apparatus for detecting fluorescence of a sample |
EP1147774A1 (en) | 2000-04-20 | 2001-10-24 | Stichting Dienst Landbouwkundig Onderzoek | Method for improving the quality of sperm for artificial insemination of animals |
NZ551401A (en) | 2000-05-09 | 2009-12-24 | Xy Inc | A particle differentiation apparatus which differentiates between X-chromosome bearing and Y-chromosome bearing populations of spermatozoa |
CA2858892C (en) * | 2000-05-09 | 2019-06-11 | Xy, Llc | A particle differentiation apparatus for spermatozoa |
WO2001090295A1 (en) | 2000-05-19 | 2001-11-29 | Cytomation, Inc. | A rapid multi-material sample input system |
US6590911B1 (en) | 2000-06-02 | 2003-07-08 | Coherent, Inc. | Passively modelocked harmonic-generating laser |
US6784981B1 (en) * | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
US6700130B2 (en) * | 2001-06-29 | 2004-03-02 | Honeywell International Inc. | Optical detection system for flow cytometry |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
US6503698B1 (en) | 2000-06-16 | 2003-01-07 | The United States Of America As Represented By The Secretary Of Agriculture | Cryopreservation of swine embryos |
WO2001094908A2 (en) | 2000-06-07 | 2001-12-13 | Lockheed Martin Naval Electronics And Surveillance Systems | System and method to detect the presence of a target organism within an air sample using flow cytometry |
EP1294293A4 (en) | 2000-06-12 | 2009-11-04 | Xy Inc | INTEGRATED FLUID MANAGEMENT SYSTEM USING ISOLATED POPULATIONS OF X- AND Y-CHROMOSOME-CARRYING SPERMATOZOES |
DE10031028B4 (de) | 2000-06-26 | 2008-09-04 | Gnothis Holding Sa | Verfahren zur Selektion von Partikeln |
GB0016920D0 (en) | 2000-07-10 | 2000-08-30 | Univ Cambridge Tech | Decondensation of DNA |
US7193706B2 (en) | 2000-08-02 | 2007-03-20 | Arizona Board Of Regents, Acting On Behalf Of Arizona State University | Computer interfaced scanning fluorescence lifetime microscope applied to directed evolution |
CN1267946C (zh) | 2000-08-10 | 2006-08-02 | 奥斯兰姆施尔凡尼亚公司 | 在使用期限内具有降低的色移的显示器件 |
US20040005582A1 (en) | 2000-08-10 | 2004-01-08 | Nanobiodynamics, Incorporated | Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators |
EP1315418A4 (en) | 2000-08-10 | 2004-01-14 | Gtc Biotherapeutics Inc | SPERM CRYOPRESERVATION |
FR2813283B1 (fr) | 2000-08-25 | 2003-02-14 | Valois Sa | Distributeur a pompe integree |
FR2813182A1 (fr) * | 2000-08-29 | 2002-03-01 | Saadollah Moazzezi | Methode pour concentrer des spermatozoides mobiles dans un liquide, et dispositif de mise en oeuvre |
EP1190684A1 (en) | 2000-09-05 | 2002-03-27 | Universiteit Gent | Device and method for artificial insemination of bovines and other animals |
US20020028434A1 (en) | 2000-09-06 | 2002-03-07 | Guava Technologies, Inc. | Particle or cell analyzer and method |
PL366083A1 (en) | 2000-09-08 | 2005-01-24 | Iowa State University Research Foundation, Inc. | Novel prkag3 alleles and use of the same as genetic markers for reproductive and meat quality traits |
EP1334347A1 (en) | 2000-09-15 | 2003-08-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
GB0023041D0 (en) | 2000-09-20 | 2000-11-01 | Univ Manchester | Identification apparatus |
CN1325909C (zh) | 2000-09-27 | 2007-07-11 | 清华大学 | 用于微粒操纵与微粒导向的装置及其使用方法 |
WO2002026114A2 (en) | 2000-09-27 | 2002-04-04 | Bitensky Mark W | Cellular diagnostic arrays, methods of using and processes for producing same |
BR0005045A (pt) | 2000-09-28 | 2002-05-14 | Marcos Fernando De Resende Mat | Método para sexagem de espermatozóides usando a via clássica do sistema complemento, com eliminação da via alternativa pela inativação da proteina "b" |
US7258774B2 (en) | 2000-10-03 | 2007-08-21 | California Institute Of Technology | Microfluidic devices and methods of use |
US20040031071A1 (en) | 2000-10-05 | 2004-02-12 | Xy, Inc. | System of hysteroscopic insemination of mares |
NZ525667A (en) | 2000-10-05 | 2005-07-29 | Xy Inc | System of hysteroscopic insemination of mammals especially mares |
AU2002211913A1 (en) | 2000-10-12 | 2002-04-22 | Amnis Corporation | Multipass cavity for illumination and excitation of moving objects |
JP2004537712A (ja) | 2000-10-18 | 2004-12-16 | バーチャル・アレイズ・インコーポレーテッド | 多重細胞分析システム |
SG160186A1 (en) | 2000-10-23 | 2010-04-29 | Medical Instill Tech Inc | Fluid dispenser having a rigid vial and flexible inner bladder |
CA2428326A1 (en) | 2000-11-09 | 2002-05-16 | University Of Guelph | Mammalian sex selection using genetic modification |
US6667459B1 (en) | 2000-11-21 | 2003-12-23 | Hypertherm, Inc. | Configurable nozzle baffle apparatus and method |
AU1980202A (en) | 2000-11-22 | 2002-06-03 | Pharmacia Corporation | Methods and apparatus for producing gender enriched sperm |
SE0004777D0 (sv) * | 2000-12-22 | 2000-12-22 | Amersham Pharm Biotech Ab | Separation of X-and Y-sperm cells |
AU2002220018A1 (en) | 2000-11-29 | 2002-06-11 | Colorado State University | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
US20020064808A1 (en) | 2000-11-29 | 2002-05-30 | Mutz Mitchell W. | Focused acoustic energy for ejecting cells from a fluid |
US6849423B2 (en) | 2000-11-29 | 2005-02-01 | Picoliter Inc | Focused acoustics for detection and sorting of fluid volumes |
US20020064809A1 (en) | 2000-11-29 | 2002-05-30 | Mutz Mitchell W. | Focused acoustic ejection cell sorting system and method |
US20050048563A1 (en) | 2000-11-30 | 2005-03-03 | Novasite Pharmaceuticals, Inc | Membrane molecule indicator compositions and methods |
US6576291B2 (en) | 2000-12-08 | 2003-06-10 | Massachusetts Institute Of Technology | Preparation of nanocrystallites |
EP1352237A4 (en) | 2000-12-15 | 2009-03-04 | Beckman Coulter Inc | ELECTROCONDUCTIVE CONTAINMENT SYSTEM |
US6577387B2 (en) | 2000-12-29 | 2003-06-10 | Johnson & Johnson Vision Care, Inc. | Inspection of ophthalmic lenses using absorption |
EP1355887B1 (fr) | 2001-01-29 | 2007-08-15 | Universite De Geneve | Derives d'acyclonucleosides pyrimidiniques, leur procede de preparation et leur utilisation |
US6673095B2 (en) | 2001-02-12 | 2004-01-06 | Wound Healing Of Oklahoma, Inc. | Apparatus and method for delivery of laser light |
US7029916B2 (en) | 2001-02-21 | 2006-04-18 | Maxcyte, Inc. | Apparatus and method for flow electroporation of biological samples |
US6760587B2 (en) | 2001-02-23 | 2004-07-06 | Qualcomm Incorporated | Forward-link scheduling in a wireless communication system during soft and softer handoff |
CA2440592C (en) | 2001-03-12 | 2012-05-15 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Oxidation-reduction sensitive green fluorescent protein variants |
US6797139B2 (en) | 2001-03-19 | 2004-09-28 | Applera Corporation | Detection cell for guiding excitation light therein and method for using same |
US6706163B2 (en) | 2001-03-21 | 2004-03-16 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
US20050081256A1 (en) | 2001-03-22 | 2005-04-14 | Forsberg Erik J. | Sex- specific selection of sperm from transgenic animals |
EP1245944B1 (en) | 2001-03-29 | 2007-02-14 | Sysmex Corporation | Flow cytometer |
AU2002251449B2 (en) | 2001-03-29 | 2008-01-31 | Cellect Technologies Corp. | Methods devices and systems for sorting and separating particles |
US6674525B2 (en) | 2001-04-03 | 2004-01-06 | Micronics, Inc. | Split focusing cytometer |
JP2002311027A (ja) | 2001-04-09 | 2002-10-23 | Hitachi Software Eng Co Ltd | ビーズ、ビーズ製造方法、フローサイトメータ及びプログラム |
US7043500B2 (en) * | 2001-04-25 | 2006-05-09 | Board Of Regents, The University Of Texas Syxtem | Subtractive clustering for use in analysis of data |
US6416190B1 (en) | 2001-04-27 | 2002-07-09 | University Of Chicago | Apparatus for using optical tweezers to manipulate materials |
US20020186375A1 (en) | 2001-05-01 | 2002-12-12 | Asbury Charles L. | Device and methods for detecting samples in a flow cytometer independent of variations in fluorescence polarization |
KR100938061B1 (ko) | 2001-05-10 | 2010-01-21 | 아크조 노벨 엔.브이. | 무기 고체 입자들의 효과적인 전환을 위한 연속 방법 및장치 |
WO2002092161A1 (en) | 2001-05-10 | 2002-11-21 | Biophan, Llc | Miniaturized particle analyzer |
US7345758B2 (en) | 2001-05-17 | 2008-03-18 | Cytopeia | Apparatus for analyzing and sorting biological particles |
WO2002092247A1 (en) | 2001-05-17 | 2002-11-21 | Cytomation, Inc. | Flow cytometer with active automated optical alignment system |
US20020182590A1 (en) | 2001-05-25 | 2002-12-05 | Vanderbilt University | Determining protein function in cell culture using RNA interference |
US20030048433A1 (en) | 2001-06-01 | 2003-03-13 | Jean-Marie Desjonqueres | Cytometer signal processing system and method |
FR2825987B1 (fr) | 2001-06-19 | 2003-12-12 | Valois Sa | Distributeur de produit fluide |
JP4903319B2 (ja) | 2001-07-11 | 2012-03-28 | 日本電気株式会社 | 移動局及び周波数帯域検出方法 |
US7704728B2 (en) | 2001-07-18 | 2010-04-27 | The University Of Michigan | Microfluidic gravity pump with constant flow rate |
US7105355B2 (en) * | 2001-07-18 | 2006-09-12 | The Regents Of The University Of Michigan | Flow cytometers and detection system of lesser size |
FR2828281B1 (fr) | 2001-08-02 | 2004-12-31 | Biocytex | Dispositif pour l'analyse d'un echantillon notamment par cytometrie de flux |
AU2002320399A1 (en) | 2001-09-01 | 2003-03-18 | Pharmacia Corporation | Staining and sorting genomes and chromosomes using sequence-specific polyamides |
DE10151216A1 (de) | 2001-10-16 | 2003-04-24 | Zeiss Carl Jena Gmbh | Verfahren zur optischen Erfassung von charakteristischen Größen einer beleuchteten Probe |
US20030078703A1 (en) | 2001-10-19 | 2003-04-24 | Surromed, Inc. | Cytometry analysis system and method using database-driven network of cytometers |
US6838289B2 (en) | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
US6831279B2 (en) | 2001-11-27 | 2004-12-14 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Laser diode-excited biological particle detection system |
CN1322755C (zh) | 2001-12-18 | 2007-06-20 | 汤姆森许可公司 | 为联网设备的设置菜单生成图文显示的方法和设备 |
JP4263895B2 (ja) | 2001-12-20 | 2009-05-13 | ジョンソンディバーシー株式会社 | 液切れセンサおよびそれを用いた液体供給装置 |
AU2002363895A1 (en) | 2001-12-31 | 2003-07-15 | Institut Fur Physikalische Hochtechnologie E.V. | Cell sorting system for the size-based sorting or separation of cells suspended in a flowing fluid |
AU2002361220A1 (en) | 2001-12-31 | 2003-07-15 | Institut Fur Physikalische Hochtechnologie E.V. | Micro-recess array for size-dependent sorting or separation of cells suspended in a flowing medium and method for analysing the functional activity of individual cells |
US6780377B2 (en) | 2002-01-22 | 2004-08-24 | Dakocytomation Denmark A/S | Environmental containment system for a flow cytometer |
US6698627B2 (en) | 2002-02-19 | 2004-03-02 | Valois S.A.S. | Fluid dispenser |
US6849394B2 (en) | 2002-02-21 | 2005-02-01 | Minitube Of America | Compositions comprising reproductive cell media and methods for using such compositions |
AU2003219836A1 (en) | 2002-02-27 | 2003-09-09 | The Regents Of The University Of Michigan | Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor |
US7223371B2 (en) | 2002-03-14 | 2007-05-29 | Micronics, Inc. | Microfluidic channel network device |
US20030175980A1 (en) | 2002-03-14 | 2003-09-18 | Hayenga Jon W. | Ribbon flow cytometry and cell sorting |
EP1345026B1 (en) * | 2002-03-15 | 2010-05-05 | Affymetrix, Inc. | System and method for scanning of biological materials |
JP2004000144A (ja) | 2002-03-29 | 2004-01-08 | Aisin Seiki Co Ltd | 細胞分離選別装置、細胞整列用基板 |
US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
JP4196577B2 (ja) * | 2002-04-05 | 2008-12-17 | ニプロ株式会社 | 精液濾過フィルター |
GB0214340D0 (en) | 2002-06-21 | 2002-07-31 | Multipex Photonics Ltd | Apparatus for characterising a sample by an optical pulse |
CA2490334A1 (en) | 2002-06-28 | 2004-01-08 | Monsanto Technology Llc | Swine genetics business system |
WO2004006916A1 (en) | 2002-07-10 | 2004-01-22 | Applied Research Systems Ars Holding Nv | Use of compounds for increasing spermatozoa motility |
CN1787739B (zh) | 2002-07-22 | 2011-03-30 | Xy有限责任公司 | 精子处理系统 |
CA2532376C (en) | 2002-08-01 | 2015-05-12 | Colorado State University Research Foundation | Low pressure sperm cell separation system |
BRPI0313476B1 (pt) | 2002-08-15 | 2015-06-23 | Xy Llc | Citômetro de fluxo de alta resolução |
US6598499B1 (en) | 2002-09-10 | 2003-07-29 | Illinois Tool Works Inc. | Universal setting tool for adhesively bonded rebar and threaded rod anchors |
US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
JP3983151B2 (ja) | 2002-09-25 | 2007-09-26 | ダイワ精工株式会社 | 魚釣用スピニングリール |
US20040061853A1 (en) | 2002-09-27 | 2004-04-01 | Blasenheim Barry J. | Prism-based flow cytometry excitation optics |
US7201875B2 (en) | 2002-09-27 | 2007-04-10 | Becton Dickinson And Company | Fixed mounted sorting cuvette with user replaceable nozzle |
US6941005B2 (en) | 2002-11-01 | 2005-09-06 | Coulter International Corp. | Monitoring and control of droplet sorting |
AU2003298682A1 (en) | 2002-11-20 | 2004-06-15 | University Of Virginia Patent Foundation | Isolation of sperm cells from other biological materials using microfabricated devices and related methods thereof |
WO2004059282A2 (en) | 2002-12-19 | 2004-07-15 | Monsanto Technology Llc | Method and means for early detection of pregnancy in animals by combination testing |
EP1845529B1 (en) | 2003-02-19 | 2011-05-04 | Panasonic Corporation | Recording medium, playback apparatus and recording method |
CA2752312C (en) | 2003-03-28 | 2018-06-19 | Inguran, Llc | Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm |
MX345105B (es) * | 2003-03-28 | 2017-01-16 | Inguran Llc * | Método de fotodaño para separar partículas. |
EP1608382B1 (en) | 2003-03-28 | 2007-08-15 | Monsanto Technology LLC | Process for the staining of sperm |
CN1232231C (zh) | 2003-04-10 | 2005-12-21 | 李喜和 | 以精子分离、胚胎性别鉴定为基础的家畜性别控制方法 |
AU2004242121B2 (en) | 2003-05-15 | 2010-06-24 | Xy, Llc. | Efficient haploid cell sorting for flow cytometer systems |
US20050011582A1 (en) | 2003-06-06 | 2005-01-20 | Haug Jeffrey S. | Fluid delivery system for a flow cytometer |
US7460223B2 (en) * | 2003-09-19 | 2008-12-02 | Applied Biosystems Inc. | Inverted orientation for a microplate |
US7603199B2 (en) | 2003-11-27 | 2009-10-13 | Honda Motor Co., Ltd. | Control device for mobile body |
NZ530972A (en) | 2004-02-05 | 2005-04-29 | Embrionics Ltd | A method and apparatus for orientating and selecting cells |
AU2005228893B2 (en) | 2004-03-29 | 2010-08-19 | Inguran, Llc | Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations |
DE602005018907D1 (de) | 2004-03-29 | 2010-03-04 | Inguran Llc | Verwendung einer oxidations-/reduktionsreaktionen intrazellulär und/oder extrazellulär regulierenden zusammensetzung in einem anfärbe- oder sortierungsverfahren für spermatozoen |
JP2008507287A (ja) | 2004-07-22 | 2008-03-13 | モンサント テクノロジー エルエルシー | 精子細胞の集団を富化する方法 |
USRE46559E1 (en) | 2004-07-27 | 2017-09-26 | Beckman Coulter, Inc. | Enhancing flow cytometry discrimination with geometric transformation |
US20060118167A1 (en) | 2004-12-03 | 2006-06-08 | Xy, Inc. | Pressure regulated continuously variable volume container for fluid delivery |
US20060147894A1 (en) | 2004-12-30 | 2006-07-06 | Vicam, L.P. | Jacketed vessel for holding semen for sex biasing mammals through artificial insemination and systems and methods for enhancing the probability of sex biasing using the same |
US7527605B2 (en) | 2005-06-28 | 2009-05-05 | Ethicon Endo-Surgery, Inc. | Medical-balloon inflator |
US7591064B2 (en) | 2005-07-20 | 2009-09-22 | Hitachi Global Storage Technologies Netherlands B.V. | Method of fabrication for tape medium read head with unitary formation of multiple elements |
US7618770B2 (en) | 2005-07-29 | 2009-11-17 | Xy, Inc. | Methods and apparatus for reducing protein content in sperm cell extenders |
JPWO2007029538A1 (ja) | 2005-09-02 | 2009-03-19 | 国立大学法人京都大学 | 2次元フォトニック結晶面発光レーザ光源 |
EP1954303A2 (en) * | 2005-10-19 | 2008-08-13 | Scott Josephson | Improved reproductive management |
JP4126065B2 (ja) | 2006-01-17 | 2008-07-30 | 株式会社 丸 七 製 作 所 | 精米機用残留米排出装置、およびそれを用いた精米機 |
DE102006035136A1 (de) | 2006-07-29 | 2008-01-31 | Evonik Degussa Gmbh | Zink und Mangan enthaltende Oxidpartikel |
JP4126081B1 (ja) | 2007-08-17 | 2008-07-30 | 株式会社柳沢技研 | 傾斜微細孔加工方法 |
PL2304020T3 (pl) | 2008-06-30 | 2019-06-28 | Microbix Biosystems Inc. | Sposób i urządzenie do sortowania komórek |
JP5078929B2 (ja) | 2009-03-17 | 2012-11-21 | 三井造船株式会社 | セルソータおよびサンプル分別方法 |
US9470617B2 (en) | 2010-04-07 | 2016-10-18 | Sony Corporation | Flow cytometry apparatus |
-
2004
- 2004-03-29 MX MX2012005672A patent/MX345105B/es unknown
- 2004-03-29 CA CA2518882A patent/CA2518882C/en not_active Expired - Lifetime
- 2004-03-29 EP EP10184283.9A patent/EP2298231B1/en not_active Expired - Lifetime
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